YU45802B - Postupak za dobijanje farmaceutski aktivnih fosfino-ugljovodoničnih kompleksnih jedinjenja metala viii grupe - Google Patents
Postupak za dobijanje farmaceutski aktivnih fosfino-ugljovodoničnih kompleksnih jedinjenja metala viii grupeInfo
- Publication number
- YU45802B YU45802B YU181786A YU181786A YU45802B YU 45802 B YU45802 B YU 45802B YU 181786 A YU181786 A YU 181786A YU 181786 A YU181786 A YU 181786A YU 45802 B YU45802 B YU 45802B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- compound
- iii
- solvent
- anion
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 239000002184 metal Substances 0.000 title abstract 3
- 229910052751 metal Inorganic materials 0.000 title abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 title abstract 2
- 150000002739 metals Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 5
- 239000002904 solvent Substances 0.000 abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 150000001450 anions Chemical class 0.000 abstract 4
- 238000009835 boiling Methods 0.000 abstract 4
- 239000012299 nitrogen atmosphere Substances 0.000 abstract 4
- 239000011541 reaction mixture Substances 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 3
- 239000010948 rhodium Substances 0.000 abstract 3
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 abstract 2
- 229910002651 NO3 Inorganic materials 0.000 abstract 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 abstract 2
- 239000011574 phosphorus Substances 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- QFMZQPDHXULLKC-UHFFFAOYSA-N 1,2-bis(diphenylphosphino)ethane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 QFMZQPDHXULLKC-UHFFFAOYSA-N 0.000 abstract 1
- NIPPJMSKAOITEK-UHFFFAOYSA-N 2-diphenylarsanylethyl(diphenyl)phosphane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CC[As](C=1C=CC=CC=1)C1=CC=CC=C1 NIPPJMSKAOITEK-UHFFFAOYSA-N 0.000 abstract 1
- NCKJIJSEWKIXAT-QURGRASLSA-N [(e)-2-diphenylphosphanylethenyl]-diphenylphosphane Chemical group C=1C=CC=CC=1P(C=1C=CC=CC=1)/C=C/P(C=1C=CC=CC=1)C1=CC=CC=C1 NCKJIJSEWKIXAT-QURGRASLSA-N 0.000 abstract 1
- JAZCEXBNIYKZDI-UHFFFAOYSA-N [Ir+] Chemical compound [Ir+] JAZCEXBNIYKZDI-UHFFFAOYSA-N 0.000 abstract 1
- -1 anion compound Chemical class 0.000 abstract 1
- 229910052785 arsenic Inorganic materials 0.000 abstract 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 abstract 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- MUJIDPITZJWBSW-UHFFFAOYSA-N palladium(2+) Chemical compound [Pd+2] MUJIDPITZJWBSW-UHFFFAOYSA-N 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 abstract 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0033—Iridium compounds
- C07F15/004—Iridium compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/006—Palladium compounds
- C07F15/0066—Palladium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0073—Rhodium compounds
- C07F15/008—Rhodium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/04—Nickel compounds
- C07F15/045—Nickel compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/06—Cobalt compounds
- C07F15/065—Cobalt compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
POSTUPAK ZA DOBIJANJE FARMACEUTSKI AKTIVNIH FOSFINO-UGLJOVODONICNIH KOMPLEKSNIH JEDINJENJA METALA VIII GRUPE, koja imaju opstu formulu: u kojoj D1 predstavlja fosfor a D2 fosfor ili arsen; A predstavlja (CH2)2, (CH2)3 ili cis-CH=CH; X1 i X2 oba, ukoliko su prisutni predstavljaju halo ili nitrato, ili X1 i X2 zajedno predstavljaju perokso; Y, ukoliko je prisutno, predstavlja halogenid, nitrat, perhlorat, triflat ili tetrahloroferat (III); n ima vrednost 0,1 ili 2; i M predstavlja Fe(II), Fe(III), Co(II), Rh(I), Rh(III), Ir(I), IR(III), Ni(II) ili Pd(ii), naznac en time, sto so metala M, gde M predstavlja Fe(II), Fe(III), Co(II), Rh(III), Ir(III), Pd(II) ili Ni(II), sa anjonom Y, gde Y ima znacenje kao gore, reaguje sa ligandom izabranim iz grupe koja se sastoji od 1,2-bis (difenilfosfino) etana, 1-difenilfosfino-2-difenilarsino etana i cis-1,2-bis(difenilfosfino) etilena, u atmosferi azota, u rastvaracu kao sto su metanol, etanol, aceton ili njihove smese, na temperaturi od sobne do temperature kljucanja reakcione smese; ili sto (cis, cis-1,5-ciklo-cktadien) rodijumsko (I) ili iridijumsko (I) polazno jedinjenje reaguje sa jedinjenjem anjona Y i sa ligandom kao sto je definisano gore, u atmosferi azota, u rastvaracu kao sto su aceton, benzol ili tetrahidrofuran, na temperaturi od sobne do temperature kljucanja reakcione smese; ili sto bis (acetonitril) paladijumsko (II) polazno jedinjenje reaguje sa ligandom kao sto je definisano gore, u atmosferi azota, u rastvaracu kao sto je benzol ili dimetilformamid, na temperaturi kljucanja reakcione smese; i sto se, prema potrebi, vrsi zamena anjona Y u dobijenom jedinjenju formule (I) sa drugim anjonom, reakcijom jedinjenja formule (I) sa viskom jedinjenja drugog anjona, u rastvaracu kao sto su etanol, voda ili njihova smesa, u atmosferi azota, na temperaturi od sobne do temperature kljucanja reakcione smese; ili se, prema potrebi, jedinjenje formule (I) u kome X1 i X2 imaju nezavisna znacenja, prevodi u jedinjenje u kome X1 i X2 zajedno predstavljaju perokso, izlaganjem jedinjenja formule (I) dejstvu vazduha, na sobnoj temperaturi, u rastvaracu kao sto je dihlorometan.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8502929A NL8502929A (nl) | 1985-10-25 | 1985-10-25 | Groep viii-overgangsmetaal-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke groep viii-overgangsmetaal-complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU181786A YU181786A (en) | 1988-02-29 |
| YU45802B true YU45802B (sh) | 1992-07-20 |
Family
ID=19846766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU181786A YU45802B (sh) | 1985-10-25 | 1986-10-24 | Postupak za dobijanje farmaceutski aktivnih fosfino-ugljovodoničnih kompleksnih jedinjenja metala viii grupe |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4831170A (sh) |
| EP (1) | EP0227127B1 (sh) |
| JP (1) | JPS62161795A (sh) |
| KR (1) | KR870003787A (sh) |
| CN (3) | CN86107219A (sh) |
| AT (1) | ATE63122T1 (sh) |
| AU (1) | AU601954B2 (sh) |
| CA (1) | CA1269395A (sh) |
| DE (1) | DE3679045D1 (sh) |
| DK (1) | DK511786A (sh) |
| ES (1) | ES2039199T3 (sh) |
| FI (1) | FI85861C (sh) |
| GR (1) | GR3001910T3 (sh) |
| HU (2) | HU203557B (sh) |
| IL (1) | IL80416A0 (sh) |
| NL (1) | NL8502929A (sh) |
| NO (1) | NO172585B (sh) |
| NZ (1) | NZ218072A (sh) |
| PT (1) | PT83612B (sh) |
| YU (1) | YU45802B (sh) |
| ZA (1) | ZA868162B (sh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1282218A (zh) * | 1997-10-15 | 2001-01-31 | 波拉克斯生物药品 | 使用砷化合物治疗原发性及转移性肿瘤疾病的组合物及方法 |
| JP5015451B2 (ja) * | 2005-04-18 | 2012-08-29 | 日本化学工業株式会社 | ホスフィン遷移金属錯体、その製造方法およびそれを含有する抗癌剤 |
| WO2009081366A1 (en) * | 2007-12-20 | 2009-07-02 | Richard John Bowen | Palladium and platinum phosphine complexes and their use as anti-tumour agents |
| WO2009104167A1 (en) * | 2008-02-22 | 2009-08-27 | Mintek | A substance or composition for the treatment of cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3084179A (en) * | 1959-02-27 | 1963-04-02 | Ici Ltd | Phosphorous-containing-ligand stabilized transition metal compounds |
| US3345392A (en) * | 1964-03-24 | 1967-10-03 | American Cyanamid Co | Organophosphorus-copper complex compounds |
| GB1085762A (en) * | 1965-04-30 | 1967-10-04 | Ici Ltd | Complex organic iridium compounds and their use as catalysts |
| FR2116905A5 (fr) * | 1970-12-10 | 1972-07-21 | Inst Francais Du Petrole | Nouveaux coordinats bidentes,leur fabrication et leurs applications |
| US3939188A (en) * | 1972-03-24 | 1976-02-17 | Exxon Research And Engineering Company | Preparation of zerovalent phosphine substituted rhodium compounds and their use in the selective carbonylation of olefins |
| US3954821A (en) * | 1975-06-30 | 1976-05-04 | E. I. Du Pont De Nemours And Company | Carbon dioxide complexes of Rh, Ir, Ni, Pd, and Pt |
| US4268454A (en) * | 1978-12-21 | 1981-05-19 | Allied Chemical Corporation | Anionic group VIII metal hydride catalysts |
| US4302401A (en) * | 1980-01-23 | 1981-11-24 | Exxon Research & Engineering Co. | Tetraalkyl phosphonium substituted phosphine and amine transition metal complexes |
| US4331818A (en) * | 1980-03-19 | 1982-05-25 | The Procter & Gamble Company | Chiral phospine ligand |
| CA1238854A (en) * | 1984-02-01 | 1988-07-05 | David T. Hill | ANTITUMOR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING TUMORS EMPLOYING ¬.alpha.,W- BIS(DISUBSTITUTEDPHOSPHINO)HYDROCARBON| DIGOLD (I) DIGOLD (III), DISILVER (I) AND DICOPPER (I) DERIVATIVES |
| CA1244764A (en) * | 1984-06-04 | 1988-11-15 | Randall K. Johnson | Tumor cell growth-inhibiting pharmaceutical compositions containing phosphino-hydrocarbon-gold, silver or copper complexes |
-
1985
- 1985-10-25 NL NL8502929A patent/NL8502929A/nl not_active Application Discontinuation
-
1986
- 1986-10-23 AT AT86201853T patent/ATE63122T1/de not_active IP Right Cessation
- 1986-10-23 DE DE8686201853T patent/DE3679045D1/de not_active Expired - Fee Related
- 1986-10-23 EP EP86201853A patent/EP0227127B1/en not_active Expired - Lifetime
- 1986-10-23 ES ES198686201853T patent/ES2039199T3/es not_active Expired - Lifetime
- 1986-10-24 PT PT83612A patent/PT83612B/pt not_active IP Right Cessation
- 1986-10-24 CA CA000521403A patent/CA1269395A/en not_active Expired - Fee Related
- 1986-10-24 HU HU903471A patent/HU203557B/hu not_active IP Right Cessation
- 1986-10-24 FI FI864327A patent/FI85861C/fi not_active IP Right Cessation
- 1986-10-24 NO NO864270A patent/NO172585B/no unknown
- 1986-10-24 YU YU181786A patent/YU45802B/sh unknown
- 1986-10-24 DK DK511786A patent/DK511786A/da not_active Application Discontinuation
- 1986-10-24 US US06/922,655 patent/US4831170A/en not_active Expired - Fee Related
- 1986-10-24 HU HU864487A patent/HU200609B/hu not_active IP Right Cessation
- 1986-10-24 IL IL80416A patent/IL80416A0/xx unknown
- 1986-10-25 CN CN86107219A patent/CN86107219A/zh active Pending
- 1986-10-25 JP JP61252843A patent/JPS62161795A/ja active Pending
- 1986-10-25 KR KR1019860008963A patent/KR870003787A/ko not_active Ceased
- 1986-10-27 ZA ZA868162A patent/ZA868162B/xx unknown
- 1986-10-27 AU AU64413/86A patent/AU601954B2/en not_active Ceased
- 1986-10-28 NZ NZ218072A patent/NZ218072A/en unknown
-
1991
- 1991-03-16 CN CN91101598A patent/CN1057962A/zh active Pending
- 1991-05-03 GR GR91400587T patent/GR3001910T3/el unknown
-
1992
- 1992-05-28 CN CN92104058A patent/CN1067430A/zh active Pending
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