WO2024257028A3 - Fermentation material - Google Patents

Fermentation material Download PDF

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Publication number
WO2024257028A3
WO2024257028A3 PCT/IB2024/055825 IB2024055825W WO2024257028A3 WO 2024257028 A3 WO2024257028 A3 WO 2024257028A3 IB 2024055825 W IB2024055825 W IB 2024055825W WO 2024257028 A3 WO2024257028 A3 WO 2024257028A3
Authority
WO
WIPO (PCT)
Prior art keywords
sphingoid base
fermentation material
acetylated
hydrogen
double
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2024/055825
Other languages
French (fr)
Other versions
WO2024257028A2 (en
Inventor
Fabio Pereira
Javier VARELA
Ricardo Figueiredo
Bogdan KURPIL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cataya Bio Shanghai Co Ltd
Original Assignee
Cataya Bio Shanghai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cataya Bio Shanghai Co Ltd filed Critical Cataya Bio Shanghai Co Ltd
Priority to CN202480039649.6A priority Critical patent/CN121443747A/en
Publication of WO2024257028A2 publication Critical patent/WO2024257028A2/en
Publication of WO2024257028A3 publication Critical patent/WO2024257028A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/84—Pichia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/18—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with another compound as one donor, and incorporation of one atom of oxygen (1.14.18)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a spray dried fermentation material comprising at least 8 wt.% acetylated derivative of a sphingoid base of formula (1), wherein R1 is C11-C24 alkyl, which may be saturated or contain one or more double and/or triple bonds, and/or which may contain one or more functional groups, the functional group being preferably selected from the group consisting of a hydroxyl group, R2 is hydrogen or -OH, the bond may be a double or a single bond when R2 is hydrogen, or is a single bond when R2 is -OH, and wherein said acetylated derivative of the sphingoid base comprises a mixture of tri- and di- acetylated derivatives of said sphingoid base in a ratio from about 1:0.2 to about 0.2:1, correspondingly. The invention discloses a method of producing the spray dried fermentation material and cells that are capable of fermenting the acetylated derivatives of the sphingoid base.
PCT/IB2024/055825 2023-06-14 2024-06-14 Fermentation material Ceased WO2024257028A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202480039649.6A CN121443747A (en) 2023-06-14 2024-06-14 Fermentation materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT118722 2023-06-14
PT11872223 2023-06-14

Publications (2)

Publication Number Publication Date
WO2024257028A2 WO2024257028A2 (en) 2024-12-19
WO2024257028A3 true WO2024257028A3 (en) 2025-02-27

Family

ID=91953875

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2024/055825 Ceased WO2024257028A2 (en) 2023-06-14 2024-06-14 Fermentation material

Country Status (2)

Country Link
CN (1) CN121443747A (en)
WO (1) WO2024257028A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121369379B (en) * 2025-12-17 2026-04-07 浙江省农业科学院 Application of a natural metabolite, D-erythro-dihydrosphingosine, in the control of plant pathogenic fungi.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006048458A2 (en) * 2004-11-05 2006-05-11 Cosmoferm B.V. Microbial strains producing sphingoid bases or derivatives thereof
WO2017033463A1 (en) * 2015-08-24 2017-03-02 Ajinomoto Co., Inc. Method for producing sphingoid base or sphingolipid
WO2022158993A1 (en) * 2021-01-25 2022-07-28 Carbocode S.A. Method for the production of d-erythro-sphingosine and analogs thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030143659A1 (en) 1996-03-28 2003-07-31 Hendrik Louis Bijl Process for the preparation of a granular microbial biomass and isolation of a compound thereform

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006048458A2 (en) * 2004-11-05 2006-05-11 Cosmoferm B.V. Microbial strains producing sphingoid bases or derivatives thereof
WO2017033463A1 (en) * 2015-08-24 2017-03-02 Ajinomoto Co., Inc. Method for producing sphingoid base or sphingolipid
WO2022158993A1 (en) * 2021-01-25 2022-07-28 Carbocode S.A. Method for the production of d-erythro-sphingosine and analogs thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BÖRGEL D. ET AL: "Metabolic engineering of the non-conventional yeast Pichia ciferrii for production of rare sphingoid bases", METABOLIC ENGINEERING, vol. 14, no. 4, 1 July 2012 (2012-07-01), pages 412 - 426, XP055037974, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2012.03.003 *
SCHORSCH C. ET AL: "Biotechnological production of sphingoid bases and their applications", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 97, no. 10, 12 April 2013 (2013-04-12), pages 4301 - 4308, XP035328938, ISSN: 0175-7598, [retrieved on 20130412], DOI: 10.1007/S00253-013-4878-X *
TER VELD F.: "Production of tetraacetyl phytosphingosine (TAPS) in Wickerhamomyces ciferrii is catalyzed by acetyltransferases Sli1p and Atf2p", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 97, no. 19, 15 January 2013 (2013-01-15), Berlin/Heidelberg, pages 8537 - 8546, XP093163710, ISSN: 0175-7598, DOI: 10.1007/s00253-012-4670-3 *

Also Published As

Publication number Publication date
CN121443747A (en) 2026-01-30
WO2024257028A2 (en) 2024-12-19

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