WO2024254612A3 - An ultrasound-activated ultrasound contrast agent - Google Patents

An ultrasound-activated ultrasound contrast agent Download PDF

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Publication number
WO2024254612A3
WO2024254612A3 PCT/US2024/033302 US2024033302W WO2024254612A3 WO 2024254612 A3 WO2024254612 A3 WO 2024254612A3 US 2024033302 W US2024033302 W US 2024033302W WO 2024254612 A3 WO2024254612 A3 WO 2024254612A3
Authority
WO
WIPO (PCT)
Prior art keywords
ultrasound
contrast agent
activated
sterilized
amino groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/033302
Other languages
French (fr)
Other versions
WO2024254612A2 (en
Inventor
Travis J. Williams
Jesse Tong-Pin Yen
Van Khanh DO
Andy Yu-How CHANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital Los Angeles
University of Southern California USC
Original Assignee
Childrens Hospital Los Angeles
University of Southern California USC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital Los Angeles, University of Southern California USC filed Critical Childrens Hospital Los Angeles
Publication of WO2024254612A2 publication Critical patent/WO2024254612A2/en
Publication of WO2024254612A3 publication Critical patent/WO2024254612A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Acoustics & Sound (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

An ultrasound-activated ultrasound contrast agent includes a sterilized liquid carrier; and a sterilized polymer dispersed and/or dissolved in the sterilized liquid carrier. Advantageously, the sterilized polymer includes amino groups that are at least partially functionalized with CO2 at a plurality of the amino groups.
PCT/US2024/033302 2023-06-09 2024-06-10 An ultrasound-activated ultrasound contrast agent Ceased WO2024254612A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363471994P 2023-06-09 2023-06-09
US63/471,994 2023-06-09

Publications (2)

Publication Number Publication Date
WO2024254612A2 WO2024254612A2 (en) 2024-12-12
WO2024254612A3 true WO2024254612A3 (en) 2025-05-08

Family

ID=93796432

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/033302 Ceased WO2024254612A2 (en) 2023-06-09 2024-06-10 An ultrasound-activated ultrasound contrast agent

Country Status (1)

Country Link
WO (1) WO2024254612A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1232837A (en) * 1983-04-15 1988-02-16 Jurgen Hilmann Ultrasound contrast agent containing microparticles and gas micro-bubbles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1232837A (en) * 1983-04-15 1988-02-16 Jurgen Hilmann Ultrasound contrast agent containing microparticles and gas micro-bubbles

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHANG ANDY Y, SYED HELAL, NUSSBAUM ZOE, DO VAN, WILLIAMS TRAVIS J, YEN JESSE T: "Selective release of CO2-loaded nanoparticles for vesicoureteral reflux imaging", PEDIATRIC UROLOGY FALL CONGRESS, SOCIETY FOR PEDIATRIC UROLOGY, US, 21 September 2023 (2023-09-21), US, pages 1 - 2, XP093311827, Retrieved from the Internet <URL:https://fallcongress.spuonline.org/program/2023/53.cgi> *
HAN XIANGJUN, XU KE, TARATULA OLENA, FARSAD KHASHAYAR: "Applications of nanoparticles in biomedical imaging", NANOSCALE, vol. 11, no. 3, 17 January 2019 (2019-01-17), UK, pages 799 - 819, XP093311821, ISSN: 2040-3364, DOI: 10.1039/C8NR07769J *
LUO WENLI, LI ZHAOJIAN, ZHANG LING, XIE XINGYI: "Polyethylenimine-CO2 adduct templated CaCO3 nanoparticles as anticancer drug carrier", CANCER NANOTECHNOLOGY, vol. 14, no. 7, 1 December 2023 (2023-12-01), AT, pages 1 - 21, XP093311789, ISSN: 1868-6958, DOI: 10.1186/s12645-023-00156-z *
ZHANG KUN, XU HUIXIONG, CHEN HANGRONG, JIA XIAOQING, ZHENG SHUGUANG, CAI XIAOJUN, WANG RONGHUI, MOU JUAN, ZHENG YUANYI, SHI JIANLI: "CO 2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation", THERANOSTICS, vol. 5, no. 11, 12 September 2015 (2015-09-12), AU , pages 1291 - 1302, XP093311803, ISSN: 1838-7640, DOI: 10.7150/thno.12691 *
ZHAO CHONG, ZHOU BENQING: "Polyethyleneimine-Based Drug Delivery Systems for Cancer Theranostics", JOURNAL OF FUNCTIONAL BIOMATERIALS, vol. 14, no. 1, CH , pages 12 - 12-27, XP093311812, ISSN: 2079-4983, DOI: 10.3390/jfb14010012 *
ZHOU BENQING, XIONG ZUOGANG, WANG PENG, PENG CHEN, SHEN MINGWU, MIGNANI SERGE, MAJORAL JEAN-PIERRE, SHI XIANGYANG: "Targeted tumor dual mode CT/MR imaging using multifunctional polyethylenimine-entrapped gold nanoparticles loaded with gadolinium", DRUG DELIVERY, vol. 25, no. 1, 1 January 2018 (2018-01-01), US , pages 178 - 186, XP093311816, ISSN: 1071-7544, DOI: 10.1080/10717544.2017.1422299 *

Also Published As

Publication number Publication date
WO2024254612A2 (en) 2024-12-12

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