ZA200301427B - Valproic acid derivatives for the treatment of pain. - Google Patents

Valproic acid derivatives for the treatment of pain. Download PDF

Info

Publication number: ZA200301427B
Authority: ZA; South Africa
Prior art keywords: effective dose; pain; amount; therapeutically effective; prophylactically effective
Prior art date: 2000-08-17

Application number

ZA200301427A

Other languages

English (en)

Inventor

Mitchell Shirvan

Meir Bialer

Original Assignee

Teva Pharma

Yissum Res Dev Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-17

Filing date

2003-02-21

Publication date

2004-02-23

2003-02-21 Application filed by Teva Pharma, Yissum Res Dev Co filed Critical Teva Pharma

2004-02-23 Publication of ZA200301427B publication Critical patent/ZA200301427B/en

Links

208000002193 Pain Diseases 0.000 title claims description 76
230000036407 pain Effects 0.000 title claims description 71
NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical class CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 title description 14
238000011282 treatment Methods 0.000 title description 12
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA200301427A 2000-08-17 2003-02-21 Valproic acid derivatives for the treatment of pain. ZA200301427B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22597700P	2000-08-17	2000-08-17
US22597300P	2000-08-17	2000-08-17

Publications (1)

Publication Number	Publication Date
ZA200301427B true ZA200301427B (en)	2004-02-23

Family

ID=26920105

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200301427A ZA200301427B (en)	2000-08-17	2003-02-21	Valproic acid derivatives for the treatment of pain.

Country Status (21)

Country	Link
US (3)	US20020052418A1 (cs)
EP (1)	EP1311256B1 (cs)
JP (1)	JP2004505999A (cs)
KR (1)	KR100851955B1 (cs)
CN (1)	CN100462069C (cs)
AT (1)	ATE301995T1 (cs)
AU (1)	AU8830801A (cs)
CA (1)	CA2418455A1 (cs)
CZ (1)	CZ2004362A3 (cs)
DE (1)	DE60112766T2 (cs)
DK (1)	DK1311256T3 (cs)
ES (1)	ES2245377T3 (cs)
HU (1)	HUP0401867A2 (cs)
IL (2)	IL154470A0 (cs)
MX (1)	MXPA03001458A (cs)
NO (1)	NO20030724L (cs)
NZ (1)	NZ524687A (cs)
PL (1)	PL363041A1 (cs)
SI (1)	SI1311256T1 (cs)
WO (1)	WO2002013766A2 (cs)
ZA (1)	ZA200301427B (cs)

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* Cited by examiner, † Cited by third party
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ATE327744T1 (de)	2001-03-20	2006-06-15	Sanol Arznei Schwarz Gmbh	Neue verwendung von peptidverbindungen bei der behandlung von nicht-neuropathischem entzündungsschmerz
DE60100055T2 (de) *	2001-03-21	2003-07-24	Schwarz Pharma Ag	Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen
US20040175423A1 (en) *	2003-02-05	2004-09-09	Daniella Licht	Sustained release formulation of N- (2-propylpentanoyl) glycinamide and related compounds
US20040176463A1 (en) *	2003-02-05	2004-09-09	Daniella Licht	Immediate release formulation of n-(2-propylpentanoyl)glycinamide
IL157751A0 (en) *	2003-02-28	2004-03-28	Yissum Res Dev Co	New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them
EP1491188A1 (en) *	2003-06-25	2004-12-29	G2M Cancer Drugs AG	Topical use of valproic acid for the prevention or treatment of skin disorders
US20060004098A1 (en) *	2003-07-28	2006-01-05	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Compounds useful for treating neurological disorders
US7794987B2 (en)	2003-12-02	2010-09-14	Ucb Pharma Gmbh	Method for treating central neuropathic pain
US20060009384A1 (en) *	2003-12-05	2006-01-12	David Rudd	Novel use of peptide compounds for treating status epilepticus or related conditions
EP1579858A1 (en) *	2004-03-26	2005-09-28	Schwarz Pharma Ag	Novel use of peptide compounds for treating pain in painful diabetic neuropathy
US20100256179A1 (en) *	2004-03-26	2010-10-07	Ucb Pharma Gmbh	Combination therapy for pain in painful diabetic neuropathy
US20070042969A1 (en) *	2004-03-26	2007-02-22	Srz Properties, Inc.	Combination therapy for pain in painful diabetic neuropathy
KR20070007931A (ko) *	2004-04-16	2007-01-16	쉬바르츠파르마에이지	만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도
EP1604655A1 (en)	2004-06-09	2005-12-14	Schwarz Pharma Ag	Novel use of peptide compounds for treating pain in trigeminal neuralgia
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2001
- 2001-08-17 DK DK01968030T patent/DK1311256T3/da active
- 2001-08-17 KR KR1020037002061A patent/KR100851955B1/ko not_active Expired - Fee Related
- 2001-08-17 CN CNB018171346A patent/CN100462069C/zh not_active Expired - Fee Related
- 2001-08-17 EP EP01968030A patent/EP1311256B1/en not_active Expired - Lifetime
- 2001-08-17 WO PCT/US2001/025919 patent/WO2002013766A2/en not_active Ceased
- 2001-08-17 IL IL15447001A patent/IL154470A0/xx unknown
- 2001-08-17 DE DE60112766T patent/DE60112766T2/de not_active Expired - Lifetime
- 2001-08-17 JP JP2002518914A patent/JP2004505999A/ja active Pending
- 2001-08-17 MX MXPA03001458A patent/MXPA03001458A/es active IP Right Grant
- 2001-08-17 ES ES01968030T patent/ES2245377T3/es not_active Expired - Lifetime
- 2001-08-17 AT AT01968030T patent/ATE301995T1/de not_active IP Right Cessation
- 2001-08-17 AU AU8830801A patent/AU8830801A/xx not_active Withdrawn
- 2001-08-17 CA CA002418455A patent/CA2418455A1/en not_active Abandoned
- 2001-08-17 US US09/932,370 patent/US20020052418A1/en not_active Abandoned
- 2001-08-17 CZ CZ2004362A patent/CZ2004362A3/cs unknown
- 2001-08-17 NZ NZ524687A patent/NZ524687A/en unknown
- 2001-08-17 SI SI200130418T patent/SI1311256T1/sl unknown
- 2001-08-17 PL PL01363041A patent/PL363041A1/xx not_active Application Discontinuation
- 2001-08-17 HU HU0401867A patent/HUP0401867A2/hu unknown
2003
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- 2003-02-14 NO NO20030724A patent/NO20030724L/no not_active Application Discontinuation
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Also Published As

Publication number	Publication date
US20040204495A1 (en)	2004-10-14
US8288442B2 (en)	2012-10-16
EP1311256A4 (en)	2004-03-24
US20020052418A1 (en)	2002-05-02
EP1311256A2 (en)	2003-05-21
DE60112766D1 (de)	2005-09-22
NZ524687A (en)	2005-01-28
EP1311256B1 (en)	2005-08-17
DE60112766T2 (de)	2006-03-30
WO2002013766A2 (en)	2002-02-21
HUP0401867A2 (hu)	2004-12-28
CZ2004362A3 (cs)	2005-01-12
CN1551762A (zh)	2004-12-01
SI1311256T1 (sl)	2005-12-31
CA2418455A1 (en)	2002-02-21
US20090281045A1 (en)	2009-11-12
IL154470A0 (en)	2003-09-17
NO20030724D0 (no)	2003-02-14
PL363041A1 (en)	2004-11-15
WO2002013766A3 (en)	2002-06-20
KR100851955B1 (ko)	2008-08-12
IL154470A (en)	2010-11-30
KR20030036691A (ko)	2003-05-09
ATE301995T1 (de)	2005-09-15
NO20030724L (no)	2003-02-14
MXPA03001458A (es)	2004-05-04
ES2245377T3 (es)	2006-01-01
DK1311256T3 (da)	2005-11-28
JP2004505999A (ja)	2004-02-26
AU8830801A (en)	2002-02-25
CN100462069C (zh)	2009-02-18

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HUE033180T2 (en)	2017-11-28	Peptide compounds for the treatment of difficult to cure epileptic diseases
AU2007260207A1 (en)	2007-12-21	Pharmaceutical composition with synergistic anticonvulsant effect
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JP2008539250A (ja)	2008-11-13	アテローム性動脈硬化症を処置するための方法
US6555585B2 (en)	2003-04-29	Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder
AU2001288308B2 (en)	2007-03-08	Valproic acid derivatives for the treatment of pain
CA2566362A1 (en)	2005-12-08	Treating seizures using ice inhibitors
AU2001288308A1 (en)	2002-05-23	Valproic acid derivatives for the treatment of pain
Jin et al.	2022	Preclinical evaluation of drug treatment options for sleep‐related epileptiform spiking in Alzheimer's disease
HK1067555A (en)	2005-04-15	Valproic acid derivatives for the treatment of pain
US20040176463A1 (en)	2004-09-09	Immediate release formulation of n-(2-propylpentanoyl)glycinamide
KR20240049578A (ko)	2024-04-16	트리카프릴린을 이용한 편두통 및 관련 두통 증상 치료 방법
JPH0645539B2 (ja)	1994-06-15	鎮痛剤