WO2026072994A1 - Méthodes de traitement d'une maladie cardiovasculaire - Google Patents

Méthodes de traitement d'une maladie cardiovasculaire

Info

Publication number
WO2026072994A1
WO2026072994A1 PCT/US2025/048234 US2025048234W WO2026072994A1 WO 2026072994 A1 WO2026072994 A1 WO 2026072994A1 US 2025048234 W US2025048234 W US 2025048234W WO 2026072994 A1 WO2026072994 A1 WO 2026072994A1
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
antibody
patient
crp
weeks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/048234
Other languages
English (en)
Inventor
Sandeep Kulkarni
Yung CHYUNG
Susan Dana Jones
Ryan Iarrobino
W. Bradford MIDDLEKAUFF
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tourmaline Bio Inc
Original Assignee
Tourmaline Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2024/048932 external-priority patent/WO2025072725A1/fr
Application filed by Tourmaline Bio Inc filed Critical Tourmaline Bio Inc
Publication of WO2026072994A1 publication Critical patent/WO2026072994A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente divulgation concerne des méthodes de traitement d'une maladie cardiovasculaire, et en particulier d'une maladie cardiovasculaire athéroscléreuse (ASCVD), comprenant l'administration sous-cutanée à un patient qui en a besoin d'une dose thérapeutiquement efficace d'un anticorps anti-interleukine-6 (anti-IL-6) ou d'un fragment d'anticorps. L'invention concerne en outre des agents pharmacologiquement actifs, des compositions, des méthodes et/ou des posologies pour le traitement d'une maladie cardiovasculaire.
PCT/US2025/048234 2024-09-27 2025-09-26 Méthodes de traitement d'une maladie cardiovasculaire Pending WO2026072994A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USPCT/US2024/048932 2024-09-27
PCT/US2024/048932 WO2025072725A1 (fr) 2023-09-28 2024-09-27 Méthodes de traitement d'une maladie cardiovasculaire
US202563808433P 2025-05-19 2025-05-19
US63/808,433 2025-05-19

Publications (1)

Publication Number Publication Date
WO2026072994A1 true WO2026072994A1 (fr) 2026-04-02

Family

ID=99308844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2025/048234 Pending WO2026072994A1 (fr) 2024-09-27 2025-09-26 Méthodes de traitement d'une maladie cardiovasculaire

Country Status (1)

Country Link
WO (1) WO2026072994A1 (fr)

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