WO2025146190A1 - Dispositif et système d'ablation par ultrasons - Google Patents

Dispositif et système d'ablation par ultrasons Download PDF

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Publication number
WO2025146190A1
WO2025146190A1 PCT/CN2025/070629 CN2025070629W WO2025146190A1 WO 2025146190 A1 WO2025146190 A1 WO 2025146190A1 CN 2025070629 W CN2025070629 W CN 2025070629W WO 2025146190 A1 WO2025146190 A1 WO 2025146190A1
Authority
WO
WIPO (PCT)
Prior art keywords
ablation
ultrasonic
control unit
impedance
flexible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/CN2025/070629
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English (en)
Chinese (zh)
Inventor
郭久林
冒志刚
陈红
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Golden Leaf Med Tec Co Ltd
Original Assignee
Shanghai Golden Leaf Med Tec Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Golden Leaf Med Tec Co Ltd filed Critical Shanghai Golden Leaf Med Tec Co Ltd
Publication of WO2025146190A1 publication Critical patent/WO2025146190A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22001—Angioplasty, e.g. PCTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22062—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation to be filled with liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22065—Functions of balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22084—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0043—Ultrasound therapy intra-cavitary
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0052—Ultrasound therapy using the same transducer for therapy and imaging

Definitions

  • the invention relates to an ultrasonic ablation device and also to a corresponding ultrasonic ablation system, belonging to the technical field of medical devices.
  • Ultrasonic ablation technology refers to the use of the characteristics of ultrasound waves that can pass through human tissues and focus on specific target areas, concentrating energy to a sufficient intensity, causing the focal area to reach an instantaneous high temperature, destroying the target tissue, and manifesting itself as coagulative necrosis in histopathology, thereby achieving the purpose of destroying the lesion area, while the tissue outside the lesion area is not damaged.
  • current ultrasonic ablation equipment generally has the problem of being unable to provide real-time feedback on the ablation process, and manual ablation needs to be started and terminated during the operation. This not only prolongs the operation time, but may also cause the blood vessels to be blocked for a long time, thereby causing adverse reactions in some patients.
  • most existing ultrasonic ablation balloons are rigid in design, making it difficult to adapt to the shapes of different blood vessels and cavities, and have poor wall adhesion, which will affect the ablation effect and fail to achieve the best therapeutic effect.
  • the primary technical problem to be solved by the present invention is to provide an ultrasonic ablation device.
  • an ultrasonic ablation device comprising:
  • a control unit used for automatic control of ultrasonic ablation
  • a catheter the proximal end of which is connected to the control unit, the catheter at least comprising a water inlet cavity, a water outlet cavity and a wire cavity through which a wire is passed;
  • An ultrasonic transducer is arranged at the distal end of the catheter and is electrically connected to the control unit through the wire, so as to switch between an ablation mode and a measurement mode under the control of the control unit; wherein, in the ablation mode, the ultrasonic transducer is used to perform ultrasonic ablation on the area to be ablated; and in the measurement mode, the ultrasonic transducer is used to measure the temperature and tissue morphology of the area to be ablated;
  • a flexible ablation balloon is sleeved on the outside of the ultrasonic transducer and is connected to the water inlet cavity and the water outlet cavity;
  • a flexible electrode mounted on the outside of the flexible ablation balloon and electrically connected to the control unit, for detecting impedance
  • a pressure sensor installed inside the flexible ablation balloon and electrically connected to the control unit, for detecting water pressure
  • control unit is used to receive the impedance and water pressure, and judge whether the flexible ablation balloon is completely attached to the wall according to a first judgment logic
  • the first judgment logic specifically includes:
  • the impedance value does not reach a preset impedance range, and/or the water pressure does not reach a preset water pressure range, it is determined that the flexible ablation balloon is not completely attached to the wall.
  • the ultrasonic transducer generates a single ultrasonic wave, and the distance to the blood vessel wall is calculated by analyzing the echo signal, thereby obtaining the ablation area.
  • the switching logic specifically includes:
  • the preset time duration is used as the switching condition, and the switching is performed every preset time duration
  • the control unit receives the impedance, water pressure, temperature and tissue morphology of the area to be ablated, and outputs different powers according to the difference between the temperature of the area to be ablated and a preset temperature; wherein, when it is necessary to calculate the output power, the ultrasonic transducer switches to a measurement mode to measure the temperature of the area to be ablated, so as to calculate the output power using the control unit; when the output power calculation is completed, the ultrasonic transducer automatically switches to an ablation mode and continues for a preset time until an ultrasonic ablation is completed, and automatically switches to a measurement mode after an ultrasonic ablation is completed to calculate the next output power; the ultrasonic transducer repeatedly switches between the measurement mode and the ablation mode until the ablation end point is reached.
  • the second judgment logic specifically includes:
  • the main control module is used to process signals and data and control automated ablation
  • a signal generator connected to the main control module, for receiving and sending ultrasonic signals
  • a power amplifier connected to the signal generator, for amplifying the ultrasonic signal
  • a gating module connected to the power amplifier, for selecting the number of signal channels
  • a phase voltage and current module connected to the main control module, for detecting parameters and outputting a matching ultrasonic frequency
  • the ultrasonic ablation device further comprises:
  • a display connected to the control unit, for displaying data
  • the catheter further comprises a guidewire cavity, in which a guidewire is passed through, so as to control the bending direction of the catheter.
  • the flexible ablation balloon is made of silicone and the flexible electrode is a flexible circuit board.
  • an ultrasonic ablation system comprising the ultrasonic ablation device mentioned above.
  • the control unit controls the ultrasonic transducer to continuously switch between the ablation mode and the temperature measurement mode to achieve automatic ablation, and automatically determines the ablation endpoint during the ablation process, shortening the operation time and reducing the patient's adverse reactions during the operation.
  • FIG1 is a schematic structural diagram of an ultrasonic ablation device provided by an embodiment of the present invention.
  • an ultrasonic ablation device provided by an embodiment of the present invention includes a control unit 1, a catheter 2, an ultrasonic transducer 3, a flexible ablation balloon 4, a flexible electrode 5 and a pressure sensor 6.
  • the control unit 1 can control the ultrasonic transducer 3 to switch between the ablation mode and the measurement mode until the ablation process is completed.
  • the flexible electrode 5 arranged on the outside of the flexible ablation balloon 4 and the pressure sensor 6 arranged on the inside of the flexible ablation balloon 4 are both connected to the control unit 1, so that the control unit 1 can judge whether the flexible ablation balloon 4 is completely attached to the wall through changes in impedance and pressure.
  • the control unit 1 is used for automatic control of ultrasonic ablation.
  • the control unit 1 specifically includes a main control module 11, a signal generator 12, a power amplifier 13, a gating module 14, a phase voltage and current module 15, and an impedance matching module 16.
  • the main control module 11 is used to process signals and data and control automated ablation.
  • the signal generator 12 is connected to the main control module 11 for receiving and sending ultrasonic signals.
  • the power amplifier 13 is connected to the signal generator 12 for amplifying ultrasonic signals.
  • the gating module 14 is connected to the power amplifier 13 for selecting the number of signal channels.
  • the phase voltage and current module 15 is connected to the main control module 11 for detecting parameters and outputting matching ultrasonic frequencies.
  • the impedance matching module 16 is connected to the main control module 11 for detecting matching impedance and outputting ultrasonic signals of matching power.
  • the proximal end of the catheter 2 is connected to the control unit 1, and the distal end of the catheter 2 is used to extend into the blood vessel.
  • the catheter 2 is a multi-lumen tube, at least including a water inlet chamber 201, a water outlet chamber 202, a guide wire chamber 203 and a guide wire chamber 204.
  • the water inlet chamber 201 and the water outlet chamber 202 are respectively connected to the water inlet and the water outlet of the external water supply device for water circulation.
  • a guide wire 210 is inserted into the guide wire chamber 203 to electrically connect the ultrasonic transducer 3 at the distal end of the catheter 2 with the control unit 1.
  • a guide wire 220 is inserted into the guide wire chamber 204 to control the bending direction of the catheter 2, thereby driving the catheter 2 to enter different vascular tissues. It can be understood that the catheter 2 can also be provided with other cavities as needed, which are not specifically limited here.
  • the ultrasonic transducer 3 is disposed at the distal end of the catheter 2 and is electrically connected to the gating module 14 of the control unit 1 through a wire 210, so as to switch between the ablation mode and the measurement mode according to the number of signal channels under the control of the gating module 14.
  • the ultrasonic transducer 3 converts the electrical signal into mechanical vibration to continuously generate ultrasonic waves, and heats the area to be ablated within the energy focus range of the sound wave transmission, thereby achieving the effect of ultrasonic ablation.
  • the ultrasonic transducer 3 converts the pulsed electrical signal into a mechanical signal to generate a single ultrasonic wave, and calculates the tissue morphology change and temperature change by analyzing the echo signal, thereby realizing the measurement of the temperature and tissue morphology of the area to be ablated.
  • the ultrasonic ablation device further comprises a display 7 and an alarm 8.
  • the display 7 is connected to the control unit 1 for data display; the alarm 8 is connected to the control unit 1 to sound an alarm when the data is abnormal.
  • the main control module 11 of the control unit 1 can determine whether the flexible ablation balloon 4 is completely attached to the wall according to the first judgment logic by receiving impedance and water pressure, so as to ensure the wall adhesion of the flexible ablation balloon 4.
  • the ultrasonic transducer 3 switches to the ablation mode and releases ultrasonic waves to perform ultrasonic ablation on the area to be ablated.
  • the ultrasonic transducer 3 automatically switches to the measurement mode, scans, and feeds back the scanned measurement data to the main control module 11 for processing.
  • the switching logic specifically includes: taking a preset duration as a switching condition, switching is performed once every preset duration.
  • the control unit receives impedance, water pressure, temperature and tissue morphology of the area to be ablated, and outputs different powers according to the difference between the temperature of the area to be ablated and the preset temperature.
  • the ultrasonic transducer first starts the measurement mode, performs the first temperature measurement on the area to be ablated, and after the first temperature measurement is completed, the temperature data is sent to the controller to calculate the first output power.
  • the ultrasonic transducer When the first output power calculation is completed, the ultrasonic transducer automatically switches to the ablation mode to release ultrasonic waves to perform the first ablation on the area to be ablated (for a preset duration). When the first ablation is completed, the ultrasonic transducer automatically switches to the measurement mode to perform a second temperature measurement on the area to be ablated, so as to calculate the second output power through the controller; when the second output power calculation is completed, the ultrasonic transducer switches to the ablation mode to release ultrasonic waves to perform the second ablation on the area to be ablated (for a preset duration), and this cycle is repeated until the ablation end point is reached.
  • the second judgment logic specifically includes: when the temperature of the area to be ablated measured in the measurement mode reaches a preset temperature and remains stable for a preset time, and the water pressure and impedance drop to a theoretical value range, it is determined that the ablation end point has been reached.
  • the ultrasonic ablation device performs self-inspection and sends the self-inspection data to the main control module 11 , which is visualized through the display 7 .
  • the pressure sensor 6 detects the change of water pressure
  • the flexible electrode 5 detects the change of impedance, so as to transmit the change of water pressure and impedance to the main control module 11 in real time, so as to use the main control module 11 to judge whether the flexible ablation balloon 4 is completely attached to the wall through the first judgment logic.
  • the main control system 11 opens the drainage hole and maintains the corresponding water pressure to ensure that the flexible ablation balloon 4 maintains the state of being attached to the wall, and the physiological saline inside the balloon is continuously circulated, so as to cool down the ultrasonic transducer 3 and the flexible ablation balloon 4.
  • the main control module 11 sends an ultrasonic signal through the signal generator 12, and the signal is amplified by the power amplifier 13.
  • the phase voltage and current module 15 starts to work and feeds back parameters to the main control module 11 in real time for phase detection.
  • the main control module 11 adjusts the parameters of the signal generator 12 to complete phase matching.
  • phase-matched signal is sent to the ultrasonic transducer 3 via a suitable number of channels selected by the gating module 14 .
  • the ultrasonic transducer 3 works in a cycle to switch between the ablation mode and the temperature measurement mode according to a preset switching logic, and feeds back the ultrasonic data in the measurement mode to the main control module 11, so that the temperature and tissue morphology of the area to be ablated can be determined by the main control module 11.
  • the embodiment of the present invention further provides an ultrasonic ablation system, which includes the above-mentioned ultrasonic ablation device.
  • the ultrasonic ablation system may also include a control handle and a control host connected to the above-mentioned ultrasonic ablation device, wherein the control handle is controlled by the operator, and the catheter 2 can be pulled and pushed to allow the above-mentioned ultrasonic ablation device to enter the tissue.
  • control host is connected to the control unit 1 of the above-mentioned ultrasonic ablation device through communication (the control unit 1 here can also be a component of the control host) to achieve temperature control, energy control, etc. of the ultrasonic transducer 3, so that the ultrasonic transducer 3 will repeatedly switch between the measurement mode and the ablation mode until the ablation end point is reached.
  • the ultrasonic ablation system can also include functions such as three-dimensional mapping, differentiation of tissue density, tissue crushing (plaque, thrombus, etc.), and ultrasonic angiography, so as to cooperate with the ultrasonic ablation device to complete the ultrasonic ablation surgery.
  • the ultrasonic ablation device and system provided by the embodiments of the present invention have the following beneficial effects:
  • the main control module 11 controls the ultrasonic transducer 3 to continuously switch between the ablation mode and the temperature measurement mode to achieve automatic ablation, and automatically determines the ablation endpoint during the ablation process, thereby shortening the operation time and reducing the adverse reactions of the patient during the operation.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne un dispositif et un système d'ablation par ultrasons. Le dispositif d'ablation par ultrasons comprend : une partie de commande, utilisée pour la commande automatique d'ablation par ultrasons ; un cathéter, relié à la partie de commande et comprenant au moins une cavité d'entrée d'eau, une cavité de sortie d'eau et une cavité de fil ; un transducteur ultrasonore, placé à l'extrémité distale du cathéter et relié à la partie de commande de façon à pouvoir passer d'un mode d'ablation à un mode de mesure, le transducteur ultrasonore étant utilisé pour une ablation par ultrasons en mode d'ablation, et pour une mesure de température en mode de mesure ; un ballonnet d'ablation flexible, emmanché à l'extérieur du transducteur ultrasonore ; une électrode flexible, montée sur le côté externe du ballonnet et utilisée pour mesurer l'impédance ; et un capteur de pression, monté sur le côté interne du ballonnet et utilisé pour mesurer la pression de l'eau, la partie de commande étant utilisée pour recevoir l'impédance, la pression d'eau et la température de façon à déterminer, sur la base d'une première logique de détermination, si le ballonnet d'ablation flexible est complètement fixé à une paroi de vaisseau, commander le transducteur ultrasonore, sur la base d'une logique de commutation, pour effectuer une commutation de mode, et déterminer, sur la base d'une seconde logique de détermination, si un point d'extrémité d'ablation est atteint.
PCT/CN2025/070629 2024-01-05 2025-01-05 Dispositif et système d'ablation par ultrasons Pending WO2025146190A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202410021220.6A CN117883723A (zh) 2024-01-05 2024-01-05 一种超声消融设备及系统
CN202410021220.6 2024-01-05

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Publication Number Publication Date
WO2025146190A1 true WO2025146190A1 (fr) 2025-07-10

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117883723A (zh) * 2024-01-05 2024-04-16 上海魅丽纬叶医疗科技有限公司 一种超声消融设备及系统

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011095937A1 (fr) * 2010-02-05 2011-08-11 Koninklijke Philips Electronics N.V. Ablation et imagerie ultrasonore combinees
CN219895850U (zh) * 2023-05-17 2023-10-27 杭州科嘉生物技术有限公司 一种变径超声消融结构及消融导管
CN117179853A (zh) * 2023-08-23 2023-12-08 上海魅丽纬叶医疗科技有限公司 一种超声消融球囊贴壁的自动判断方法及系统
CN117179854A (zh) * 2023-08-23 2023-12-08 上海魅丽纬叶医疗科技有限公司 一种血管内神经消融终点的自动判断方法及系统
CN117883723A (zh) * 2024-01-05 2024-04-16 上海魅丽纬叶医疗科技有限公司 一种超声消融设备及系统

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011095937A1 (fr) * 2010-02-05 2011-08-11 Koninklijke Philips Electronics N.V. Ablation et imagerie ultrasonore combinees
CN219895850U (zh) * 2023-05-17 2023-10-27 杭州科嘉生物技术有限公司 一种变径超声消融结构及消融导管
CN117179853A (zh) * 2023-08-23 2023-12-08 上海魅丽纬叶医疗科技有限公司 一种超声消融球囊贴壁的自动判断方法及系统
CN117179854A (zh) * 2023-08-23 2023-12-08 上海魅丽纬叶医疗科技有限公司 一种血管内神经消融终点的自动判断方法及系统
CN117883723A (zh) * 2024-01-05 2024-04-16 上海魅丽纬叶医疗科技有限公司 一种超声消融设备及系统

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