ZA200201466B - Pharmaceutical agent comprising a benzamide derivative as active ingredient. - Google Patents

Pharmaceutical agent comprising a benzamide derivative as active ingredient. Download PDF

Info

Publication number: ZA200201466B
Authority: ZA; South Africa
Prior art keywords: pharmaceutical formulation; formulation according; sodium; group; formula
Prior art date: 1999-08-16

Application number

ZA200201466A

Other languages

English (en)

Inventor

Tsuneji Suzuki

Tomoyuki Ando

Masahiko Ishibashi

Masahiro Sakabe

Ikuo Sakai

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-16

Filing date

2002-02-21

Publication date

2002-09-02

2002-02-21 Application filed by Schering Ag filed Critical Schering Ag

2002-09-02 Publication of ZA200201466B publication Critical patent/ZA200201466B/en

Links

150000003936 benzamides Chemical class 0.000 title claims description 17
239000004480 active ingredient Substances 0.000 title description 22
239000008177 pharmaceutical agent Substances 0.000 title description 3
239000008194 pharmaceutical composition Substances 0.000 claims description 59
239000000203 mixture Substances 0.000 claims description 35
238000009472 formulation Methods 0.000 claims description 30
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 28
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 27
-1 organic acid salt Chemical class 0.000 claims description 26
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 25
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 18
239000000654 additive Substances 0.000 claims description 15
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 14
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 14
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 14
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 14
235000019359 magnesium stearate Nutrition 0.000 claims description 14
238000000034 method Methods 0.000 claims description 14
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 14
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 13
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims description 13
229950008138 carmellose Drugs 0.000 claims description 13
150000003839 salts Chemical class 0.000 claims description 13
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 12
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 12
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 12
235000010355 mannitol Nutrition 0.000 claims description 12
239000002904 solvent Substances 0.000 claims description 12
239000000126 substance Substances 0.000 claims description 12
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 10
239000011575 calcium Substances 0.000 claims description 10
229910052791 calcium Inorganic materials 0.000 claims description 10
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 10
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 9
239000011230 binding agent Substances 0.000 claims description 9
239000011248 coating agent Substances 0.000 claims description 9
239000007884 disintegrant Substances 0.000 claims description 9
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 9
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 9
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 9
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 9
239000012669 liquid formulation Substances 0.000 claims description 9
239000000314 lubricant Substances 0.000 claims description 9
239000000546 pharmaceutical excipient Substances 0.000 claims description 9
239000011736 potassium bicarbonate Substances 0.000 claims description 9
229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 9
235000015497 potassium bicarbonate Nutrition 0.000 claims description 9
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 9
229910000029 sodium carbonate Inorganic materials 0.000 claims description 9
235000017550 sodium carbonate Nutrition 0.000 claims description 9
239000007787 solid Substances 0.000 claims description 9
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 8
SLINHMUFWFWBMU-UHFFFAOYSA-N Triisopropanolamine Chemical compound CC(O)CN(CC(C)O)CC(C)O SLINHMUFWFWBMU-UHFFFAOYSA-N 0.000 claims description 8
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 8
LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 claims description 8
229940043276 diisopropanolamine Drugs 0.000 claims description 8
239000008187 granular material Substances 0.000 claims description 8
239000011734 sodium Substances 0.000 claims description 8
229940083542 sodium Drugs 0.000 claims description 8
229910052708 sodium Inorganic materials 0.000 claims description 8
239000000454 talc Substances 0.000 claims description 8
229910052623 talc Inorganic materials 0.000 claims description 8
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 7
ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims description 7
239000004475 Arginine Substances 0.000 claims description 7
RVEWUBJVAHOGKA-WOYAITHZSA-N Arginine glutamate Chemical compound OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RVEWUBJVAHOGKA-WOYAITHZSA-N 0.000 claims description 7
239000004471 Glycine Substances 0.000 claims description 7
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 7
239000004288 Sodium dehydroacetate Substances 0.000 claims description 7
229920002472 Starch Polymers 0.000 claims description 7
230000000996 additive effect Effects 0.000 claims description 7
239000001099 ammonium carbonate Substances 0.000 claims description 7
235000012501 ammonium carbonate Nutrition 0.000 claims description 7
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 7
229960003121 arginine Drugs 0.000 claims description 7
229960004484 carbachol Drugs 0.000 claims description 7
AIXAANGOTKPUOY-UHFFFAOYSA-N carbachol Chemical compound [Cl-].C[N+](C)(C)CCOC(N)=O AIXAANGOTKPUOY-UHFFFAOYSA-N 0.000 claims description 7
229940109239 creatinine Drugs 0.000 claims description 7
PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims description 7
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 7
229910000397 disodium phosphate Inorganic materials 0.000 claims description 7
235000019800 disodium phosphate Nutrition 0.000 claims description 7
229960002449 glycine Drugs 0.000 claims description 7
235000013923 monosodium glutamate Nutrition 0.000 claims description 7
229910000027 potassium carbonate Inorganic materials 0.000 claims description 7
235000011181 potassium carbonates Nutrition 0.000 claims description 7
235000010413 sodium alginate Nutrition 0.000 claims description 7
239000000661 sodium alginate Substances 0.000 claims description 7
229940005550 sodium alginate Drugs 0.000 claims description 7
239000001509 sodium citrate Substances 0.000 claims description 7
235000019259 sodium dehydroacetate Nutrition 0.000 claims description 7
229940079839 sodium dehydroacetate Drugs 0.000 claims description 7
229940073490 sodium glutamate Drugs 0.000 claims description 7
235000011121 sodium hydroxide Nutrition 0.000 claims description 7
239000001488 sodium phosphate Substances 0.000 claims description 7
DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 claims description 7
235000019698 starch Nutrition 0.000 claims description 7
239000008107 starch Substances 0.000 claims description 7
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 7
229940038773 trisodium citrate Drugs 0.000 claims description 7
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 6
229920000881 Modified starch Polymers 0.000 claims description 6
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 6
BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 claims description 6
229910021529 ammonia Inorganic materials 0.000 claims description 6
229940015826 dihydroxyaluminum aminoacetate Drugs 0.000 claims description 6
238000007908 dry granulation Methods 0.000 claims description 6
VRVKOZSIJXBAJG-TYYBGVCCSA-M monosodium fumarate Chemical compound [Na+].OC(=O)\C=C\C([O-])=O VRVKOZSIJXBAJG-TYYBGVCCSA-M 0.000 claims description 5
229920001223 polyethylene glycol Polymers 0.000 claims description 5
239000004320 sodium erythorbate Substances 0.000 claims description 5
235000010352 sodium erythorbate Nutrition 0.000 claims description 5
RBWSWDPRDBEWCR-RKJRWTFHSA-N sodium;(2r)-2-[(2r)-3,4-dihydroxy-5-oxo-2h-furan-2-yl]-2-hydroxyethanolate Chemical compound [Na+].[O-]C[C@@H](O)[C@H]1OC(=O)C(O)=C1O RBWSWDPRDBEWCR-RKJRWTFHSA-N 0.000 claims description 5
235000019263 trisodium citrate Nutrition 0.000 claims description 5
239000002202 Polyethylene glycol Substances 0.000 claims description 3
235000015424 sodium Nutrition 0.000 claims description 2
229940125904 compound 1 Drugs 0.000 description 14
239000007857 degradation product Substances 0.000 description 11
238000000354 decomposition reaction Methods 0.000 description 9
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
239000007788 liquid Substances 0.000 description 8
230000000052 comparative effect Effects 0.000 description 7
201000010099 disease Diseases 0.000 description 7
239000004615 ingredient Substances 0.000 description 6
239000000843 powder Substances 0.000 description 6
235000012222 talc Nutrition 0.000 description 6
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 5
235000009697 arginine Nutrition 0.000 description 5
239000013068 control sample Substances 0.000 description 5
229940079593 drug Drugs 0.000 description 5
239000003814 drug Substances 0.000 description 5
229940068918 polyethylene glycol 400 Drugs 0.000 description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
239000002552 dosage form Substances 0.000 description 4
239000008101 lactose Substances 0.000 description 4
AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical group C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 4
229920000136 polysorbate Polymers 0.000 description 4
239000000523 sample Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 3
229920002261 Corn starch Polymers 0.000 description 3
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
239000002253 acid Substances 0.000 description 3
239000002246 antineoplastic agent Substances 0.000 description 3
235000001465 calcium Nutrition 0.000 description 3
239000002775 capsule Substances 0.000 description 3
229920002678 cellulose Polymers 0.000 description 3
239000001913 cellulose Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
239000008120 corn starch Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000000839 emulsion Substances 0.000 description 3
239000007924 injection Substances 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000000047 product Substances 0.000 description 3
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 3
235000012239 silicon dioxide Nutrition 0.000 description 3
239000000829 suppository Substances 0.000 description 3
239000000725 suspension Substances 0.000 description 3
239000006188 syrup Substances 0.000 description 3
235000020357 syrup Nutrition 0.000 description 3
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
238000005550 wet granulation Methods 0.000 description 3
208000023275 Autoimmune disease Diseases 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
206010028980 Neoplasm Diseases 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
208000026935 allergic disease Diseases 0.000 description 2
SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 2
229940024606 amino acid Drugs 0.000 description 2
235000001014 amino acid Nutrition 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
210000004204 blood vessel Anatomy 0.000 description 2
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
206010012601 diabetes mellitus Diseases 0.000 description 2
239000003623 enhancer Substances 0.000 description 2
238000001415 gene therapy Methods 0.000 description 2
239000008103 glucose Substances 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
239000007902 hard capsule Substances 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
230000003054 hormonal effect Effects 0.000 description 2
BDAGIHXWWSANSR-NJFSPNSNSA-N hydroxyformaldehyde Chemical compound O[14CH]=O BDAGIHXWWSANSR-NJFSPNSNSA-N 0.000 description 2
229960003444 immunosuppressant agent Drugs 0.000 description 2
239000003018 immunosuppressive agent Substances 0.000 description 2
150000007529 inorganic bases Chemical class 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 description 2
229910052808 lithium carbonate Inorganic materials 0.000 description 2
HQRPHMAXFVUBJX-UHFFFAOYSA-M lithium;hydrogen carbonate Chemical compound [Li+].OC([O-])=O HQRPHMAXFVUBJX-UHFFFAOYSA-M 0.000 description 2
150000007522 mineralic acids Chemical class 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
235000005985 organic acids Nutrition 0.000 description 2
150000007530 organic bases Chemical class 0.000 description 2
229950008882 polysorbate Drugs 0.000 description 2
229940068965 polysorbates Drugs 0.000 description 2
239000008213 purified water Substances 0.000 description 2
208000017520 skin disease Diseases 0.000 description 2
235000017557 sodium bicarbonate Nutrition 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
239000007901 soft capsule Substances 0.000 description 2
229910000018 strontium carbonate Inorganic materials 0.000 description 2
WJMMDJOFTZAHHS-UHFFFAOYSA-L strontium;carbonic acid;carbonate Chemical compound [Sr+2].OC([O-])=O.OC([O-])=O WJMMDJOFTZAHHS-UHFFFAOYSA-L 0.000 description 2
239000013589 supplement Substances 0.000 description 2
VZOQYVHEWHJIBG-UHFFFAOYSA-N 2-(aminomethyl)benzamide Chemical compound NCC1=CC=CC=C1C(N)=O VZOQYVHEWHJIBG-UHFFFAOYSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
208000018522 Gastrointestinal disease Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
108010033040 Histones Proteins 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
229930064664 L-arginine Natural products 0.000 description 1
235000014852 L-arginine Nutrition 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
HDVDLQFPDLTOSI-UHFFFAOYSA-L O[AlH]O Chemical compound O[AlH]O HDVDLQFPDLTOSI-UHFFFAOYSA-L 0.000 description 1
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
239000001744 Sodium fumarate Substances 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
235000011054 acetic acid Nutrition 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
235000011114 ammonium hydroxide Nutrition 0.000 description 1
229960004246 arginine glutamate Drugs 0.000 description 1
108010013835 arginine glutamate Proteins 0.000 description 1
239000000872 buffer Substances 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
230000000850 deacetylating effect Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
230000004069 differentiation Effects 0.000 description 1
MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
229940026231 erythorbate Drugs 0.000 description 1
235000010350 erythorbic acid Nutrition 0.000 description 1
229940050411 fumarate Drugs 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
230000003394 haemopoietic effect Effects 0.000 description 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
229960003511 macrogol Drugs 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
235000001055 magnesium Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229940117841 methacrylic acid copolymer Drugs 0.000 description 1
229920003145 methacrylic acid copolymer Polymers 0.000 description 1
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
239000006187 pill Substances 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940005573 sodium fumarate Drugs 0.000 description 1
235000019294 sodium fumarate Nutrition 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Dermatology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200201466A 1999-08-16 2002-02-21 Pharmaceutical agent comprising a benzamide derivative as active ingredient. ZA200201466B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP22955199A JP2001064177A (ja)	1999-08-16	1999-08-16	ベンズアミド誘導体を有効成分とする製剤

Publications (1)

Publication Number	Publication Date
ZA200201466B true ZA200201466B (en)	2002-09-02

Family

ID=16893948

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200201466A ZA200201466B (en)	1999-08-16	2002-02-21	Pharmaceutical agent comprising a benzamide derivative as active ingredient.

Country Status (29)

Country	Link
EP (1)	EP1207881B1 (pl)
JP (2)	JP2001064177A (pl)
KR (1)	KR100683876B1 (pl)
CN (1)	CN1205931C (pl)
AR (1)	AR031074A1 (pl)
AU (1)	AU780151B2 (pl)
BG (1)	BG65662B1 (pl)
BR (1)	BR0013283A (pl)
CA (1)	CA2380757C (pl)
CY (1)	CY1116273T1 (pl)
CZ (1)	CZ302924B6 (pl)
DK (1)	DK1207881T3 (pl)
EE (1)	EE05331B1 (pl)
ES (1)	ES2536705T3 (pl)
HK (1)	HK1046501B (pl)
HR (1)	HRP20020181B1 (pl)
HU (1)	HU230386B1 (pl)
IL (1)	IL148169A0 (pl)
MX (1)	MXPA02001575A (pl)
NO (1)	NO328957B1 (pl)
NZ (1)	NZ517356A (pl)
PL (1)	PL201388B1 (pl)
PT (1)	PT1207881E (pl)
RU (1)	RU2257206C2 (pl)
SK (1)	SK287547B6 (pl)
TW (1)	TWI245630B (pl)
UA (1)	UA73316C2 (pl)
WO (1)	WO2001012193A1 (pl)
ZA (1)	ZA200201466B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2001081031A (ja) *	1999-08-30	2001-03-27	Schering Ag	溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤
EP1319409A4 (en) *	2000-09-22	2006-05-03	Takeda Pharmaceutical	SOLID PREPARATIONS
AU2003220119A1 (en)	2002-03-07	2003-09-22	University Of Delaware	Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phage beta protein, or hydroxyurea
GB0316206D0 (en) *	2003-07-10	2003-08-13	Glaxo Group Ltd	Pharmaceutical formulation
KR20090125209A (ko)	2007-03-28	2009-12-03	산텐 세이야꾸 가부시키가이샤	히스톤 탈아세틸화 효소 저해 작용을 갖는 화합물을 유효 성분으로서 함유하는 안압 하강제
KR101405615B1 (ko) *	2007-08-27	2014-06-12	(주)아모레퍼시픽	조성물 내 ｐＨ 조절을 통해 안정화된 벤즈아미드 화합물을함유하는 피부 외용제 조성물, 및 그 벤즈아미드 화합물안정화 방법
SI2350005T1 (sl) *	2008-08-29	2012-03-30	Bayer Pharma AG	Polimorf B N aminofenil N piridin il metoksikarbonilaminometil benzamida MS
GB2462893B (en) *	2008-08-29	2010-10-13	Bayer Schering Pharma Ag	N-(2-aminophenyl)-4-[N-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (MS-275) polymorph B
TWI645863B (zh) *	2013-04-04	2019-01-01	日商第一三共股份有限公司	胺基羧酸之鹽的固形組成物
US10603285B2 (en)	2015-03-19	2020-03-31	Daiichi Sankyo Company, Limited	Solid preparation including colorant
BR112017019918B1 (pt)	2015-03-19	2023-11-07	Daiichi Sankyo Company, Limited	Preparação sólida farmacêutica, e, método para produzir uma preparação sólida farmacêutica para estabilizar uma preparação sólida farmacêutica
WO2020027019A1 (ja)	2018-07-30	2020-02-06	第一三共株式会社	安定化剤を含有する医薬品の固形製剤
WO2020153520A1 (ko) *	2019-01-25	2020-07-30	(주)아모레퍼시픽	벤조산아마이드 화합물 및 용해보조제를 포함하는 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU706415A1 (ru) *	1978-04-12	1979-12-30	Ташкентский Государственный Университет Им.В.И.Ленина	Итаконоил анабазин в качестве дыхательного аналептика
CZ284687B6 (cs) *	1986-04-30	1999-02-17	Dainippon Pharmaceutical Co., Ltd.	Substituovaný benzamidový derivát, způsob jeho výroby a farmaceutický prostředek na jeho bázi
US6174905B1 (en) *	1996-09-30	2001-01-16	Mitsui Chemicals, Inc.	Cell differentiation inducer
JP3354090B2 (ja) *	1996-09-30	2002-12-09	シエーリングアクチエンゲゼルシャフト	分化誘導剤

1999
- 1999-08-16 JP JP22955199A patent/JP2001064177A/ja active Pending
2000
- 2000-08-07 TW TW089115860A patent/TWI245630B/zh not_active IP Right Cessation
- 2000-08-15 AR ARP000104212A patent/AR031074A1/es active IP Right Grant
- 2000-08-16 AU AU64427/00A patent/AU780151B2/en not_active Expired
- 2000-08-16 RU RU2002106815/15A patent/RU2257206C2/ru active
- 2000-08-16 CZ CZ20020540A patent/CZ302924B6/cs not_active IP Right Cessation
- 2000-08-16 ES ES00951523.0T patent/ES2536705T3/es not_active Expired - Lifetime
- 2000-08-16 PL PL353449A patent/PL201388B1/pl unknown
- 2000-08-16 SK SK209-2002A patent/SK287547B6/sk not_active IP Right Cessation
- 2000-08-16 NZ NZ517356A patent/NZ517356A/en not_active IP Right Cessation
- 2000-08-16 HR HRP20020181AA patent/HRP20020181B1/hr not_active IP Right Cessation
- 2000-08-16 UA UA2002032040A patent/UA73316C2/uk unknown
- 2000-08-16 HK HK02107641.6A patent/HK1046501B/zh not_active IP Right Cessation
- 2000-08-16 CN CNB008117187A patent/CN1205931C/zh not_active Expired - Lifetime
- 2000-08-16 MX MXPA02001575A patent/MXPA02001575A/es active IP Right Grant
- 2000-08-16 IL IL14816900A patent/IL148169A0/xx active IP Right Grant
- 2000-08-16 CA CA002380757A patent/CA2380757C/en not_active Expired - Lifetime
- 2000-08-16 BR BR0013283-7A patent/BR0013283A/pt not_active Application Discontinuation
- 2000-08-16 HU HU0203226A patent/HU230386B1/hu unknown
- 2000-08-16 WO PCT/EP2000/008011 patent/WO2001012193A1/en not_active Ceased
- 2000-08-16 JP JP2001516539A patent/JP4854158B2/ja not_active Expired - Lifetime
- 2000-08-16 PT PT951523T patent/PT1207881E/pt unknown
- 2000-08-16 EE EEP200200073A patent/EE05331B1/xx unknown
- 2000-08-16 KR KR1020027002002A patent/KR100683876B1/ko not_active Expired - Lifetime
- 2000-08-16 DK DK00951523.0T patent/DK1207881T3/da active
- 2000-08-16 EP EP00951523.0A patent/EP1207881B1/en not_active Expired - Lifetime
2002
- 2002-02-15 NO NO20020774A patent/NO328957B1/no not_active IP Right Cessation
- 2002-02-21 ZA ZA200201466A patent/ZA200201466B/en unknown
- 2002-03-14 BG BG106516A patent/BG65662B1/bg unknown
2015
- 2015-05-13 CY CY20151100423T patent/CY1116273T1/el unknown

Also Published As

Publication number	Publication date
JP2003507330A (ja)	2003-02-25
JP4854158B2 (ja)	2012-01-18
MXPA02001575A (es)	2003-10-14
KR20020020815A (ko)	2002-03-15
AR031074A1 (es)	2003-09-10
HK1046501A1 (en)	2003-01-17
SK287547B6 (sk)	2011-01-04
BG106516A (en)	2002-10-31
ES2536705T3 (es)	2015-05-27
EP1207881B1 (en)	2015-04-01
UA73316C2 (uk)	2005-07-15
CA2380757A1 (en)	2001-02-22
NO20020774L (no)	2002-03-04
BG65662B1 (bg)	2009-05-29
PL353449A1 (pl)	2003-11-17
RU2257206C2 (ru)	2005-07-27
EE200200073A (et)	2003-04-15
HRP20020181B1 (hr)	2016-01-29
HUP0203226A2 (hu)	2003-01-28
NO20020774D0 (no)	2002-02-15
CN1370068A (zh)	2002-09-18
EP1207881A1 (en)	2002-05-29
NZ517356A (en)	2003-07-25
CZ2002540A3 (cs)	2002-06-12
CZ302924B6 (cs)	2012-01-18
BR0013283A (pt)	2002-04-23
CA2380757C (en)	2009-01-27
HUP0203226A3 (en)	2003-12-29
EE05331B1 (et)	2010-08-16
PT1207881E (pt)	2015-06-05
CN1205931C (zh)	2005-06-15
JP2001064177A (ja)	2001-03-13
AU6442700A (en)	2001-03-13
AU780151B2 (en)	2005-03-03
HU230386B1 (hu)	2016-03-29
RU2002106815A (ru)	2004-01-27
NO328957B1 (no)	2010-06-28
IL148169A0 (en)	2002-09-12
KR100683876B1 (ko)	2007-02-15
PL201388B1 (pl)	2009-04-30
CY1116273T1 (el)	2017-02-08
SK2092002A3 (en)	2002-07-02
HRP20020181A2 (en)	2005-10-31
WO2001012193A1 (en)	2001-02-22
TWI245630B (en)	2005-12-21
HK1046501B (zh)	2005-09-30
DK1207881T3 (da)	2015-06-22

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CA2382886C (en)	2009-06-09	Benzamide formulation with histone deacetylase inhibitor activity
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JP2931409B2 (ja)	1999-08-09	パラセタモール及びドンペリドンのフィルムコーティング錠
EP4122483B1 (en)	2025-04-30	Oral pharmaceutical composition
KR20100020480A (ko)	2010-02-22	Ｄｐｐ-ｉｖ 저해제를 위한 안정한 약제학적 제제
KR100465895B1 (ko)	2005-01-13	파라세타몰을 포함하는 경구용 정제
CZ296381B6 (cs)	2006-03-15	Farmaceutický prostredek
JP3586471B2 (ja)	2004-11-10	トラセミド含有医薬組成物
CN103833713A (zh)	2014-06-04	硝克柳胺化合物晶iii型、其制法和其药物组合物与用途
US5091191A (en)	1992-02-25	Pharmaceutical composition with improved dissolution property
AU606330B2 (en)	1991-02-07	Sulphonamide /diaminopyrimidine compositions for the treatment of microbial infections
KR910004481B1 (ko)	1991-06-29	용출성이 개량된 제제 조성물