WO2024254340A3 - Microfluidic integrated cmos based impedance array biosensor - Google Patents

Microfluidic integrated cmos based impedance array biosensor Download PDF

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Publication number
WO2024254340A3
WO2024254340A3 PCT/US2024/032858 US2024032858W WO2024254340A3 WO 2024254340 A3 WO2024254340 A3 WO 2024254340A3 US 2024032858 W US2024032858 W US 2024032858W WO 2024254340 A3 WO2024254340 A3 WO 2024254340A3
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WO
WIPO (PCT)
Prior art keywords
fluidic system
electrode
electrode array
electronic component
detection circuit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/032858
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French (fr)
Other versions
WO2024254340A2 (en
Inventor
Nam-Seog Kim
Jungkyu KIM
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University of Utah Research Foundation Inc
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University of Utah Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation Inc filed Critical University of Utah Research Foundation Inc
Priority to KR1020267000116A priority Critical patent/KR20260018969A/en
Priority to EP24820056.0A priority patent/EP4724205A2/en
Publication of WO2024254340A2 publication Critical patent/WO2024254340A2/en
Publication of WO2024254340A3 publication Critical patent/WO2024254340A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/028—Circuits therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/27—Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Electrochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

A point-of-care diagnostic device configured to measure characteristics of a biological sample. The point-of-care device includes an electronic component package and a complementary metal-oxide-semiconductor (CMOS) biosensor formed on the electronic component package. The CMOS biosensor includes a fluidic system, an electrode array in fluid communication with the fluidic system, and an impedance detection circuit in electrical communication with the electrode detection circuit. The fluidic system is formed on the electronic component package and is configured to transport fluid. The electrode array in fluid communication with the fluidic system and includes a plurality of electrode pairs. The electrode array having a surface coating with an antibody. The impedance detection circuit is in electrical communication with the electrode array and is configured to detect an electrical impedance change caused by a binding of the biological sample to the antibody on each of the electrode pairs.
PCT/US2024/032858 2023-06-06 2024-06-06 Microfluidic integrated cmos based impedance array biosensor Ceased WO2024254340A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020267000116A KR20260018969A (en) 2023-06-06 2024-06-06 Integrated microfluidic CMOS-based impedance array biosensor
EP24820056.0A EP4724205A2 (en) 2023-06-06 2024-06-06 Microfluidic integrated cmos based impedance array biosensor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363471375P 2023-06-06 2023-06-06
US63/471,375 2023-06-06

Publications (2)

Publication Number Publication Date
WO2024254340A2 WO2024254340A2 (en) 2024-12-12
WO2024254340A3 true WO2024254340A3 (en) 2025-04-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/032858 Ceased WO2024254340A2 (en) 2023-06-06 2024-06-06 Microfluidic integrated cmos based impedance array biosensor

Country Status (3)

Country Link
EP (1) EP4724205A2 (en)
KR (1) KR20260018969A (en)
WO (1) WO2024254340A2 (en)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6443179B1 (en) * 2001-02-21 2002-09-03 Sandia Corporation Packaging of electro-microfluidic devices
US20130271811A1 (en) * 2010-12-15 2013-10-17 Switch Materials, Inc. Variable transmittance optical filter with substantially co-planar electrode system
US20140162308A1 (en) * 2011-05-04 2014-06-12 Texas State University Device and method for identifying microbes and counting microbes and determining antimicrobial sensitivity
US20150060284A1 (en) * 2002-09-24 2015-03-05 Duke University Apparatuses and Methods for Manipulating Droplets
US20170326552A1 (en) * 2014-11-26 2017-11-16 Imec Vzw Compact Fluid Analysis Device and Method to Fabricate
US20190039060A1 (en) * 2017-08-03 2019-02-07 The Board Of Trustees Of The Leland Stanford Junior University Massive microfluidics for multiplexed counting
US10718732B2 (en) * 2007-12-21 2020-07-21 The Trustees Of Columbia University In The City Of New York Active CMOS sensor array for electrochemical biomolecular detection
US20220065807A1 (en) * 2020-09-02 2022-03-03 California Institute Of Technology Multiplexed sensor for ultra-fast and low-cost covid-19 diagnosis and monitoring
WO2022109225A1 (en) * 2020-11-20 2022-05-27 The Trustees Of Princeton University System and method for pneumatic-free electronically driven microfluidics to allow massive scalability with integrated cellular and biomolecular detection
US20220291211A1 (en) * 2021-03-12 2022-09-15 University Of Utah Research Foundation Microfluidic microparticle-labeled impedance sensor array for enhancing bioassay sensitivity

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6443179B1 (en) * 2001-02-21 2002-09-03 Sandia Corporation Packaging of electro-microfluidic devices
US20150060284A1 (en) * 2002-09-24 2015-03-05 Duke University Apparatuses and Methods for Manipulating Droplets
US10718732B2 (en) * 2007-12-21 2020-07-21 The Trustees Of Columbia University In The City Of New York Active CMOS sensor array for electrochemical biomolecular detection
US20130271811A1 (en) * 2010-12-15 2013-10-17 Switch Materials, Inc. Variable transmittance optical filter with substantially co-planar electrode system
US20140162308A1 (en) * 2011-05-04 2014-06-12 Texas State University Device and method for identifying microbes and counting microbes and determining antimicrobial sensitivity
US20170326552A1 (en) * 2014-11-26 2017-11-16 Imec Vzw Compact Fluid Analysis Device and Method to Fabricate
US20190039060A1 (en) * 2017-08-03 2019-02-07 The Board Of Trustees Of The Leland Stanford Junior University Massive microfluidics for multiplexed counting
US20220065807A1 (en) * 2020-09-02 2022-03-03 California Institute Of Technology Multiplexed sensor for ultra-fast and low-cost covid-19 diagnosis and monitoring
WO2022109225A1 (en) * 2020-11-20 2022-05-27 The Trustees Of Princeton University System and method for pneumatic-free electronically driven microfluidics to allow massive scalability with integrated cellular and biomolecular detection
US20220291211A1 (en) * 2021-03-12 2022-09-15 University Of Utah Research Foundation Microfluidic microparticle-labeled impedance sensor array for enhancing bioassay sensitivity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KWEON SOON-JAE; SHIN SEONGHEON; PARK JEONG-HO; SUH JI-HOON; YOO HYUNG-JOUN: "A CMOS low-power polar demodulator for electrical bioimpedance spectroscopy using adaptive self-sampling schemes", 2016 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS), 17 October 2016 (2016-10-17), pages 284 - 287, XP033051067, DOI: 10.1109/BioCAS.2016.7833787 *

Also Published As

Publication number Publication date
EP4724205A2 (en) 2026-04-15
KR20260018969A (en) 2026-02-09
WO2024254340A2 (en) 2024-12-12

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