ZA200005239B - Quinolin-4-yl derivatives I. - Google Patents

Quinolin-4-yl derivatives I.

Info

Publication number
ZA200005239B
ZA200005239B ZA200005239A ZA200005239A ZA200005239B ZA 200005239 B ZA200005239 B ZA 200005239B ZA 200005239 A ZA200005239 A ZA 200005239A ZA 200005239 A ZA200005239 A ZA 200005239A ZA 200005239 B ZA200005239 B ZA 200005239B
Authority
ZA
South Africa
Prior art keywords
quinolin
derivatives
Prior art date
Application number
ZA200005239A
Other languages
English (en)
Inventor
Alexander Alanine
Bernd Buettelmann
Georg Jaeschke
Rene Wyler
Serge Burner
Marie-Paule Heitz Neidhart
Emmanuel Pinard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200005239B publication Critical patent/ZA200005239B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4
    • C07D215/46Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200005239A 1999-10-01 2000-09-28 Quinolin-4-yl derivatives I. ZA200005239B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99119539 1999-10-01

Publications (1)

Publication Number Publication Date
ZA200005239B true ZA200005239B (en) 2001-04-16

Family

ID=8239107

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200005239A ZA200005239B (en) 1999-10-01 2000-09-28 Quinolin-4-yl derivatives I.

Country Status (26)

Country Link
US (1) US6440995B1 (cs)
JP (1) JP3523174B2 (cs)
KR (1) KR100398561B1 (cs)
CN (1) CN1181059C (cs)
AR (1) AR025882A1 (cs)
AT (1) ATE281436T1 (cs)
AU (1) AU774363B2 (cs)
BR (1) BR0004548A (cs)
CA (1) CA2321324A1 (cs)
CO (1) CO5200789A1 (cs)
CZ (1) CZ20003575A3 (cs)
DE (1) DE60015471T2 (cs)
ES (1) ES2230017T3 (cs)
HR (1) HRP20000639A2 (cs)
HU (1) HUP0003861A3 (cs)
ID (1) ID27525A (cs)
IL (1) IL138777A0 (cs)
MA (1) MA26752A1 (cs)
NO (1) NO20004892L (cs)
NZ (1) NZ507141A (cs)
PE (1) PE20010648A1 (cs)
PL (1) PL342876A1 (cs)
PT (1) PT1088818E (cs)
SG (1) SG164268A1 (cs)
TR (1) TR200002831A3 (cs)
ZA (1) ZA200005239B (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6831087B2 (en) * 2001-11-09 2004-12-14 Hoffmann-La Roche Inc. Pyridine substituted isoquinoline derivatives
ES2252656T3 (es) * 2002-02-13 2006-05-16 F. Hoffmann-La Roche Ag Nuevos derivados de piridina y quinolina.
US7648984B2 (en) * 2004-07-13 2010-01-19 Glaxo Group Limited Antibacterial agents
US20100267712A1 (en) * 2007-09-27 2010-10-21 The United States of America, as represented by the Secretary, Department of Health and Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
DK3154957T3 (da) * 2014-06-16 2020-02-17 Fundacion Para La Investig Medica Aplicada Hidtil ukendte forbindelser som dobbelte inhibitorer af histonmethyltransferaser og dna-methyltransferaser
CN107427506A (zh) * 2014-10-14 2017-12-01 拉霍拉敏感及免疫学研究所 低分子量蛋白酪氨酸磷酸酶的抑制剂及其用途
KR20170074178A (ko) * 2015-12-21 2017-06-29 제이엔씨 주식회사 중합성 액정 화합물, 조성물, 그 액정 중합막류 및 이들의 용도
CN105646462B (zh) * 2016-01-19 2019-04-05 河南大学 芸香宁碱衍生物、其制备方法及应用
WO2018204176A1 (en) 2017-05-01 2018-11-08 Sanford Burnham Prebys Medical Discovery Institute Inhibitors of low molecular weight protein tyrosine phosphatase (lmptp) and uses thereof
US20230098872A1 (en) * 2021-03-26 2023-03-30 Cedilla Therapeutics, Inc. Tead inhibitors and uses thereof
JP7819547B2 (ja) * 2022-03-22 2026-02-25 東レ株式会社 フェナントロリン誘導体の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE440008C (de) 1924-03-29 1927-05-04 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Chinolinderivaten
US4560692A (en) 1984-07-18 1985-12-24 Hoffmann-La Roche Inc. 4-Piperidino-2-phenylquinolines
GB9125515D0 (en) 1991-11-29 1992-01-29 Merck Sharp & Dohme Therapeutic agents
US5441963A (en) 1991-12-20 1995-08-15 Merrell Dow Pharmaceuticals Potentiation of NMDA antagonists

Also Published As

Publication number Publication date
ES2230017T3 (es) 2005-05-01
IL138777A0 (en) 2001-10-31
US6440995B1 (en) 2002-08-27
CO5200789A1 (es) 2002-09-27
BR0004548A (pt) 2001-05-29
AU774363B2 (en) 2004-06-24
DE60015471D1 (de) 2004-12-09
TR200002831A2 (tr) 2001-04-20
HU0003861D0 (en) 2000-12-28
DE60015471T2 (de) 2005-10-27
MA26752A1 (fr) 2004-12-20
CZ20003575A3 (cs) 2001-11-14
AU6132400A (en) 2001-04-05
CN1181059C (zh) 2004-12-22
KR100398561B1 (ko) 2003-09-19
NZ507141A (en) 2002-05-31
NO20004892D0 (no) 2000-09-29
PE20010648A1 (es) 2001-06-13
HUP0003861A2 (hu) 2001-10-28
CA2321324A1 (en) 2001-04-01
ID27525A (id) 2001-04-12
HUP0003861A3 (en) 2002-09-30
SG164268A1 (en) 2010-09-29
CN1290698A (zh) 2001-04-11
PT1088818E (pt) 2005-03-31
ATE281436T1 (de) 2004-11-15
JP3523174B2 (ja) 2004-04-26
KR20010050738A (ko) 2001-06-15
JP2001097952A (ja) 2001-04-10
NO20004892L (no) 2001-04-02
AR025882A1 (es) 2002-12-18
PL342876A1 (en) 2001-04-09
HRP20000639A2 (en) 2001-06-30
TR200002831A3 (tr) 2001-04-20

Similar Documents

Publication Publication Date Title
ZA200000894B (en) 4-Phenyl-pyridine derivatives.
ZA200201055B (en) Amino-triazolopyridine derivatives.
GB9904103D0 (en) Quinoline derivatives
ZA200007593B (en) Quinoline Derivatives.
GC0000183A (en) 3-Phenyl-pyridine derivatives
ZA200109595B (en) 13-methyl-erythromycin derivatives.
GC0000338A (en) 5-Phenyl-pyrimidine derivatives
IL148837A0 (en) Isoxazolecarboxamide derivatives
GC0000191A (en) 4-Phenyl-pyrimidine derivatives
ZA200005447B (en) Quinolin-4-yl derivatives II.
ZA200005239B (en) Quinolin-4-yl derivatives I.
GC0000256A (en) Ethanesulfonyl-piperidine derivatives
GB9925880D0 (en) B-Carboline derivatives
ZA200201276B (en) 3-Amino-2-phenyl-propane derivatives.
IL150132A0 (en) Cyclopenteneone derivatives
IL145949A0 (en) 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
MXPA01011285A (es) Derivados de tio-oxindol.
ZA200107632B (en) Thio-oxindole derivatives.
ZA993232B (en) Arylthiazolidinedione derivatives.
ZA200203703B (en) New Phenalkyloxy-phenyl derivatives.
ZA200109864B (en) Quinazoline derivatives.
GB9904102D0 (en) Quinoline derivatives
GB9904104D0 (en) Quinoline derivatives
GB9904105D0 (en) Quinoline derivatives
GB9907134D0 (en) Antimor napthylcombretastatin derivatives