WO2024201530A1 - Dispositif de dosage programmable et procédé associé - Google Patents

Dispositif de dosage programmable et procédé associé Download PDF

Info

Publication number
WO2024201530A1
WO2024201530A1 PCT/IN2024/050336 IN2024050336W WO2024201530A1 WO 2024201530 A1 WO2024201530 A1 WO 2024201530A1 IN 2024050336 W IN2024050336 W IN 2024050336W WO 2024201530 A1 WO2024201530 A1 WO 2024201530A1
Authority
WO
WIPO (PCT)
Prior art keywords
feeding disc
apertures
flowable
dosing device
hopper
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2024/050336
Other languages
English (en)
Inventor
Karan Singh
Werner Bongers
Mahesh Barde
Shashank PAWAR
Rohit Yadav
Jitendra MESTRY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vantage Nutrition LLP
Scitech Centre
Original Assignee
Vantage Nutrition LLP
Scitech Centre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vantage Nutrition LLP, Scitech Centre filed Critical Vantage Nutrition LLP
Publication of WO2024201530A1 publication Critical patent/WO2024201530A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations

Definitions

  • the present disclosure pertains to the field of a metering device for metering and dispensing contents into capsules.
  • capsules are manufactured in various sizes and shapes comprising a capsule cap and a capsule body.
  • the capsule cap is introduced into the capsule body or vice versa.
  • Capsules are generally oblong in shape, vary in size, and can be assembled using a variety of structures and methods.
  • a capsule cap is telescopically fitted onto the capsule body such that a radially inward projecting ring defined by the capsule cap is introduced into a radial groove define by the capsule body.
  • the capsule cap and capsule body can be configured such that a friction fit between the two components can be achieved when they are assembled.
  • the capsule cap is capable of being removed from the capsule body in order to introduce material, such as powders or granules, coated pellets, tablets, micro-tablets, smaller capsules, and various combinations of any of the mentioned forms. It is also possible to fill liquids, provided that the material of the capsule (generally gelatin, although there are other alternatives) is not soluble in the solvent used in the formulation. Subsequently, the capsule cap can be releasably attached to the capsule body to seal the material within the capsule such that the capsule can be used. [0003] Once the medication or other powdered, granular, or liquid material has been placed in the capsule bodies, the caps of the capsule shells are concurrently replaced on to the open mouths of the capsule body shells. The caps and the bodies are then concurrently pressed toward each other a sufficient distance so that the annular, radially inwardly protruding ring on each capsule cap engages the outwardly facing annular groove on the outer wall of a capsule body.
  • material such as powders or gran
  • Capsule fillers are invented to facilitate the capsule filling process.
  • traditional capsule fillers there are several drawbacks with traditional capsule fillers.
  • all of the capsules in the capsule receiving holes are filled; even not all the capsules are actually required. In this case, empty capsules are made, which will cause the capsules damage by repeating quite often a time.
  • the demand of customized drug capsulation is increasing. Drug customization is needed because different drugs are applied for different disease treatment. Such customised capsules require a precise dosing of the medicaments into the capsules.
  • a capsule filling machine according to the "Gravitation System” is almost similar to that of the "Die Compression System” in its mechanical aspects.
  • the application of the “Gravitation System” machine is however restricted to the granular material, such as, granules and fine granules which have excellent fluidity, and the machine is hardly applicable to the handling of the powdery material which has poor fluidity.
  • the machine is generally composed of a metering chamber of a predetermined capacity provided on its metering disk. The granular material piled up on the upper surface of the disk is gravitated down into the chamber wherein the material is portioned. In the next step, the portioned material in the metering chamber is then allowed to fall down into the body of the hard gelatin capsule positioned under the outlet of the metering chamber with virtually no artificial force.
  • the adjustment on the capacity of the metering chamber is usually performed by lateral insertion of a capacity-restricting means, for instance, a comb-teeth type device, into the metering chamber.
  • a capacity-restricting means for instance, a comb-teeth type device
  • Application of this type of adjustment is, however, restricted to a machine having metering chambers of just two rows at most. Therefore, the adjustment in a machine having the chambers in three or more rows must have been made by interchanging the metering disks of various thickness.
  • the present invention is directed to a dosing device for repeatedly dosing volumetrically measured amounts of flowable material.
  • the device of the present invention has a hopper with a spout for storing the flowable flowable material.
  • the device further has a movable feeding disc beneath the hopper.
  • the movable feeding disc is rotatable about a vertical axis.
  • the movable feeding disc is provided with a plurality of cross sectionally round apertures at the periphery of the movable feeding disc.
  • the device further has a stationary bottom plate positioned below the movable feeding disc, the stationary bottom plate comprises a dispending port through which flowable flowable material is dispensed from the dosing device.
  • the device has a capsule body holder adapted to receive the volumetrically measured amount of flowable material through the dispending port. Furthermore, the device also comprises a drive motor comprising an electric motor which is connected to drive a geneva drive mechanism and being adapted to effect relative movement of the movable feeding disc to sequentially bring each aperture in communication with the dispensing port.
  • a method of dosing volumetrically measured amounts of flowable flowable material into capsules whereby the method has the steps of dropping, a pre-determined amount of flowable flowable material from a hopper to upper surface of a movable feeding disc.
  • the method includes rotating a feeding disc by a drive motor such that the flowable material travels down into a plurality of apertures.
  • the method involves rotating the feeding disc and scrapping the excess flowable material from the apertures by means of a scrapper means when the feeding disc reaches the scrapper means thereby creating a metered dose in the apertures.
  • the next step includes rotating the feeding disc and dispensing the metered dose radially from the apertures through a dispensing port into a capsule body holder comprising a capsule body; wherein the dispensing occurs when the feeding disc the apertures and the dispensing port come in line with each other.
  • FIGURE 1 illustrates a programmable dosing device in accordance with an embodiment of the invention.
  • FIGURE 2 illustrates a movable feeding disc in accordance with an embodiment of the invention.
  • FIGURE 3 illustrates a programmable dosing device in accordance with an embodiment of the invention.
  • FIGURE 4 shows a method of dosing volumetrically measured amounts of flowable material into capsules in accordance with an embodiment of the invention.
  • the numbers expressing quantities of ingredients, properties such as concentration, and so forth, used to describe and claim certain embodiments of the invention are to be understood as being modified in some instances by the term “about.” Accordingly, in some embodiments, the numerical parameters set forth in the written description are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable.
  • the drive motor 103 is below the feeding disc 105.
  • the drive motor 103 comprises an electric motor which is connected to drive a geneva drive mechanism which, in turn, effects rotation of feeding disc 105 in the pre-determined direction.
  • the drive motor 103 runs continually but the geneva drive mechanism ensures the feeding disc 105 rotates at a predetermined maximum speed, slows down, momentarily stops, speeds up, and resumes maximum speed.
  • the device also comprises a stationary horizontally disposed bottom plate (not shown in the figure) below the feeding disk 105 and having a material dispensing hole (not shown in the figure) therethrough beneath which the capsule body holder 113 passes.
  • the dispensing hole is offset or displaced from (i.e., not in registering with) the hopper funnel.
  • the apertures 109 receive the flowable material such that the bottom plate cooperates with the feeding disc 105 to close off the lower end of the apertures 109 and thereby define a chamber of predetermined volume into which flowable material is received.
  • the flowable material filled apertures 109 passes through the scrapper 107.
  • the scrapper 107 operates to level off or sweep away any excess flowable material protruding from the flowable material filled apertures 109 so that only a predetermined measured volume of material remains in the apertures 109.
  • the flowable material filled apertures 109 moves into registry with the dispensing hole in the bottom plate, momentarily stops thereat and the flowable material falls through the dispensing hole into a capsule body in the capsule body holder 113, whereupon upper plate rotation resumes to repeat the cycle.
  • the production capacity of the device 100 can be increased by providing a plurality of spaced-apart apertures in the feeding disc which are circumferentially arranged around the axis of rotation of the feeding disc. Further productivity increases can be achieved by using a feeding disc having a plurality of apertures and by providing two or more circumferentially spaced apart hoppers and corresponding plurality of circumferentially spaced apart dispensing holes in the bottom plate.
  • programmable dosing device 100 may be provided with a housing (not shown) to confine and contain any stray material escaping from feeding disk 105 or from between the apertures 109 thereby prevent the material from contaminating the area round the device 100.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Basic Packing Technique (AREA)

Abstract

La présente divulgation se réfère à un dispositif de dosage pour doser et distribuer des contenus dans des capsules. Le dispositif (100) représenté dans la figure 1 permet de doser et de distribuer des contenus dans des capsules. La matière fluide peut, par exemple, se présenter sous la forme de produits pulvérulents ou granulaires tels que des pastilles, des micro-comprimés ou analogue.
PCT/IN2024/050336 2023-03-31 2024-03-29 Dispositif de dosage programmable et procédé associé Ceased WO2024201530A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202321024916 2023-03-31
IN202321024916 2023-03-31

Publications (1)

Publication Number Publication Date
WO2024201530A1 true WO2024201530A1 (fr) 2024-10-03

Family

ID=92904155

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2024/050336 Ceased WO2024201530A1 (fr) 2023-03-31 2024-03-29 Dispositif de dosage programmable et procédé associé

Country Status (1)

Country Link
WO (1) WO2024201530A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200078269A1 (en) * 2018-09-06 2020-03-12 Scitech Centre Tamping assembly

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200078269A1 (en) * 2018-09-06 2020-03-12 Scitech Centre Tamping assembly

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