YU94802A - 3-prolekovi 2'-deoksi-beta-l-nukleozida - Google Patents

3-prolekovi 2'-deoksi-beta-l-nukleozida

Info

Publication number
YU94802A
YU94802A YU94802A YUP94802A YU94802A YU 94802 A YU94802 A YU 94802A YU 94802 A YU94802 A YU 94802A YU P94802 A YUP94802 A YU P94802A YU 94802 A YU94802 A YU 94802A
Authority
YU
Yugoslavia
Prior art keywords
deoxy
hepatitis
nucleosides
compounds
administered
Prior art date
Application number
YU94802A
Other languages
English (en)
Inventor
Martin L. Bryant
Giles Gosselin
Jean-Louis Imbach
Original Assignee
Idenix (Cayman) Limited
Centre National Da La Recherche Scientifique (Cnrs)
L'universite Montpellier Ii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix (Cayman) Limited, Centre National Da La Recherche Scientifique (Cnrs), L'universite Montpellier Ii filed Critical Idenix (Cayman) Limited
Publication of YU94802A publication Critical patent/YU94802A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ovaj pronalazak se odnosi na jedinjenja, smeše i metode lečenja domaćina zaraženog hepatitis B virusom. Posebno, izložena su jedinjenja smeše 3'-estra 2'- deoksi-ГЎ-L-nukleozida, koja se mogu primeniti bilo sama bilo u kombinaciji sa drugim anti-hepatitis B-agensima. Opisana su jedinjenja i smeše 3',5'-estara 2'-deoksi-ГЎ-L-nukleozida, koja se mogu primeniti bilo sama bilo u kombinaciji sa drugim anti-hepatitis B agensima.[The present invention relates to compounds, compositions and methods for the treatment of a host infected with a hepatitis B virus. Specifically, compounds and compositions of 3'-esters of 2'-deoxy-ГЎ-L-nucleosides are disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents. Compounds and compositions of 3',5'-esters of 2'-deoxy-ГЎ-L-nucleosides are disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents, are also disclosed.
YU94802A 2000-06-15 2001-06-15 3-prolekovi 2'-deoksi-beta-l-nukleozida YU94802A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21210000P 2000-06-15 2000-06-15

Publications (1)

Publication Number Publication Date
YU94802A true YU94802A (sh) 2006-03-03

Family

ID=22789563

Family Applications (1)

Application Number Title Priority Date Filing Date
YU94802A YU94802A (sh) 2000-06-15 2001-06-15 3-prolekovi 2'-deoksi-beta-l-nukleozida

Country Status (28)

Country Link
EP (1) EP1296995B1 (sh)
JP (1) JP4639032B2 (sh)
KR (2) KR20030032967A (sh)
CN (3) CN101012259A (sh)
AP (1) AP1771A (sh)
AR (1) AR035711A1 (sh)
AT (1) ATE411332T1 (sh)
AU (2) AU2001266927B2 (sh)
BR (1) BR0111732A (sh)
CA (1) CA2413163C (sh)
CZ (1) CZ2003122A3 (sh)
DE (1) DE60136181D1 (sh)
EA (1) EA005774B1 (sh)
ES (1) ES2317912T3 (sh)
IL (3) IL153379A0 (sh)
MA (1) MA27126A1 (sh)
MX (1) MXPA02012443A (sh)
MY (1) MY141594A (sh)
NO (1) NO20026001L (sh)
NZ (2) NZ523632A (sh)
OA (1) OA12384A (sh)
PE (1) PE20020216A1 (sh)
PL (1) PL360404A1 (sh)
PY (1) PY0114386A (sh)
UY (1) UY26779A1 (sh)
WO (1) WO2001096353A2 (sh)
YU (1) YU94802A (sh)
ZA (2) ZA200300168B (sh)

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PY0111577A (es) 2000-05-23 2017-01-02 Idenix Cayman Ltd Métodos y composiciones para el tratamiento del virus de la hepatitis c
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
AP2006003708A0 (en) 2000-05-26 2006-08-31 Idenix Cayman Ltd Methods and compositions for treating flavivirusesand pestiviruses
AU2002330154A1 (en) 2001-09-28 2003-04-07 Centre National De La Recherche Scientifique Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
PT1523489E (pt) 2002-06-28 2014-06-24 Centre Nat Rech Scient Profármacos de nucleósido modificado em 2' e 3' para tratamento de infecções por flaviridae
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US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN1678326A (zh) 2002-06-28 2005-10-05 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
AU2003278816A1 (en) 2002-09-13 2004-04-30 Idenix (Cayman) Limited ss-L-2'-DEOXYNUCLEOSIDES FOR THE TREATMENT OF RESISTANT HBV STRAINS AND COMBINATION THERAPIES
RU2005118421A (ru) 2002-11-15 2006-01-20 Айденикс (Кайман) Лимитед (Ky) 2'-разветвленные нуклеозиды и мутация flaviviridae
PL377287A1 (pl) 2002-12-12 2006-01-23 Idenix (Cayman) Limited Sposób wytwarzania 2'-rozgałęzionych nukleozydów
WO2004084453A2 (en) 2003-03-20 2004-09-30 Microbiologica Quimica E Farmaceutica Ltd. METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES
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RU2361875C2 (ru) 2003-06-30 2009-07-20 Айденикс (Кайман) Лимитед СИНТЕЗ β-L-2'-ДЕЗОКСИНУКЛЕОЗИДОВ
US7754718B2 (en) 2004-05-05 2010-07-13 Yale University Antiviral helioxanthin analogs
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
MX2007003085A (es) 2004-09-14 2007-08-02 Pharmasset Inc Preparacion de 2'-fluoro-2'-alquilo sustituido u otras ribofuranosil pirimidinas y purinas opcionalmente sustituidas y sus derivados.
US7524831B2 (en) 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
AR054778A1 (es) 2005-06-17 2007-07-18 Novartis Ag Uso de sangliferina en hcv
GB0609178D0 (en) * 2006-05-09 2006-06-21 Univ Cardiff Novel compounds
US7897737B2 (en) 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
TW200946541A (en) 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
US8148503B2 (en) 2008-06-11 2012-04-03 Lasergen, Inc. Nucleotides and nucleosides and methods for their use in DNA sequencing
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JP6104504B2 (ja) 2008-12-23 2017-03-29 ギリアド ファーマセット エルエルシー ヌクレオシド類似体
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TWI515000B (zh) 2010-04-01 2016-01-01 伊迪尼克製藥公司 用於治療病毒感染之化合物及醫藥組合物
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CN103842369A (zh) 2011-03-31 2014-06-04 埃迪尼克斯医药公司 用于治疗病毒感染的化合物和药物组合物
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Also Published As

Publication number Publication date
EP1296995B1 (en) 2008-10-15
BR0111732A (pt) 2003-06-24
KR20070048277A (ko) 2007-05-08
ZA200300168B (en) 2004-07-07
JP2004533403A (ja) 2004-11-04
AU2001266927B2 (en) 2006-12-14
ZA200404306B (en) 2005-06-15
MA27126A1 (fr) 2005-01-03
JP4639032B2 (ja) 2011-02-23
CN1295242C (zh) 2007-01-17
PE20020216A1 (es) 2002-04-16
PY0114386A (es) 2004-04-01
EA005774B1 (ru) 2005-06-30
WO2001096353A3 (en) 2002-04-18
KR20030032967A (ko) 2003-04-26
IL178864A0 (en) 2007-03-08
NO20026001L (no) 2003-02-12
CZ2003122A3 (cs) 2003-06-18
UY26779A1 (es) 2001-12-28
ATE411332T1 (de) 2008-10-15
CA2413163A1 (en) 2001-12-20
OA12384A (en) 2006-04-17
NZ535246A (en) 2006-06-30
NO20026001D0 (no) 2002-12-13
EP1296995A2 (en) 2003-04-02
EA200300023A1 (ru) 2003-08-28
CA2413163C (en) 2008-11-18
AP2003002713A0 (en) 2003-03-31
CN101012259A (zh) 2007-08-08
NZ523632A (en) 2005-03-24
DE60136181D1 (de) 2008-11-27
AU6692701A (en) 2001-12-24
IL153379A (en) 2007-02-11
CN1900104A (zh) 2007-01-24
PL360404A1 (pl) 2004-09-06
MXPA02012443A (es) 2004-09-10
IL153379A0 (en) 2003-07-06
ES2317912T3 (es) 2009-05-01
AP1771A (en) 2007-08-23
WO2001096353A2 (en) 2001-12-20
CN1452627A (zh) 2003-10-29
MY141594A (en) 2010-05-14
AR035711A1 (es) 2004-07-07

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