WO2024254588A3 - Capillary-embedded rapid adaptable multiscale bioprinting for engineering large vascularized tissues - Google Patents

Capillary-embedded rapid adaptable multiscale bioprinting for engineering large vascularized tissues Download PDF

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Publication number
WO2024254588A3
WO2024254588A3 PCT/US2024/033235 US2024033235W WO2024254588A3 WO 2024254588 A3 WO2024254588 A3 WO 2024254588A3 US 2024033235 W US2024033235 W US 2024033235W WO 2024254588 A3 WO2024254588 A3 WO 2024254588A3
Authority
WO
WIPO (PCT)
Prior art keywords
spinneret
capillary
bioprinting
multiscale
adaptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/033235
Other languages
French (fr)
Other versions
WO2024254588A2 (en
Inventor
George Zhuo TAN
Imtiaz QAVI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas Tech University TTU
Texas Tech University System
Original Assignee
Texas Tech University TTU
Texas Tech University System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas Tech University TTU, Texas Tech University System filed Critical Texas Tech University TTU
Publication of WO2024254588A2 publication Critical patent/WO2024254588A2/en
Publication of WO2024254588A3 publication Critical patent/WO2024254588A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B29C64/227—Driving means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Zoology (AREA)
  • Manufacturing & Machinery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Optics & Photonics (AREA)
  • Prostheses (AREA)

Abstract

A capillary-incorporated bioprinting system for rapid engineering of vascularized tissues, the system comprising a three-dimensional printing head, wherein the three-dimensional printing head is configured on a three-axis linear stage; a spinneret, wherein the spinneret is configured on a horizontal linear stage and the spinneret is affixed above the three-dimensional printing head; a UV light source, wherein the UV light source is operatively coupled to the three-dimensional printing head and the spinneret, and adjacent to the spinneret; and a pair of parallel bars, wherein the pair of parallel bars are configured to collect a plurality of electrospun aligned microtubes.
PCT/US2024/033235 2023-06-08 2024-06-10 Capillary-embedded rapid adaptable multiscale bioprinting for engineering large vascularized tissues Ceased WO2024254588A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363507065P 2023-06-08 2023-06-08
US63/507,065 2023-06-08

Publications (2)

Publication Number Publication Date
WO2024254588A2 WO2024254588A2 (en) 2024-12-12
WO2024254588A3 true WO2024254588A3 (en) 2025-04-10

Family

ID=93796484

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/033235 Ceased WO2024254588A2 (en) 2023-06-08 2024-06-10 Capillary-embedded rapid adaptable multiscale bioprinting for engineering large vascularized tissues

Country Status (1)

Country Link
WO (1) WO2024254588A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090208577A1 (en) * 2008-02-14 2009-08-20 Wake Forest University Health Sciences Inkjet Printing of Tissues and Cells
US20120058174A1 (en) * 2009-02-17 2012-03-08 West Jennifer L Fabrication of interconnected model vasculature
US20160288414A1 (en) * 2013-11-04 2016-10-06 University Of Iowa Research Foundation Bioprinter and methods of using same
US20170247430A1 (en) * 2014-09-26 2017-08-31 University Of South Carolina Novel biofabrication techniques for the implementation of intrinsic tissue geometries to an in vitro collagen hydrogel
EP4039475A1 (en) * 2021-02-03 2022-08-10 AJL Ophthalmic, S.A. 3d printer to generate curved biological tissue

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090208577A1 (en) * 2008-02-14 2009-08-20 Wake Forest University Health Sciences Inkjet Printing of Tissues and Cells
US20120058174A1 (en) * 2009-02-17 2012-03-08 West Jennifer L Fabrication of interconnected model vasculature
US20160288414A1 (en) * 2013-11-04 2016-10-06 University Of Iowa Research Foundation Bioprinter and methods of using same
US20170247430A1 (en) * 2014-09-26 2017-08-31 University Of South Carolina Novel biofabrication techniques for the implementation of intrinsic tissue geometries to an in vitro collagen hydrogel
EP4039475A1 (en) * 2021-02-03 2022-08-10 AJL Ophthalmic, S.A. 3d printer to generate curved biological tissue

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SOORIYAARACHCHI DILSHAN, WU JIAXIN, FENG AIXIN, ISLAM MAKSUD, TAN GEORGE Z: "Hybrid Fabrication of Biomimetic Meniscus Scaffold by 3D Printing and Parallel Electrospinning", PROCEDIA MANUFACTURING, vol. 34, 1 January 2019 (2019-01-01), 43rd North American Manufacturing Research Conference, NAMRC 43, 8-12 June 2015, UNC Charlotte, North Carolina, United States , pages 528 - 534, XP093303086, ISSN: 2351-9789, DOI: 10.1016/j.promfg.2019.06.216 *

Also Published As

Publication number Publication date
WO2024254588A2 (en) 2024-12-12

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