YU75403A - Vodeni amfotericin b preparat - Google Patents
Vodeni amfotericin b preparatInfo
- Publication number
- YU75403A YU75403A YU75403A YUP75403A YU75403A YU 75403 A YU75403 A YU 75403A YU 75403 A YU75403 A YU 75403A YU P75403 A YUP75403 A YU P75403A YU 75403 A YU75403 A YU 75403A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- amphotericin
- compositions
- aqueous composition
- sterilised
- autoclaving
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 title abstract 4
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 title abstract 4
- 229960003942 amphotericin b Drugs 0.000 title abstract 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 208000037026 Invasive Fungal Infections Diseases 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Opisani su parenteralni vodeni preparati male toksičnosti bez dimetil sulfoksida. Preparati se suštinski sastoje u dodavanju amfotericina B, fosfolipida i natrijum hlorida. Preparati se sterilišu sa autoklaviranjem. Opisan je postupak dobijanja ovih preparata bez korišćenja rastvarača za rastvaranje amfotericina B. Preparati su namenjeni za tretman napada gljivičnih infekcija.[A low toxicity parenteral dimethyl sulfoxide free aqueous compositions containing Amphotericin B are described. The compositions essentially consist of in addition to Amphotericin B, phospholipids and sodium chloride. The compositions are sterilised by autoclaving. The process of making these compositions without the use of solvents for dissolving Amphotericin B have been described. The compositions are indicated for the treatment of invasive fungal infections.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN217MU2001 IN188924B (sh) | 2001-03-01 | 2001-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU75403A true YU75403A (sh) | 2006-05-25 |
Family
ID=11097223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU75403A YU75403A (sh) | 2001-03-01 | 2001-03-16 | Vodeni amfotericin b preparat |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20040137049A1 (sh) |
| EP (1) | EP1368041B1 (sh) |
| JP (1) | JP2004523566A (sh) |
| KR (1) | KR100810067B1 (sh) |
| CN (1) | CN1255114C (sh) |
| AT (1) | ATE274913T1 (sh) |
| AU (1) | AU2001250643B2 (sh) |
| BG (1) | BG108188A (sh) |
| BR (1) | BR0116922A (sh) |
| CA (1) | CA2438847A1 (sh) |
| CZ (1) | CZ20032264A3 (sh) |
| DE (1) | DE60105322T2 (sh) |
| DK (1) | DK1368041T3 (sh) |
| EA (1) | EA006241B1 (sh) |
| ES (1) | ES2227172T3 (sh) |
| IN (1) | IN188924B (sh) |
| MX (1) | MXPA03007777A (sh) |
| NZ (1) | NZ528281A (sh) |
| PT (1) | PT1368041E (sh) |
| SK (1) | SK10742003A3 (sh) |
| WO (1) | WO2002069983A1 (sh) |
| YU (1) | YU75403A (sh) |
| ZA (1) | ZA200307307B (sh) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| JP2006069929A (ja) * | 2004-08-31 | 2006-03-16 | Konica Minolta Medical & Graphic Inc | 真菌症治療製剤およびその製造方法 |
| EP1799266A2 (en) * | 2004-09-13 | 2007-06-27 | Bharat Serums & Vaccines Ltd. | Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| CN100418536C (zh) * | 2005-04-06 | 2008-09-17 | 河南省眼科研究所 | 一种用于眼科的抗真菌药物组合物 |
| KR101106510B1 (ko) | 2006-05-30 | 2012-01-20 | 인타르시아 세라퓨틱스 인코포레이티드 | 투피스, 내부채널 삼투압 전달 시스템 유동 조절기 |
| EP2359808B1 (en) | 2006-08-09 | 2013-05-22 | Intarcia Therapeutics, Inc | Osmotic delivery systems and piston assemblies |
| WO2008133908A2 (en) | 2007-04-23 | 2008-11-06 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| RU2547990C2 (ru) | 2009-09-28 | 2015-04-10 | Интарсия Терапьютикс, Инк. | Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства |
| KR101629521B1 (ko) * | 2010-03-16 | 2016-06-13 | 우석대학교 산학협력단 | 난용성 약물 가용화 및 생체막 투과증진을 위한 알코올성 수상을 내상으로 하는 리포좀, 리포좀 조성물 및 리포좀의 제조방법 |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| CN102525921B (zh) * | 2012-02-06 | 2013-08-07 | 西安力邦制药有限公司 | 2,2’,6,6’-四异丙基-4,4’-二联苯酚脂微球制剂及其制备方法 |
| US9744191B2 (en) | 2012-03-19 | 2017-08-29 | Yale University | Antimicrobial compositions and methods |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| RU2730996C2 (ru) | 2015-06-03 | 2020-08-26 | Интарсия Терапьютикс, Инк. | Системы установки и извлечения имплантата |
| EP3222324B1 (en) | 2016-03-23 | 2020-05-13 | Wayne State University | Valproate as a topical anti-fungal treatment |
| KR102574993B1 (ko) | 2016-05-16 | 2023-09-06 | 인타르시아 세라퓨틱스 인코포레이티드 | 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법 |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| JP7286542B2 (ja) | 2017-01-03 | 2023-06-05 | インターシア セラピューティクス，インコーポレイティド | Ｇｌｐ－１受容体アゴニストの持続的投与及び薬物の同時投与を含む方法 |
| CN108344811A (zh) * | 2017-01-24 | 2018-07-31 | 北京泰德制药股份有限公司 | 一种注射用脂质体中有机溶剂残留的检测方法 |
| CN108309955B (zh) * | 2018-04-27 | 2020-06-02 | 武昌理工学院 | 一种聚明胶肽结合型紫杉醇纳米颗粒的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1338736C (fr) * | 1986-12-05 | 1996-11-26 | Roger Baurain | Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation |
| US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
| US5100662A (en) * | 1989-08-23 | 1992-03-31 | The Liposome Company, Inc. | Steroidal liposomes exhibiting enhanced stability |
| FR2651680B1 (fr) * | 1989-09-14 | 1991-12-27 | Medgenix Group Sa | Nouveau procede de preparation de microparticules lipidiques. |
| US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| JP3956402B2 (ja) * | 1996-03-04 | 2007-08-08 | 日本油脂株式会社 | アンホテリシンｂ運搬体 |
| US6180136B1 (en) * | 1998-11-10 | 2001-01-30 | Idexx Laboratories, Inc. | Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use |
-
2001
- 2001-03-01 IN IN217MU2001 patent/IN188924B/en unknown
- 2001-03-16 PT PT01923963T patent/PT1368041E/pt unknown
- 2001-03-16 MX MXPA03007777A patent/MXPA03007777A/es active IP Right Grant
- 2001-03-16 AT AT01923963T patent/ATE274913T1/de not_active IP Right Cessation
- 2001-03-16 CA CA002438847A patent/CA2438847A1/en not_active Abandoned
- 2001-03-16 WO PCT/IN2001/000040 patent/WO2002069983A1/en not_active Ceased
- 2001-03-16 CN CNB018231632A patent/CN1255114C/zh not_active Expired - Fee Related
- 2001-03-16 ES ES01923963T patent/ES2227172T3/es not_active Expired - Lifetime
- 2001-03-16 KR KR1020037011489A patent/KR100810067B1/ko not_active Expired - Fee Related
- 2001-03-16 US US10/469,624 patent/US20040137049A1/en not_active Abandoned
- 2001-03-16 EP EP01923963A patent/EP1368041B1/en not_active Expired - Lifetime
- 2001-03-16 DK DK01923963T patent/DK1368041T3/da active
- 2001-03-16 DE DE60105322T patent/DE60105322T2/de not_active Expired - Lifetime
- 2001-03-16 BR BR0116922-0A patent/BR0116922A/pt active Search and Examination
- 2001-03-16 NZ NZ528281A patent/NZ528281A/en not_active IP Right Cessation
- 2001-03-16 AU AU2001250643A patent/AU2001250643B2/en not_active Ceased
- 2001-03-16 SK SK1074-2003A patent/SK10742003A3/sk unknown
- 2001-03-16 YU YU75403A patent/YU75403A/sh unknown
- 2001-03-16 CZ CZ20032264A patent/CZ20032264A3/cs unknown
- 2001-03-16 EA EA200300948A patent/EA006241B1/ru not_active IP Right Cessation
- 2001-03-16 JP JP2002569158A patent/JP2004523566A/ja active Pending
-
2003
- 2003-09-18 ZA ZA200307307A patent/ZA200307307B/en unknown
- 2003-09-23 BG BG108188A patent/BG108188A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03007777A (es) | 2003-12-08 |
| ATE274913T1 (de) | 2004-09-15 |
| EP1368041A1 (en) | 2003-12-10 |
| WO2002069983A1 (en) | 2002-09-12 |
| US20040137049A1 (en) | 2004-07-15 |
| CA2438847A1 (en) | 2002-09-12 |
| EA200300948A1 (ru) | 2004-04-29 |
| ZA200307307B (en) | 2004-04-20 |
| KR20040018337A (ko) | 2004-03-03 |
| AU2001250643B2 (en) | 2007-03-22 |
| EA006241B1 (ru) | 2005-10-27 |
| BG108188A (bg) | 2004-09-30 |
| SK10742003A3 (sk) | 2004-01-08 |
| DE60105322D1 (de) | 2004-10-07 |
| IN188924B (sh) | 2002-11-23 |
| EP1368041B1 (en) | 2004-09-01 |
| JP2004523566A (ja) | 2004-08-05 |
| CN1255114C (zh) | 2006-05-10 |
| PT1368041E (pt) | 2005-01-31 |
| CN1505519A (zh) | 2004-06-16 |
| BR0116922A (pt) | 2004-04-27 |
| DE60105322T2 (de) | 2005-09-15 |
| KR100810067B1 (ko) | 2008-03-05 |
| DK1368041T3 (da) | 2005-01-17 |
| CZ20032264A3 (cs) | 2003-12-17 |
| NZ528281A (en) | 2006-11-30 |
| ES2227172T3 (es) | 2005-04-01 |
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