WO2026041452A2 - Procédé de production de composés terpéniques - Google Patents

Procédé de production de composés terpéniques

Info

Publication number
WO2026041452A2
WO2026041452A2 PCT/EP2025/072822 EP2025072822W WO2026041452A2 WO 2026041452 A2 WO2026041452 A2 WO 2026041452A2 EP 2025072822 W EP2025072822 W EP 2025072822W WO 2026041452 A2 WO2026041452 A2 WO 2026041452A2
Authority
WO
WIPO (PCT)
Prior art keywords
compound
polypeptide
diphosphate
seq
terpenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2025/072822
Other languages
English (en)
Inventor
Daniel SOLIS ESCALANTE
Michel Schalk
Qi Wang
Andrew MUCHLINSKI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Firmenich SA
Original Assignee
Firmenich SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Firmenich SA filed Critical Firmenich SA
Publication of WO2026041452A2 publication Critical patent/WO2026041452A2/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y307/00—Hydrolases acting on carbon-carbon bonds (3.7)
    • C12Y307/01—Hydrolases acting on carbon-carbon bonds (3.7) in ketonic substances (3.7.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne un procédé de production d'un composé d'alcool terpénique. La présente invention concerne un procédé in vivo de production dudit composé dans une cellule recombinante. La présente invention concerne également une cellule recombinante qui peut être utilisée dans ledit procédé. La présente invention concerne également des procédés de préparation d'autres dérivés du composé d'alcool terpénique, qui servent de composés utiles pour la production d'ingrédients de parfumerie.
PCT/EP2025/072822 2024-08-19 2025-08-07 Procédé de production de composés terpéniques Pending WO2026041452A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2024113155 2024-08-19
CNPCT/CN2024/113155 2024-08-19
EP24207121.5 2024-10-17
EP24207121 2024-10-17

Publications (1)

Publication Number Publication Date
WO2026041452A2 true WO2026041452A2 (fr) 2026-02-26

Family

ID=96698606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2025/072822 Pending WO2026041452A2 (fr) 2024-08-19 2025-08-07 Procédé de production de composés terpéniques

Country Status (1)

Country Link
WO (1) WO2026041452A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396670A (en) 1980-04-08 1983-08-02 The Wiggins Teape Group Limited Process for the production of microcapsules
WO2009101126A1 (fr) 2008-02-15 2009-08-20 Firmenich Sa Procédé de production de sclaréol
WO2020011883A1 (fr) 2018-07-10 2020-01-16 Firmenich Sa Procédé de production biocatalytique de composés terpéniques
WO2021005097A1 (fr) 2019-07-10 2021-01-14 Firmenich Sa Procédé biocatalytique pour la dégradation maîtrisée de composés terpéniques

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396670A (en) 1980-04-08 1983-08-02 The Wiggins Teape Group Limited Process for the production of microcapsules
WO2009101126A1 (fr) 2008-02-15 2009-08-20 Firmenich Sa Procédé de production de sclaréol
WO2020011883A1 (fr) 2018-07-10 2020-01-16 Firmenich Sa Procédé de production biocatalytique de composés terpéniques
WO2021005097A1 (fr) 2019-07-10 2021-01-14 Firmenich Sa Procédé biocatalytique pour la dégradation maîtrisée de composés terpéniques

Non-Patent Citations (39)

* Cited by examiner, † Cited by third party
Title
"American Society for Bacteriology", 1981, WASHINGTON D. C., article "Manual of Methods for General Bacteriology"
"Cloning Vectors", 1985, ELSEVIER
A. BATEMANE. BIRNEYL. CERRUTIR. DURBINL. ETWILLERS. R. EDDYS. GRIFFITHS-JONESK. L. HOWEM. MARSHALLE. L. L. SONNHAMMER, NUCLEIC ACIDS RESEARCH, vol. 30, no. 1, 2002, pages 276 - 280
AUSUBEL, F.M. ET AL.: "Current Protocols in Molecular Biology", 1987, WILEY INTERSCIENCE
BARETTINO DFEIGENBUTZ MVALCÁREL RSTUNNENBERG HG, NUCLEIC ACIDS RES, vol. 22, 1994, pages 1593
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EI-GEBALI S ET AL., NUCLEIC ACIDS RES., vol. 47, 2019, pages D427 - D432
FALLON, A. ET AL., APPLICATIONS OF HPLC IN BIOCHEMISTRY IN: LABORATORY TECHNIQUES IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, BD., 1987, pages 17
FINN, NUCLEIC ACIDS RESEARCH, vol. 34, 2006, pages D247 - 251
FINN, NUCLEIC ACIDS RESEARCH, vol. 38, 2010, pages D211 - 222
GIETZWOODS, METHODS ENZYMOL., vol. 350, 2002, pages 87 - 96
GOEDDEL: "Gene Expression Technology: Methods in Enzymology", 1990, ACADEMIC PRESS, pages: 185
GREENER ACALLAHAN MJERPSETH B: "An efficient random mutagenesis technique using an E.coli mutator strain", 1996, HUMANA PRESS, pages: 89 - 90
K. BRUYNINCKXM. DUSSELIER, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, vol. 7, 2019, pages 8041 - 8054
K. DIETRICH ET AL., ACTA POLYMERICA, vol. 40, 1989, pages 243
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MALAKHOVA ET AL., BIOTEKHNOLOGIYA, vol. 11, 1996, pages 27 - 32
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NUCLEIC ACIDS RES., vol. 40, no. D1, 2012, pages D1178 - D1186
PATEK, APPL. ENVIRON. MICROBIOL., vol. 60, 1994, pages 133 - 140
PAYSAN-LAFOSSE TBLUM MCHUGURANSKY SGREGO TPINTO BLSALAZAR GABILESCHI MLBORK PBRIDGE ACOLWELL L, NUCLEIC ACIDS RESEARCH, November 2022 (2022-11-01)
PEARSONLIPMAN, PROC. NATL. ACAD, SCI. (USA, vol. 85, no. 8, 1988, pages 2444 - 2448
REETZ MTJAEGER K-E, TOPICS CURR CHEM, vol. 200, 1999, pages 31
RINALDI, M. A ET AL., NATURAL PRODUCT REPORTS, vol. 39, no. 1, 2022, pages 90 - 118, Retrieved from the Internet <URL:https://doi.org/10.1039/D1NP00025J>
SAMBROOK, JFRITSCH, E.F.MANIATIS, T.: "Molecular cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY
SAMBROOKRUSSELL: "Molecular Cloning", 2001, COLD SPRING HARBOR LABORATORY PRESS
SATO, T. ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, no. 44, 2011, pages 17540 - 17543
SCHENK ET AL., BIOSPEKTRUM, vol. 3, 2006, pages 277 - 279
SCHMIDT ET AL., BIOPROCESS ENGINEER., vol. 19, 1998, pages 67 - 70
SCHULTZ ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 5857 - 5864
SONNHAMMER, NUCLEIC ACIDS RESEARCH, vol. 26, 1998, pages 320 - 322
STEMMER WPC, NATURE, vol. 370, 1994, pages 389
STEMMER WPC, PROC NATL ACAD SCI USA, vol. 91, 1994, pages 10747
T.J. SILHAVYM.L. BERMANL.W. ENQUIST: "Biotechnologie - Lehrbuch der angewandten Mikrobiologie", 1984, COLD SPRING HARBOR LABORATORY
TATIANA ET AL., FEMS MICROBIOL LETT., vol. 174, 1999, pages 247 - 250
WESTFALL ET AL., PROC NATL ACAD SCI USA, vol. 109, 2012, pages E111 - 118

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