WO2024255905A1 - Dispositif de détection de composés organiques volatils - Google Patents

Dispositif de détection de composés organiques volatils Download PDF

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Publication number
WO2024255905A1
WO2024255905A1 PCT/CN2024/099583 CN2024099583W WO2024255905A1 WO 2024255905 A1 WO2024255905 A1 WO 2024255905A1 CN 2024099583 W CN2024099583 W CN 2024099583W WO 2024255905 A1 WO2024255905 A1 WO 2024255905A1
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Prior art keywords
layer
voc
semipermeable membrane
substance
detecting
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PCT/CN2024/099583
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English (en)
Inventor
Tsz Wing CHOW
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Zenxtag Technology Ltd
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Zenxtag Technology Ltd
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Priority to CN202480038571.6A priority Critical patent/CN121713060A/zh
Publication of WO2024255905A1 publication Critical patent/WO2024255905A1/fr
Anticipated expiration legal-status Critical
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G01N33/4975—Physical analysis of biological material of gaseous biological material, e.g. breath other than oxygen, carbon dioxide or alcohol, e.g. organic vapours
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7723—Swelling part, also for adsorption sensor, i.e. without chemical reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/773—Porous polymer jacket; Polymer matrix with indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/775—Indicator and selective membrane
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7776—Index
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/783—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour for analysing gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/80—Indicating pH value

Definitions

  • the present invention generally relates to device, systems and method for detecting of volatile organic compounds (VOCs) . More particularly, the invention relates detecting of VOCs using a device or systems comprising a semipermeable membrane and a detecting substance and the invention relates the method using the said device or systems.
  • VOCs volatile organic compounds
  • Volatile organic compounds are a class of molecules with high vapor pressure at room temperature, and many have the potential to cause damage to both environment and human health. Some VOCs are also indicators or biomarkers for diseases. The ability to accurately detect the presence of VOCs may therefore be helpful in areas such as air quality monitoring, biomedical diagnostics, industrial processes, security and occupational health, etc.
  • Conventional techniques for the detection of volatile organic compounds include mass spectrometry, gas chromatography, and ion mobility spectroscopy. However, those are bench-top techniques, which require trained personnels, large setups, high operational cost and sophisticated equipment, and require a significant amount of time to generate results, thereby limiting their on-site applicability.
  • the present disclosure provides a device for detecting volatile organic compounds (VOC) , comprising:
  • the detection layer comprising (i) a detecting substance which responses to the VOC, and (ii) a matrix substance;
  • the semipermeable membrane allows the pass through of the VOC but does not allow the pass through of the detecting substance in the detection layer.
  • the semipermeable membrane is water permeable.
  • the semipermeable membrane is detecting substance impermeable.
  • the semipermeable membrane is natural.
  • the semipermeable membrane is synthetic.
  • the semipermeable membrane is cellulosic.
  • the semipermeable membrane is made of the substance selected from the group consisting of cellophane, cellulose acetate (CA) , polyurethane (PU) , polytrifluorochloroethylene (PCTFE) , polyvinyl chloride (PVC) , polysulfone (PS) , polyvinylidene fluoride (PVDF) , polyethylene (PE) , polyacrylonitrile (PAN) , polyvinyl alcohol (PVA) and polyimide (PI) .
  • cellophane cellulose acetate (CA) , polyurethane (PU) , polytrifluorochloroethylene (PCTFE) , polyvinyl chloride (PVC) , polysulfone (PS) , polyvinylidene fluoride (PVDF) , polyethylene (PE) , polyacrylonitrile (PAN) , polyvinyl alcohol (PVA) and polyimide (PI) .
  • CA cellophane
  • the semipermeable membrane is made of cellulose acetate (CA) .
  • the VOC is hazardous to human health.
  • the VOC is a marker for a disease.
  • the VOC is a metabolite of a mammal.
  • the VOC comprising aldehydes, ketones, amines, thiols, esters, or carboxylic acids.
  • the VOC is generated by the spoilage of food.
  • the VOC is an amine
  • the VOC is tryptamine, ⁇ -phenylethylamine, putrescine, cadaverine, histamine, octopamine, tyramine, spermidine or spermine.
  • the detecting substance is a pH indicator.
  • the detecting substance is a protein, a nucleic acid, a polymer, a small molecule, or a nanomaterial.
  • the detecting substance is nano gold, nano silver, CdS quantum dots or carbon quantum dots.
  • the detecting substance is nano silver.
  • the detecting substance is an organometallic complex.
  • the detecting substance is a bimetallic complex.
  • the detecting substance can generate a signal when respond to the VOC.
  • the measurable signal is a change in fluorescence spectrum or visible spectrum of the detecting substance.
  • the measurable signal is a change in refractive index of the detecting substance.
  • the measurable signal is a change in the volume or thickness of the detection layer.
  • the matrix substance is a polymer.
  • the matrix substance is a natural polymer.
  • the matrix substance is cellulose or chemically modified cellulose.
  • the matrix substance is PVA.
  • the matrix substance is hydrogel.
  • the matrix substance is paper pulp.
  • the detection layer further comprising a stabilizer for stabilizing the detecting substance.
  • the detection layer further comprising a suspending agent.
  • the detection layer further comprising a moisturizer.
  • the moisturizer is glycol or glycerol.
  • the device further comprising a first adhesive layer between the semipermeable membrane layer and the detection layer.
  • the device further comprising a second adhesive layer between the substrate layer and the detection layer.
  • the detection layer comprising an adhesive agent which can assemble the substrate layer and the semipermeable membrane layer.
  • an adhesive tape for detecting volatile organic compounds (VOC) comprising:
  • the present disclosure provides a system for detecting volatile organic compounds (VOC) , comprising a container and the device described herein.
  • VOC volatile organic compounds
  • system further comprising an observation window.
  • the present disclosure provides the use of the system described herein, comprising
  • the present disclosure provides the use of the device described herein in diagnosis of a disease, comprising:
  • the disease is a cancer, an infectious disease or a chronic disease.
  • the cancer is selected from the group consisting of neuroblastoma, lymphoma, leukemia, melanoma, glioma, small cell lung cancer, breast carcinoma, ovarian cancer, soft tissue sarcomas, osteosarcoma, Ewing’s sarcoma, desmoplastic round cell tumor, rhabdomyosarcoma, retinoblastoma, non-small cell lung cancer, renal cell cancer, Wilms tumor, prostate cancer, gastric cancer, endometrial cancer, pancreatic cancer, and colon cancer.
  • the disease is an infectious disease
  • the disease is a chronic disease.
  • the disease is Alzheimer’s disease.
  • the disease is diabetes.
  • the present disclosure provides a kit for disease diagnosis comprising the device described herein.
  • FIG. 1 shows an exemplary design of the device with five layers.
  • FIG. 2 shows an exemplary design of the device with three layers, wherein the detection layer comprising a detecting region and an adhesive region.
  • FIG. 3A depicts the response of the label fabricated with pH paper and Red litmus paper to TME (trimethylamine) .
  • FIG. 3B depicts the response of the label fabricated with pH paper and Blue litmus paper to acetic acid.
  • FIG. 3C depicts the response of the label fabricated with a FeFe-based filter paper to TME (trimethylamine) .
  • the articles “a, ” “an, ” and “the” are used herein to refer to one or to more than one (i.e., to at least one) of the grammatical object of the article.
  • “acompound” means one compound or more than one compound.
  • the term “and/or” indicates that one or more of the stated cases may occur, alone or in combination with at least one of the stated cases, up to with all of the stated cases, and in the invention generally.
  • components A, B, and C can consist of (i.e., contain only) components A, B, and C, or can contain not only components A, B, and C but also one or more other components.
  • the defined steps can be carried out in any order or simultaneously (except where the context excludes that possibility) , and the method can include one or more other steps which are carried out before any of the defined steps, between two of the defined steps, or after all the defined steps (except where the context excludes that possibility) .
  • the term “at least” followed by a number is used herein to denote the start of a range beginning with that number (which may be a range having an upper limit or no upper limit, depending on the variable being defined) .
  • “at least 1” means 1 or more than 1.
  • the term “at most” followed by a number is used herein to denote the end of a range ending with that number (which may be a range having 1 or 0 as its lower limit, or a range having no lower limit, depending upon the variable being defined) .
  • “at most 4” means 4 or less than 4
  • “at most 40%” means 40%or less than 40%.
  • a range is given as “ (a first number) to (a second number) ” or “ (a first number) – (a second number) , ” this means a range whose lower limit is the first number and whose upper limit is the second number.
  • 25 to 100 mm means a range whose lower limit is 25 mm, and whose upper limit is 100 mm.
  • the invention provides a multilayer detection device, which physically isolates the subject to be detected from the detected substance but does not affect the detection performance.
  • the present disclosure provides a device for detecting volatile organic compounds (VOC) , comprising:
  • the detection layer comprising (i) a detecting substance which responses to the VOC, and (ii) a matrix substance;
  • the device further comprising a first adhesive layer between the semipermeable membrane layer and the detection layer.
  • the device further comprising a second adhesive layer between the substrate layer and the detection layer.
  • FIG. 1 An exemplary design is shown in FIG. 1. From top to bottom, the device comprising a semipermeable membrane layer (1) , a first adhesive layer (4) , a detection layer (2) , a second adhesive layer (4) , and a substrate layer (5) .
  • the detection layer comprising an adhesive agent which can assemble the substrate layer and the semipermeable membrane layer.
  • VOC volatile organic compounds
  • a detecting region (21) comprising a detecting substance which response to the VOC, and a matrix substance
  • Semipermeable membrane is a kind of membrane that only allows certain molecules or ions to diffuse in and out.
  • the semipermeable membrane allows the pass through of the VOC but does not allow the pass through of the detecting substance in the detection layer.
  • the semipermeable membrane is water permeable.
  • the semipermeable membrane is detecting substance impermeable.
  • the semipermeable membrane is natural. Natural semi-permeable membranes including frog skin, bladder membrane or parchment.
  • the semipermeable membrane is synthetic. Artificial semipermeable membranes include a variety of materials designed for the purposes of filtration, such as those used in reverse osmosis, which only allow water to pass. In some embodiments, the semipermeable membrane is cellulosic.
  • the semipermeable membrane is made of the substance selected from the group consisting of cellophane, cellulose acetate (CA) , polyurethane (PU) , polytrifluorochloroethylene (PCTFE) , polyvinyl chloride (PVC) , polysulfone (PS) , polyvinylidene fluoride (PVDF) , polyethylene (PE) , polyacrylonitrile (PAN) , polyvinyl alcohol (PVA) and polyimide (PI) .
  • the semipermeable membrane is made of cellulose acetate (CA) .
  • the systems and methods described herein may be used to detect VOCs in a nearby or surrounding environment (e.g., for detection and/or tracking of threats) .
  • detection systems and methods may sense the presence and/or distance of trace species (e.g., explosives, gunpowder, ammonium nitrate, opioids, biological agents, other trace VOC species, etc. ) .
  • trace species e.g., explosives, gunpowder, ammonium nitrate, opioids, biological agents, other trace VOC species, etc.
  • systems and methods such as that described herein may be used to detect VOCs in the breath of a user for diagnosis and/or tracking of medical conditions or other health state (e.g., COVID-19) .
  • the VOC is hazardous to human health.
  • the VOC is a marker for a disease. In some embodiments, the VOC is a metabolite of a mammal. In some embodiments, the VOC comprising aldehydes, ketones, amines, thiols, esters, or carboxylic acids.
  • metabolite are derivatives resulting from metabolic process in the body of a subject.
  • metabolites may result from oxidation, reduction, hydrolysis, amidation, deamidation, esterification, deesterification, enzymatic cleavage, and the like, of a compound
  • exhaled breath detection technology is a new method for disease diagnosis, which has been widely concerned by researchers since its development.
  • non-infectious diseases such as bronchial asthma, lung cancer, breast cancer, colorectal cancer, etc.
  • infectious diseases such as tuberculosis, COVID-19
  • pathogenic microorganisms can produce a wide range of VOCs, such as hydrocarbons, alcohols, ketones, nitrogen-containing and sulfur-containing compounds, etc. after infecting the body.
  • Metabolism of pathogenic microorganisms may affect exhaled breath components. Different species of microorganisms produce different kinds of VOC when they grow and metabolize in human tissue microenvironment, which makes it possible to detect their metabolic spectrum and specific substances.
  • the detection of exhaled VOC has the advantages of non-invasive, simple sampling and high speed, and has great application value.
  • the VOC is generated by the spoilage of food.
  • the VOC is an amine. Protein-rich foods, such as seafood and meat, will be invaded by microorganisms during food processing and manufacturing, and proteins will be decomposed, and then converted into biogenic amines by decarboxylase. Biogenic amines are one of the markers of food spoilage. Therefore, the monitoring of biogenic amines is very important for freshness evaluation.
  • the VOC is tryptamine, ⁇ -phenylethylamine, putrescine, cadaverine, histamine, octopamine, tyramine, spermidine or spermine.
  • the detecting substance can be selected according to the VOC to be detected.
  • the detecting substance may be a protein, a nucleic acid, a polymer, a small molecule, or a nanomaterial.
  • the detecting substance is a pH indicator. In some embodiments, the detecting substance is bromocresol green, bromocresol purple, bromocresol blue, methyl red, anthocyanin, beta-carotene, curcumin, alizarin, or alkannin.
  • the detecting substance may be nano material.
  • gold nanoparticles can be loaded to determine volatile biogenic amines and sulfides to monitor the freshness of raw meat, raw fish and raw crustaceans.
  • the detecting substance is nano gold, nano silver, CdS quantum dots or carbon quantum dots.
  • the detecting substance is an organometallic complex.
  • the detecting substance is a bimetallic complex.
  • the detecting substance is the coumpod of formulae I (also called as “FeFe” ) :
  • the detecting substance is:
  • the detecting substance is:
  • the detecting substance can generate a signal when respond to the VOC.
  • the measurable signal is a change in fluorescence spectrum or visible spectrum of the detecting substance.
  • the measurable signal is a change in refractive index of the detecting substance.
  • the measurable signal is a change in the volume or thickness of the detection layer.
  • Appropriate matrix materials can improve the practicability of labels, make them into desired forms, such as label type, color block array type, and even distribute pigments throughout food packaging.
  • Common matrix substance are bio-based materials such as filter paper, polymer compound, protein and polysaccharide.
  • the matrix substance is a polymer.
  • the matrix substance is a natural polymer.
  • the matrix substance is a protein. In some embodiments, the matrix substance is gelatin, soybean protein or zein.
  • the matrix substance is a polysaccharide. In some embodiments, the matrix substance is chitosan, cellulose, starch, carrageenin alginate, agarose. In some embodiments, the matrix substance is cellulose or chemically modified cellulose.
  • the matrix substance is synthetic polymer.
  • the matrix substance is PVA, or polylactic acid (PLA) .
  • the matrix substance is hydrogel.
  • the detecting substance may be entrapped in hydrogel, for example, hydroxymethylcellulose, gelatin and poly- (methylmethacylate) .
  • the detecting substance may be in the form of microcapsules (for example, liposomes, albumin microspheres, microemulsions, nanoparticles and nanocapsules) or in macroemulsions.
  • the matrix substance is paper pulp. In some embodiments, the matrix substance is filter paper.
  • a portable, reusable paper-based detection layer can be obtained by techniques known in the art. A typical process is, take a piece of filter paper and immerse it into the detecting substance solution, then air dry the paper to get the paper-based sensors.
  • the detection layer further comprising a stabilizer for stabilizing the detecting substance.
  • compositions of matrix substance containing any appropriate solvents and optionally other compounds such as, but not limited to, stabilizers, antimicrobial agents, antioxidants, pH modifiers, surfactants, modifiers and combinations of these.
  • the carriers and stabilizers vary with the requirements of the particular compound, but typically include nonionic surfactants (Tweens, Pluronics, or polyethylene glycol) , sorbitan esters, oleic acid, lecithin, amino acids such as glycine, buffers, salts, sugars or sugar alcohols.
  • the detection layer further comprising a suspending agent.
  • suspending agents are carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, sodium alginate, polyvinyl-pyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents such as lecithin or condensation products of an alkylene oxide with fatty acids (for example polyoxethylene stearate) , or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaethyleneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides, for example polyethylene sorbitan monooleate.
  • the detection layer further comprising a moisturizer.
  • the moisturizer is glycol or glycerol.
  • the present invention also provides some designs based on device described herein, which can achieve the same technical effects. It should be understood that variations of these designs are included in the present invention.
  • the present disclosure provides an adhesive tape for detecting volatile organic compounds (VOC) , wherein the detection layer is interposed between a release layer and semipermeable membrane layer.
  • VOC detection device in form of adhesive tape is more simple to use and more efficient.
  • the adhesive tape comprising:
  • the release layer covers the top surface of the adhesive layer prior to use of the device to protect the adhesive layer from inactivation by ambient dust or other contaminants.
  • the release layer has a sufficient surface area and shape to extend at least to the peripheral edges of the adhesive layer.
  • the release layer can be any convenient release layer or system as known in the art.
  • the layer can comprise a siliconized polyester release tab or siliconized release paper.
  • the present disclosure provides a system for detecting volatile organic compounds (VOC) , comprising a container and the device described herein.
  • VOC volatile organic compounds
  • system further comprising an observation window.
  • the system comprising the device and an observation window can be a food package. Exmeple of food package can refer to U.S. Pat. No. 9,983,185.
  • the present disclosure provides the use of the system described herein, comprising
  • the device described herein can be integrated into a mask (or in other ways) to detect the exhaled VOCs by the human body, so as to achieve the purpose of detecting biomarkers.
  • the present disclosure provides the use of the device described herein in diagnosis of a disease, comprising:
  • the disease is a cancer, an infectious disease or a chronic disease.
  • the cancer is selected from the group consisting of neuroblastoma, lymphoma, leukemia, melanoma, glioma, small cell lung cancer, breast carcinoma, ovarian cancer, soft tissue sarcomas, osteosarcoma, Ewing’s sarcoma, desmoplastic round cell tumor, rhabdomyosarcoma, retinoblastoma, non-small cell lung cancer, renal cell cancer, Wilms tumor, prostate cancer, gastric cancer, endometrial cancer, pancreatic cancer, and colon cancer.
  • the disease is an infectious disease
  • the disease is a chronic disease.
  • the disease is Alzheimer’s disease.
  • the disease is diabetes.
  • the present disclosure provides a kit for disease diagnosis comprising the device described herein.
  • kits can further include, if desired, one or more of various conventional pharmaceutical kit components, such as, for example, containers with one or more pharmaceutically acceptable carriers, additional containers etc., as will be readily apparent to a person skilled in the art.
  • kit components such as, for example, containers with one or more pharmaceutically acceptable carriers, additional containers etc., as will be readily apparent to a person skilled in the art.
  • Instructions, either as inserts or as labels, indicating quantities of the components to be administered, guidelines for administration, and/or guidelines for mixing the components, can also be included in the kit.
  • a formaldehyde detecting device was assembled according to FIG. 2, using commercially available formaldehyde test paper as the detection layer, with the semipermeable membrane layer is CA, the substrate layer is PVC film. Double sided tape was used for assembling of these layers.
  • the color of formaldehyde test paper was changed within 15mins, indicating the response of the device to the formaldehyde gas.
  • a pH detecting device was assembled according to FIG. 2, using commercially available pH paper as the detection layer, with the semipermeable membrane layer is CA, the substrate layer is PVC film. Double sided tape was used for assembling of these layers.
  • a biogenic amine device was assembled according to FIG. 2
  • the semipermeable membrane layer is CA
  • the substrate layer is PVC film. Double sided tape was used for assembling of these layers.
  • the color of detection layer was changed within 15mins, indicating the response of the device to the histamine gas.
  • a calibration curve was prepared to correlate the levels of biological amines with bacterial counts using the label prepared using the structure decirbied herein with the loading of compound (I) . Subsequently, the levels of biological amines in food samples (ham, cheese, lobster, lamb fillet, salmon fish) stored for three days was measured to estimate the bacterial counts. The results are presented in Table 1.
  • circuits, systems, networks, processes, and other elements in the invention may be shown as components in block diagram form in order not to obscure the embodiments in unnecessary detail.
  • well-known circuits, processes, algorithms, structures, and techniques may be shown without unnecessary detail in order to avoid obscuring the embodiments.
  • a process may correspond to a method, a function, a procedure, a subroutine, a subprogram, etc.
  • a process corresponds to a function
  • its termination corresponds to a return of the function to the calling function or the main function.
  • embodiments may be implemented, at least in part, either manually or automatically.
  • Manual or automatic implementations may be executed, or at least assisted, through the use of machines, hardware, software, firmware, middleware, microcode, hardware description languages, or any combination thereof.
  • the program code or code segments to perform the necessary tasks may be stored in a machine readable medium.
  • a processor (s) may perform the necessary tasks.

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  • Pathology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

L'invention concerne un système, un dispositif et un procédé conçus pour analyser des composés organiques volatils (COV). Le système ou le dispositif comprend une couche de membrane semi-perméable (1), que les COV peuvent traverser ; une couche de détection (2), qui comprend une substance de détection qui peut réagir aux COV et une substance de matrice ; éventuellement, une couche de substrat (3).
PCT/CN2024/099583 2023-06-15 2024-06-17 Dispositif de détection de composés organiques volatils Ceased WO2024255905A1 (fr)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0663239A2 (fr) * 1994-01-12 1995-07-19 Dr. Bruno Lange GmbH Dispositif pour l'analyse chimique des composants d'un échantillon
CN111650005A (zh) * 2020-02-10 2020-09-11 江苏盖亚环境科技股份有限公司 一种土壤VOCs检测系统和检测方法
US20210010942A1 (en) * 2019-07-01 2021-01-14 Washington State University Colorimetric sensor for detection of food spoilage
CN112630092A (zh) * 2020-12-15 2021-04-09 阜阳科优检测科技有限公司 一种基于半透膜的土壤污染原位检测装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0663239A2 (fr) * 1994-01-12 1995-07-19 Dr. Bruno Lange GmbH Dispositif pour l'analyse chimique des composants d'un échantillon
US20210010942A1 (en) * 2019-07-01 2021-01-14 Washington State University Colorimetric sensor for detection of food spoilage
CN111650005A (zh) * 2020-02-10 2020-09-11 江苏盖亚环境科技股份有限公司 一种土壤VOCs检测系统和检测方法
CN112630092A (zh) * 2020-12-15 2021-04-09 阜阳科优检测科技有限公司 一种基于半透膜的土壤污染原位检测装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIU YING, TU CHEN, DING ZHENYU, ZHANG YANKUN, WANG XIAOKANG, CAI GUOJUN, WU MENG, LUO YONGMING: "Research Progresses on the Application of Membrane Interface Probe in the Investigation of Organic Contaminated Sites", RESEARCH OF ENVIRONMENTAL SCIENCES, vol. 35, no. 7, 1 July 2022 (2022-07-01), pages 1725 - 1734, XP093247494, ISSN: 1001-6929, DOI: 10.13198/j.issn.1001-6929.2022.04.11 *

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