WO2024259730A1 - Gel douche anti-séborrhéique et anti-acnéique et son procédé de production - Google Patents

Gel douche anti-séborrhéique et anti-acnéique et son procédé de production Download PDF

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Publication number
WO2024259730A1
WO2024259730A1 PCT/CN2023/102162 CN2023102162W WO2024259730A1 WO 2024259730 A1 WO2024259730 A1 WO 2024259730A1 CN 2023102162 W CN2023102162 W CN 2023102162W WO 2024259730 A1 WO2024259730 A1 WO 2024259730A1
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Prior art keywords
acne
extract
oil
shower gel
skin
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Ceased
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PCT/CN2023/102162
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English (en)
Chinese (zh)
Inventor
周干文
潘康奕
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Guo Zanhui
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Guo Zanhui
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention relates to the field of daily cosmetics, and in particular to an oil-controlling and acne-removing shower gel and a preparation method thereof.
  • the present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides an oil-controlling acne-removing shower gel and a preparation method thereof.
  • An oil-controlling and acne-removing shower gel comprises the following raw materials in percentage by weight: 10-18% of a surfactant, 0.3-1% of a thickener, 0.5-2% of sodium chloride, 0.05-0.2% of a pH regulator, 0.1-0.6% of azelaic acid, 0.1-0.5% of capryloyl glycine, 0.1-0.6% of a plant mite remover, 0.2-2% of a sophora flavescens extract, 0.01-0.1% of an epilobium fleischerii extract, 0.1-0.5% of a sugar isomer mixture, 0.1-0.5% of sodium ascorbyl phosphate, 0.5-1.5% of a tremella extract, 0.01-0.2% of a gentian extract, 0.6% of a preservative and the remainder of water.
  • the surfactant is composed of sodium laureth sulfate, sodium methyl cocoyl taurate, cocamidopropyl betaine, sodium lauroamphoacetate, and cocamide methyl MEA.
  • the plant acaricide is composed of thyme extract, rosemary water, 1,3-propylene glycol, dichlorobenzyl alcohol and phenoxyethanol.
  • the thickener consists of tocopherol and PEG-120 methyl glucose dioleate.
  • the sugar isomer mixture comprises sugar isomers, water, citric acid and sodium citrate.
  • the pH adjuster is potassium hydroxide.
  • the above-mentioned oil-controlling and acne-removing shower gel is prepared by a preparation method comprising the following steps:
  • Azelaic acid also known as azelaic acid
  • azelaic acid is currently mainly used to treat melanoma, chloasma, rosacea, hyperpigmentation, acne, etc.
  • Mechanism of action of azelaic acid inhibiting skin oil secretion.
  • Androgen especially dihydrotestosterone, induces the activity of sebaceous glands, which is one of the causes of acne.
  • 5a-reductase in sebaceous glands can increase the bioconversion of testosterone into dihydrotestosterone, and azelaic acid can produce a competitive concentration inhibitory effect on this reductase, thereby reducing oil secretion of the skin; it has an anti-keratinization effect on normal skin and acne-infected skin, reduces the synthesis of filamentous keratin, prevents excessive keratinization of hair follicles, and unclogs pores.
  • the epilobium yaker extract added to the formula also has a strong inhibitory effect on 5a-reductase.
  • capryloyl glycine For acne/pimples caused by excessive growth of Propionibacterium acnes, capryloyl glycine has good skin affinity and is mild to the skin. At the same time, it can achieve a good inhibitory effect on Propionibacterium acnes and Staphylococcus aureus in a relatively short time (2min-5min), and has a significant effect on the prevention and treatment of acne and pimples. Therefore, this formula selects capryloyl glycine as the active ingredient to inhibit Propionibacterium acnes, which fully considers its characteristics of short action time and high action efficiency, and also considers its mildness to the skin.
  • Sophora flavescens extract has a broad-spectrum antibacterial property, which can not only inhibit the biosynthesis of bacteria, but also affect the biological oxidation process of bacteria.
  • the anti-inflammatory mechanism of Sophora flavescens extract is due to the stabilization of the red blood cell membrane, and it has a strong immunomodulatory effect. It can exert its anti-inflammatory effect through the changes in immune cells, cytokines and other inflammatory regulatory factors. It has a good effect on eczema and dermatitis, can relieve skin itching caused by inflammation, and accelerate the repair of acne skin.
  • a plant-based mite remover is added to the formula.
  • the main active ingredients of the mite remover are: thyme extract, rosemary, water and dichlorobenzyl alcohol. It has a strong killing and repelling effect on various types of mites. It can effectively prevent or relieve acne caused by mites.
  • the compatibility mechanism of the acne-removing and oil-controlling ingredients in this formula covers various pathogenesis of acne/pimples, and can achieve more significant acne-removing and oil-controlling effects. At the same time, it also takes into account the mildness and safety of the overall formula, and is suitable for a wider range of people. It can not only be used for acne removal on acne-prone skin, but also for daily cleansing to prevent acne.
  • FIG1 is a schematic diagram of the effect of use by subject 1;
  • FIG2 is a schematic diagram of the effect of use by subject 2;
  • the preparation method is as follows:
  • the plant mite remover used in this application is produced and provided by Guangdong Dimei New Material Technology Co., Ltd.
  • Test substance original cosmetic final product (diluted to 1% aqueous solution).
  • Control blank filter paper control.
  • Subjects A total of 30 subjects, including 1 male and 29 females, aged 21 to 59 years old, with an average age of 39.77 ⁇ 12.14 years old, met the voluntary inclusion criteria.
  • Test method Select qualified patch test equipment and use closed patch test method. Place about 0.020mL-0.025mL (liquid) of diluted test substance in the patch tester and apply it to the back of the subject with low-allergenic tape. Remove the test substance after 24 hours and observe the skin reaction at 0.5, 24 and 48 hours after removal. Record the results according to the skin reaction grading standard in the "Technical Specification for Safety of Cosmetics" (2015 edition).
  • Test substance original cosmetic final product
  • Subjects A total of 30 subjects (33 subjects were enrolled and 3 subjects dropped out), including 14 females and 16 males, aged 18 to 40 years old, with an average age of 29.50 ⁇ 6.31 years old, who met the subject inclusion criteria.
  • Test environment temperature: 20°C ⁇ 22°C, humidity: 40% ⁇ 60%, and real-time dynamic monitoring.
  • At least 30 subjects were recruited to use the test samples for 28 consecutive days.
  • the improvement level of acne lesions was evaluated subjectively and by doctors.
  • Antera 3D was used to collect and analyze the corresponding parameters of acne on the subjects' backs.
  • the test probe SM815 was used to measure the oil content on the skin surface. The changes in various indicators before and after use were compared to determine the acne removal and oil control effects of the product.
  • Acute inflammation or other skin diseases on the back such as eczema, lupus erythematosus, seborrheic dermatitis, psoriasis, severe epidermal exfoliation, etc.
  • Any medications taken orally or topically in the past month that may affect skin condition or reaction such as antihistamines, antibiotics, insulin, anti-inflammatory drugs, vitamin A, steroid drugs, aspirin, thyroid drugs, etc.
  • Humidity 40% to 60% Sit quietly for 30 minutes without drinking water or beverages. Keep the subject relaxed and avoid touching the back.
  • the test area was the back.
  • the subjects When bathing, take an appropriate amount of the test product to replace the usual bath products, rub the whole body gently and then wash. Use once a day for 28 consecutive days.
  • the subjects are prohibited from using acne-removing, oil-controlling, anti-inflammatory and antibacterial preparations; the subjects are prohibited from dripping, injecting, orally or taking other forms of preparations that affect acne-removing and oil-control tests; the subjects are mainly indoor activities and avoid long-term exposure to outdoor light.
  • the subjects filled out a questionnaire in the human efficacy laboratory to evaluate the back condition and record the score.
  • the 7-point scoring method was used to score the product in four aspects: skin feel, use effect, mildness and use satisfaction, and then make a judgment, and record it once for each follow-up visit.
  • the dermatologists evaluated the acne lesions on the subjects' backs in the photos before using the product (D0) and 28 days after using the product (D28).
  • the improvement of the lesion symptoms before and after use of the subjects was scored using the ISGA scale (Table 2), and the percentage of lesion reduction was calculated.
  • the subjects After resting for 30 minutes in the human efficacy evaluation room, the subjects were photographed with the Antera 3D skin image analyzer at the back acne site. The average volume of acne in the test area was obtained through software analysis. The SM815 was used to detect the skin oil value at the test site. The measured value was used as the baseline value (D0). The product was then distributed and the use method was instructed. The subjects were required to return for a visit 28 days (D28) after using the product and undergo the same indicator test.
  • test of the same subject should be completed by the same instrument and the same tester.
  • the test site should be kept consistent between the two test time points.
  • the 7-point scoring method (Table 5) was used to score the product's use effect, mildness, and use satisfaction in the questionnaire.
  • the subjects' evaluation and satisfaction with the product's use experience and efficacy were analyzed.
  • Dermatologists evaluated the acne lesions on the subjects' backs before and after using the product.
  • the ISGA scale was used to score the improvement of the lesion symptoms before and after use, and the percentage of lesion reduction was calculated.
  • the percentage of lesion reduction was calculated using Formula 1.
  • the ISGA skin lesion score showed a downward trend after using the product.
  • the percentage of skin lesion reduction was 36.51%, and there was a very significant difference between the two (p ⁇ 0.01).
  • the acne area images taken by Antera3D can be analyzed by software to measure the average volume change of acne in the AOI selected area at different time points. By comparing the average volume change of acne before and after use, the acne removal effect of the product can be reflected.
  • Average acne volume reduction rate (average acne volume before using the product - average acne volume after using the product) / Average volume of acne before using the product ⁇ 100%
  • test results are shown in Table 12 and Figure 4 (paired t-test was used to analyze the difference between the baseline value and the return visit time point value of the average volume of acne. Significant differences are marked with *p ⁇ 0.05, **p ⁇ 0.01):
  • the average volume of acne showed a downward trend after using the product, and decreased by 74.17% after 28 days of use (D28), which was significantly different from the baseline value (p ⁇ 0.01).
  • the average volume of acne after using the product was lower than the baseline value.
  • the oil control effect of the product can be reflected.
  • Skin oil content reduction rate (oil content before using the product - oil content after using the product) / oil content before using the product ⁇ 100%
  • the oil content on the skin surface showed a downward trend after using the product. After 28 days of use (D28), it decreased by 45.39%, which was significantly different from the baseline value (p ⁇ 0.01). After using the product, the oil content on the skin surface was lower than the baseline value.
  • the ISGA score can be reduced, the overall acne lesions on the back can be improved, the average volume of acne on the back can be reduced, the oil content on the back can be reduced, and the acne and oil control effects can be achieved.
  • more than 50% of the subjects gave positive comments on the product's skin feel, acne removal, oil control effects, mildness and satisfaction, indicating that the product has acne removal and oil control effects.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
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  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un gel douche anti-séborrhéique et anti-acnéique, comprenant les composants de matière première suivants en pourcentage en poids : 10 à 18 % d'un tensioactif, 0,3 à 1 % d'un agent épaississant, 0,5 à 2 % de chlorure de sodium, 0,05 à 0,2 % d'un régulateur de pH, 0,1 à 0,6 % d'acide azélaïque, 0,1 à 0,5 % de caprylylglycine, 0,1 à 0,6 % d'un acaricide végétal, 0,2 à 2 % d'un extrait de radix sophorae flavescentis, 0,01 à 0,1 % d'un extrait d'Epilobium fleischeri, 0,1 à 0,5 % d'un mélange d'isomérate de saccharide, 0,1 à 0,5 % de phosphate d'ascorbyle de sodium, 0,5 à 1,5 % d'un extrait de Tremella, 0,01 à 0,2 % d'un extrait de gentiane, 0,3 à 0,7 % d'un conservateur, et le reste d'eau.
PCT/CN2023/102162 2023-06-19 2023-06-25 Gel douche anti-séborrhéique et anti-acnéique et son procédé de production Ceased WO2024259730A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202310728677.6A CN116617136A (zh) 2023-06-19 2023-06-19 一种控油祛痘沐浴露及其制备方法
CN202310728677.6 2023-06-19

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CN119405574A (zh) * 2025-01-06 2025-02-11 广州华淼生物科技研究院有限公司 一种祛痘组合物、用途和祛痘产品
CN121221437A (zh) * 2025-12-02 2025-12-30 华南理工大学 一种含生物基材料的介孔硅石控油蓬松组合物

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CN118845536B (zh) * 2024-07-03 2025-08-22 广州汇创化妆品有限公司 一种祛痘磨砂沐浴露及其制备方法
CN118924651B (zh) * 2024-09-20 2025-01-24 珑玥实业(广州)有限公司 一种具有去屑作用的组合物及其制备方法
CN121129691A (zh) * 2025-10-24 2025-12-16 王叔和(武汉)生物科技工程有限公司 一种控油祛痘纳米组合物及其制备方法和应用

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