WO2024254436A3 - Glande de prostate humaine bio-modifiée et modèle de maladie - Google Patents

Glande de prostate humaine bio-modifiée et modèle de maladie Download PDF

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Publication number
WO2024254436A3
WO2024254436A3 PCT/US2024/032983 US2024032983W WO2024254436A3 WO 2024254436 A3 WO2024254436 A3 WO 2024254436A3 US 2024032983 W US2024032983 W US 2024032983W WO 2024254436 A3 WO2024254436 A3 WO 2024254436A3
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WO
WIPO (PCT)
Prior art keywords
channel
region
human prostate
prostate gland
disease model
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/032983
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English (en)
Other versions
WO2024254436A2 (fr
Inventor
Linan Jiang
Cynthia MIRANTI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Arizona
Original Assignee
University of Arizona
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Filing date
Publication date
Application filed by University of Arizona filed Critical University of Arizona
Publication of WO2024254436A2 publication Critical patent/WO2024254436A2/fr
Publication of WO2024254436A3 publication Critical patent/WO2024254436A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne des dispositifs microfluidiques, des plateformes d'organe sur puce (par exemple imitant la glande de la prostate humaine), et leurs utilisations. Le dispositif microfluidique comprend au moins deux couches et une membrane poreuse entre celles-ci. Chaque couche comprend un canal, et le premier canal et le second canal sont alignés de telle sorte qu'une première région d'un premier canal chevauche une région du second canal, et une seconde région du premier canal ne chevauche pas une seconde région du second canal. Un modèle de maladie utilisant les dispositifs microfluidiques comprend (i) le placement d'un premier type de cellules dans le premier canal et (ii) l'écoulement d'un premier milieu de culture cellulaire à travers le premier canal. Facultativement, à l'étape (i), un second type de cellules dans le second canal et à l'étape (ii) un second milieu de culture cellulaire s'écoule à travers le second canal. Les dispositifs microfluidiques peuvent être utilisés dans le criblage et le test de médicaments.
PCT/US2024/032983 2023-06-07 2024-06-07 Glande de prostate humaine bio-modifiée et modèle de maladie Ceased WO2024254436A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363506691P 2023-06-07 2023-06-07
US63/506,691 2023-06-07

Publications (2)

Publication Number Publication Date
WO2024254436A2 WO2024254436A2 (fr) 2024-12-12
WO2024254436A3 true WO2024254436A3 (fr) 2025-05-08

Family

ID=93794630

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/032983 Ceased WO2024254436A2 (fr) 2023-06-07 2024-06-07 Glande de prostate humaine bio-modifiée et modèle de maladie

Country Status (1)

Country Link
WO (1) WO2024254436A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110250585A1 (en) * 2008-07-16 2011-10-13 Children's Medical Center Corporation Organ mimic device with microchannels and methods of use and manufacturing thereof
US20180119081A1 (en) * 2015-04-14 2018-05-03 President And Fellows Of Harvard College Microfluidic Device Having Offset, High-Shear Seeding Channels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110250585A1 (en) * 2008-07-16 2011-10-13 Children's Medical Center Corporation Organ mimic device with microchannels and methods of use and manufacturing thereof
US20180119081A1 (en) * 2015-04-14 2018-05-03 President And Fellows Of Harvard College Microfluidic Device Having Offset, High-Shear Seeding Channels

Also Published As

Publication number Publication date
WO2024254436A2 (fr) 2024-12-12

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