ZA200401270B - Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-A] pyrimidin-4-one and 7-pyrimidinyl-2,3-dihyroimi-dazo[1,2-A]pyrimidin-5(1H)one derivatives for neurodegenerative disorders. - Google Patents

Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-A] pyrimidin-4-one and 7-pyrimidinyl-2,3-dihyroimi-dazo[1,2-A]pyrimidin-5(1H)one derivatives for neurodegenerative disorders. Download PDF

Info

Publication number
ZA200401270B
ZA200401270B ZA200401270A ZA200401270A ZA200401270B ZA 200401270 B ZA200401270 B ZA 200401270B ZA 200401270 A ZA200401270 A ZA 200401270A ZA 200401270 A ZA200401270 A ZA 200401270A ZA 200401270 B ZA200401270 B ZA 200401270B
Authority
ZA
South Africa
Prior art keywords
pyrimidin
tetrahydro
pyrimido
ethyl
phenyl
Prior art date
Application number
ZA200401270A
Other languages
English (en)
Inventor
Thierry Gallet
Patrick Lardenois
Alistair Lochead
Severine Marguerie
Alain Nedelec
Mourad Saady
Franck Slowinski
Philippe Yaiche
Original Assignee
Sanofi Aventis
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis, Mitsubishi Pharma Corp filed Critical Sanofi Aventis
Publication of ZA200401270B publication Critical patent/ZA200401270B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200401270A 2001-09-21 2004-02-17 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-A] pyrimidin-4-one and 7-pyrimidinyl-2,3-dihyroimi-dazo[1,2-A]pyrimidin-5(1H)one derivatives for neurodegenerative disorders. ZA200401270B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01402431A EP1295884A1 (fr) 2001-09-21 2001-09-21 Dérivés de 2-Pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-Pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one

Publications (1)

Publication Number Publication Date
ZA200401270B true ZA200401270B (en) 2005-03-10

Family

ID=8182882

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200401270A ZA200401270B (en) 2001-09-21 2004-02-17 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-A] pyrimidin-4-one and 7-pyrimidinyl-2,3-dihyroimi-dazo[1,2-A]pyrimidin-5(1H)one derivatives for neurodegenerative disorders.

Country Status (3)

Country Link
EP (1) EP1295884A1 (fr)
CN (1) CN100391959C (fr)
ZA (1) ZA200401270B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1340759A1 (fr) * 2002-02-28 2003-09-03 Sanofi-Synthelabo Dérivés de la 1-alkyl, 1-(hétéroalkyl)alkyl et 1-(aryl)alkyl-7-pyrimidin-4-ylimidazo[1,2-a]pyrimidin-5(1H)-one
EP1454909B1 (fr) * 2003-03-07 2008-08-20 Sanofi Aventis 8'-pyridinyl-dihydrospiro-(cycloalkyl)-pyrimido(1,2-a) pyrimidin-6-one et les dérivés du 8'-pyrimidinyl-dihydrospiro-(cycloalkyl)-pyrimido(1,2-a)pyrimidin-6-one et leurs utilisation contre les maladies neurodégénératives
EP1454900A1 (fr) * 2003-03-07 2004-09-08 Sanofi-Synthelabo Procédé de préparation de pyridinyl et pyrimidinyl bêta-céto esters mono-fluorés
EP1557417B1 (fr) * 2003-12-19 2007-03-07 Sanofi-Aventis Dérivés de 8'-pyri(mi)dinyl-dihydrospiro-[cycloaklyamine]-pyrimido[1,2-a]pyrimidin-6-one substitués
EP1734963A4 (fr) 2004-04-02 2008-06-18 Merck & Co Inc Methode destinee a traiter des hommes presentant des troubles metaboliques et anthropometriques
EP2275095A3 (fr) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenese par modulation des recepteurs muscariniques
EP2258358A3 (fr) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenèse avec un inhibiteur de l'acetylcholinestérase
EP1940389A2 (fr) 2005-10-21 2008-07-09 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
EP2382975A3 (fr) 2006-05-09 2012-02-29 Braincells, Inc. Neurogénèse par modulation d'angiotensine
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2012027331A1 (fr) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions et procédés pour traiter ou prévenir un syndrome métabolique et des maladies et troubles associés
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016528A1 (fr) * 1996-10-11 1998-04-23 Chiron Corporation Inhibiteurs puriques de glycogene synthase kinase 3 (gsk3)
EP0948496A2 (fr) * 1996-12-05 1999-10-13 Amgen inc. Composes substitues a base de pyrimidone et de pyridone et procedes d'utilisation
CN100335479C (zh) * 1999-12-17 2007-09-05 希龙公司 糖元合成酶激酶3的双环抑制剂
FR2804959B1 (fr) * 2000-02-15 2006-04-28 Centre Nat Rech Scient Utilisation de derives de paullones pour la fabrication de medicaments

Also Published As

Publication number Publication date
CN100391959C (zh) 2008-06-04
EP1295884A1 (fr) 2003-03-26
CN1827619A (zh) 2006-09-06

Similar Documents

Publication Publication Date Title
EP1430056B1 (fr) Derives de 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidine-4-one et de 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1h)one utilises pour le traitement de maladies neurodegeneratives
US7462621B2 (en) Use of substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a] pyrimidin-5(1H)one derivatives as therapeutic agents
AU2002342798A1 (en) Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives for neurodegenerative disorders
ZA200401270B (en) Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-A] pyrimidin-4-one and 7-pyrimidinyl-2,3-dihyroimi-dazo[1,2-A]pyrimidin-5(1H)one derivatives for neurodegenerative disorders.
KR101070149B1 (ko) 8-치환된-6,7,8,9-테트라히드로피리미도[1,2-ａ]피리미딘-4-온 유도체
EP1603915B1 (fr) Derives de 8'-pyridinyl-dihydrospiro-(cycloalkyl)-pyrimido (1,2-a) pyrimidin-6-one et de 8'-pyrimidinyl-dihydrospiro-(cycloalkyl)-pyrimido (1,2-a) pyrimidin-6-one substitues et utilisation de ces derives contre les maladies neurodegeneratives
KR101070075B1 (ko) 치환된8-퍼플루오로알킬-6,7,8,9-테트라히드로피리미도[1,2-ａ]피리미딘-4-온 유도체
AU2002350487A1 (en) Substituted 2-pyridinyl-6,7,8,9- tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
EP1295885A1 (fr) Dérivés de 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one et 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one substitués
AU2003214127C1 (en) 1-[alkyl], 1-[heteroaryl)alkyl] and 1-[aryl)alkyl]-7-(pyrimidin-4-yl)-imadazo[1,2-a] pyrimidin-5(1H)-one derivatives
EP1340761A1 (fr) Dérivés substitués de la 2-pyridinyl-6,7,8,8-tétrahydropyrimido[1,2-a]pyrimidin-4-one et de la 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one
EP1340760A1 (fr) Dérivés de la 2-pyrimidinyl-6,7,8,9-tétrahydro[1,2-a]pyrimidin-4-one et de la 7-pyrimidinyl-2,3-dihydro[1,2-a]pyrimidin-5(1H)one