WO2024254966A1 - Multi-needle steep pulse ablation electrode device, radio frequency ablation device, method, and system - Google Patents

Abstract

Disclosed in the present invention are a multi-needle steep pulse ablation electrode device, a radio frequency ablation device, a method, and a system. A plurality of energy application units are configured to be inserted and slidably connected to the distal end surface of a handheld shell along a preset trajectory; a driving part is provided in the handheld shell; the driving part separately drives the energy application units to slide on the distal end surface of the handheld shell along the preset trajectory, to adjust the distance between the energy application units and the area of an energy application execution region formed by fitting of execution ends of the energy application units, so as to adapt to a preset energy application region requiring energy application on a target tumor. The problem of being difficult to accurately control the distance between needles and the ablation area present in existing steep pulse ablation electrodes is solved. After the adjustment made to adapt to the target tumor, by means of delivery or puncturing, the execution ends of the energy application units can reach the target tumor to implement energy application, so as to perform steep pulse ablation on the target tumor in the energy application execution region.

Description

Multi-needle steep pulse ablation electrode device, radiofrequency ablation device, method and system Technical Field

The present invention belongs to the technical field of medical devices, and in particular relates to a multi-needle steep pulse ablation electrode device, a radiofrequency ablation device, a method and a system.

Background Art

Cancer is one of the major diseases that threaten human health and life. According to data released by the World Union Against Cancer (UICC), in 2008, the number of cancer patients worldwide was 12.7 million, of which 7.6 million died. According to a survey and statistical report by the Chinese Ministry of Health, in the past 30 years, the cancer mortality rate has increased by more than 80%. Currently, cancer has become an important disease that causes death among urban and rural residents and the number one killer of health. The report of the World Health Organization (WHO) also pointed out that globally, the number of new cancer cases and cancer patient mortality will increase at an annual rate of 1%, and the rate of increase will be faster in developing countries such as China, Russia, and India. It is estimated that by 2030, there will be 27 million new cancer cases worldwide and the number of people who will die from cancer will reach 17 million.

Currently, the main cancer treatments include surgery, radiotherapy and chemotherapy. However, these traditional treatments are limited by their indications, contraindications and side effects, so the treatment effects are still not ideal. Therefore, seeking new cancer treatments has always been an important topic in the medical and biomedical engineering fields.

Research in recent years has found that after the electroporation effect occurs in cells, as the pulse intensity increases and the pulse action time increases, irreversible electrical breakdown of the cell membrane will occur, causing the cell membrane to rupture and eventually cell death. Taking advantage of this feature, researchers have proposed irreversible electropuncture therapy. As a new type of non-thermal tumor ablation method, irreversible electroporation therapy is to apply electric pulses to cancer tissue to cause irreversible electrical breakdown of cancer cells, thereby destroying the living conditions of cancer cells and achieving the purpose of killing cancer cells. However, the steep pulse ablation electrodes currently on the market have the following problems: First, steep pulse ablation electrodes require the use of multiple electrodes during treatment, but in this process it is difficult to ensure the parallelism between the electrodes or that the electrodes are in the same plane. Second, the spacing between the steep pulse ablation electrodes cannot be precisely controlled, and the electrode spacing will affect the electric field coverage of the tumor during treatment. Third, during treatment, the ablation area cannot be changed arbitrarily according to the size or shape of the lesion. If you want to achieve complete ablation, you have to change the puncture position or electrode model, which will increase the difficulty of the operation and increase the operation time.

Summary of the invention

In order to solve the above problems, the present invention provides a multi-needle steep pulse ablation electrode device, a radiofrequency ablation device, a method and a system to solve the problem that it is difficult to accurately control the spacing between the needles and the ablation area in the existing steep pulse ablation electrodes. The technical solution is as follows:

A multi-needle steep pulse ablation electrode device of the present invention defines the area where energy is required to be applied to the target tissue as a preset energy application area, including:

Handheld housing;

A plurality of energy application units, wherein the connection ends of the energy application units are configured to be inserted into and slidably connected to the distal end surface of the handheld housing along a preset trajectory, and the execution ends of the plurality of energy application units are located in the same plane and cooperate to form an energy application execution area;

A driving unit is disposed in the handheld housing, and a power input end of the driving unit extends out of the handheld housing, and a power output end of the driving unit is respectively connected to a plurality of the energy application units;

The driving part is configured so that the power input end receives external power input, and the power output end outputs driving force to drive the plurality of energy application units, which slide along the preset trajectories corresponding to the respective energy application units, so as to adjust the energy application execution area to match the preset energy application area.

In the multi-needle steep pulse ablation electrode device of the present invention, the preset trajectories of the multiple energy application units are configured to converge toward the center of the distal end surface of the handheld shell and/or diverge outward from the center of the distal end surface of the handheld shell.

In the multi-needle steep pulse ablation electrode device of the present invention, the shape of the energy application execution area is configured as a regular polygon.

The multi-needle steep pulse ablation electrode device of the present invention defines the direction perpendicular to the distal end surface of the handheld housing as the vertical direction, and the direction parallel to the distal end surface of the handheld housing as the horizontal direction;

The driving part includes a power input unit, a power execution unit and a plurality of connecting sliding units; the connecting sliding units are respectively connected to the corresponding energy application units and are slidably connected to the inner cavity of the handheld shell along the preset trajectory; the output end of the power input unit extends into the handheld shell The inner cavity of the body is connected to each of the connecting sliding units through a power execution unit; the power execution unit is configured to receive the power input of the power input unit and convert the power input into driving each of the connecting sliding units and the energy application unit to slide laterally.

In the multi-needle steep pulse ablation electrode device of the present invention, the power input unit is a vertical power input mechanism, the power execution unit includes a vertical slider and an elastic force supply unit, and the connecting sliding unit is a horizontal slider provided with a guiding inclined surface;

The input end of the vertical power input mechanism extends out of the handheld housing, and the output end of the vertical power input mechanism is connected to the vertical slider, which is used to drive the vertical slider to move vertically; the vertical slider is provided with a plurality of driving inclined surfaces arranged around, and the driving inclined surfaces are inclined toward the center of the distal end surface of the handheld housing; a plurality of transverse sliders are arranged around the circumference of the vertical slider, and the driving inclined surfaces correspond to the guide inclined surfaces one by one; the elastic force supply unit is respectively connected to each of the transverse sliders, and is used to provide an elastic force for the transverse slider to move toward the vertical slider;

Driven by the elastic force supply unit, the guiding inclined surface of each of the transverse sliders is attached to the driving inclined surface, and the transverse position of the transverse slider relative to the vertical slider is adjusted along the preset trajectory according to the vertical relative position change of the vertical slider.

The multi-needle steep pulse ablation electrode device of the present invention, the vertical power input mechanism comprises a rotating member, an adjusting screw and a fixing nut;

The fixing nut is fixed to the vertical sliding block; the adjusting screw is arranged vertically, and the adjusting screw is threadedly connected to the fixing nut; the rotating member is fixed to one end of the adjusting screw and extends out of the handheld housing.

In the multi-needle steep pulse ablation electrode device of the present invention, the rotating part includes a knob and a vertical elastic part; the bottom end of the knob is provided with an extension boss extending outward for abutting against the proximal end surface of the handheld shell; the two ends of the vertical elastic part are respectively connected to the extension boss and the vertical slider.

In the multi-needle steep pulse ablation electrode device of the present invention, the elastic force supply unit is an annular compression spring;

An elastic member groove is provided on one side of each of the transverse slide blocks away from the center of the distal end surface of the handheld housing. The annular compression spring surrounds each of the transverse slide blocks and is embedded in the corresponding elastic member groove.

The multi-needle steep pulse ablation electrode device of the present invention, the vertical slider comprises a slider body and a vertical guide structure and a plurality of oblique guide structures arranged on the slider body;

The outer contour of the vertical guide structure is in contact with the inner cavity wall of the handheld housing; the oblique guide structure includes two guide plates vertically and spaced apart on the slider body, and the lower ends of the two guide plates are each provided with an oblique cut surface facing the center of the distal end surface of the handheld housing, and the two corresponding oblique cut surfaces together form the driving inclined surface;

A protruding structure is disposed on the upper end of the transverse sliding block, and two sides of the protruding structure are respectively provided with oblique step surfaces that cooperate to form the guiding inclined surface.

In the multi-needle steep pulse ablation electrode device of the present invention, an embedding through groove arranged vertically and extending to the protruding structure is provided in the transverse sliding block.

In the multi-needle steep pulse ablation electrode device of the present invention, the lower end of the transverse slider is provided with an extension slide extending toward at least one side of the preset track;

The distal surface of the handheld shell is a distal bottom plate structure, which includes a chassis and a cover plate; the chassis is respectively provided with guide grooves corresponding to each of the preset trajectories, and the width of the guide grooves matches the overall size of the extension slide; the bottom surface of the guide groove is provided with a long strip through groove for the energy application unit to pass through; the cover plate is covered on the chassis and is provided with guide openings corresponding to the guide grooves one by one, and the width of the guide openings matches the width of the transverse slider.

In the multi-needle steep pulse ablation electrode device of the present invention, the base plate and the cover plate are respectively provided with insertion openings for the vertical sliding block to be inserted.

In the multi-needle steep pulse ablation electrode device of the present invention, the power input unit is a rotating member, the power execution unit is a plurality of intermediate transmission members, and the connecting sliding unit is a transverse sliding member;

The first ends of the plurality of intermediate transmission members are respectively rotatably connected to the rotating member and offset from the rotating axis of the rotating member, and at least part of the rotating member extends out of the handheld housing; the second end of the intermediate transmission member is rotatably connected to the transverse slider;

The distal end surface of the handheld shell is a chassis, and the chassis is provided with a plurality of long strip through slots for the energy application unit to pass through, and the trajectory of the long strip through slots is the preset trajectory; the transverse slider slides on the chassis, and the energy application unit is clamped on the transverse slider and extends out of the corresponding long strip through slots.

In the multi-needle steep pulse ablation electrode device of the present invention, the power input unit is a vertical power input mechanism, the power execution unit is a plurality of oblique connecting rods, and the connecting sliding unit is a transverse sliding block;

The input end of the vertical power input mechanism extends out of the handheld housing. The output end of the input mechanism is respectively connected to the first end of each of the oblique connecting rods in rotation and/or swinging manner, so as to drive the first end of the oblique connecting rod to move vertically; the second end of the oblique connecting rod is respectively connected to the corresponding transverse sliding block in rotation and/or swinging manner;

The distal end surface of the handheld shell is a chassis, and the chassis is provided with a plurality of long strip through slots for the energy application unit to pass through, and the trajectory of the long strip through slots is the preset trajectory; the transverse slider slides on the chassis, and the energy application unit is clamped on the transverse slider and extends out of the corresponding long strip through slots.

The multi-needle steep pulse ablation electrode device of the present invention, the power execution unit also includes a supporting connecting rod, the first end of which is rotatably and/or swingably connected to the handheld shell, and the second end of which is rotatably and/or swingably connected to the rod body of the oblique connecting rod.

The multi-needle steep pulse ablation electrode device of the present invention, the vertical power input mechanism comprises a rotating member, an adjusting screw, a connecting slider and a vertical elastic member;

The adjusting screw is vertically arranged in the handheld shell, and the adjusting screw is threadedly connected to the proximal end surface of the handheld shell, the connecting slider is rotatably connected to the adjusting screw, and the connecting slider is respectively connected to the first end of each of the oblique connecting rods; the rotating member is fixed to one end of the adjusting screw and extends out of the handheld shell; the two ends of the vertical elastic member are respectively connected to the handheld shell and the connecting slider.

In the multi-needle steep pulse ablation electrode device of the present invention, the energy applying unit is a metal puncture needle.

In the multi-needle steep pulse ablation electrode device of the present invention, the number of the energy application units is three, four or five.

A method of using a multi-needle steep pulse ablation electrode device of the present invention is used to ablate a target tissue, comprising:

A multi-needle steep pulse ablation electrode device is provided: it further comprises a handheld shell, a plurality of energy application units and a driving part; the connection ends of the plurality of energy application units are configured to be inserted and slidably connected to the distal end surface of the handheld shell along a preset trajectory, the execution ends of the plurality of energy application units are located in the same plane, and cooperate to form an energy application execution area; the driving part is arranged in the handheld shell, and the power input end of the driving part extends out of the handheld shell, and the power output end of the driving part is respectively connected to the plurality of energy application units; the driving part is configured so that the power input end receives external power input, and the power output end outputs a driving force to drive the plurality of energy application units to slide respectively along the corresponding preset trajectories;

The driving part is configured to receive external power input to drive each of the energy application units to slide along its preset trajectory to obtain the energy application execution area matching the preset energy application area;

The multi-needle steep pulse ablation electrode device is configured so that each of the energy application units delivers or punctures to a target position corresponding to the target tissue;

Each of the energy application units is configured to deliver energy to a target tissue.

A tumor ablation device of the present invention comprises:

A carrier carrying a plurality of treatment units; wherein the connection ends of the plurality of treatment units are configured to be inserted and slidably connected to the distal end surface of the carrier along a preset trajectory, and the execution ends of the treatment units are located in the same plane and cooperate to form an energy application execution area;

The driving unit is arranged in the carrier, and the power output end of the driving unit is respectively connected to each of the treatment units; the driving unit is configured to drive each of the treatment units to slide along the corresponding preset trajectory to adjust the energy application execution area to match the preset tumor ablation area.

A minimally invasive medical system of the present invention comprises any one of the multi-needle steep pulse ablation electrode devices described above.

Due to the adoption of the above technical solution, the present invention has the following advantages and positive effects compared with the prior art:

In one embodiment of the present invention, multiple energy application units are configured to be inserted and connected to the distal end of the handheld shell by sliding along a preset trajectory. A driving unit is arranged inside the handheld shell, and the driving unit drives each energy application unit to slide along the preset trajectory on the distal end of the handheld shell, thereby adjusting the spacing between each energy application unit and the area of the energy application execution area formed by the execution end of each energy application unit to adapt to the preset energy application area required to apply energy to the target tumor, solving the problem of the difficulty in accurately controlling the spacing between each needle and the ablation area in the existing steep pulse ablation electrode. After adjusting to adapt to the target tumor, the execution end of the energy application unit can be delivered or inserted to reach the target tumor for energy application, so as to perform steep pulse ablation on the target tumor in the energy application execution area.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a schematic diagram of a multi-needle steep pulse ablation electrode device excluding a handheld housing according to a first embodiment of the present invention;

FIG2 is a cross-sectional view of a multi-needle steep pulse ablation electrode device according to Embodiment 1 of the present invention;

FIG3 is a schematic diagram of a multi-needle steep pulse ablation electrode device according to Embodiment 1 of the present invention;

FIG4 is a schematic diagram of a chassis of a multi-needle steep pulse ablation electrode device according to Embodiment 1 of the present invention;

FIG5 is a schematic diagram of a cover plate of a multi-needle steep pulse ablation electrode device according to Embodiment 1 of the present invention;

FIG6 is a schematic diagram of a transverse slider of a multi-needle steep pulse ablation electrode device according to Embodiment 1 of the present invention;

FIG7 is a cross-sectional view of a transverse slider of the multi-needle steep pulse ablation electrode device according to the first embodiment of the present invention;

FIG8 is a schematic diagram of a vertical slider of a multi-needle steep pulse ablation electrode device according to Embodiment 1 of the present invention;

FIG9 is a cross-sectional view of a vertical slider of the multi-needle steep pulse ablation electrode device according to the first embodiment of the present invention;

FIG10 is a schematic diagram of the cooperation between the vertical slider and the horizontal slider of the multi-needle steep pulse ablation electrode device according to the first embodiment of the present invention;

FIG11 is a cross-sectional view of the cooperation between the vertical slider and the horizontal slider of the multi-needle steep pulse ablation electrode device according to the first embodiment of the present invention;

FIG12 is a schematic diagram of a knob of a multi-needle steep pulse ablation electrode device according to Embodiment 1 of the present invention;

FIG13 is a cross-sectional view of a knob of a multi-needle steep pulse ablation electrode device according to Embodiment 1 of the present invention;

FIG14 is a front view of the multi-needle steep pulse ablation electrode device of Embodiment 2 of the present invention excluding the handheld housing;

FIG15 is a schematic diagram of a multi-needle steep pulse ablation electrode device excluding the handheld housing according to the second embodiment of the present invention;

FIG16 is a cross-sectional view of a multi-needle steep pulse ablation electrode device according to Embodiment 3 of the present invention;

FIG. 17 is a schematic diagram of the multi-needle steep pulse ablation electrode device according to the third embodiment of the present invention excluding the handheld housing.

Explanation of reference numerals: 1: energy application unit; 2: chassis; 201: guide groove; 202: long strip groove; 3: cover plate; 301: guide opening; 4: annular compression spring; 5: horizontal slider; 501: guide slope; 502: embedded through groove; 503: elastic member groove; 6: vertical slider; 601: guide plate; 602: guide interval; 603: blind hole; 604: through hole; 7: vertical elastic member; 8: knob; 801: knob threaded hole; 802: semicircular long groove; 803: extension boss; 9: adjustment screw; 10: fixed Fixed nut; 11: handheld housing; 12: rotating shaft; 13: intermediate transmission member; 14: connecting slider; 15: oblique connecting rod; 16: supporting connecting rod.

DETAILED DESCRIPTION

The following is an explanation of the embodiments of the present invention by specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention. It should be understood that the orientation or position relationship indicated by the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc. is based on the orientation or position relationship shown in the drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first", "second", etc. are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, the features defined as "first", "second", etc. may explicitly or implicitly include one or more of the features. In the description of the present invention, unless otherwise specified, the meaning of "multiple" is two or more.

It should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood by specific circumstances.

In addition, in the description of this application, the "proximal end" and "distal end" of "proximal end" are commonly used terms in the medical field. Specifically, the "proximal end" is the end close to the operator, the "proximal end surface" is the end surface close to the operator, the "distal end" is the end away from the operator, and the "distal end surface" is the end surface away from the operator.

Embodiment 1

1 to 13 , in one embodiment, a multi-needle steep pulse ablation electrode device defines the area where energy is required to be applied to the target tissue as a preset energy application area, and includes a handheld housing 11 , a plurality of energy application units 1 and a driving unit.

The connection ends of the multiple energy application units 1 are configured to be inserted and slidably connected along a preset track. On the distal end surface of the handheld housing 11 , the execution ends of the multiple energy application units 1 are located in the same plane and cooperate to form an energy application execution area.

The driving part is arranged in the handheld housing 11, and the power input end of the driving part extends out of the handheld housing 11, and the power output end of the driving part is respectively connected to the multiple energy application units 1. The driving part is configured to receive external power input at the power input end, and output driving force from the power output end to drive the multiple energy application units 1, respectively sliding along the preset tracks corresponding to each energy application unit 1, so as to adjust the energy application execution area to match the preset energy application area.

In this embodiment, multiple energy application units 1 are configured to be inserted and connected to the distal end of the handheld housing 11 by sliding along a preset trajectory. A driving unit is arranged inside the handheld housing 11, and the driving unit drives each energy application unit 1 to slide along the preset trajectory on the distal end of the handheld housing 11, thereby adjusting the spacing between each energy application unit 1 and the area of the energy application execution area formed by the execution end of each energy application unit 1, so as to adapt to the preset energy application area where the target tumor needs to apply energy, thereby solving the problem of the difficulty in accurately controlling the spacing between each needle and the ablation area in the existing steep pulse ablation electrode. After adjusting to adapt to the target tumor, the execution end of the energy application unit 1 can be delivered or inserted to reach the target tumor for energy application, so as to perform steep pulse ablation on the target tumor in the energy application execution area.

The specific structure of the multi-needle steep pulse ablation electrode device of this embodiment is further described below:

In this embodiment, the preset trajectories of the above-mentioned multiple energy application units 1 are configured to converge toward the center of the distal end surface of the handheld housing 11 or diverge outward. That is, the preset trajectory can be set as a straight line, specifically a long strip through slot 202 opened on the ray diverging outward from the center point of the distal end surface of the handheld housing 11, and the rays where each preset trajectory is located are arranged at equal angles. Of course, in other embodiments, the preset trajectory can also be set as a curve or other forms, such as a curve deflected toward the center point around the distal end surface, which is not specifically limited here.

In this embodiment, the shape of the energy application execution area can be specifically configured as a regular polygon. That is, the number of energy application units 1 is the same as the number of endpoints of the regular polygon, and adjacent energy application units 1 are arranged equidistantly and centered on the center point of the distal end surface. The number of energy application units 1 is three, four, five or more, which can be determined according to needs.

The direction perpendicular to the distal end surface of the handheld housing 11 is defined as the vertical direction, and the direction parallel to the distal end surface of the handheld housing 11 is defined as the horizontal direction.

In this embodiment, the driving unit may specifically include a power input unit, a power execution unit and a plurality of Connecting sliding unit. The connecting sliding units are respectively connected to the corresponding energy application units 1, and are slidably connected to the inner cavity of the handheld shell 11 along a preset trajectory. The output end of the power input unit extends into the inner cavity of the handheld shell 11, and is connected to each connecting sliding unit through a power execution unit. The power execution unit is configured to receive the power input of the power input unit, and convert the power input into driving each connecting sliding unit and the energy application unit 1 to slide laterally. Among them, the power input unit is a component for receiving external power input, the power execution unit is a power conversion mechanism that converts the input power into a power driving the connecting sliding unit to slide on the distal surface, and the connecting sliding unit is a component used to connect the energy application unit 1 and realize sliding.

6 to 11 , further, the power input unit of this embodiment may be a vertical power input mechanism, the power execution unit includes a vertical slider 6 and an elastic force supply unit, and the connecting sliding unit may be a transverse slider 5 provided with a guide slope 501 .

The input end of the vertical power input mechanism extends out of the handheld housing 11, and the output end of the vertical power input mechanism is connected to the vertical slider 6, which is used to output the vertical driving force and drive the vertical slider 6 to move vertically. Several transverse sliders 5 are arranged to be evenly distributed around the vertical slider 6, and the driving inclined surface corresponds to the guide inclined surface 501 one by one. The guide inclined surface 501 is an inclined surface that is inclined toward the center of the distal surface and tilted downward (the direction of the proximal surface of the handheld housing 11 toward the distal surface is downward). The vertical slider 6 is provided with several driving inclined surfaces arranged around, which correspond to the transverse slider 5 one by one, and the driving inclined surface is parallel to the guide inclined surface 501 (that is, it is also an inclined surface that is inclined toward the center of the distal surface of the handheld housing 11 and tilted downward). The elastic force supply unit is respectively connected to each transverse slider 5, which is used to provide an elastic force to push the transverse slider 5 toward the vertical slider 6, that is, the direction of providing the elastic force is toward the center of the distal surface of the handheld housing 11.

Driven by the elastic force supply unit, the guide slope 501 of each transverse slider 5 is fitted to the driving slope, and the transverse position of the transverse slider 5 relative to the vertical slider 6 is adjusted along the preset track by the vertical relative position change of the vertical slider 6. The vertical slider 6 moves downward to push each transverse slider 5 outward, so that the transverse slider 5 moves along the preset track in the direction away from the center of the distal end surface of the handheld housing 11; the vertical slider 6 moves upward to release the transverse limit of the transverse slider 5, and each transverse slider 5 moves along the preset track in the direction close to the center of the distal end surface of the handheld housing 11 under the elastic force of the elastic force supply unit until it fits the vertical slider 6.

Specifically, the vertical power input mechanism may include a rotating member, an adjusting screw 9 and a fixing nut 10. The adjusting screw 9 is arranged vertically and rotatably connected to the inner cavity of the handheld housing 11, and the adjusting screw 9 fixes the nut 10. The rotating member is fixed to one end of the adjusting screw 9 close to the proximal end surface of the handheld housing 11 and extends outward from the The hand-held housing 11. The fixing nut 10 is threadedly connected to the adjusting screw 9, and the fixing nut 10 is fixed on the vertical slider 6. Specifically, a blind hole 603 can be opened on the proximal end surface (upper end surface) of the vertical slider 6, and the fixing nut 10 can be fixedly set in the blind hole 603, and a through hole 604 can be set on the bottom surface of the blind hole 603 for the adjusting screw 9 to pass through.

Referring to Figures 12 and 13, in this embodiment, the rotating member includes a knob 8 and a vertical elastic member 7. The bottom center of the knob 8 has a knob 8 threaded hole, which forms a threaded fit with the adjusting screw 9. When the knob 8 is rotated, the adjusting screw 9 will also rotate accordingly. The outer surface of the knob 8 can be provided with some evenly arranged semicircular long grooves 802, which mainly play an anti-slip role. Further, the bottom end of the knob 8 is provided with an extension boss 803 extending outward, which is used to abut against the proximal surface of the handheld housing 11 (that is, the proximal surface of the handheld housing 11 is provided with an opening that allows the knob 8 to extend but does not allow the extension boss 803 to extend). The two ends of the vertical elastic member 7 are respectively connected to the extension boss 803 and the vertical slider 6, which are used to maintain the knob 8 always abutting against the proximal surface of the handheld housing 11. The vertical elastic member 7 can be specifically a compression spring.

When the knob 8 is rotated, the adjusting screw 9 is driven to rotate, and the fixing nut 10 threadedly connected thereto is fixed on the vertical slider 6 and will not rotate. Under the action of the thread, the fixing nut 10 will move in the vertical direction, thereby driving the vertical slider 6 to move up and down.

Furthermore, the elastic force supply unit may be specifically an annular compression spring 4. Correspondingly, each transverse slider 5 is provided with an elastic member groove 503 on one side away from the center of the distal end surface of the handheld housing 11, and the annular compression spring 4 surrounds each transverse slider 5 and is embedded in the corresponding elastic member groove 503, and provides the elastic force required by the transverse slider 5 through its annular inward contraction force.

In this embodiment, the vertical slider 6 specifically includes a slider body and a vertical guide structure and a plurality of oblique guide structures arranged on the slider body. The outer contour of the vertical guide structure fits with the inner cavity wall of the handheld shell 11. The inner cavity of the handheld shell 11 can be a cylindrical cavity, and the outer contour (outer ring surface) of the vertical guide structure can be a circle that matches the cylindrical side surface of the cylindrical cavity. The oblique guide structure can specifically include two guide plates 601 vertically and spaced apart on the slider body, and the lower ends of the two guide plates 601 are both provided with oblique cut surfaces facing the center of the distal end surface of the handheld shell 11, and the two corresponding oblique cut surfaces together form a driving inclined surface.

The upper end of the transverse slider 5 is provided with a corresponding protruding structure, and both sides of the protruding structure are provided with oblique step surfaces that cooperate to form the guiding inclined surface 501. That is, when the guiding inclined surface 501 is in contact with the driving inclined surface, the protruding structure always extends into the guiding gap 602 formed between the two guide plates 601, and can guide the relative position movement between the transverse slider 5 and the vertical slider 6.

Furthermore, in order to ensure sufficient clamping of the energy application unit 1, a vertically arranged embedding groove 502 extending to the raised structure is provided in the transverse slider 5, that is, the connecting end of the energy application unit 1 can be inserted into and extended from the embedding groove 502, thereby ensuring a longer clamping length and achieving the purpose of stable clamping.

In this embodiment, in order to guide the transverse slider 5 along the preset trajectory, the lower end of the transverse slider 5 may be provided with an extension slide extending toward at least one side of the preset trajectory, which may actually be two extension slides extending toward both sides of the predicted trajectory (not the two ends of the trajectory).

Referring to Fig. 4 and Fig. 5, the distal end surface of the handheld housing 11 may be a distal bottom plate structure, which includes a chassis 2 and a cover plate 3, which may be threadedly connected. The chassis 2 is provided with guide grooves 201 corresponding to each preset trajectory, and the width of the guide grooves 201 matches the overall size of the extension slide, and the bottom surface of the guide grooves 201 is provided with the above-mentioned long strip through grooves 202 for the energy application unit 1 to pass through. The cover plate 3 is covered on the chassis 2 and is provided with guide openings 301 corresponding to the guide grooves 201 one by one, and the width of the guide openings 301 matches the width of the transverse slider 5. That is, the chassis 2 and the cover plate 3 cooperate to form a sliding chamber adapted to the transverse slider 5 and the extension slides on both sides thereof.

Furthermore, since the vertical slider 6 of this embodiment slides up and down, it may interfere with the chassis 2 and the cover plate 3 in some scenarios, so the chassis 2 and the cover plate 3 are respectively provided with insertion openings for the vertical slider 6 to extend therein for avoidance.

In this embodiment, the energy application unit 1 can specifically be a metal puncture needle, and multiple metal puncture needles are electrically connected to the high-voltage pulse power supply respectively, wherein at least one metal puncture needle is an input electrode (used to introduce high-frequency and high-voltage pulse current into the energy application execution area), and at least one metal puncture needle is a recovery electrode (used to extract high-frequency and high-voltage pulse current).

The specific technical means of this embodiment are described below:

The multi-needle steep pulse ablation electrode device of this embodiment solves the problem that the high-voltage steep pulse treatment technology cannot accurately control the spacing between needles and arbitrarily adjust the ablation area during tumor ablation surgery. At the same time, it also solves the problem that other normal tissues may be damaged when surgically removing tumors.

1. The multi-needle steep pulse ablation electrode device of this embodiment makes the metal puncture needles parallel to each other and the movement trajectories of each metal puncture needle are in the same plane through the cooperation of the transverse slider 5 with the guide groove 201 of the chassis 2 and the upper cover plate 3, and the structure that the embedded through groove 502 of the transverse slider 5 for fixing the tail end of the metal puncture needle is perpendicular to the chassis 2, so that the metal puncture needles are parallel to each other and the movement trajectories of each metal puncture needle are in the same plane, ensuring that multiple metal puncture needles can pierce the same lesion tissue at the same time and are parallel to each other, solving the problem that medical staff need to hold or limit the device in steep pulse ablation surgery. The electrode device itself can keep the needles parallel to each other, avoiding the need for other limiting devices or medical staff holding electrodes to ensure the parallelism of the needles during the treatment process, thereby reducing the difficulty of the operation.

2. The multi-needle steep pulse ablation electrode device of this embodiment can accurately control the distance between each needle by adjusting the threaded connection structure of the screw 9, the knob 8 and the fixing nut 10, as well as the cooperation between the fixing nut 10 and the blind hole 603 of the vertical slider 6 and the cooperation between the guide bevel 501 and the driving bevel. Because when the knob 8 rotates one thread each time, the adjusting screw 9 will rotate one thread, and then the vertical slider 6 will move one pitch up or down, and the vertical slider 6 will push the transverse slider 5 to move a certain distance. Therefore, the distance between each needle can be accurately controlled by this threaded connection structure and the cooperation between the transverse slider 5 and the vertical slider 6, which solves the problem that when the high-voltage steep pulse treatment technology is used for surgical ablation, a high-voltage pulse will be applied between two electrodes for tumor ablation, and the electrode spacing will affect the range of the electric field covering the tumor and the field strength distribution during treatment, thereby affecting the ablation effect. Accurately controlling the distance between the electrodes can accurately control the range of the electric field covering the tumor and the field strength distribution, thereby achieving a complete ablation effect without damaging other normal tissues.

3. The electrode of the present invention can adjust the ablation area of the electrode arbitrarily through the cooperation of the guiding inclined surface 501 and the driving inclined surface, and the cooperation of the elastic groove 503 of the horizontal slider 5 and the annular compression spring 4. When the vertical slider 6 moves downward, it will push the electrode to move outward from the center of the chassis 2, and the ablation area of the electrode will increase; when the vertical slider 6 moves upward, the annular compression spring 4 will tighten, so that the guiding inclined surface 501 of the horizontal slider 5 is always matched with the driving inclined surface of the vertical slider 6, and the horizontal slider 5 is also moved toward the center of the chassis 2, and the ablation area of the electrode device is reduced. In this way, the ablation area of the electrode can be adjusted arbitrarily, which solves the problem that during tumor ablation, the electrode itself cannot change the ablation area according to the size and shape of the tumor, and can only change the ablation area by replacing electrodes of different specifications or puncture positions, so as to completely ablate the tumor, reducing the difficulty of surgery and improving the flexibility of the electrode in clinical application. In this way, during treatment, the ablation area of the electrode can be changed according to the size and shape of the tumor. There is no need to replace electrodes of different specifications or change the puncture position to achieve a complete ablation effect, which simplifies the surgical operation and saves surgical time.

At the same time, the size of the distance between the needle bodies is achieved through this thread structure. Every time a thread is turned, the distance between the needle bodies will change to a certain extent, that is, the distance between the needle bodies can be accurately controlled by the thread. In this way, during the operation, the range of the electric field covering the tumor and the field strength distribution during treatment will not be affected by the inability to accurately control the electrode spacing, thereby affecting the ablation effect.

4. The electrode of the present invention ablates the lesion tissue by combining surgery and high-voltage steep pulse ablation technology, which not only solves the problem of damaging other normal tissues when surgically removing the lesion tissue, but also solves the problem of it being difficult to accurately locate the lesion tissue when treating the lesion tissue with high-voltage steep pulse ablation technology, making it impossible to completely ablate the lesion tissue, thereby enhancing the therapeutic effect of the surgery.

Embodiment 2

14 and 15 , this embodiment provides a multi-needle steep pulse ablation electrode device based on the above-mentioned embodiment 1, and adjusts the arrangement of the driving part, as follows:

In this embodiment, the power input unit may be a rotating member, the power execution unit may be a plurality of intermediate transmission members 13 , and the connecting sliding unit may be a transverse sliding member 5 .

The first ends of the intermediate transmission members 13 are respectively rotatably connected to the rotating members (the direction of the rotation axis is vertical, which can be realized by the rotating shaft 12), and are offset from the rotation axis of the rotating members, and at least part of the rotating members extend out of the handheld housing 11. The second ends of the intermediate transmission members 13 are rotatably connected to the transverse slider 5 (similarly, the direction of the rotation axis is vertical, which can be realized by the rotating shaft 12).

The distal end surface of the handheld housing 11 is a chassis 2, and the chassis 2 is provided with a plurality of long strip through slots 202 for the energy application unit 1 to pass through, and the trajectory of the long strip through slots 202 is a preset trajectory. The transverse slider 5 slides on the chassis 2, and the energy application unit 1 is clamped on the transverse slider 5 and extends out of the corresponding long strip through slots 202. Of course, the arrangement of the distal end surface can also be a combination of the chassis 2 and the cover plate 3 in the above-mentioned embodiment 1.

When the number of energy application units 1 is four, the preset trajectory can be four long strip through slots 202 arranged at 90° on the chassis 2. The transverse slider 5 is connected to the intermediate transmission member 13, and the intermediate transmission member 13 is connected to the rotating member (i.e., the knob 8) through the rotating shaft 12, and they can rotate with each other. There is a circular through slot in the transverse slider 5 for fixing the energy application unit 1. When the knob 8 is turned, the intermediate transmission member 13 will rotate and move accordingly, and the movement of the intermediate transmission member 13 will cause the transverse slider 5 to rotate and move. Since the energy application unit 1 is fixed on the transverse slider 5, the energy application unit 1 will also move, but the movement path of the energy application unit 1 is limited by the needle track (long strip through slot 202) on the chassis 2. When the energy application unit 1 moves, the spacing between the energy application units 1 will change, thereby changing the ablation area. Because the movement of the energy application unit 1 occurs in the same plane and the energy application units 1 are initially parallel to each other, the execution ends of each energy application unit 1 are always in the same plane.

Embodiment 3

16 and 17 , this embodiment also provides a multi-needle steep pulse ablation electrode device based on the above-mentioned embodiment 1, and adjusts the arrangement of the driving part, as follows:

In this embodiment, the power input unit is a vertical power input mechanism, the power execution unit is a plurality of oblique connecting rods 15 , and the connecting sliding unit is a transverse sliding block 5 .

The input end of the vertical power input mechanism extends out of the handheld housing 11, and the output end of the vertical power input mechanism is connected to the first end of each oblique link 15 in rotation and/or swinging manner, so as to drive the first end of the oblique link 15 to perform vertical movement. The second end of the oblique link 15 is connected to the corresponding horizontal slider 5 in rotation and/or swinging manner (if the preset trajectory is a straight line, only rotation is required).

Similar to the second embodiment, the distal end surface of the handheld housing 11 is a chassis 2, and the chassis 2 is provided with a plurality of long strip through slots 202 for the energy application unit 1 to pass through, and the trajectory of the long strip through slots 202 is a preset trajectory. The transverse slider 5 slides on the chassis 2, and the energy application unit 1 is clamped on the transverse slider 5 and extends out of the corresponding long strip through slots 202. Of course, the arrangement of the distal end surface can also be a combination of the chassis 2 and the cover plate 3 in the above-mentioned first embodiment.

Furthermore, in order to ensure the stability of the movement of the diagonal link, the power execution unit also includes a support link 16, the first end of the support link 16 is rotatably and/or swingably connected to the handheld shell 11, and the second end of the support link 16 is rotatably and/or swingably connected to the rod body of the diagonal link 15 (specifically, it can be the midpoint or other position of the diagonal link 15).

Specifically, the vertical power input mechanism may include a rotating member, an adjusting screw 9, a connecting slider 14 and a vertical elastic member 7; the adjusting screw 9 is vertically arranged in the handheld shell 11, and the adjusting screw 9 is threadedly connected to the proximal surface of the handheld shell 11, the connecting slider 14 is rotationally connected to the adjusting screw 9, and the connecting slider 14 is respectively connected to the first end of each oblique connecting rod 15; the rotating member is fixed to one end of the adjusting screw 9 and extends out of the handheld shell 11; the two ends of the vertical elastic member 7 are respectively connected to the handheld shell 11 and the connecting slider 14.

When there are four energy application units 1, the preset track can be four long strip through slots 202 arranged at 90 degrees on the chassis 2. A cylinder with a threaded hole can be set in the center of the chassis 2 for the movement of the adjustment screw 9 on the rotating member (knob 8). There is a circular through hole in the transverse slider 5 for fixing the energy application unit 1. The transverse slider 5 is connected to the oblique connecting rod 15, the oblique connecting rod 15 and the supporting connecting rod 16, and the oblique connecting rod 15 and the connecting slider 14 through a piston pin, and it They can rotate relative to each other. The adjusting screw 9 is located at the bottom center of the knob 8, which forms a threaded fit with the chassis 2. When the knob 8 is turned, the knob 8 will move downward, thereby causing the connecting slider 14 to move downward. The movement of the connecting slider 14 will drive the rotation of the oblique connecting rod 15 and the supporting connecting rod 16, and the rotation of the oblique connecting rod 15 will cause the transverse slider 5 to move, and the energy application unit 1 will also move. When the energy application unit 1 moves, the spacing between the energy application units 1 will change, thereby changing the ablation area. Because the movement of the energy application units 1 occurs in the same plane and the energy application units 1 are initially parallel to each other, the execution ends of each energy application unit 1 are always in the same plane.

Embodiment 4

This embodiment, based on the above-mentioned embodiments 1 to 3, provides a method for using a multi-needle steep pulse ablation electrode device for ablating tumor tissue, including:

The first step is to provide a multi-needle steep pulse ablation electrode device: it further comprises a handheld shell 11, a plurality of energy application units 1 and a driving unit. The connection ends of the plurality of energy application units 1 are configured to be inserted and slidably connected to the distal surface of the handheld shell 11 along a preset trajectory, and the execution ends of the plurality of energy application units 1 are located in the same plane and cooperate to form an energy application execution area. The driving unit is disposed in the handheld shell 11, and the power input end of the driving unit extends out of the handheld shell 11, and the power output end of the driving unit is respectively connected to the plurality of energy application units 1. The driving unit is configured such that the power input end receives external power input, and the power output end outputs a driving force to drive the plurality of energy application units 1 to slide along their corresponding preset trajectories respectively.

In the second step, the driving unit is configured to drive each metal puncture needle to slide along its preset trajectory by rotating the knob 8 to obtain an energy application execution area that matches the preset energy application area of the corresponding tumor tissue.

In the third step, the multi-needle steep pulse ablation electrode device is configured so that each energy application unit 1 delivers or punctures to the target position corresponding to the target tissue.

Each energy application unit 1 is configured to deliver energy to a target tissue.

The method of this embodiment can be applied to in vitro experiments using a multi-needle steep pulse ablation electrode device to detect the accuracy of the energy application execution area formed by the device.

Embodiment 5

This embodiment provides a radiofrequency ablation device based on the above-mentioned embodiment 1, defines the area where energy is required to be applied to the target tissue as a preset radiofrequency ablation area, and includes a handheld housing 11, a plurality of energy application units 1 and a driving part.

The connecting ends of the energy application units 1 are configured to be inserted and slidably connected to the distal end surface of the handheld housing 11 along a preset trajectory. The execution ends of multiple energy application units 1 are located in the same plane and cooperate to form a radiofrequency ablation execution area.

The driving part is arranged in the handheld housing 11, and the power input end of the driving part extends out of the handheld housing 11, and the power output end of the driving part is respectively connected to the multiple energy application units 1. The driving part is configured to receive external power input at the power input end, and output driving force from the power output end to drive the multiple energy application units 1 to slide along the preset tracks corresponding to each energy application unit 1, so as to adjust the radiofrequency ablation execution area to match the preset radiofrequency ablation area.

In this embodiment, multiple energy application units 1 are configured to be inserted and connected to the distal end of the handheld shell 11 by sliding along a preset trajectory. A driving unit is provided in the handheld shell 11, and the driving unit drives each energy application unit 1 to slide along the preset trajectory on the distal end of the handheld shell 11, thereby adjusting the spacing between each energy application unit 1 and the area of the radio frequency ablation execution area formed by the execution end of each energy application unit 1, so as to adapt to the preset radio frequency ablation area where energy needs to be applied to the target tumor, thereby solving the problem of the difficulty in accurately controlling the spacing between each needle and the ablation area in the existing steep pulse ablation electrodes. After adjusting to adapt to the target tumor, the execution end of the energy application unit 1 can be delivered or inserted to reach the target tumor to apply energy, so as to perform radio frequency ablation on the target tumor in the radio frequency ablation execution area.

The difference between this embodiment and the above-mentioned embodiment 1 is that the energy application unit 1 of this embodiment is used for radiofrequency ablation, and can be specifically a radiofrequency ablation needle. When the radiofrequency current in the radiofrequency ablation needle flows through human tissue, the rapid change of the electromagnetic field causes the polarized water molecules in the tissue to move at high speed, generating heat (i.e., endogenous heat effect), causing the water inside and outside the cells to evaporate, dry, shrink and fall off, resulting in aseptic necrosis, thereby achieving the purpose of treatment.

Embodiment 6

This embodiment provides a tumor ablation device, including a carrier carrying a plurality of treatment units and a driving unit.

The connection ends of the plurality of treatment units are configured to be inserted and slidably connected along a preset trajectory. The distal end surface of the carrier and the execution end of the treatment unit are located in the same plane and cooperate to form an energy application execution area. The driving unit is arranged in the carrier, and the power output end of the driving unit is connected to each treatment unit respectively. The driving unit is configured to drive each treatment unit to slide along its corresponding preset trajectory respectively, so as to adjust the energy application execution area to match the preset tumor ablation area.

Embodiment 7

This embodiment provides a medical minimally invasive system based on the above-mentioned embodiments one to four. The medical minimally invasive system configures multiple energy application units 1 to be inserted and slidably connected to the distal end surface of the handheld shell 11 along a preset trajectory. A driving unit is set in the handheld shell 11, and the driving unit drives each energy application unit 1 to slide along the preset trajectory on the distal end surface of the handheld shell 11, thereby adjusting the spacing between each energy application unit 1 and the area of the energy application execution area formed by the execution end of each energy application unit 1, so as to adapt to the preset energy application area where the target tumor needs to apply energy, and solves the problem of the existing steep pulse ablation electrode that it is difficult to accurately control the spacing between each needle and the ablation area. After adjusting to adapt to the target tumor, the execution end of the energy application unit 1 can be delivered or inserted to reach the target tumor for energy application, so as to ablate the target tumor in the energy application execution area.

Application Examples

This application example illustrates the specific application based on the above-mentioned embodiments one to four: first, the spacing between each metal puncture needle and the ablation area are matched to the corresponding tumor target by rotating the knob 8, and the metal puncture needle is inserted into the patient's diseased part by holding it in the handheld part, and then the high-voltage pulse power supply is turned on. The high-frequency and high-voltage pulse current output by it is introduced into the patient's diseased part through one or more of the metal puncture needles, and the remaining metal puncture needles are used as loop electrodes to introduce the high-frequency and high-voltage pulse current into the input end of the high-voltage pulse power supply. When the high-frequency and high-voltage pulse current passes through the patient's diseased cells, the high-frequency and high-voltage pulse current will destroy the cell membrane of the diseased cells, thereby killing the diseased cells. Since the metal puncture needles are used as loop electrodes, the high-frequency and high-voltage pulse current only passes through the diseased part and will not damage healthy cells outside the diseased tissue.

The embodiments of the present invention are described in detail above in conjunction with the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, if these changes fall within the scope of the claims of the present invention and their equivalents, they still fall within the protection scope of the present invention.

Claims (16)

A multi-needle steep pulse ablation electrode device, characterized in that the area where energy is required to be applied to the target tissue is defined as a preset energy application area, including: Handheld housing; A plurality of energy application units, wherein the connection ends of the energy application units are configured to be inserted into and slidably connected to the distal end surface of the handheld housing along a preset trajectory, and the execution ends of the plurality of energy application units are located in the same plane and cooperate to form an energy application execution area; A driving unit is disposed in the handheld housing, and a power input end of the driving unit extends out of the handheld housing, and a power output end of the driving unit is respectively connected to a plurality of the energy application units; The driving part is configured so that the power input end receives external power input, and the power output end outputs driving force to drive the plurality of energy application units, which slide along the preset trajectories corresponding to the respective energy application units, so as to adjust the energy application execution area to match the preset energy application area. The multi-needle steep pulse ablation electrode device as described in claim 1 is characterized in that the preset trajectories of the multiple energy application units are configured to converge toward the center of the distal end surface of the handheld shell and/or diverge outward from the center of the distal end surface of the handheld shell, and the shape of the energy application execution area is configured as a regular polygon. The multi-needle steep pulse ablation electrode device according to claim 1, characterized in that the direction perpendicular to the distal end surface of the handheld shell is defined as the vertical direction, and the direction parallel to the distal end surface of the handheld shell is defined as the horizontal direction; The driving part includes a power input unit, a power execution unit and a plurality of connecting sliding units; the connecting sliding units are respectively connected to the corresponding energy application units, and are slidably connected to the inner cavity of the handheld shell along the preset trajectory; the output end of the power input unit extends into the inner cavity of the handheld shell, and is connected to each of the connecting sliding units through the power execution unit; the power execution unit is configured to receive the power input of the power input unit, and convert the power input into driving each of the connecting sliding units and the energy application unit to slide laterally. The multi-needle steep pulse ablation electrode device according to claim 3, characterized in that the power input unit is a vertical power input mechanism, the power execution unit includes a vertical slider and an elastic force supply unit, and the connecting sliding unit is a transverse slider provided with a guide slope; The input end of the vertical power input mechanism extends out of the handheld housing, and the output end of the vertical power input mechanism is connected to the vertical slider, which is used to drive the vertical slider to move vertically; the vertical slider is provided with a plurality of driving inclined surfaces arranged around, and the driving inclined surfaces are inclined toward the center of the distal end surface of the handheld housing; a plurality of transverse sliders are arranged around the circumference of the vertical slider, and the driving inclined surfaces correspond to the guide inclined surfaces one by one; the elastic force supply unit is respectively connected to each of the transverse sliders, and is used to provide an elastic force for the transverse slider to move toward the vertical slider; Driven by the elastic force supply unit, the guiding inclined surface of each of the transverse sliders is attached to the driving inclined surface, and the transverse position of the transverse slider relative to the vertical slider is adjusted along the preset trajectory according to the vertical relative position change of the vertical slider. The multi-needle steep pulse ablation electrode device according to claim 4, characterized in that the vertical power input mechanism comprises a rotating member, an adjusting screw and a fixing nut; The fixing nut is fixed to the vertical slider; the adjusting screw is arranged vertically, and the adjusting screw is threadedly connected to the fixing nut; the rotating member is fixed to one end of the adjusting screw and extends out of the handheld housing; The rotating member includes a knob and a vertical elastic member; the bottom end of the knob is provided with an extension boss extending outwards, which is used to abut against the proximal end surface of the handheld housing; the two ends of the vertical elastic member are respectively connected to the extension boss and the vertical slider; The elastic force supply unit is an annular compression spring; An elastic member groove is provided on one side of each of the transverse slide blocks away from the center of the distal end surface of the handheld housing. The annular compression spring surrounds each of the transverse slide blocks and is embedded in the corresponding elastic member groove. The multi-needle steep pulse ablation electrode device according to claim 4, characterized in that the vertical slider comprises a slider body and a vertical guide structure and a plurality of oblique guide structures provided on the slider body; The outer contour of the vertical guide structure is in contact with the inner cavity wall of the handheld housing; the oblique guide structure includes two guide plates vertically and spaced apart on the slider body, and the lower ends of the two guide plates are each provided with an oblique cut surface facing the center of the distal end surface of the handheld housing, and the two corresponding oblique cut surfaces together form the driving inclined surface; A protruding structure is provided at the upper end of the transverse sliding block, and two sides of the protruding structure are respectively provided with inclined step surfaces that cooperate to form the guiding inclined surface; An embedding through groove is vertically arranged in the transverse sliding block and extends to the protruding structure. The multi-needle steep pulse ablation electrode device according to claim 4, characterized in that the lower end of the lateral slider is provided with an extension slide extending toward at least one side of the preset track; The distal surface of the handheld shell is a distal bottom plate structure, which includes a chassis and a cover plate; the chassis is respectively provided with guide grooves corresponding to each of the preset trajectories, and the width of the guide grooves matches the overall size of the extension slide; the bottom surface of the guide groove is provided with a long strip through groove for the energy application unit to pass through; the cover plate is covered on the chassis and is provided with guide openings corresponding to the guide grooves one by one, and the width of the guide openings matches the width of the horizontal slider, and the chassis and the cover plate are respectively provided with insertion openings for the vertical slider to extend into. The multi-needle steep pulse ablation electrode device according to claim 3, characterized in that the power input unit is a rotating member, the power execution unit is a plurality of intermediate transmission members, and the connecting sliding unit is a transverse sliding member; The first ends of the plurality of intermediate transmission members are respectively rotatably connected to the rotating member and offset from the rotating axis of the rotating member, and at least part of the rotating member extends out of the handheld housing; the second end of the intermediate transmission member is rotatably connected to the transverse slider; The distal end surface of the handheld shell is a chassis, and the chassis is provided with a plurality of long strip through slots for the energy application unit to pass through, and the trajectory of the long strip through slots is the preset trajectory; the transverse slider slides on the chassis, and the energy application unit is clamped on the transverse slider and extends out of the corresponding long strip through slots. The multi-needle steep pulse ablation electrode device according to claim 3, characterized in that the power input unit is a vertical power input mechanism, the power execution unit is a plurality of oblique connecting rods, and the connecting sliding unit is a transverse sliding block; The input end of the vertical power input mechanism extends out of the handheld housing, and the output end of the vertical power input mechanism is respectively connected to the first end of each of the oblique connecting rods for rotation and/or swinging, so as to drive the first end of the oblique connecting rod to perform vertical movement; the second end of the oblique connecting rod is respectively connected to the corresponding transverse slider for rotation and/or swinging; The distal end surface of the handheld shell is a chassis, and the chassis is provided with a plurality of long strip through slots for the energy application unit to pass through, and the trajectory of the long strip through slots is the preset trajectory; the transverse slider slides on the chassis, and the energy application unit is clamped on the transverse slider and extends out of the corresponding long strip through slots. The multi-needle steep pulse ablation electrode device as described in claim 9 is characterized in that the power execution unit also includes a support link, a first end of the support link is rotatably and/or swingably connected to the handheld shell, and a second end of the support link is rotatably and/or swingably connected to the rod body of the oblique link. The multi-needle steep pulse ablation electrode device according to claim 10, characterized in that the vertical power input mechanism comprises a rotating member, an adjusting screw, a connecting slider and a vertical elastic member; The adjusting screw is vertically arranged in the handheld shell, and the adjusting screw is threadedly connected to the proximal end surface of the handheld shell, the connecting slider is rotatably connected to the adjusting screw, and the connecting slider is respectively connected to the first end of each of the oblique connecting rods; the rotating member is fixed to one end of the adjusting screw and extends out of the handheld shell; the two ends of the vertical elastic member are respectively connected to the handheld shell and the connecting slider. The multi-needle steep pulse ablation electrode device according to claim 1 is characterized in that the energy application unit is a metal puncture needle, and the number of the energy application units is three, four or five. A method for using a multi-needle steep pulse ablation electrode device, comprising: A multi-needle steep pulse ablation electrode device is provided: it further comprises a handheld shell, a plurality of energy application units and a driving part; the connection ends of the plurality of energy application units are configured to be inserted and slidably connected to the distal end surface of the handheld shell along a preset trajectory, the execution ends of the plurality of energy application units are located in the same plane, and cooperate to form an energy application execution area; the driving part is arranged in the handheld shell, and the power input end of the driving part extends out of the handheld shell, and the power output end of the driving part is respectively connected to the plurality of energy application units; the driving part is configured so that the power input end receives external power input, and the power output end outputs a driving force to drive the plurality of energy application units to slide respectively along the corresponding preset trajectories; The driving part is configured to receive external power input to drive each of the energy application units to slide along its preset trajectory to obtain the energy application execution area that matches the preset energy application area. A radiofrequency ablation device, characterized in that the area where energy is required to be applied to the target tissue is defined as a preset radiofrequency ablation area, comprising: Handheld housing; A plurality of energy application units, wherein the connection ends of the energy application units are configured to be inserted into and slidably connected to the distal end surface of the handheld housing along a preset trajectory, and the execution ends of the plurality of energy application units are located in the same plane and cooperate to form a radiofrequency ablation execution area; A driving unit is disposed in the handheld housing, and a power input end of the driving unit extends out of the handheld housing, and a power output end of the driving unit is respectively connected to a plurality of the energy application units; The driving unit is configured such that the power input end receives external power input, and the power output end outputs driving force to drive the multiple energy application units to slide along the preset trajectory corresponding to each energy application unit, so as to adjust the radio frequency ablation execution area to match the preset radio frequency ablation area. A tumor ablation device, comprising: A carrier carrying a plurality of treatment units; wherein the connection ends of the plurality of treatment units are configured to be inserted and slidably connected to the distal end surface of the carrier along a preset trajectory, and the execution ends of the treatment units are located in the same plane and cooperate to form an energy application execution area; The driving unit is arranged in the carrier, and the power output end of the driving unit is respectively connected to each of the treatment units; the driving unit is configured to drive each of the treatment units to slide along the corresponding preset trajectory to adjust the energy application execution area to match the preset tumor ablation area. A medical minimally invasive system, characterized by comprising a multi-needle steep pulse ablation electrode device as described in any one of claims 1 to 12.