ZA200300084B - Carrier-free <103>Pd brachytherapy seeds. - Google Patents

Carrier-free <103>Pd brachytherapy seeds. Download PDF

Info

Publication number: ZA200300084B
Authority: ZA; South Africa
Prior art keywords: substrate; carrier; free; seed; cancer
Prior art date: 2000-07-17

Application number

ZA200300084A

Other languages

English (en)

Inventor

Michael Drobnik

Dave Bolenbaugh

Irene Pahigianis

Christopher Drobnik

Pamela S Dahl

Scott Romanoff

Original Assignee

Mediphysics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-17

Filing date

2003-01-03

Publication date

2004-04-05

2003-01-03 Application filed by Mediphysics Inc filed Critical Mediphysics Inc

2004-04-05 Publication of ZA200300084B publication Critical patent/ZA200300084B/en

Links

238000002725 brachytherapy Methods 0.000 title claims abstract description 56
239000000758 substrate Substances 0.000 claims abstract description 139
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical group [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 172
229910052751 metal Inorganic materials 0.000 claims description 70
239000002184 metal Substances 0.000 claims description 70
230000005855 radiation Effects 0.000 claims description 42
229910052763 palladium Inorganic materials 0.000 claims description 40
238000000034 method Methods 0.000 claims description 36
238000000151 deposition Methods 0.000 claims description 35
230000008021 deposition Effects 0.000 claims description 32
PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 31
239000000203 mixture Substances 0.000 claims description 26
239000011248 coating agent Substances 0.000 claims description 25
238000000576 coating method Methods 0.000 claims description 25
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 21
229910052802 copper Inorganic materials 0.000 claims description 21
239000010949 copper Substances 0.000 claims description 21
201000010099 disease Diseases 0.000 claims description 20
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
238000011282 treatment Methods 0.000 claims description 18
229910052759 nickel Inorganic materials 0.000 claims description 16
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 15
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 14
239000004411 aluminium Substances 0.000 claims description 14
229910052782 aluminium Inorganic materials 0.000 claims description 14
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 14
239000010936 titanium Substances 0.000 claims description 14
229910052719 titanium Inorganic materials 0.000 claims description 14
229910052709 silver Inorganic materials 0.000 claims description 13
239000004332 silver Substances 0.000 claims description 13
239000000126 substance Substances 0.000 claims description 12
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 10
206010028980 Neoplasm Diseases 0.000 claims description 10
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 10
238000004519 manufacturing process Methods 0.000 claims description 9
239000003638 chemical reducing agent Substances 0.000 claims description 8
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
229910002804 graphite Inorganic materials 0.000 claims description 7
239000010439 graphite Substances 0.000 claims description 7
229920000642 polymer Polymers 0.000 claims description 6
239000002253 acid Substances 0.000 claims description 5
208000014829 head and neck neoplasm Diseases 0.000 claims description 5
229910052742 iron Inorganic materials 0.000 claims description 5
229910052697 platinum Inorganic materials 0.000 claims description 5
206010046766 uterine cancer Diseases 0.000 claims description 5
208000003174 Brain Neoplasms Diseases 0.000 claims description 4
206010006187 Breast cancer Diseases 0.000 claims description 4
208000026310 Breast neoplasm Diseases 0.000 claims description 4
206010033128 Ovarian cancer Diseases 0.000 claims description 4
206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
206010060862 Prostate cancer Diseases 0.000 claims description 4
208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
206010003246 arthritis Diseases 0.000 claims description 4
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
229910052737 gold Inorganic materials 0.000 claims description 4
239000010931 gold Substances 0.000 claims description 4
229910052741 iridium Inorganic materials 0.000 claims description 4
GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims description 4
239000011133 lead Substances 0.000 claims description 4
229910052716 thallium Inorganic materials 0.000 claims description 4
BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 claims description 4
206010008342 Cervix carcinoma Diseases 0.000 claims description 3
229910001069 Ti alloy Inorganic materials 0.000 claims description 3
206010065584 Urethral stenosis Diseases 0.000 claims description 3
208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 3
208000002495 Uterine Neoplasms Diseases 0.000 claims description 3
201000010881 cervical cancer Diseases 0.000 claims description 3
201000010260 leiomyoma Diseases 0.000 claims description 3
201000007270 liver cancer Diseases 0.000 claims description 3
208000014018 liver neoplasm Diseases 0.000 claims description 3
201000001441 melanoma Diseases 0.000 claims description 3
208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 3
230000002062 proliferating effect Effects 0.000 claims description 3
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 3
201000001988 urethral stricture Diseases 0.000 claims description 3
229910000838 Al alloy Inorganic materials 0.000 claims description 2
229910000881 Cu alloy Inorganic materials 0.000 claims description 2
229910000990 Ni alloy Inorganic materials 0.000 claims description 2
239000010935 stainless steel Substances 0.000 claims description 2
229910001220 stainless steel Inorganic materials 0.000 claims description 2
229910052715 tantalum Inorganic materials 0.000 claims description 2
GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 2
208000025421 tumor of uterus Diseases 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims 5
239000008139 complexing agent Substances 0.000 claims 2
208000026037 malignant tumor of neck Diseases 0.000 claims 2
KDLHZDBZIXYQEI-OIOBTWANSA-N palladium-103 Chemical compound [103Pd] KDLHZDBZIXYQEI-OIOBTWANSA-N 0.000 abstract description 5
230000002285 radioactive effect Effects 0.000 description 35
239000000463 material Substances 0.000 description 26
229910052703 rhodium Inorganic materials 0.000 description 24
239000010948 rhodium Substances 0.000 description 24
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 24
210000001519 tissue Anatomy 0.000 description 22
239000011162 core material Substances 0.000 description 17
230000000694 effects Effects 0.000 description 15
239000000243 solution Substances 0.000 description 13
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
150000002739 metals Chemical class 0.000 description 10
230000001225 therapeutic effect Effects 0.000 description 8
201000011510 cancer Diseases 0.000 description 6
238000007772 electroless plating Methods 0.000 description 6
238000003466 welding Methods 0.000 description 6
238000002513 implantation Methods 0.000 description 5
238000001959 radiotherapy Methods 0.000 description 5
238000002560 therapeutic procedure Methods 0.000 description 5
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 4
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 4
239000000908 ammonium hydroxide Substances 0.000 description 4
239000002775 capsule Substances 0.000 description 4
238000009826 distribution Methods 0.000 description 4
239000007943 implant Substances 0.000 description 4
-1 palladium ions Chemical class 0.000 description 4
238000009827 uniform distribution Methods 0.000 description 4
238000010521 absorption reaction Methods 0.000 description 3
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
229910052921 ammonium sulfate Inorganic materials 0.000 description 3
235000011130 ammonium sulphate Nutrition 0.000 description 3
230000002238 attenuated effect Effects 0.000 description 3
238000010276 construction Methods 0.000 description 3
238000001514 detection method Methods 0.000 description 3
238000009713 electroplating Methods 0.000 description 3
238000007747 plating Methods 0.000 description 3
239000007787 solid Substances 0.000 description 3
YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 3
238000012800 visualization Methods 0.000 description 3
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
XMBWDFGMSWQBCA-YPZZEJLDSA-N iodane Chemical compound [125IH] XMBWDFGMSWQBCA-YPZZEJLDSA-N 0.000 description 2
229940044173 iodine-125 Drugs 0.000 description 2
230000003211 malignant effect Effects 0.000 description 2
239000003550 marker Substances 0.000 description 2
229910017604 nitric acid Inorganic materials 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000004033 plastic Substances 0.000 description 2
WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 2
229910000342 sodium bisulfate Inorganic materials 0.000 description 2
238000012360 testing method Methods 0.000 description 2
238000002604 ultrasonography Methods 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
229910000851 Alloy steel Inorganic materials 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
KVCWSJZUKMSPLM-UHFFFAOYSA-N O.O[PH2]=O Chemical compound O.O[PH2]=O KVCWSJZUKMSPLM-UHFFFAOYSA-N 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
229910045601 alloy Inorganic materials 0.000 description 1
239000000956 alloy Substances 0.000 description 1
235000019270 ammonium chloride Nutrition 0.000 description 1
QZPSXPBJTPJTSZ-UHFFFAOYSA-N aqua regia Chemical compound Cl.O[N+]([O-])=O QZPSXPBJTPJTSZ-UHFFFAOYSA-N 0.000 description 1
239000011260 aqueous acid Substances 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
239000011324 bead Substances 0.000 description 1
229910052790 beryllium Inorganic materials 0.000 description 1
ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
239000002026 chloroform extract Substances 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
150000004696 coordination complex Chemical class 0.000 description 1
230000007797 corrosion Effects 0.000 description 1
238000005260 corrosion Methods 0.000 description 1
230000007423 decrease Effects 0.000 description 1
238000005137 deposition process Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000010894 electron beam technology Methods 0.000 description 1
238000005530 etching Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
201000010536 head and neck cancer Diseases 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
238000003384 imaging method Methods 0.000 description 1
230000003116 impacting effect Effects 0.000 description 1
239000011261 inert gas Substances 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
238000007733 ion plating Methods 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
230000001678 irradiating effect Effects 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
239000007769 metal material Substances 0.000 description 1
150000002815 nickel Chemical class 0.000 description 1
RRIWRJBSCGCBID-UHFFFAOYSA-L nickel sulfate hexahydrate Chemical compound O.O.O.O.O.O.[Ni+2].[O-]S([O-])(=O)=O RRIWRJBSCGCBID-UHFFFAOYSA-L 0.000 description 1
229940116202 nickel sulfate hexahydrate Drugs 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
239000011368 organic material Substances 0.000 description 1
230000002611 ovarian Effects 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
230000035515 penetration Effects 0.000 description 1
ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000012857 radioactive material Substances 0.000 description 1
238000006722 reduction reaction Methods 0.000 description 1
VEMKTZHHVJILDY-UHFFFAOYSA-N resmethrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-UHFFFAOYSA-N 0.000 description 1
238000007789 sealing Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229960000999 sodium citrate dihydrate Drugs 0.000 description 1
125000006850 spacer group Chemical group 0.000 description 1
238000004544 sputter deposition Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
229920002994 synthetic fiber Polymers 0.000 description 1
229940071240 tetrachloroaurate Drugs 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
150000004684 trihydrates Chemical class 0.000 description 1
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
239000010937 tungsten Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
230000003245 working effect Effects 0.000 description 1
238000004846 x-ray emission Methods 0.000 description 1

Classifications

- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1027—Interstitial radiation therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1024—Seeds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/12—All metal or with adjacent metals
- Y10T428/12493—Composite; i.e., plural, adjacent, spatially distinct metal components [e.g., layers, joint, etc.]
- Y10T428/12535—Composite; i.e., plural, adjacent, spatially distinct metal components [e.g., layers, joint, etc.] with additional, spatially distinct nonmetal component
- Y10T428/12556—Organic component
- Y10T428/12569—Synthetic resin
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/12—All metal or with adjacent metals
- Y10T428/12493—Composite; i.e., plural, adjacent, spatially distinct metal components [e.g., layers, joint, etc.]
- Y10T428/12535—Composite; i.e., plural, adjacent, spatially distinct metal components [e.g., layers, joint, etc.] with additional, spatially distinct nonmetal component
- Y10T428/12625—Free carbon containing component
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/12—All metal or with adjacent metals
- Y10T428/12493—Composite; i.e., plural, adjacent, spatially distinct metal components [e.g., layers, joint, etc.]
- Y10T428/12771—Transition metal-base component
- Y10T428/12861—Group VIII or IB metal-base component
- Y10T428/12875—Platinum group metal-base component

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Physics & Mathematics (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Optics & Photonics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pathology (AREA)
General Engineering & Computer Science (AREA)
High Energy & Nuclear Physics (AREA)
Radiology & Medical Imaging (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dispersion Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Radiation-Therapy Devices (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Developing Agents For Electrophotography (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

ZA200300084A 2000-07-17 2003-01-03 Carrier-free <103>Pd brachytherapy seeds. ZA200300084B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US21876700P	2000-07-17	2000-07-17

Publications (1)

Publication Number	Publication Date
ZA200300084B true ZA200300084B (en)	2004-04-05

Family

ID=22816428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200300084A ZA200300084B (en)	2000-07-17	2003-01-03	Carrier-free <103>Pd brachytherapy seeds.

Country Status (10)

Country	Link
US (1)	US7988612B2 (de)
EP (1)	EP1301216B1 (de)
AT (1)	ATE329625T1 (de)
AU (1)	AU2002224529A1 (de)
BR (1)	BR0112554A (de)
CA (1)	CA2413822A1 (de)
DE (1)	DE60120702T2 (de)
MX (1)	MXPA03000528A (de)
WO (1)	WO2002007784A2 (de)
ZA (1)	ZA200300084B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1545705A4 (de)	2000-11-16	2010-04-28	Microspherix Llc	Flexibler und/oder elastischer brachytherapie-seed oder strang
US6761680B2 (en) *	2001-11-02	2004-07-13	Richard A. Terwilliger	Delivery system and method for interstitial radiation therapy using seed strands constructed with preformed strand housing
US7060020B2 (en)	2001-11-02	2006-06-13	Ideamatrix, Inc.	Delivery system and method for interstitial radiation therapy
US7074291B2 (en)	2001-11-02	2006-07-11	Worldwide Medical Technologies, L.L.C.	Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings
US6997862B2 (en)	2003-05-13	2006-02-14	Ideamatrix, Inc.	Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing
US7736293B2 (en)	2005-07-22	2010-06-15	Biocompatibles Uk Limited	Implants for use in brachytherapy and other radiation therapy that resist migration and rotation
US8187159B2 (en)	2005-07-22	2012-05-29	Biocompatibles, UK	Therapeutic member including a rail used in brachytherapy and other radiation therapy
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2001
- 2001-07-16 BR BR0112554-0A patent/BR0112554A/pt not_active IP Right Cessation
- 2001-07-16 DE DE60120702T patent/DE60120702T2/de not_active Expired - Lifetime
- 2001-07-16 WO PCT/US2001/022271 patent/WO2002007784A2/en not_active Ceased
- 2001-07-16 AT AT01984306T patent/ATE329625T1/de not_active IP Right Cessation
- 2001-07-16 CA CA002413822A patent/CA2413822A1/en not_active Abandoned
- 2001-07-16 AU AU2002224529A patent/AU2002224529A1/en not_active Abandoned
- 2001-07-16 US US10/333,195 patent/US7988612B2/en not_active Expired - Fee Related
- 2001-07-16 EP EP01984306A patent/EP1301216B1/de not_active Expired - Lifetime
- 2001-07-16 MX MXPA03000528A patent/MXPA03000528A/es active IP Right Grant
2003
- 2003-01-03 ZA ZA200300084A patent/ZA200300084B/en unknown

Also Published As

Publication number	Publication date
BR0112554A (pt)	2003-06-24
EP1301216A2 (de)	2003-04-16
DE60120702T2 (de)	2007-06-14
WO2002007784A3 (en)	2003-01-03
AU2002224529A1 (en)	2002-02-05
WO2002007784A2 (en)	2002-01-31
ATE329625T1 (de)	2006-07-15
CA2413822A1 (en)	2002-01-31
DE60120702D1 (de)	2006-07-27
MXPA03000528A (es)	2004-09-10
US20060052654A1 (en)	2006-03-09
US7988612B2 (en)	2011-08-02
EP1301216B1 (de)	2006-06-14

Publication	Publication Date	Title
AU2001266592B2 (en)	2005-03-17	Radiation delivery devices and methods for their manufacture
EP1149389B1 (de)	2006-11-08	Brachytherapiesamen
US6419621B1 (en)	2002-07-16	Coiled brachytherapy device
CA2370532C (en)	2008-04-29	Capsule seed
AU2001266592A1 (en)	2002-02-14	Radiation delivery devices and methods for their manufacture
US6471630B1 (en)	2002-10-29	Transmutable radiotherapy device
AU690616B2 (en)	1998-04-30	X-ray emitting interstitial implants
WO1997019706A1 (en)	1997-06-05	Radioisotope dispersed in a matrix for brachytherapy
WO1997019706A9 (en)	1997-08-28	Radioisotope dispersed in a matrix for brachytherapy
EP1301216B1 (de)	2006-06-14	Trägerfreie 103pd brachytherapiesamen
AU778456B2 (en)	2004-12-09	Neutron brachytherapy device and method
EP1232771B1 (de)	2006-04-12	Radioaktive Kapsel
AU2008200015A1 (en)	2008-01-31	Carrier-free 103ZPd brachytherapy seeds