WO2026087635A1 - Dérivés de dihydrobenzoxazine - Google Patents

Dérivés de dihydrobenzoxazine

Info

Publication number
WO2026087635A1
WO2026087635A1 PCT/EP2025/080568 EP2025080568W WO2026087635A1 WO 2026087635 A1 WO2026087635 A1 WO 2026087635A1 EP 2025080568 W EP2025080568 W EP 2025080568W WO 2026087635 A1 WO2026087635 A1 WO 2026087635A1
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl
trifluoromethyl
chloro
thia
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2025/080568
Other languages
English (en)
Inventor
Ioana BALTARETU
Annick Goergler
Laura GUASCH PAMIES
Eleonora JOVCHEVA
Dmitry MAZUNIN
Christa Ulrike OBST-SANDER
Tristan Denis Constantin René REUILLON
Andrea Samuel TOMIO
Claudio ZAMBALDO
William John Zuercher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Hoffmann La Roche Inc
Original Assignee
F Hoffmann La Roche AG
Hoffmann La Roche Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Hoffmann La Roche Inc filed Critical F Hoffmann La Roche AG
Publication of WO2026087635A1 publication Critical patent/WO2026087635A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés hétérocycliques de formule générale (I) dans laquelle A, R1, R2, R3, R4, R5, R6, RA1, RA2 et L sont tels que définis dans la description, des compositions comprenant les composés et des procédés d'utilisation des composés.
PCT/EP2025/080568 2024-10-24 2025-10-23 Dérivés de dihydrobenzoxazine Pending WO2026087635A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP24208558 2024-10-24
EP24208558.7 2024-10-24

Publications (1)

Publication Number Publication Date
WO2026087635A1 true WO2026087635A1 (fr) 2026-04-30

Family

ID=93284471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2025/080568 Pending WO2026087635A1 (fr) 2024-10-24 2025-10-23 Dérivés de dihydrobenzoxazine

Country Status (1)

Country Link
WO (1) WO2026087635A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015171610A2 (fr) * 2014-05-05 2015-11-12 Lycera Corporation Sulfonamide de tétrahydroquinoline et composés apparentés destinés à servir d'agonistes de rory et pour le traitement de maladies
WO2017040963A1 (fr) * 2015-09-03 2017-03-09 Forma Therapeutics, Inc. Inhibiteurs de hdac8 bicyclique [6,6] fusionnée
WO2023179600A1 (fr) * 2022-03-21 2023-09-28 杭州德睿智药科技有限公司 Nouveaux composés macrohétérocycliques substitués et leur utilisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015171610A2 (fr) * 2014-05-05 2015-11-12 Lycera Corporation Sulfonamide de tétrahydroquinoline et composés apparentés destinés à servir d'agonistes de rory et pour le traitement de maladies
WO2017040963A1 (fr) * 2015-09-03 2017-03-09 Forma Therapeutics, Inc. Inhibiteurs de hdac8 bicyclique [6,6] fusionnée
WO2023179600A1 (fr) * 2022-03-21 2023-09-28 杭州德睿智药科技有限公司 Nouveaux composés macrohétérocycliques substitués et leur utilisation

Non-Patent Citations (22)

* Cited by examiner, † Cited by third party
Title
"Boronic Acids - Preparation and Applications in Organic Synthesis and Medicine", 2005, JOHN WILEY & SONS
"Reductive alkylation - Preparation of Amines", CATALYTIC HYDROGENATION OVER PLATINUM METALS, pages 291 - 303
A. SUZUKI, ORGANOMET. CHEM., vol. 576, 1999, pages 147 - 168
A. SUZUKI, PURE APPL. CHEM., vol. 63, 1991, pages 419 - 422
A. SUZUKIN. MIYAURA, CHEM. REV., vol. 95, 1995, pages 2457 - 2483
ANGEWANDTE CHEMIE, vol. 58, 2019, pages 17118 - 17129
BARANYR. B. MERRIFIELD, J. AM. CHEM. SOC., vol. 99, 1977, pages 7363
BORCHBERNSTEIN, J. AM. CHEM. SOC, vol. 93, 1971, pages 2897
BROWN, H. C.KRISHNAMURTHY, S.: "Selective Reductions. 20. Borane-Methyl Sulfide: A Highly Convenient, Stable, and Selective Reagent for the Reduction of Representative Organic Compounds", J. AM. CHEM. SOC., vol. 94, 1972, pages 7159 - 7161
CHEM. REV., vol. 109, no. 6, 2009, pages 2551
CHEM. SOC. REV., vol. 40, 2011, pages 5084
H. WALDMANN ET AL., ANGEW. CHEM. INT. ED. ENGL., vol. 35, 1996, pages 2056
HECK, R. F.: "The Palladium-Catalyzed Arylation of Enol Esters, Halides, and Dienes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 90, no. 20, 1968, pages 5518 - 5526
JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 10, 2013, pages 3980 - 3995
no. 1203566-77-1
ORG. CHEM. FRONT., vol. 2, 2015, pages 739
ORG. LETT., vol. 20, 2018, pages 4218 - 4222
R.H. GRUBBS, S. MILLER, G.C. FU, ACC. CHEM. RES., vol. 28, 1995, pages 446 - 452
SPENCER JONATHAN A. ET AL: "Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase [delta]", ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 7, 3 June 2020 (2020-06-03), US, pages 1386 - 1391, XP093287996, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.0c00061 *
T. W. GREENEP. G. M. WUTTS: "Protective Groups in Organic Chemistry", 2006, JOHN WILEY & SONS
TANG, T. P.; ELLMAN, J. A.: "The tert- Butanesulfinyl Group: An Ideal Chiral Directing Group and Boc-Surrogate for the Asymmetric Synthesis and Applications of β-Amino Acids", J. ORG. CHEM., vol. 64, 1999, pages 12 - 13, XP000916153, DOI: 10.1021/jo9820824
V. POLSHETTIWAR ET AL., CHEM. SUS. CHEM., vol. 3, 2010, pages 502 - 522

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