WO2024254518A3 - Compositions de particules d'administration de lipides et leur procédé d'utilisation - Google Patents

Compositions de particules d'administration de lipides et leur procédé d'utilisation Download PDF

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Publication number
WO2024254518A3
WO2024254518A3 PCT/US2024/033099 US2024033099W WO2024254518A3 WO 2024254518 A3 WO2024254518 A3 WO 2024254518A3 US 2024033099 W US2024033099 W US 2024033099W WO 2024254518 A3 WO2024254518 A3 WO 2024254518A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid
delivery particles
lipid delivery
delivery
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/033099
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English (en)
Other versions
WO2024254518A2 (fr
Inventor
Dave PAJEROWSKI
Peter CABECEIRAS
Jeffrey L. Lee
Yi Yu
Karol BUDZIK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nvelop Therapeutics Inc
Original Assignee
Nvelop Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nvelop Therapeutics Inc filed Critical Nvelop Therapeutics Inc
Publication of WO2024254518A2 publication Critical patent/WO2024254518A2/fr
Publication of WO2024254518A3 publication Critical patent/WO2024254518A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente divulgation concerne des particules d'administration de lipides pour l'administration de charges utiles à travers une membrane cellulaire dans la cellule cible. La présente divulgation concerne des particules d'administration de lipides comprenant une membrane lipidique sur le côté extérieur et une protéine chimérique dans le noyau, comprenant un domaine transmembranaire, une charge utile hétérologue et un lieur clivable par une protéase exprimée dans les cellules cibles. Les systèmes et les procédés présentement décrits assurent : la capacité de produire les particules d'administration de lipides et la capacité d'administrer des charges utiles telles que des protéines et des petites molécules dans les cellules cibles.
PCT/US2024/033099 2023-06-07 2024-06-07 Compositions de particules d'administration de lipides et leur procédé d'utilisation Ceased WO2024254518A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363471691P 2023-06-07 2023-06-07
US63/471,691 2023-06-07

Publications (2)

Publication Number Publication Date
WO2024254518A2 WO2024254518A2 (fr) 2024-12-12
WO2024254518A3 true WO2024254518A3 (fr) 2025-03-06

Family

ID=93796415

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/033099 Ceased WO2024254518A2 (fr) 2023-06-07 2024-06-07 Compositions de particules d'administration de lipides et leur procédé d'utilisation

Country Status (1)

Country Link
WO (1) WO2024254518A2 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070196386A1 (en) * 2006-02-21 2007-08-23 Vu Halong N Stable retrovirus and methods of use
US20200308234A1 (en) * 2019-03-29 2020-10-01 Trustees Of Boston University Chimeric antigen receptor (car) modulation
WO2021113772A1 (fr) * 2019-12-06 2021-06-10 Scribe Therapeutics Inc. Systèmes d'administration de particules
US20220193223A1 (en) * 2014-04-23 2022-06-23 Modernatx, Inc. Nucleic acid vaccines
US20220259617A1 (en) * 2019-06-13 2022-08-18 The General Hospital Corporation Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070196386A1 (en) * 2006-02-21 2007-08-23 Vu Halong N Stable retrovirus and methods of use
US20220193223A1 (en) * 2014-04-23 2022-06-23 Modernatx, Inc. Nucleic acid vaccines
US20200308234A1 (en) * 2019-03-29 2020-10-01 Trustees Of Boston University Chimeric antigen receptor (car) modulation
US20220259617A1 (en) * 2019-06-13 2022-08-18 The General Hospital Corporation Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells
WO2021113772A1 (fr) * 2019-12-06 2021-06-10 Scribe Therapeutics Inc. Systèmes d'administration de particules

Also Published As

Publication number Publication date
WO2024254518A2 (fr) 2024-12-12

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