YU295A - PROCEDURES FOR PREVENTING PROTEIN DEGRADATION C - Google Patents
PROCEDURES FOR PREVENTING PROTEIN DEGRADATION CInfo
- Publication number
- YU295A YU295A YU295A YU295A YU295A YU 295 A YU295 A YU 295A YU 295 A YU295 A YU 295A YU 295 A YU295 A YU 295A YU 295 A YU295 A YU 295A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- apc
- present
- procedures
- preventing
- protein degradation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000017854 proteolysis Effects 0.000 title 1
- 101800004937 Protein C Proteins 0.000 abstract 2
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 2
- 101800001700 Saposin-D Proteins 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 229960000856 protein c Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 230000007281 self degradation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
POSTUPCI ZA SPREČAVANJE DEGRADACIJE PROTEINA C - Ovaj pronalazak se odnosi na postupke za sprecavanje ili smanjivanje autodegradacije aktiviranog proteina C. Ovaj pronalazak je najbolje prikazan primerima vrSenjem prerade, prečiSćavanja i/ili skladiStenja aktiviranog proteina C na niskom pH, na primer na oko pH 6.3 do oko pH 6.5. Autodegradacija aPC može takodje biti smahjeha in-kubiranjem aPC u 3 M karbamidu (potpuna regeneracija aPC aktivnosti se pbstiže posle uklanjanja reagensa za denaturizaciju) ili inkubiranjem aPC u prisustvu ekstiemnih koncentracija soli. Ovaj pronalazak takodje obuhvata aPC formulacije koje održavaju aPC na niskom pH, u reagensu za denaturizaciju, ili na ekstremnim koncentracijama soli.METHODS FOR PREVENTING DEGRADATION OF PROTEIN C - The present invention relates to methods for preventing or reducing autodegradation of activated protein C. The present invention is best illustrated by examples of processing, purifying and / or storing activated protein C at low pH, for example at about pH 6.3 to about pH 6.5. Self-degradation of aPC can also be accomplished by incubating aPC in 3 M urea (complete regeneration of aPC activity is achieved after removal of the denaturing reagent) or by incubating aPC in the presence of extremal salt concentrations. The present invention also encompasses aPC formulations that maintain aPC at low pH, in denaturing reagent, or at extreme salt concentrations.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17783294A | 1994-01-05 | 1994-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU295A true YU295A (en) | 1997-09-30 |
Family
ID=22650141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU295A YU295A (en) | 1994-01-05 | 1995-01-04 | PROCEDURES FOR PREVENTING PROTEIN DEGRADATION C |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP0662513B1 (en) |
| JP (1) | JP3778588B2 (en) |
| KR (1) | KR950032287A (en) |
| CN (1) | CN1109891A (en) |
| AT (1) | ATE201045T1 (en) |
| AU (1) | AU1003195A (en) |
| BR (1) | BR9500017A (en) |
| CA (1) | CA2139468C (en) |
| CO (1) | CO4600680A1 (en) |
| CZ (1) | CZ1395A3 (en) |
| DE (2) | DE69520844T2 (en) |
| DK (1) | DK0662513T3 (en) |
| ES (1) | ES2156190T3 (en) |
| FI (1) | FI115635B (en) |
| GR (1) | GR3036277T3 (en) |
| HU (1) | HUT70465A (en) |
| IL (1) | IL112236A (en) |
| LU (2) | LU90992I2 (en) |
| NL (1) | NL300108I2 (en) |
| NO (2) | NO320157B1 (en) |
| NZ (1) | NZ270271A (en) |
| PE (1) | PE43995A1 (en) |
| PL (1) | PL180703B1 (en) |
| PT (1) | PT662513E (en) |
| RU (1) | RU2167936C2 (en) |
| SI (1) | SI0662513T1 (en) |
| UA (1) | UA39178C2 (en) |
| YU (1) | YU295A (en) |
| ZA (1) | ZA9514B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA55448C2 (en) | 1997-04-28 | 2003-04-15 | Елі Ліллі Енд Компані | Pharmaceutical formulations of activated protein с |
| EP1557463A1 (en) * | 1997-04-28 | 2005-07-27 | Eli Lilly & Company | Improved methods for processing activated protein C |
| US6630137B1 (en) | 1997-04-28 | 2003-10-07 | Eli Lilly And Company | Activated protein C formulations |
| US7204981B2 (en) | 2000-03-28 | 2007-04-17 | Eli Lilly And Company | Methods of treating diseases with activated protein C |
| CA2410567A1 (en) | 2000-05-24 | 2001-11-29 | Eli Lilly And Company | Formulations and use of activated protein c and protein c zymogen for treating hypercoagulable states |
| US20080125580A1 (en) * | 2006-07-14 | 2008-05-29 | Genentech, Inc. | Refolding of Recombinant Proteins |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950513A (en) * | 1965-12-03 | 1976-04-13 | Novo Terapeutisk Laboratorium A/S | Process of stabilizing therapeutically useful plasmin solutions |
| US3557002A (en) * | 1967-11-15 | 1971-01-19 | Procter & Gamble | Stabilized aqueous enzyme preparation |
| GB2105521A (en) * | 1981-08-12 | 1983-03-23 | Univ Surrey | Antenna |
| AT402262B (en) * | 1991-06-20 | 1997-03-25 | Immuno Ag | MEDICINAL ACTIVATED PROTEIN C |
-
1994
- 1994-12-22 NZ NZ270271A patent/NZ270271A/en unknown
-
1995
- 1995-01-03 ZA ZA9514A patent/ZA9514B/en unknown
- 1995-01-03 KR KR1019950000002A patent/KR950032287A/en not_active Abandoned
- 1995-01-03 CO CO95000126A patent/CO4600680A1/en unknown
- 1995-01-03 AU AU10031/95A patent/AU1003195A/en not_active Abandoned
- 1995-01-03 IL IL11223695A patent/IL112236A/en not_active IP Right Cessation
- 1995-01-03 NO NO19950018A patent/NO320157B1/en not_active IP Right Cessation
- 1995-01-03 CZ CZ9513A patent/CZ1395A3/en unknown
- 1995-01-03 PE PE1995258411A patent/PE43995A1/en not_active Application Discontinuation
- 1995-01-03 CA CA002139468A patent/CA2139468C/en not_active Expired - Fee Related
- 1995-01-03 PL PL95306671A patent/PL180703B1/en unknown
- 1995-01-04 FI FI950044A patent/FI115635B/en not_active IP Right Cessation
- 1995-01-04 DE DE69520844T patent/DE69520844T2/en not_active Expired - Lifetime
- 1995-01-04 EP EP95300042A patent/EP0662513B1/en not_active Expired - Lifetime
- 1995-01-04 AT AT95300042T patent/ATE201045T1/en active
- 1995-01-04 DE DE2002199053 patent/DE10299053I2/en active Active
- 1995-01-04 EP EP00203385A patent/EP1087011A3/en not_active Withdrawn
- 1995-01-04 CN CN95101130A patent/CN1109891A/en active Pending
- 1995-01-04 RU RU95100178/13A patent/RU2167936C2/en active
- 1995-01-04 PT PT95300042T patent/PT662513E/en unknown
- 1995-01-04 SI SI9530503T patent/SI0662513T1/en unknown
- 1995-01-04 JP JP00008695A patent/JP3778588B2/en not_active Expired - Fee Related
- 1995-01-04 HU HU9500021A patent/HUT70465A/en unknown
- 1995-01-04 DK DK95300042T patent/DK0662513T3/en active
- 1995-01-04 BR BR9500017A patent/BR9500017A/en not_active IP Right Cessation
- 1995-01-04 UA UA95018011A patent/UA39178C2/en unknown
- 1995-01-04 YU YU295A patent/YU295A/en unknown
- 1995-01-04 ES ES95300042T patent/ES2156190T3/en not_active Expired - Lifetime
-
2001
- 2001-07-24 GR GR20010401126T patent/GR3036277T3/en unknown
-
2002
- 2002-12-03 NL NL300108C patent/NL300108I2/en unknown
- 2002-12-18 LU LU90992C patent/LU90992I2/en unknown
- 2002-12-18 LU LU90993C patent/LU90993I2/en unknown
-
2006
- 2006-05-02 NO NO2006006C patent/NO2006006I1/en unknown
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