WO2024258190A1 - Composition de coloration capillaire pour cheveux gris prématurés et son procédé de préparation - Google Patents

Composition de coloration capillaire pour cheveux gris prématurés et son procédé de préparation Download PDF

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WO2024258190A1
WO2024258190A1 PCT/KR2024/008083 KR2024008083W WO2024258190A1 WO 2024258190 A1 WO2024258190 A1 WO 2024258190A1 KR 2024008083 W KR2024008083 W KR 2024008083W WO 2024258190 A1 WO2024258190 A1 WO 2024258190A1
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extract
hair
mpc
pomegranate
composition
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Korean (ko)
Inventor
권영지
장수빈
최재환
윤석균
강승현
채다은
공봉주
김현나
박천호
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Cosmax Inc
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Cosmax Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/10—Preparations for permanently dyeing the hair

Definitions

  • the present invention relates to a hair dye composition and a method for producing the same, and more particularly, to a hair dye composition comprising a pomegranate extract, a metal phenolic complex (MPC), and melanin or a precursor thereof, and a method for producing the same.
  • a hair dye composition comprising a pomegranate extract, a metal phenolic complex (MPC), and melanin or a precursor thereof, and a method for producing the same.
  • hair dyes can be classified into temporary hair dyes, semi-permanent hair dyes, and permanent hair dyes based on the persistence and durability of the color dyed on the hair.
  • permanent hair dyes are divided into oxidation hair dyes, metallic hair dyes, and vegetable hair dyes based on the dyes used, and most hair dyes currently in use are oxidation hair dyes that use oxidation dye precursors and oxidation dyes such as amino compounds.
  • oxidation hair dyes are chemical hair dyes containing synthetic dyes, and they have problems such as hair damage, rashes and contact skin reactions, and vision impairment when used frequently, as well as causing leukemia, bladder cancer, uterine cancer, and breast cancer. They cannot be used by pregnant women due to their toxicity, and they have disadvantages such as an unpleasant odor when dyeing.
  • henna is collected from a plant that grows in tropical regions such as India and the Middle East, and has been used for hair dyeing by humans for thousands of years.
  • ink, walnut, indigo, and chamomile are also used, and each color represents a red series, walnut represents a brown series, ink represents a black series, indigo represents a blue series, and chamomile represents a yellow series.
  • pomegranates are cultivated in Korea, China, Japan, Taiwan, and other countries, and the fruit is known to have astringent, blood purifying, and antioxidant effects due to its rich content of carbohydrates, amino acids, vitamins, minerals, pectin, and tannin.
  • the ellagic acid contained in it is known to have strong anticancer, antioxidant, and acid secretion inhibition effects.
  • Pomegranate peel is called pomegranate peel in oriental medicine and is used as an astringent for diarrhea, dysentery, abdominal pain, and leukorrhea, and is also known to be effective in treating itchy skin, athlete's foot, ringworm, and scabies.
  • pomegranate being used as a natural dye for human hair, but compared to non-oxidizing hair dyes using commercially available pyrogallol, the ⁇ E value is low, resulting in low coverage of gray hair.
  • non-oxidizing hair dyes with pyrogallol as the main ingredient have the limitation that the hair color at the beginning of dyeing is dark blue with a lot of blue added, resulting in an unnatural color.
  • Metal-phenol complexes are compounds of metal and phenol, which are formed by the interaction of metal ions and phenol compounds under specific conditions. These compounds are stabilized by the electronic interaction between the positive charge of the metal ion and the negative charge of the phenol.
  • the metal ion generally refers to a transition metal or an alkali metal, such as iron (II) gluconate, and phenol is a heterocyclic compound that has hydrogen and one oxygen atom.
  • the interaction between metal and phenol can be formed in various ways, the most common form is that the hydrogen atom of phenol combines with the metal ion to form a hydroxyl (oxy) group, and the metal ion is stabilized by interacting with the negative charge of phenol.
  • MPC is used in various fields such as antioxidant, catalyst, and bioactive material.
  • MPC The structure and properties of MPC vary depending on the type of metal and phenol compound used, and it is known that it can act as a dye and exhibit a dyeing effect. These compounds are formed based on the interaction of specific metal ions and phenol compounds, which plays an important role in forming colors.
  • the dyeing effect of MPC is mainly caused by two mechanisms: first, color is formed by charge transfer (complex formation) between metal ions and phenol compounds, and second, MPC can act as a dye by structural interaction formed between metal ions and phenol compounds.
  • the hair surface is composed of proteins, and gallic acid or iron (II) enters between hair surface proteins through hydrophobic interactions and coordination bonds and binds to free molecules or small complexes of hair fibers to form a solid coating on the hair surface, which acts to change the color of the hair.
  • II gallic acid or iron
  • the color produced by MPC varies depending on the type of metal and phenol compounds used and the bonding structure, and some compounds exhibit specific colors such as red, blue, green, or purple, which means that the properties of the hair dye can vary depending on how the MPC composition and ratio are composed.
  • Iron (II) gluconate is a compound that combines iron, a mineral, and glutamic acid, an amino acid, and can be used as a substance that can promote the absorption and utilization of iron in the human body.
  • Iron is an essential substance for maintaining skin health, and is involved in the oxygen supply to skin cells, collagen production, and recovery of skin tissue, and helps protect the skin from oxidation and prevent skin aging.
  • Glutamic acid can improve hair health by supplying moisture to the hair and strengthening the hair structure to improve elasticity and strength.
  • Iron is known to exhibit various colors depending on conditions and that the color also changes depending on the interaction with other substances, but detailed research or information is required on how glutamic acid or Fe-glutamate interacts with which pigment and in what way, and what role it plays in hair dyeing.
  • Tannic acid is a polyphenol compound found in plants, and is mainly contained in wine, beans, etc. In general, it has the property of soothing the skin and reducing inflammation, so it is useful for improving skin troubles such as dermatitis and tingling, and can help increase skin elasticity and improve wrinkles or loose skin. It also has antibacterial properties, so it can help prevent skin infections and maintain skin balance. In particular, it is known to have the effect of improving dull scalp along with sebum control when used in hair products, and it is known that it can be used to naturally absorb pigments and produce a dyeing effect, but additional research is needed because the dyeing power varies depending on the substance and conditions used.
  • Gallic acid is a polyphenol compound found in plant fruits, tea, wine, etc. It helps protect the skin from oxidation through its strong antioxidant action and has anti-inflammatory and antibacterial effects, so it is known to help relieve skin troubles such as dermatitis, acne, and wounds. It also strengthens and adds shine to hair, so using products containing gallic acid can form a protective film on the hair, preventing damage from the external environment, maintaining moisture, and keeping the hair soft. Gallic acid is also used as a color enhancer in cooking, but there is not much research on hair dyeing.
  • (Poly)hydroxyindole is an indole compound, and like tannic acid, it is found in plant and animal tissues, and mainly plays a role related to the biosynthesis of melanin, a skin pigment. It has antioxidant effects, so it can help protect the skin from oxidation and preserve the skin from environmental damage, and it can provide a natural dyeing effect on the skin or hair through interaction with melanin, but the dyeing power varies depending on the substance, conditions, and concentration used together, and it is important to establish the correct method of use to obtain the desired result.
  • the inventors of the present invention confirmed that the gray hair cover hair dyeing effect exhibited by a gray hair dyeing composition containing a pomegranate extract, a metal phenolic complex (MPC), and melanin or a precursor thereof is significantly superior.
  • a gray hair dyeing composition containing a pomegranate extract, a metal phenolic complex (MPC), and melanin or a precursor thereof is significantly superior.
  • the purpose of the present invention is to provide a hair dye composition
  • a hair dye composition comprising two or more selected from the group consisting of a pomegranate extract; MPC (Metal phenolic complex); and melanin or a precursor thereof.
  • Another object of the present invention is to provide a method for producing a hair dye composition, which comprises a mixing step of mixing two or more selected from the group consisting of a pomegranate extract; MPC (Metal phenolic complex); and melanin or a precursor thereof.
  • Another object of the present invention relates to a use of a hair dye composition
  • a hair dye composition comprising two or more selected from the group consisting of a pomegranate extract; MPC (Metal phenolic complex); and melanin or a precursor thereof for hair dyeing.
  • the present invention relates to a hair dye composition for gray hair and a method for producing the same.
  • a hair dye composition comprising a pomegranate extract, a metal phenolic complex (MPC), and melanin or a precursor thereof according to the present invention exhibits an excellent gray hair dyeing effect.
  • MPC metal phenolic complex
  • the present inventors have confirmed that the gray hair cover hair dyeing effect exhibited by a gray hair dye composition comprising a pomegranate extract, MPC, and melanin or a precursor thereof is significantly superior.
  • One aspect of the present invention is a hair dye composition
  • a hair dye composition comprising two or more selected from the group consisting of a plant extract; a metal-phenol complex MPC; and melanin or a precursor thereof.
  • the plant extract may include at least one selected from the group consisting of a pomegranate extract, a blueberry extract, a cacao extract, an apricot extract, a persimmon extract, a grape extract, an avocado extract, an apple extract, a beet extract, and an odi extract, and more specifically, may be a pomegranate extract.
  • the pomegranate extract may be at least one extract selected from the group consisting of flowers, fruits, seeds, leaves, branches, stems, and roots of a pomegranate tree.
  • the above pomegranate extract may contain 40 to 100 wt% of the pomegranate flower extract, preferably 45 to 100 wt%, 50 to 100 wt%, 55 to 100 wt%, 60 to 100 wt%, 65 to 100 wt%, 70 to 100 wt%, 75 to 100 wt%, 80 to 100 wt%, or 85 to 100 wt%, for example, but not limited to, 90 to 100 wt%.
  • the above 'extract' includes a solvent crude extract, a specific solvent soluble extract (solvent fraction) and a solvent fraction of a solvent crude extract, and the pomegranate extract may be in a solution, concentrate or powder state.
  • the above pomegranate extract may be a crude extract obtained by extracting pomegranate with water and at least one solvent selected from the group consisting of straight-chain or branched alcohols having 1 to 4 carbon atoms.
  • the amount is 10% or more but less than 100% (v/v), 20% or more but less than 100% (v/v), 30% or more but less than 100% (v/v), 40% or more but less than 100% (v/v), 50% or more but less than 100% (v/v), 60% or more but less than 100% (v/v), 70% or more but less than 100% (v/v), 10% or more but less than 90% (v/v), 20% or more but less than 90% (v/v), 30% or more but less than 90% (v/v), 40% or more but less than 90% (v/v), 50% or more but less than 90% (v/v),
  • the alcohol aqueous solution may be at least one selected from the group consisting of a methanol aqueous solution, an ethanol aqueous solution, a propanol aqueous solution, and a butanol aqueous solution, and may be, for example, an ethanol aqueous solution, but is not limited thereto.
  • the pomegranate extract according to the present invention may be a solvent fraction obtained by fractionating a solvent crude extract with an additional solvent, and for example, may be a solvent fraction obtained by using at least one solvent selected from the group consisting of ethyl ether, ethyl acetate, and butanol in the solvent crude extract.
  • the solvent crude extract obtained by extracting the pomegranate with water and at least one solvent selected from the group consisting of straight-chain or branched alcohols having 1 to 4 carbon atoms may be a solvent fraction using at least one solvent selected from the group consisting of ethyl ether, ethyl acetate, and butanol.
  • One aspect of the present invention relates to a method for producing a pomegranate extract.
  • the above pomegranate extract includes a solvent crude extract and a solvent fraction of pomegranate and is as described above.
  • the above pomegranate extract may be a crude extract obtained by extracting pomegranate with water and at least one solvent selected from the group consisting of straight-chain or branched alcohols having 1 to 4 carbon atoms.
  • the solvent is 10% or more but less than 100% (v/v), 20% or more but less than 100% (v/v), 30% or more but less than 100% (v/v), 40% or more but less than 100% (v/v), 50% or more but less than 100% (v/v), 60% or more but less than 100% (v/v), 70% or more but less than 100% (v/v), 10% or more but less than 90% (v/v), 20% or more but less than 90% (v/v), 30% or more but less than 90% (v/v), 40% or more but less than 90% (v/v), 50% or more but less than 90% (v/v), 60% or more but less than 90% (v/v) or It may be an aqueous solution of a linear or branched alcohol having 1 to 4 carbon atoms of 70% to 90% (v/v), for example, an aqueous solution of a linear or branched alcohol having 1 to 4 carbon atoms of 80% (v/v).
  • the process for manufacturing the pomegranate extract according to the present invention is described in more detail as follows:
  • the pomegranate is cut, washed with water to remove contaminants, and then extracted at room temperature with an extraction solvent of about 10 to 50 times the weight of the pomegranate. After extraction, the filtrate is collected by filtering.
  • the extraction temperature is not particularly limited, but is preferably 15 to 110°C, and preferably 20 to 90°C.
  • the extraction process can be repeated once or several times, and in a preferred example of the present invention, a method of re-extracting after the first extraction can be adopted. This is because, in the case of mass-producing a herbal extract, even if filtered effectively, a loss occurs because the herbal medicine itself has a high moisture content, so the extraction efficiency is low only with the first extraction, so this is to prevent this. In addition, as a result of verifying the extraction efficiency at each stage, it was revealed that about 80 to 90% of the total extraction amount is extracted by the second extraction.
  • the obtained residue when the extraction process is repeated twice, the obtained residue is again reflux-extracted with about 5 to 15 times the volume of the extraction solvent, preferably 8 to 12 times the volume. After extraction, it is filtered and combined with the previously obtained filtrate, and concentrated under reduced pressure to produce the 000 extract.
  • the extraction efficiency can be increased, but the extract of the present invention is not limited to the extraction number.
  • the amount of solvent used in the production of the above pomegranate extract is too small, stirring becomes difficult and the solubility of the extract decreases, resulting in a decrease in extraction efficiency. If the amount is too large, the amount of solvent used in the next purification step increases, which is not economical and may cause handling problems. Therefore, it is recommended that the amount of solvent used be within the above range.
  • the filtered extract thus obtained can be azeotropically concentrated 1 to 5 times, preferably 2 to 3 times, with water in an amount of about 10 to 30 times by weight, preferably 15 to 25 times by weight, more preferably about 20 times by weight, of the total amount of the concentrate to adjust the content of the lower alcohol remaining so as to be suitable for use as a raw material, and then the same amount of water is added again to homogeneously suspend the resultant, followed by freeze-drying to produce a pomegranate extract in a powdered form.
  • extraction refers to a method of separating useful soluble components contained in a liquid or solid raw material by dissolving them in a solvent, and may be any method commonly used, and examples thereof include, but are not limited to, a hot water extraction method, a cold immersion extraction method, a reflux cooling extraction method, a solvent extraction method, a steam distillation method, an ultrasonic extraction method, an elution method, and a pressing method.
  • the MPC may be at least one selected from the group consisting of polyphenols and metal ion complexes.
  • the above polyphenols may include tannic acid, gallic acid or a gallic acid derivative.
  • the above metal ion complex may be an iron ion complex, and preferably, an iron gluconate complex, but is not limited thereto.
  • the above MPC may contain iron(II) D-gluconate dehydrate, tannic acid and gallic acid in a weight ratio of 1:0.1 to 2:0.2 to 4, and preferably, 1:0.2 to 2:0.5 to 4, 1:0.5 to 2:1 to 4, 1:1 to 2:2 to 4, 1:0.1 to 1:0.2 to 2, 1:0.2 to 1:0.5 to 2, or 1:0.5 to 1:1 to 2, and for example, 1:1:2, but is not limited thereto.
  • the precursor of melanin may be at least one selected from the group consisting of poly-dihydroxyindole, L-Dopaquinone, hydroxytryptophan, tyrosine, 3,4-dihydroxyphenylalanine (DOPA), dopaquinone, leucodopachrome, dopachrome, and 5,6-indolequinone, and more specifically, may be poly-dihydroxyindole, but is not limited thereto.
  • the composition may preferably include a pomegranate extract; and MPC, or may include a pomegranate extract; and melanin or a precursor thereof, or may include MPC; and melanin or a precursor thereof, for example, but is not limited thereto.
  • the pomegranate extract may be included in an amount of 0.001 to 10 wt% based on the total composition, and preferably 0.001 to 8 wt%, 0.001 to 5 wt%, 0.001 to 4 wt%, 0.001 to 3 wt%, 0.001 to 2 wt%, 0.001 to 1 wt%, 0.001 to 0.1 wt%, 0.001 to 0.05 wt%, 0.01 to 10 wt%, 0.01 to 8 wt%, 0.01 to 5 wt%, 0.01 to 4 wt%, 0.01 to 3 wt%, 0.01 to 2 wt%, 0.01 to 1 wt%, 0.01 to 0.1 wt%, 0.01 to 0.05 wt%, 0.02 to 10 %, 0.02 to 8 wt %, 0.02 to 5 wt %, 0.02 to 4 wt %, 0.02 to 3 wt %, 0.02 to 2 wt %
  • the MPC may be included in an amount of 0.001 to 10 wt% based on the total composition, and preferably 0.001 to 8 wt%, 0.001 to 5 wt%, 0.001 to 4 wt%, 0.001 to 3 wt%, 0.001 to 2 wt%, 0.001 to 1 wt%, 0.001 to 0.5 wt%, 0.01 to 10 wt%, 0.01 to 8 wt%, 0.01 to 5 wt%, 0.01 to 4 wt%, 0.01 to 3 wt%, 0.01 to 2 wt%, 0.01 to 1 wt%, 0.01 to 0.5 wt%, 0.1 to 10 wt%, 0.1 to 8 wt%, 0.1 to 5 wt%, 0.1 to 4 It may be comprised in an amount of from 0.1 to 3 wt%, from 0.1 to 2 wt%, from 0.1 to 1 wt%, from 0.1 to 0.5 wt%,
  • the melanin or its precursor may be included in an amount of 0.001 to 10 wt% based on the entire composition, and preferably 0.001 to 8 wt%, 0.001 to 5 wt%, 0.001 to 4 wt%, 0.001 to 3 wt%, 0.001 to 2 wt%, 0.001 to 1 wt%, 0.001 to 0.1 wt%, 0.001 to 0.05 wt%, 0.01 to 10 wt%, 0.01 to 8 wt%, 0.01 to 5 wt%, 0.01 to 4 wt%, 0.01 to 3 wt%, 0.01 to 2 wt%, 0.01 to 1 wt%, 0.01 to 0.1 wt%, 0.01 to 0.05 wt%, 0.02
  • the amount may be from 0.02 to 10 wt%, 0.02 to 8 wt%, 0.02 to 5 wt%, 0.02 to 4 wt%, 0.02 to 3 wt%, 0.02
  • the hair dye composition may be for hair dyeing, but is not limited thereto.
  • Another aspect of the present invention is a method for producing a hair dye composition, comprising a mixing step of mixing two or more selected from the group consisting of a plant extract; a metal-phenol complex MPC; and melanin or a precursor thereof.
  • the plant extract may include at least one selected from the group consisting of a pomegranate extract, a blueberry extract, a cacao extract, an apricot extract, a persimmon extract, a grape extract, an avocado extract, an apple extract, a beet extract, and an odi extract, and more specifically, may be a pomegranate extract.
  • the pomegranate extract may be at least one extract selected from the group consisting of flowers, fruits, seeds, leaves, branches, stems, and roots of a pomegranate tree.
  • the above pomegranate extract may contain 40 to 100 wt% of the pomegranate flower extract, preferably 45 to 100 wt%, 50 to 100 wt%, 55 to 100 wt%, 60 to 100 wt%, 65 to 100 wt%, 70 to 100 wt%, 75 to 100 wt%, 80 to 100 wt%, or 85 to 100 wt%, for example, but not limited to, 90 to 100 wt%.
  • the MPC may be at least one selected from the group consisting of polyphenols and metal ion complexes.
  • the above polyphenols may include tannic acid, gallic acid or a gallic acid derivative.
  • the above metal ion complex may be an iron ion complex, and preferably, an iron gluconate complex, but is not limited thereto.
  • the above MPC may contain iron(II) D-gluconate dehydrate, tannic acid and gallic acid in a weight ratio of 1:0.1 to 2:0.2 to 4, and preferably, 1:0.2 to 2:0.5 to 4, 1:0.5 to 2:1 to 4, 1:1 to 2:2 to 4, 1:0.1 to 1:0.2 to 2, 1:0.2 to 1:0.5 to 2, or 1:0.5 to 1:1 to 2, and for example, 1:1:2, but is not limited thereto.
  • the precursor of melanin may be at least one selected from the group consisting of poly-dihydroxyindole, L-Dopaquinone, hydroxytryptophan, tyrosine, 3,4-dihydroxyphenylalanine (DOPA), dopaquinone, leucodopachrome, dopachrome, and 5,6-indolequinone, and more specifically, may be poly-dihydroxyindole, but is not limited thereto.
  • the mixing step may be preferably performed by mixing to include a pomegranate extract; and MPC, or may be performed by mixing to include a pomegranate extract; and melanin or a precursor thereof, or may be performed by mixing to include a MPC; and melanin or a precursor thereof, for example, it may be performed by mixing to include a pomegranate extract; MPC; and melanin or a precursor thereof, but is not limited thereto.
  • the weight ratio of the pomegranate extract and the MPC may be 1:5 to 1:20, preferably 1:5 to 1:18, 1:5 to 1:15, 1:5 to 1:12, 1:5 to 1:10, 1:8 to 1:20, 1:8 to 1:18, 1:8 to 1:15, 1:8 to 1:12, 1:8 to 1:10, 1:10 to 1:20, 1:10 to 1:18, or 1:10 to 1:15, for example, but not limited thereto.
  • the weight ratio of the pomegranate extract and melanin or its precursor may be 1:5 to 5:1, and preferably 1:5 to 3:1, 1:5 to 2:1, 1:5 to 1:1, 1:3 to 5:1, 1:3 to 3:1, 1:3 to 2:1, 1:3 to 1:1, 1:2 to 5:1, 1:2 to 3:1, 1:2 to 2:1, 1:2 to 1:1, 1:1 to 5:1, or 1:1 to 3:1, for example, but not limited thereto.
  • the weight ratio of the above MPC; and melanin or its precursor may be 5:1 to 20:1, and preferably 5:1 to 18:1, 5:1 to 15:1, 5:1 to 12:1, 5:1 to 10:1, 8:1 to 20:1, 8:1 to 18:1, 8:1 to 15:1, 8:1 to 12:1, 8:1 to 10:1, 10:1 to 18:1, or 10:1 to 15:1, for example, but not limited thereto.
  • the pomegranate extract may be included in an amount of 0.001 to 10 wt% based on the total composition, and preferably 0.001 to 8 wt%, 0.001 to 5 wt%, 0.001 to 4 wt%, 0.001 to 3 wt%, 0.001 to 2 wt%, 0.001 to 1 wt%, 0.001 to 0.1 wt%, 0.001 to 0.05 wt%, 0.01 to 10 wt%, 0.01 to 8 wt%, 0.01 to 5 wt%, 0.01 to 4 wt%, 0.01 to 3 wt%, 0.01 to 2 wt%, 0.01 to 1 wt%, 0.01 to 0.1 wt%, 0.01 to 0.05 wt%, 0.02 to 10 %, 0.02 to 8 wt %, 0.02 to 5 wt %, 0.02 to 4 wt %, 0.02 to 3 wt %, 0.02 to 2 wt %
  • the MPC may be included in an amount of 0.001 to 10 wt% based on the total composition, and preferably 0.001 to 8 wt%, 0.001 to 5 wt%, 0.001 to 4 wt%, 0.001 to 3 wt%, 0.001 to 2 wt%, 0.001 to 1 wt%, 0.001 to 0.5 wt%, 0.01 to 10 wt%, 0.01 to 8 wt%, 0.01 to 5 wt%, 0.01 to 4 wt%, 0.01 to 3 wt%, 0.01 to 2 wt%, 0.01 to 1 wt%, 0.01 to 0.5 wt%, 0.1 to 10 wt%, 0.1 to 8 wt%, 0.1 to 5 wt%, 0.1 to 4 It may be comprised in an amount of from 0.1 to 3 wt%, from 0.1 to 2 wt%, from 0.1 to 1 wt%, from 0.1 to 0.5 wt%,
  • the melanin or its precursor may be included in an amount of 0.001 to 10 wt% based on the entire composition, and preferably 0.001 to 8 wt%, 0.001 to 5 wt%, 0.001 to 4 wt%, 0.001 to 3 wt%, 0.001 to 2 wt%, 0.001 to 1 wt%, 0.001 to 0.1 wt%, 0.001 to 0.05 wt%, 0.01 to 10 wt%, 0.01 to 8 wt%, 0.01 to 5 wt%, 0.01 to 4 wt%, 0.01 to 3 wt%, 0.01 to 2 wt%, 0.01 to 1 wt%, 0.01 to 0.1 wt%, 0.01 to 0.05 wt%, 0.02
  • the amount may be from 0.02 to 10 wt%, 0.02 to 8 wt%, 0.02 to 5 wt%, 0.02 to 4 wt%, 0.02 to 3 wt%, 0.02
  • the hair dye composition may be for hair dyeing, but is not limited thereto.
  • the present invention relates to a gray hair dye composition and a method for producing the same.
  • the gray hair dye composition comprising a pomegranate extract, a metal phenolic complex (MPC), and melanin or a precursor thereof is safe for the scalp and hair, and can induce a gray hair cover hair dyeing effect with a raw material not classified as a hair dye, so that it can be used as a hair dyeing material that is safe for hair and the like and has excellent efficacy while being natural and having good durability in a different way from the conventional method.
  • MPC metal phenolic complex
  • Figure 1a is a color chart showing the hair dyeing effect of a pomegranate extract according to one embodiment of the present invention.
  • Figure 1b is a photograph showing hair treated with a pomegranate extract according to one embodiment of the present invention.
  • Figure 2a is a color chart showing the hair dyeing effect of a hair dye composition containing an MPC (Metal phenolic complex) according to one embodiment of the present invention.
  • MPC Metal phenolic complex
  • FIG. 2b is a photograph showing hair treated with an MPC-containing hair dye composition according to one embodiment of the present invention.
  • FIG. 3a is a color chart showing the hair dyeing effect of a hair dye composition combining two or more of a pomegranate extract, MPC, and a melanin precursor according to one embodiment of the present invention.
  • FIG. 3b is a photograph showing hair treated with a hair dye composition comprising two or more of a pomegranate extract, MPC, and a melanin precursor according to one embodiment of the present invention.
  • FIG. 4a is a color chart showing the hair dyeing effect of a hair dye composition combining two or more of a pomegranate extract, MPC, and a melanin precursor according to one embodiment of the present invention.
  • FIG. 4b is a photograph showing a wool fiber colored by applying a hair dye composition comprising two or more of a pomegranate extract, MPC, and a melanin precursor according to one embodiment of the present invention.
  • % when used to indicate the concentration of a particular substance, unless otherwise noted, is (wt/wt)% for solid/solid, (wt/vol)% for solid/liquid, and (vol/vol)% for liquid/liquid.
  • 150 g of raw powder from the crushed pomegranate tree whole plant was extracted with D.W at 85°C for 1 hour, filtered through a filter (3 ⁇ m -> 1 ⁇ m -> 0.5 ⁇ m), concentrated until the weight became 20% of the initial raw powder amount, and diluted with 1,3-butylene glycol to the same concentration as the diluted E-pomegranate extract to prepare a pomegranate water extract.
  • Test Example 1 Method for analyzing the dyeing power of hair dye
  • Spray 3 g of the hair dye composition onto the hair allow to absorb well with the hands, and leave at room temperature (approximately 15 to 25°C) for 10 minutes. Afterwards, wash once with water, wash twice with shampoo in lukewarm water, and dry with a hair dryer for 1 minute.
  • the image with the background removed was extracted.
  • the average RGB value of the hair image was extracted using Python code, and the extracted RGB value was converted to a LAB value (using the Convert Rgb to Lab website (colormine.org/convert/rgb-to-lab)).
  • ⁇ Eab [( ⁇ L) ⁇ 2 + ( ⁇ a) ⁇ 2 + ( ⁇ b) ⁇ 2] ⁇ 0.5
  • E-pomegranate extract and pomegranate water extract at solid content concentrations of 0.01, 0.05, 0.5, and 10 wt% were each diluted in purified water and applied to hair according to the method of Test Example 1 to compare the colors.
  • a hair dye composition was prepared by mixing iron (II) D-gluconate dehydrate (699014-53-4), tannic acid, and gallic acid corresponding to the metal phenolic acid complex (MPC) according to the weight values (g) in Table 5 below, and then diluting the mixture to 5% using purified water.
  • the hair dye composition manufactured in the above Manufacturing Example 2 was applied to hair according to the method of the above Test Example 1, and the color was measured to compare the RGB values.
  • the hair color becomes darker from No. 6 to No. 1, and the hair color appears similarly dark between No. 1 and No. 7. Accordingly, the final MPC content ratio was determined based on the result of No. 7 considering the cost aspect and solubility in water. In addition, considering that MPC progresses more reacting over time, MPC was freeze-dried to produce iron (II) D-gluconate hydrate, tannic acid, and gallic acid at a weight ratio of 1:1:2 as in No. 7.
  • Manufacturing Example 3 Manufacturing of a hair dye composition containing E-pomegranate extract, polydihydroxyindole, and MPC
  • a hair dye composition was prepared by mixing E-pomegranate extract (E-pomegranate ex), MPC, and polydihydroxyindole according to the ratios in Table 8 below and using purified water as a solvent.
  • MPC used a freeze-dried powder prepared by mixing iron (II) D-gluconate hydrate, tannic acid, and gallic acid in a ratio of 1:1:2.
  • Test Example 4 Determination of the hair-salting power of E-pomegranate extract, polydihydroxyindole, and MPC
  • the hair dye composition manufactured in the above Manufacturing Example 3 was applied to hair according to the method of the above Test Example 1, and the color was measured to compare the RGB and ⁇ Eab values.
  • Test Example 5 Determination of the hair-salting power of E-pomegranate extract, polydihydroxyindole, and MPC
  • the hair dye composition manufactured in the above Manufacturing Example 3 was applied to wool fibers and sufficiently colored by hand. After that, the fibers were left at room temperature for 24 hours, and the remaining hair dye composition was removed by pressing with tissue paper until no traces were left. Then, each color was measured and the RGB and ⁇ Eab values were compared.
  • Example 4 As a result, as can be seen in Table 11, Table 12, and FIGS. 4a and 4b above, the color of the hair treated with Examples 1 to 4, as in Test Example 4, appeared darker than the color of the hair treated with Comparative Examples 1 to 3, and in particular, the hair was dyed the darkest in Example 4, in which E-pomegranate extract, polydihydroxyindole, and MPC were all mixed.

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Abstract

La présente invention concerne une composition de coloration capillaire pour cheveux gris prématurés et son procédé de préparation. La composition de coloration capillaire pour cheveux gris prématurés, comprenant un extrait de grenade, un complexe phénolique métallique (MPC), et de la mélanine ou un précurseur de celle-ci, est sans danger pour le cuir chevelu et les cheveux, et peut induire un effet de coloration capillaire qui recouvre les cheveux gris prématurés, en tant que matière première qui n'est pas classée comme colorant capillaire. Par conséquent, la composition de coloration capillaire peut être utilisée en tant que matériau de coloration capillaire qui est sans danger pour les cheveux et analogues et présente une excellente efficacité, tout en maintenant un effet naturel et durable d'une manière différente des procédés existants.
PCT/KR2024/008083 2023-06-16 2024-06-12 Composition de coloration capillaire pour cheveux gris prématurés et son procédé de préparation Ceased WO2024258190A1 (fr)

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KR1020240028127A KR102869171B1 (ko) 2023-06-16 2024-02-27 새치 염모제 조성물 및 이의 제조 방법

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