WO2026076317A1 - Anticorps bispécifiques qui se lient au mica/b et cd3 - Google Patents

Anticorps bispécifiques qui se lient au mica/b et cd3

Info

Publication number
WO2026076317A1
WO2026076317A1 PCT/US2025/049369 US2025049369W WO2026076317A1 WO 2026076317 A1 WO2026076317 A1 WO 2026076317A1 US 2025049369 W US2025049369 W US 2025049369W WO 2026076317 A1 WO2026076317 A1 WO 2026076317A1
Authority
WO
WIPO (PCT)
Prior art keywords
mica
domain
seq
nos
bispecific antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/049369
Other languages
English (en)
Inventor
Katrina BYKOVA
Matthew S. Faber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xencor Inc
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of WO2026076317A1 publication Critical patent/WO2026076317A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des anticorps anti-CD3 × anti-MICA/B et des procédés d'utilisation de tels anticorps pour le traitement de cancers.
PCT/US2025/049369 2024-10-04 2025-10-03 Anticorps bispécifiques qui se lient au mica/b et cd3 Pending WO2026076317A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202463703846P 2024-10-04 2024-10-04
US63/703,846 2024-10-04
US202463716367P 2024-11-05 2024-11-05
US63/716,367 2024-11-05

Publications (1)

Publication Number Publication Date
WO2026076317A1 true WO2026076317A1 (fr) 2026-04-09

Family

ID=97677955

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2025/049369 Pending WO2026076317A1 (fr) 2024-10-04 2025-10-03 Anticorps bispécifiques qui se lient au mica/b et cd3

Country Status (1)

Country Link
WO (1) WO2026076317A1 (fr)

Citations (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US459007A (en) 1891-09-08 Porte
WO2004029207A2 (fr) 2002-09-27 2004-04-08 Xencor Inc. Variants fc optimises et methodes destinees a leur generation
US20060134105A1 (en) 2004-10-21 2006-06-22 Xencor, Inc. IgG immunoglobulin variants with optimized effector function
US20090163699A1 (en) 2004-11-12 2009-06-25 Chamberlain Aaron Keith Fc VARIANTS WITH ALTERED BINDING TO FcRn
US7657380B2 (en) 2003-12-04 2010-02-02 Xencor, Inc. Methods of generating variant antibodies with increased host string content
US20120028304A1 (en) 2010-07-29 2012-02-02 Xencor, Inc. Antibodies with modified isoelectric points
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US20120149876A1 (en) 2010-11-05 2012-06-14 Zymeworks Inc. Stable Heterodimeric Antibody Design with Mutations in the Fc Domain
US8216805B2 (en) 1995-03-01 2012-07-10 Genentech, Inc. Knobs and holes heteromeric polypeptides
WO2014145806A2 (fr) 2013-03-15 2014-09-18 Xencor, Inc. Protéines hétérodimériques
US20140370013A1 (en) 2013-01-14 2014-12-18 Xencor, Inc. Novel heterodimeric proteins
WO2015184203A1 (fr) 2014-05-29 2015-12-03 Macrogenics, Inc. Molécules de liaison trispécifiques et leurs procédés d'utilisation
WO2016154585A1 (fr) * 2015-03-26 2016-09-29 Charles Sentman Fragments de liaison à l'antigène anti-mica, molécules hybrides, cellules exprimant ceux-ci et procédés d'utilisation
US20160355608A1 (en) 2014-11-26 2016-12-08 Xencor, Inc. Heterodimeric antibodies that bind cd3 and tumor antigens
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US9732155B2 (en) 2011-11-04 2017-08-15 Zymeworks Inc. Crystal structures of heterodimeric Fc domains
US9822186B2 (en) 2014-03-28 2017-11-21 Xencor, Inc. Bispecific antibodies that bind to CD38 and CD3
US10287352B2 (en) 2015-10-02 2019-05-14 Hoffman-La Roche Inc. Bispecific antibodies specific for PD1 and TIM3
US20220089722A1 (en) * 2018-12-29 2022-03-24 Nantong Yichen Biopharma. Co. Ltd. Heterodimeric fusion protein
US20220289839A1 (en) 2021-03-09 2022-09-15 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
WO2024102636A1 (fr) * 2022-11-07 2024-05-16 Xencor, Inc. Anticorps bispécifiques qui se lient à b7h3 et mica/b
CN119192389A (zh) * 2023-06-25 2024-12-27 合肥天港免疫药物有限公司 双特异性抗体及其应用
WO2025051141A1 (fr) * 2023-09-06 2025-03-13 合肥天港免疫药物有限公司 Anticorps bispécifique et son utilisation
US12462008B2 (en) 2021-04-23 2025-11-04 Beijing Boe Technology Development Co., Ltd. Unlocking control method and device, electronic apparatus, and computer-readable storage medium

Patent Citations (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US459007A (en) 1891-09-08 Porte
US8216805B2 (en) 1995-03-01 2012-07-10 Genentech, Inc. Knobs and holes heteromeric polypeptides
WO2004029207A2 (fr) 2002-09-27 2004-04-08 Xencor Inc. Variants fc optimises et methodes destinees a leur generation
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US7657380B2 (en) 2003-12-04 2010-02-02 Xencor, Inc. Methods of generating variant antibodies with increased host string content
US20060134105A1 (en) 2004-10-21 2006-06-22 Xencor, Inc. IgG immunoglobulin variants with optimized effector function
US20090163699A1 (en) 2004-11-12 2009-06-25 Chamberlain Aaron Keith Fc VARIANTS WITH ALTERED BINDING TO FcRn
US20120028304A1 (en) 2010-07-29 2012-02-02 Xencor, Inc. Antibodies with modified isoelectric points
US20210277150A1 (en) 2010-11-05 2021-09-09 Zymeworks Inc. STABLE HETERODIMERIC ANTIBODY DESIGN WITH MUTATIONS IN THE Fc DOMAIN
US20120149876A1 (en) 2010-11-05 2012-06-14 Zymeworks Inc. Stable Heterodimeric Antibody Design with Mutations in the Fc Domain
US10875931B2 (en) 2010-11-05 2020-12-29 Zymeworks, Inc. Stable heterodimeric antibody design with mutations in the Fc domain
US20200087414A1 (en) 2011-11-04 2020-03-19 Zymeworks Inc. STABLE HETERODIMERIC ANTIBODY DESIGN WITH MUTATIONS IN THE Fc DOMAIN
US9732155B2 (en) 2011-11-04 2017-08-15 Zymeworks Inc. Crystal structures of heterodimeric Fc domains
US10457742B2 (en) 2011-11-04 2019-10-29 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the Fc domain
US20140370013A1 (en) 2013-01-14 2014-12-18 Xencor, Inc. Novel heterodimeric proteins
WO2014145806A2 (fr) 2013-03-15 2014-09-18 Xencor, Inc. Protéines hétérodimériques
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US9822186B2 (en) 2014-03-28 2017-11-21 Xencor, Inc. Bispecific antibodies that bind to CD38 and CD3
WO2015184203A1 (fr) 2014-05-29 2015-12-03 Macrogenics, Inc. Molécules de liaison trispécifiques et leurs procédés d'utilisation
US20160355608A1 (en) 2014-11-26 2016-12-08 Xencor, Inc. Heterodimeric antibodies that bind cd3 and tumor antigens
WO2016154585A1 (fr) * 2015-03-26 2016-09-29 Charles Sentman Fragments de liaison à l'antigène anti-mica, molécules hybrides, cellules exprimant ceux-ci et procédés d'utilisation
US10287352B2 (en) 2015-10-02 2019-05-14 Hoffman-La Roche Inc. Bispecific antibodies specific for PD1 and TIM3
US20220089722A1 (en) * 2018-12-29 2022-03-24 Nantong Yichen Biopharma. Co. Ltd. Heterodimeric fusion protein
US20220289839A1 (en) 2021-03-09 2022-09-15 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
US12462008B2 (en) 2021-04-23 2025-11-04 Beijing Boe Technology Development Co., Ltd. Unlocking control method and device, electronic apparatus, and computer-readable storage medium
WO2024102636A1 (fr) * 2022-11-07 2024-05-16 Xencor, Inc. Anticorps bispécifiques qui se lient à b7h3 et mica/b
CN119192389A (zh) * 2023-06-25 2024-12-27 合肥天港免疫药物有限公司 双特异性抗体及其应用
WO2025051141A1 (fr) * 2023-09-06 2025-03-13 合肥天港免疫药物有限公司 Anticorps bispécifique et son utilisation

Non-Patent Citations (31)

* Cited by examiner, † Cited by third party
Title
"GenBank", Database accession no. NP_001035741.1
"Remington's Pharmaceutical Sciences", 1980
"UniProt", Database accession no. P09693
ALTSCHUL, S.F. ET AL.: "Basic Local Alignment Search Tool", J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
ATWELL ET AL., J. MOL. BIOL., vol. 270, 1997, pages 26
BACA ET AL., J. BIOL. CHEM., vol. 272, no. 16, 1997, pages 10678 - 10684
CARTER ET AL., J. IMMUNOL. METHODS, vol. 248, no. 1-2, 2001, pages 7 - 15
DAVIS ET AL., IMMUNOLOGICAL REVIEWS, vol. 190, 2002, pages 123 - 136
DE PASCALIS ET AL., J. IMMUNOL., vol. 169, 2002, pages 5171 - 5180
EDELMAN ET AL., PROC NATL ACAD SCI, vol. 63, 1969, pages 78 - 85
GHETIEWARD, IMMUNOL TODAY, vol. 18, no. 12, 1997, pages 592 - 598
GUNASEKARAN ET AL., J. BIOL. CHEM., vol. 285, no. 25, 2010, pages 19637
IGAWA ET AL., PEDS, vol. 23, no. 5, 2010, pages 385 - 392
JEFFERIS ET AL., IMMUNOL LETT, vol. 82, 2002, pages 57 - 65
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
KOBAYASHI ET AL., J. BIOL. CHEM., vol. 287, 2012, pages 33973 - 82
KRAUSS ET AL., PROTEIN ENGINEERING, vol. 16, no. 10, 2003, pages 753 - 759
LAFRANC ET AL., DEV. COMP. IMMUNOL., vol. 27, no. 1, 2003, pages 55 - 77
MERCHANT ET AL., NAT. BIOTECHNOL., vol. 16, no. 7, 1998, pages 677 - 81
MERCHANT ET AL., NATURE BIOTECH, vol. 16, 1998, pages 677
NEEDLEMAN, S.B.WUNSCH, CD.: "A General Method Applicable To The Search For Similarities In The Amino Acid Sequence Of Two Proteins", J. MOL. BIOL., vol. 48, 1970, pages 443
PEARSON, W.R.LIPMAN, D.J.: "Improved Tools For Biological Sequence Comparison", PROC. NATL. ACAD. SCI., vol. 85, 1988, pages 2444
PEREIRA ET AL., MABS, vol. 10, no. 5, 2018, pages 693 - 711
RADER ET AL., PROC. NATL. ACAD. SCI., vol. 95, 1998, pages 8910 - 8915
RIDGWAY ET AL., PROTEIN ENG, vol. 9, no. 7, 1996, pages 617 - 2
RIDGWAY ET AL., PROTEIN ENGINEERING, vol. 9, no. 7, 1996, pages 617
ROSOK ET AL., J. BIOL. CHEM., vol. 271, no. 37, 1996, pages 22611 - 22618
SMITH, T.F.WATERMAN, M.S.: "Comparison Of Biosequences", ADV. APPL. MATH., vol. 2, 1981, pages 482
WHITLOW ET AL., PROTEIN ENGINEERING, vol. 6, no. 8, 1993, pages 989 - 995
WU ET AL., J. MOL. BIOL., vol. 294, 1999, pages 151 - 162
YOU GIHOON ET AL: "Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies", VACCINES, vol. 9, no. 7, 2 July 2021 (2021-07-02), pages 724, XP093000326, DOI: 10.3390/vaccines9070724 *

Similar Documents

Publication Publication Date Title
US20230227581A1 (en) Heterodimeric antibodies that bind enpp3 and cd3
CA3212665A1 (fr) Anticorps heterodimeriques se liant a cd3 et a cldn6
US12365743B2 (en) Anti-CD28 x anti-PSMA antibodies
US12404329B2 (en) Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
US20240059786A1 (en) Anti-cd28 x anti-trop2 antibodies
US20240279356A1 (en) Heterodimeric antibodies that bind msln and cd3
US20230151095A1 (en) Bispecific antibodies that bind to b7h3 and nkg2d
US20250243279A1 (en) Bispecific antibodies that bind to nkp46 and mica/b
US20230340128A1 (en) Anti-cd28 x anti-msln antibodies
US20250084179A1 (en) Anti-cd28 x anti-trop2 antibodies
US20240247062A1 (en) Heterodimeric antibodies that bind claudin18.2 and cd3
IL324218A (en) Orthogonal multimeric proteins
US20240150471A1 (en) Natural killer cell antibodies with increased adcc activity
WO2024102636A1 (fr) Anticorps bispécifiques qui se lient à b7h3 et mica/b
EP4695296A1 (fr) Anticorps anti-cd28 x anti-enpp3
WO2026076317A1 (fr) Anticorps bispécifiques qui se lient au mica/b et cd3
US20240360233A1 (en) Anti-tslpr (crlf2) antibodies
WO2025090973A2 (fr) Anticorps anti-trop2, anti-pdl1 et anti-cd28