WO2025076246A1 - Sources discrètes multiples pour interrogation optique de capteur de pression à l'aide d'un réseau de points - Google Patents

Sources discrètes multiples pour interrogation optique de capteur de pression à l'aide d'un réseau de points Download PDF

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Publication number
WO2025076246A1
WO2025076246A1 PCT/US2024/049829 US2024049829W WO2025076246A1 WO 2025076246 A1 WO2025076246 A1 WO 2025076246A1 US 2024049829 W US2024049829 W US 2024049829W WO 2025076246 A1 WO2025076246 A1 WO 2025076246A1
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WIPO (PCT)
Prior art keywords
array
spots
light sources
beams
laser light
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PCT/US2024/049829
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English (en)
Inventor
Supriyo Sinha
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Verily Life Sciences LLC
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Verily Life Sciences LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/14—Arrangements specially adapted for eye photography
    • A61B3/15—Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection ; with means for relaxing
    • A61B3/152—Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection ; with means for relaxing for aligning

Definitions

  • Intraocular pressure quantifies the pressure of fluid inside the eye.
  • Many individuals suffer from disorders, such as glaucoma, that cause chronic heightened IOP. Over time, heightened IOP can cause damage to the optical nerve of the eye, leading to loss of vision.
  • treatment of glaucoma mainly involves periodically administering pharmaceutical agents to the eye to decrease IOP. These drugs can be delivered, for example, by injection or eye drops.
  • effective treatment of glaucoma requires adherence to dosage schedules and a knowledge of the patient’s IOP. The more current or recent the measurement is, the more relevant it will be and hence the more effective the resulting treatment can be.
  • the IOP for a given patient can vary significantly based on time of day, exercise, recency of medication use, and other factors. This means that any given measurement is subject to uncertainty, so it may take a plurality of measurements over time to provide confidence as to the health status of the patient. IOP measurements performed in a doctor’s office typically only take place once or twice per year. These infrequent measurements are less able to account for variation in patient IOP. Annual or biannual measurements in a doctor’s office may also grow stale or obsolete due to time lag since the previous measurement. Frequent measurements at home could allow for better treatment at lower cost. Typically, the IOP is measured using a tonometer, which is a device that is outside the eye and thus does not require a sensor within the eye.
  • Noncontact tonometry involves directing a puff or jet of air towards the patient’s eye and measuring the resulting deflection dynamics of the cornea.
  • this requires a bulky and power hungry pump arrangement that may not be practical for home use, and is not as accurate as contact tonometry.
  • a wireless, implantable, continuous IOP monitoring system has been suggested that has a commercial pressure sensing element with digital readout, and a microelectronic chip that supports wireless power/data telemetry and a wired serial communication interface with the pressure sensing element.
  • An on-chip integrated RF coil receives power from near-field RF coupling at 915 MHz, and transmits pressure measurement bits via RF-backscattering to an external reader.
  • This type of system may require precise optical alignment between the external reader and the sensor in order to ensure the measurement data is accurate. It may be difficult for some users holding the external reader to meet such precise alignment requirements leading to inaccurate measurements.
  • the information included in this Background section of the specification, including any references cited herein and any description or discussion thereof, is included for technical reference purposes only and is not to be regarded as subject matter by which the scope of the disclosure is to be bound.
  • a spatially coherent broadband light source such as a superluminescent diode (SLD) tends to have very low power, may be expensive, sensitive to feedback and the readout may be sensitive to angular alignment such that it requires a very precise alignment of the optical elements to achieve accurate measurements.
  • SLD superluminescent diode
  • one implementation may include, instead of a single broadband source, two or more narrow band laser sources (bandwidth of a few nanometers or less).
  • the sources may be spectrally combined using dichroic filters (a combination of long-pass and/or short pass filters) such that the beams are all along the same optical axis.
  • the sources may also be collimated so that they illuminate an array of pinholes uniformly.
  • the array of pinholes create an array of spots that are reimaged onto the optical pressure sensor, which allows a large portion of the sensor to be interrogated, easing alignment.
  • the sources could also be collimated to illuminate a slit uniformly, which is then reimaged onto the optical pressure sensor.
  • the reflected power may then be collected through polarization multiplexing and then split spectrally using dichroic filters (combination of long-pass and short-pass filters) and incident on linear image sensors.
  • the linear image sensors may be oriented such that the axis joining the array of spots is also the long axis of the sensor. Thus, the received power from each spot for each light source could be detected.
  • a ratio between the powers from different wavelengths could be used to determine the spacing at that point and then a curvature of the membrane could be computed to determine the IOP. Since the ratio may be dependent on the spectrum of the light source and the spectrum of a laser light source is dependent on temperature, a temperature controlled block could be used to stabilize the temperature to within a fraction of 1 degree Celsius.
  • bandpass filters could be placed either after the source or before the linear image sensor to filter out any out of band light (for example a 5-10 nm band filter could be used for this).
  • a reference reflection could be employed in the handheld to calibrate the power from each of the sources (for example by using a gold reflection target for some of the spots that do not get sent out from the handheld).
  • a pickoff after each source could also be used for calibration.
  • partial reflectors instead of dichroic filters could be used to spectrally combine the sources. Since the power of these sources are several mW and only ⁇ 10% of the power is needed, partially reflective broadband mirrors could be used to reduce the cost of the optics even further at the expense of lower transmission throughput.
  • temporal multiplexing to simplify the system may be used. In this case, the arrangement of dichroic filters at the receiver end could be omitted and instead the light sources would be pulsed in a known sequence and then the output measured from a single linear image sensor with knowledge of what light source is being measured.
  • a combination could also be used, for example, two linear image sensors could be used with four light sources by having two different time periods.
  • multiple discrete light sources can be used for optical interrogation of the pressure sensor in the eye using an array of spots.
  • the various advantages of the proposed configuration include reduced cost and easier processing since the use of linear detectors is easy, usually just using microcontrollers instead of requiring field-programmable gate arrays (FPGAs) or microprocessors, even at rates of several kHz.
  • an intraocular pressure measurement system includes an intraocular implant having a pressure sensor implantable in an eye, wherein the pressure sensor defines an optical cavity with a depth that varies based on an intraocular pressure of the eye; and an external reader device having a number of laser light sources configured to emit a plurality of beams and project an array of spots formed from the plurality of beams onto the pressure sensor, and a detector configured to receive a reflection of the array of spots off the pressure sensor that is used to measure the intraocular pressure of the eye.
  • the external reader device further includes a number of dichroic filters configured to spectrally combine the plurality of beams.
  • the external reader device further includes an array of pinholes between the number of laser light sources and the detector that are configured to form the array of spots from the spectrally combined plurality of beams.
  • the external reader device includes a polarizing beam splitter and a dichroic filter configured to selectively reflect the array of spots onto the detector.
  • the detector may include a number of detectors and the dichroic filter comprises a number of dichroic filters configured to selectively reflect the array of spots onto the number of detectors.
  • a number of bandpass filters may be positioned between the number of laser light sources and the number of detectors to filter out any out of band light.
  • the external reader device may include a number of partially reflective broadband mirrors to spectrally combine the plurality of beams and an array of pinholes configured to produce the array of spots from the spectrally combined plurality of beams.
  • a temperature controlled block may be coupled to the number of laser light sources.
  • the number of laser light sources may include narrow band laser light sources within a bandwidth of a few nanometers of less.
  • an external reader device for measuring intraocular pressure from an implant having a pressure sensor implanted in an eye having a dimension that varies according to an intraocular pressure of the eye may include a number of laser light sources configured to emit a plurality of beams and project an array of spots produced from the plurality of beams onto the pressure sensor; and a detector configured to receive a reflection of the array of spots off the pressure sensor that is used to measure the intraocular pressure of the eye.
  • the device may further include a number of dichroic filters configured to spectrally combine the plurality of beams.
  • the device may include an array of pinholes configured to produce the array of spots from the spectrally combined plurality of beams.
  • the device may further include a polarizing beam splitter and a dichroic filter configured to selectively reflect the array of spots onto the detector.
  • the detector includes a number of detectors and the dichroic filter comprises a number of dichroic filters configured to selectively reflect the array of spots onto the number of detectors.
  • a number of bandpass filters may be positioned between the number of laser light sources and the number of detectors to filter out any out of band light.
  • a number of partially reflective broadband mirrors may be included to spectrally combine the plurality of beams and an array of pinholes configured to produce the array of spots from the spectrally combined plurality of beams.
  • a temperature controlled block may also be coupled to the number of laser light sources.
  • the number of laser light sources may include a narrow band laser light source within a bandwidth of a few nanometers of less. In some aspects, the number of laser light sources include at least four laser light sources.
  • the external reader device may be a handheld external reader device that is external to the eye in which the implant is implanted.
  • FIG.1 shows an example system for measuring intraocular pressure, using a reader device and an IOP sensor implanted into an eye.
  • FIG.2 is a diagrammatic, cross-sectional representation of an example IOP measurement system in accordance with at least one embodiment of the present disclosure.
  • FIG.3 is a diagrammatic, cross-sectional representation of an example IOP measurement system in accordance with at least one embodiment of the present disclosure.
  • FIG.4 is a diagrammatic, cross-sectional representation of an example IOP measurement system in accordance with at least one embodiment of the present disclosure.
  • FIG.5 is a diagrammatic, cross-sectional representation of an example IOP measurement system in accordance with at least one embodiment of the present disclosure.
  • FIG.6 is a diagrammatic, cross-sectional representation of an example IOP measurement system in accordance with at least one embodiment of the present disclosure.
  • FIG.7 is a diagrammatic, cross-sectional representation of an example IOP measurement system in accordance with at least one embodiment of the present disclosure.
  • spatially relative terms such as “beneath”, “below”, “lower”, “above”, “upper”, and the like may be used herein for ease of description to describe one element’s or feature’s relationship to another element(s) or feature(s) as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as “below” or “beneath” other elements or features would then be oriented “above” the other elements or features. Thus, the exemplary term “below” can encompass both an orientation of above and below.
  • the device may be otherwise oriented (e.g., rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
  • the singular forms “a”, “an”, and “the” are intended to include the plural forms as well, unless the context indicates otherwise.
  • the terms “comprises” and/or “comprising” specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof.
  • the terms “or” and “and/or” as used herein are to be interpreted as inclusive or meaning any one or any combination.
  • FIG.1 shows an example system for measuring intraocular pressure, using a reader device 2 and an implant 1.
  • Implant 1 may be composed of several parts or components which cooperate to enable the intraocular pressure sensor integrated therein to detect an intraocular pressure (IOP).
  • IOP sensor implant 1 is shown implanted within the cornea of the eye.
  • implant 1 may be implanted within a sclera, anterior chamber or other portion of the eye suitable for detecting an IOP of the eye.
  • Implant 1 may be composed of several parts or components which cooperate to enable the implant 1 to measure an IOP of the eye, as will be discussed in more detail in reference to FIG.2.
  • implant 1 may be a passive device.
  • Reader device 2 may be a portable or handheld device having electronic components and/or circuitry operable to read implant 1.
  • reader device 2 may include components configured to communicate with, and receive data from, implant 1. It then processes the received measured pressure data using a processor to inform the user about their IOP.
  • FIG.2 illustrates a schematic cross-sectional side view of a general operation of the implant 1 of FIG.1 for measuring IOP.
  • interferometry may be employed on one or more reflections from the implantable sensor, of two or more narrow band laser light sources (e.g., a bandwidth of a few nanometers or less) emitted from reader device 2.
  • the intraocular pressure sensor 4 integrated into implant 1 may generally include a cavity 10 (e.g., a low-finesse cavity) formed between a rigid substrate 6 and a flexible membrane 8, whose deflection affects the depth of the cavity 10 (i.e., the distance between the substrate 6 and the membrane 8) and is indicative of IOP.
  • substrate 6 may be a clear glass substrate that is spaced apart from membrane 8 which may be a clear glass membrane (e.g., by about 5-30 microns) that moves relative to the substrate depending on the IOP.
  • the reader device 2 may include two or more narrow band laser sources that produce an array of spots that may pass through the cornea, vitreous humor, and/or aqueous humor of the eye to interrogate sensor 4.
  • Spots that are incident on the implantable pressure sensor 4 will reflect from the sensor and may be captured by reader device 2, which in turn includes a processor that determines the IOP from the reflections.
  • a reflection off a cavity will yield different measured distances between the substrate and membrane based on the viewing angle. For example, a head- on measurement (incident angle of zero degrees, measured from the normal) will yield a first distance, whereas an incident angle of 45 degrees will yield a different distance due to the geometry of the beam and cavity. Generally, a measurement taken off-normal will mimic a shorter cavity. An incident angle close to 90 degrees will generally not return a reflection to the optical interrogation system.
  • pressure sensor 4 implanted in the eye includes a diaphragm or membrane 8 and substrate 6 that together form an optical cavity 10 as previously discussed.
  • a cross-section of the cavity 10 in a plane perpendicular to FIG. 2 may be circular. IOP measurement is achieved by reimaging an array of spots produced by narrow band laser light sources of the reader 2 onto membrane 8 and/or substrate 6 of sensor 4.
  • Membrane 8 bends predictably and reversibly in proportion to increasing pressure (e.g., intraocular pressure), which in turn reduces the distance between the centers (or other corresponding points) of the two surfaces of substrate 6 and membrane 8. For example, the distance between a point on the surface of membrane 8 and a point on a surface of the substrate 6 decreases as pressure increases.
  • the membrane 8 and the substrate 6 differ in stiffness, such that for a range of expected IOP, the substrate exhibits little-to-no deflection, whereas the membrane exhibits measurable deflection. In various aspects, the stiffness of the substrate 6 exceeds the stiffness of the membrane 8 by a factor of 100 or 1000 or more. In operation, membrane 8 exhibits flexibility with respect to IOP, whereas substrate 6 exhibits rigidity.
  • FIG.2 illustrates light incident on substrate 6 first, with light that is not reflected transmitted next to membrane 8.
  • the light is incident on the membrane 8 first, with light that is not reflected transmitted next to the substrate 6. Since implant 1 is implanted within the eye, changes in the IOP within the eye will apply a pressure to membrane 8, which in turn, changes the depth of optical cavity 10.
  • Membrane 8 bends predictably and reversibly in proportion to increasing IOP, which in turn reduces the distance (or depth) between the centers (or other corresponding points) of the surfaces of substrate 6 and membrane 8. For example, the distance or depth between a point on the surface of membrane 8 and a point on a surface of the substrate 6 decreases as pressure increases.
  • membrane 8 exhibits flexibility with respect to IOP, whereas the substrate exhibits rigidity.
  • reader device 2 may interrogated by reader device 2 as previously discussed and used to determine the IOP of the eye.
  • one of the challenges for optical readout is ensuring that the measurement is not impacted by relative motion (translational or rotational) between the sensor and the light source or the handheld reader. This means that the system may need to detect when it is properly interrogating the sensor as well as minimize the chances that motion would affect the result.
  • the IOP measurement system of the present disclosure reimages or projects an array of spots onto the sensor (membrane) implanted in the eye. The reflected power from each spot is then split spectrally and collected by image sensors of the handheld reader. A ratio between the powers from different wavelengths can then be used to determine the spacing at that point and then a curvature of the membrane could be computed to determine the eye IOP.
  • FIG.3 illustrates a schematic representation of an example IOP measurement system.
  • handheld device 2 interrogates implant 1 using an array of spots 22 that are reimaged onto the IOP sensor of implant 1 and then processes the reflected power from each of the array of spots 22 to compute a curvature of the sensor membrane, and in turn, the eye IOP.
  • device 2 includes a number of light sources 12 that emit beams of light for interrogating implant 1.
  • light sources 12 may include two or more narrow band laser sources within a bandwidth of a few nanometers or less.
  • light sources 12 may include at least four or more narrow band laser light sources.
  • Light sources 12 may emit light beams that are then spectrally combined using dichroic filters 16.
  • the dichroic filters 16 may include a combination of long-pass and/or short pass filters.
  • partially reflecting mirrors may instead be used in place of the dichroic filters 16.
  • the different partially reflecting mirrors may be configured to reflect yellow/green, yellow/green/blue and/or yellow/green/blue/red wavelength light.
  • beam dumps (not shown) may also be included in the rejected paths.
  • the light sources 12 may be combined such that the beams are all along the same optical axis as shown.
  • light sources 12 may be collimated using collimation lenses 14 so that they uniformly illuminate an array of pinholes 20.
  • Array of pinholes 20 may be, for example, an elongated structure that includes a number of linearly arranged pinholes of the same size and shape. Array of pinholes 20 then produce an array of spots 22 from the collimated light which are used to interrogate implant 1. Representatively, array of spots 22 may pass through a beam splitter 26 and are imaged onto implant 1 using the lens 24 and focusing lens 30 as shown. In some aspects, beam splitter 26 may be a polarizing cube beam splitter. As previously discussed, interrogating implant 1 with array of spots 22 allows a larger portion of the IOP sensor (e.g., membrane) to be interrogated which, in turn, eases the typically precise alignment requirements necessary for accurate measurement by the handheld reader 2.
  • the IOP sensor e.g., membrane
  • QWP achromatic quarter-wave plate
  • the reflected power is then collected through polarizing multiplexing using beam splitter 26 and split spectrally using dichroic filters 36.
  • dichroic filters 36 may include a combination of long-pass and short-pass filters.
  • the reflected power passes through beam splitter 26 and filters 36 to detectors 38 as shown.
  • detectors 38 may be linear image sensors 38 that are oriented such that the axis joining the array of spots 22 is also the long axis of image sensors 38.
  • the received power from each spot from each of light sources 12 may be detected.
  • FIG.4 illustrates a schematic representation of an alternative exemplary IOP measurement system.
  • the IOP measurement system of FIG.4 may include all the same components as previously discussed in reference to FIG.3. The duplicate components and their operation will therefore not be discussed in detail in reference to FIG. 4.
  • the IOP measurement system of FIG.4 may further include bandpass filters 15 to filter out any out of band light.
  • bandpass filters 15 could be 5-10 nanometer bandpass filters.
  • Bandpass filters 15 may, in some aspects, be positioned between light sources 12 and dichroic filters 16 as shown to filter out any out of band light. In other aspects, bandpass filters 15 could alternatively be positioned before detectors 38 as illustrated by the filter structures shown in dashed lines.
  • FIG.5 illustrates a schematic representation of an alternative exemplary IOP measurement system.
  • the IOP measurement system of FIG.5 may include all the same components as previously discussed in reference to FIG.3. The duplicate components and their operation will therefore not be discussed in detail in reference to FIG. 5.
  • the IOP measurement system of FIG.5 may further include a reference reflection in the handheld reader 2 to calibrate the power from each of the sources (for example by using a gold reflection target for some of the spots that do not get sent out from the handheld).
  • a beam pickoff 42 after the collimating lens 14 of each light source 12 could be used to pick-off some of the incident beam and calibrate the power from each light source 12.
  • detectors 44 may also be arranged after pickoffs 42 to receive the picked-off beams from each light source 12.
  • one or more of detectors 44 may be photodiodes.
  • FIG.6 illustrates a schematic representation of an alternative exemplary IOP measurement system.
  • the IOP measurement system of FIG.6 may include some of the same components as previously discussed in reference to FIG.3. The duplicate components and their operation will therefore not be discussed in detail in reference to FIG. 6.
  • the arrangement of dichroic filters 36 at the receiver end as discussed in the previous configurations may be omitted.
  • the light sources 12 may be pulsed in a known sequence and then the output from a single linear image sensor or detector 38 is measured.
  • a combination of a single dichroic filter 36 and two linear image sensors or photodetectors 38 (e.g., blue + green photodetector and yellow + red photodetector) in the detection path could be used.
  • the dichroic filter 36 may have a cutoff that is between the second and third wavelengths (e.g., a cutoff at 550 nm) when numbered from increasing to decreasing wavelengths.
  • dichroic filter 36 could be a short pass and/or long pass dichroic filter. While certain aspects have been described and shown in the accompanying drawings, it is to be understood that such are merely illustrative of and not restrictive on the broad invention, and that the invention is not limited to the specific constructions and arrangements shown and described, since various other modifications may occur to those of ordinary skill in the art.
  • implant 1 is shown positioned in the anterior chamber, it is contemplated that in some configurations, implant could be implanted in the cornea or sclera.
  • implant is described as a passive device, it is contemplated that in some aspects the implant may be an active device.
  • device may also include a receiver and transmitter to communicate with implant 1, and a processor to process the output from the implant and measure IOP.
  • FIG.1 shows the sun as providing its sunlight to power implant 1
  • other sources of optical power are possible such as artificial room lighting or a lamp that is within an accessory worn by the user (e.g., eyeglasses). The description is thus to be regarded as illustrative instead of limiting.

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  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
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Abstract

L'invention concerne un système de mesure de pression intraoculaire comprenant : un implant intraoculaire ayant un capteur de pression implantable dans un œil, le capteur de pression définissant une cavité optique ayant une profondeur qui varie sur la base d'une pression intraoculaire de l'œil ; et un dispositif lecteur externe ayant un certain nombre de sources de lumière laser conçues pour émettre une pluralité de faisceaux et projeter un réseau de points formés à partir de la pluralité de faisceaux sur le capteur de pression, et un détecteur conçu pour recevoir une réflexion du réseau de points depuis le capteur de pression qui est utilisée pour mesurer la pression intraoculaire de l'œil.
PCT/US2024/049829 2023-10-06 2024-10-03 Sources discrètes multiples pour interrogation optique de capteur de pression à l'aide d'un réseau de points Pending WO2025076246A1 (fr)

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US202363588618P 2023-10-06 2023-10-06
US63/588,618 2023-10-06

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030078487A1 (en) * 2001-08-09 2003-04-24 Jeffries Robert E. Ocular pressure measuring device
US9289123B2 (en) * 2013-12-16 2016-03-22 Verily Life Sciences Llc Contact lens for measuring intraocular pressure
US10702142B1 (en) * 2017-05-19 2020-07-07 Verily Life Sciences Llc Functional retinal imaging with improved accuracy
US20220218201A1 (en) * 2019-05-13 2022-07-14 Twenty Twenty Therapeutics Llc Systems, devices and methods for optical interrogation of an implantable intraocular pressure sensor
US20220395178A1 (en) * 2021-06-10 2022-12-15 Twenty Twenty Therapeutics Llc Optical Intraocular Pressure Sensor in Cornea for Free-Space Interrogation
US20230309816A1 (en) * 2022-03-31 2023-10-05 Twenty Twenty Therapeutics Llc Visual Acuity Measurement in VR Headset

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030078487A1 (en) * 2001-08-09 2003-04-24 Jeffries Robert E. Ocular pressure measuring device
US9289123B2 (en) * 2013-12-16 2016-03-22 Verily Life Sciences Llc Contact lens for measuring intraocular pressure
US10702142B1 (en) * 2017-05-19 2020-07-07 Verily Life Sciences Llc Functional retinal imaging with improved accuracy
US20220218201A1 (en) * 2019-05-13 2022-07-14 Twenty Twenty Therapeutics Llc Systems, devices and methods for optical interrogation of an implantable intraocular pressure sensor
US20220395178A1 (en) * 2021-06-10 2022-12-15 Twenty Twenty Therapeutics Llc Optical Intraocular Pressure Sensor in Cornea for Free-Space Interrogation
US20230309816A1 (en) * 2022-03-31 2023-10-05 Twenty Twenty Therapeutics Llc Visual Acuity Measurement in VR Headset

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