WO2024254562A3 - Domaines lourds variables d'immunoglobuline modifiés ayant une immunogénicité réduite - Google Patents

Domaines lourds variables d'immunoglobuline modifiés ayant une immunogénicité réduite Download PDF

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Publication number
WO2024254562A3
WO2024254562A3 PCT/US2024/033155 US2024033155W WO2024254562A3 WO 2024254562 A3 WO2024254562 A3 WO 2024254562A3 US 2024033155 W US2024033155 W US 2024033155W WO 2024254562 A3 WO2024254562 A3 WO 2024254562A3
Authority
WO
WIPO (PCT)
Prior art keywords
variable heavy
immunoglobulin variable
reduced immunogenicity
modified immunoglobulin
heavy domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2024/033155
Other languages
English (en)
Other versions
WO2024254562A2 (fr
Inventor
Patrick L. LUPARDUS
Deepti ROKKAM
Michael TOTAGRANDE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthekine Inc
Original Assignee
Synthekine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthekine Inc filed Critical Synthekine Inc
Priority to KR1020267000338A priority Critical patent/KR20260021032A/ko
Priority to IL324785A priority patent/IL324785A/en
Priority to AU2024285577A priority patent/AU2024285577A1/en
Publication of WO2024254562A2 publication Critical patent/WO2024254562A2/fr
Publication of WO2024254562A3 publication Critical patent/WO2024254562A3/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente divulgation concerne de manière générale des anticorps à domaine unique (sdAb), tels que des fragments polypeptidiques VH, VHH et scFv, comprenant des modifications C-terminales qui ont une liaison réduite ou éliminée à des anticorps préexistants endogènes, des polypeptides isolés comprenant de telles modifications, des nucléotides codant pour de tels polypeptides, et des procédés d'utilisation de tels polypeptides d'anticorps.
PCT/US2024/033155 2023-06-07 2024-06-07 Domaines lourds variables d'immunoglobuline modifiés ayant une immunogénicité réduite Pending WO2024254562A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020267000338A KR20260021032A (ko) 2023-06-07 2024-06-07 감소된 면역원성을 갖는 변형된 이뮤노글로불린 가변 중쇄 도메인
IL324785A IL324785A (en) 2023-06-07 2024-06-07 Modified immunoglobulin variable heavy domains having reduced immunogenicity
AU2024285577A AU2024285577A1 (en) 2023-06-07 2024-06-07 Modified immunoglobulin variable heavy domains having reduced immunogenicity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363506797P 2023-06-07 2023-06-07
US63/506,797 2023-06-07

Publications (2)

Publication Number Publication Date
WO2024254562A2 WO2024254562A2 (fr) 2024-12-12
WO2024254562A3 true WO2024254562A3 (fr) 2025-03-20

Family

ID=93796476

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/033155 Pending WO2024254562A2 (fr) 2023-06-07 2024-06-07 Domaines lourds variables d'immunoglobuline modifiés ayant une immunogénicité réduite

Country Status (4)

Country Link
KR (1) KR20260021032A (fr)
AU (1) AU2024285577A1 (fr)
IL (1) IL324785A (fr)
WO (1) WO2024254562A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017172981A2 (fr) * 2016-03-29 2017-10-05 University Of Southern California Récepteurs antigéniques chimériques ciblant le cancer
WO2022040586A2 (fr) * 2020-08-21 2022-02-24 Novartis Ag Compositions et méthodes pour la génération in vivo de cellules exprimant car
WO2022061256A2 (fr) * 2020-09-21 2022-03-24 Systimmune, Inc. Complexe de liaison à l'egfr et son procédé de fabrication et d'utilisation
CN115703829A (zh) * 2021-08-16 2023-02-17 厦门大学 针对SARS-CoV-2的单域抗体及其用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017172981A2 (fr) * 2016-03-29 2017-10-05 University Of Southern California Récepteurs antigéniques chimériques ciblant le cancer
WO2022040586A2 (fr) * 2020-08-21 2022-02-24 Novartis Ag Compositions et méthodes pour la génération in vivo de cellules exprimant car
WO2022061256A2 (fr) * 2020-09-21 2022-03-24 Systimmune, Inc. Complexe de liaison à l'egfr et son procédé de fabrication et d'utilisation
CN115703829A (zh) * 2021-08-16 2023-02-17 厦门大学 针对SARS-CoV-2的单域抗体及其用途

Also Published As

Publication number Publication date
KR20260021032A (ko) 2026-02-12
WO2024254562A2 (fr) 2024-12-12
IL324785A (en) 2026-01-01
AU2024285577A1 (en) 2025-12-04

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