YU94802A - 3-prolekovi 2'-deoksi-beta-l-nukleozida - Google Patents

3-prolekovi 2'-deoksi-beta-l-nukleozida

Info

Publication number
YU94802A
YU94802A YU94802A YUP94802A YU94802A YU 94802 A YU94802 A YU 94802A YU 94802 A YU94802 A YU 94802A YU P94802 A YUP94802 A YU P94802A YU 94802 A YU94802 A YU 94802A
Authority
YU
Yugoslavia
Prior art keywords
deoxy
hepatitis
nucleosides
compounds
administered
Prior art date
Application number
YU94802A
Other languages
English (en)
Inventor
Martin L. Bryant
Giles Gosselin
Jean-Louis Imbach
Original Assignee
Idenix (Cayman) Limited
Centre National Da La Recherche Scientifique (Cnrs)
L'universite Montpellier Ii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix (Cayman) Limited, Centre National Da La Recherche Scientifique (Cnrs), L'universite Montpellier Ii filed Critical Idenix (Cayman) Limited
Publication of YU94802A publication Critical patent/YU94802A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ovaj pronalazak se odnosi na jedinjenja, smeše i metode lečenja domaćina zaraženog hepatitis B virusom. Posebno, izložena su jedinjenja smeše 3'-estra 2'- deoksi-ГЎ-L-nukleozida, koja se mogu primeniti bilo sama bilo u kombinaciji sa drugim anti-hepatitis B-agensima. Opisana su jedinjenja i smeše 3',5'-estara 2'-deoksi-ГЎ-L-nukleozida, koja se mogu primeniti bilo sama bilo u kombinaciji sa drugim anti-hepatitis B agensima.[The present invention relates to compounds, compositions and methods for the treatment of a host infected with a hepatitis B virus. Specifically, compounds and compositions of 3'-esters of 2'-deoxy-ГЎ-L-nucleosides are disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents. Compounds and compositions of 3',5'-esters of 2'-deoxy-ГЎ-L-nucleosides are disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents, are also disclosed.
YU94802A 2000-06-15 2001-06-15 3-prolekovi 2'-deoksi-beta-l-nukleozida YU94802A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21210000P 2000-06-15 2000-06-15

Publications (1)

Publication Number Publication Date
YU94802A true YU94802A (sh) 2006-03-03

Family

ID=22789563

Family Applications (1)

Application Number Title Priority Date Filing Date
YU94802A YU94802A (sh) 2000-06-15 2001-06-15 3-prolekovi 2'-deoksi-beta-l-nukleozida

Country Status (28)

Country Link
EP (1) EP1296995B1 (sh)
JP (1) JP4639032B2 (sh)
KR (2) KR20070048277A (sh)
CN (3) CN1900104A (sh)
AP (1) AP1771A (sh)
AR (1) AR035711A1 (sh)
AT (1) ATE411332T1 (sh)
AU (2) AU6692701A (sh)
BR (1) BR0111732A (sh)
CA (1) CA2413163C (sh)
CZ (1) CZ2003122A3 (sh)
DE (1) DE60136181D1 (sh)
EA (1) EA005774B1 (sh)
ES (1) ES2317912T3 (sh)
IL (3) IL153379A0 (sh)
MA (1) MA27126A1 (sh)
MX (1) MXPA02012443A (sh)
MY (1) MY141594A (sh)
NO (1) NO20026001L (sh)
NZ (2) NZ523632A (sh)
OA (1) OA12384A (sh)
PE (1) PE20020216A1 (sh)
PL (1) PL360404A1 (sh)
PY (1) PY0114386A (sh)
UY (1) UY26779A1 (sh)
WO (1) WO2001096353A2 (sh)
YU (1) YU94802A (sh)
ZA (2) ZA200300168B (sh)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1964569A3 (en) 2000-04-13 2009-07-22 Pharmasset, Inc. 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of viral infections
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
KR20080021797A (ko) 2000-05-26 2008-03-07 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
AU2002330154A1 (en) 2001-09-28 2003-04-07 Centre National De La Recherche Scientifique Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
BR0312271A (pt) 2002-06-28 2007-11-06 Idenix Cayman Ltd compostos, composições e seus usos para o tratamento de infecções por flaviviridae
PL374781A1 (en) 2002-06-28 2005-10-31 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
MXPA04012779A (es) 2002-06-28 2005-08-19 Idenix Cayman Ltd Profarmacos de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae.
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
PT1572095E (pt) 2002-09-13 2015-10-13 Novartis Ag Β-l-2'-desoxinucleósidos para tratamento de estirpes resistentes de vhb
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов
BRPI0408561A (pt) 2003-03-20 2006-03-21 Microbiol Quimica Farmaceutica métodos para manufatura de 2'-desoxi-59-l-nucleosìeos
US7595390B2 (en) 2003-04-28 2009-09-29 Novartis Ag Industrially scalable nucleoside synthesis
EP2345657A1 (en) 2003-05-30 2011-07-20 Pharmasset, Inc. Modified fluorinated nucleoside analogues
US20050059632A1 (en) 2003-06-30 2005-03-17 Richard Storer Synthesis of beta-L-2'-deoxy nucleosides
US7754718B2 (en) 2004-05-05 2010-07-13 Yale University Antiviral helioxanthin analogs
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
AU2005285045B2 (en) 2004-09-14 2011-10-13 Gilead Sciences, Inc. Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
US7524831B2 (en) 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
US20090221598A1 (en) 2005-06-17 2009-09-03 Kai Lin Use of Sanglifehrin in HCV
GB0609178D0 (en) 2006-05-09 2006-06-21 Univ Cardiff Novel compounds
US7897737B2 (en) 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
TW200946541A (en) 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
KR101677772B1 (ko) 2008-06-11 2016-11-18 레이저젠, 인코퍼레이티드 뉴클레오타이드 및 뉴클레오사이드 그리고 시퀀싱에서의 이들의 이용 방법
PT2376088T (pt) 2008-12-23 2017-05-02 Gilead Pharmasset Llc Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída
KR20110098849A (ko) 2008-12-23 2011-09-01 파마셋 인코포레이티드 뉴클레오시드 유사체
SG194404A1 (en) 2008-12-23 2013-11-29 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
PT2609923T (pt) 2010-03-31 2017-08-30 Gilead Pharmasset Llc Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo
MX2012011222A (es) 2010-04-01 2013-01-18 Centre Nat Rech Scient Compuestos y composiciones farmaceuticas para el tratamiento de infecciones virales.
AU2011336632B2 (en) 2010-11-30 2015-09-03 Gilead Pharmasset Llc Compounds
EP2691409B1 (en) 2011-03-31 2018-02-21 Idenix Pharmaceuticals LLC. Compounds and pharmaceutical compositions for the treatment of viral infections
EP2755985B1 (en) 2011-09-12 2017-11-01 Idenix Pharmaceuticals LLC Compounds and pharmaceutical compositions for the treatment of viral infections
MX342195B (es) 2011-09-13 2016-09-20 Lasergen Inc Nucleótidos de terminación de rápida fotodescomposición 5-metoxi, 3' -oh no bloqueados y métodos para secuenciación de ácido nucleico.
PL2709613T5 (pl) 2011-09-16 2020-12-14 Gilead Pharmasset Llc Metody leczenia hcv
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
PT2950786T (pt) 2013-01-31 2020-03-03 Gilead Pharmasset Llc Formulação de combinação de dois compostos antivirais
EA201690473A1 (ru) 2013-08-27 2017-03-31 ГАЙЛИД ФАРМАССЕТ ЭлЭлСи Комбинированный состав двух противовирусных соединений
US11628182B2 (en) * 2018-04-12 2023-04-18 Zogenix Mds, Inc. Prodrugs of deoxynucleosides for treatment of diseases cased by unbalanced nucleotide pools
CN116574146A (zh) * 2023-05-18 2023-08-11 沈阳农业大学 具有抗马铃薯y病毒属病毒活性的化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958013A (en) * 1989-06-06 1990-09-18 Northwestern University Cholesteryl modified oligonucleotides
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
SE9603178L (sv) * 1996-08-30 1997-09-22 Scania Cv Ab Anordning vid ett fordon för monterbar anfästning av en förarplatsmodul
ES2255295T3 (es) * 1998-08-10 2006-06-16 Idenix (Cayman) Limited 2'-deoxi-beta-l-nucleosidos para el tratamiento de la hepatitis b.

Also Published As

Publication number Publication date
EA005774B1 (ru) 2005-06-30
CN1452627A (zh) 2003-10-29
ES2317912T3 (es) 2009-05-01
EP1296995A2 (en) 2003-04-02
WO2001096353A3 (en) 2002-04-18
MXPA02012443A (es) 2004-09-10
NO20026001D0 (no) 2002-12-13
IL153379A (en) 2007-02-11
CN1900104A (zh) 2007-01-24
CN101012259A (zh) 2007-08-08
PL360404A1 (pl) 2004-09-06
JP4639032B2 (ja) 2011-02-23
JP2004533403A (ja) 2004-11-04
WO2001096353A2 (en) 2001-12-20
AR035711A1 (es) 2004-07-07
BR0111732A (pt) 2003-06-24
IL153379A0 (en) 2003-07-06
CZ2003122A3 (cs) 2003-06-18
OA12384A (en) 2006-04-17
NZ523632A (en) 2005-03-24
AP1771A (en) 2007-08-23
ZA200404306B (en) 2005-06-15
PE20020216A1 (es) 2002-04-16
AU6692701A (en) 2001-12-24
MA27126A1 (fr) 2005-01-03
EA200300023A1 (ru) 2003-08-28
MY141594A (en) 2010-05-14
ZA200300168B (en) 2004-07-07
EP1296995B1 (en) 2008-10-15
IL178864A0 (en) 2007-03-08
NO20026001L (no) 2003-02-12
KR20070048277A (ko) 2007-05-08
CA2413163A1 (en) 2001-12-20
CN1295242C (zh) 2007-01-17
KR20030032967A (ko) 2003-04-26
AU2001266927B2 (en) 2006-12-14
PY0114386A (es) 2004-04-01
CA2413163C (en) 2008-11-18
ATE411332T1 (de) 2008-10-15
AP2003002713A0 (en) 2003-03-31
UY26779A1 (es) 2001-12-28
DE60136181D1 (de) 2008-11-27
NZ535246A (en) 2006-06-30

Similar Documents

Publication Publication Date Title
YU94802A (sh) 3-prolekovi 2'-deoksi-beta-l-nukleozida
EA200600582A1 (ru) Способы и композиции для лечения вирусного гепатита с
BR9712544A (pt) Inibidores de proteases de serina, particularmente protease ns3 do vìrus hapatite c
BR0311132A (pt) Inibidores do vìrus da hepatite c
IS8448A (is) Lifrarbólgu C-veirutálmar
BR0113666A (pt) Inibidores da protease peptidomimética
AU3376699A (en) Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
WO2001074768A3 (en) Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
WO2005054430A3 (en) Hepatitis c virus inhibitors
ID27787A (id) Senyawa, komposisi dan metode untuk pengobatan atau pencegahan infeksi yang disebabkan oleh virus dan penyakit-penyakit yang berkaitan
BRPI0515596A (pt) composição farmacêutica usada para o tratamento e/ou prevenção de hcv, e, métodos de inibir rna polimerase ns5b de hepatite c de tratar ou prevenir infecção por hepatite c em um mamìfero
EA200300819A1 (ru) Производные нуклеозидов в качестве ингибиторов рнк-зависимой рнк вирусной полимеразы
DE69837934D1 (de) Multisystemisches kümmerwuchssyndrom durch viren in schweine
EA200200502A1 (ru) Способ введения ингибитора фосфодиэстеразы 4
BR0311223A (pt) Método para o uso de derivados de piranindol para tratar infecção pelo vìrus da hepatite c
MXPA02011969A (es) Metodos para el tratamiento de padecimientos virales con il-18 y combinaciones de il-18.
ES2105923B1 (es) Composiciones para el tratamiento de una infeccion y una enfermedad causadas por el virus de la hepatitis b (hbv).
ATE493408T1 (de) Antiinfektiöse mittel
WO2001014576A3 (en) Process and intermediates for the preparation of isoxazolecaroxamides and analogues
DE60038023D1 (de) Neue gbv sequenz
UA37622A (uk) 1,5-піперидил - 3,7-біс/діетаноламіну/ - піримідил ізовалеріанат, що використовується для діагностики вірусних інфекцій