ZA200401905B - Treating surfaces to enhance bio-compatibility. - Google Patents
Treating surfaces to enhance bio-compatibility. Download PDFInfo
- Publication number
- ZA200401905B ZA200401905B ZA200401905A ZA200401905A ZA200401905B ZA 200401905 B ZA200401905 B ZA 200401905B ZA 200401905 A ZA200401905 A ZA 200401905A ZA 200401905 A ZA200401905 A ZA 200401905A ZA 200401905 B ZA200401905 B ZA 200401905B
- Authority
- ZA
- South Africa
- Prior art keywords
- polymer
- group
- alkoxysilane
- solution
- diisocyanate
- Prior art date
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229940123237 Taxane Drugs 0.000 description 1
- 238000012793 UV/ Vis spectrometry Methods 0.000 description 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
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- 125000001931 aliphatic group Chemical class 0.000 description 1
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- 125000002947 alkylene group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
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- 229940127218 antiplatelet drug Drugs 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical group NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 239000006227 byproduct Substances 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
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- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 229960000640 dactinomycin Drugs 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
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- 238000002651 drug therapy Methods 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
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- 238000007429 general method Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
- 229960001008 heparin sodium Drugs 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- DCPMPXBYPZGNDC-UHFFFAOYSA-N hydron;methanediimine;chloride Chemical compound Cl.N=C=N DCPMPXBYPZGNDC-UHFFFAOYSA-N 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- ZDZOTLJHXYCWBA-BSEPLHNVSA-N molport-006-823-826 Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-BSEPLHNVSA-N 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- ZONODCCBXBRQEZ-UHFFFAOYSA-N platinum tungsten Chemical compound [W].[Pt] ZONODCCBXBRQEZ-UHFFFAOYSA-N 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 239000005056 polyisocyanate Substances 0.000 description 1
- 229920001228 polyisocyanate Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229910001936 tantalum oxide Inorganic materials 0.000 description 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002885 thrombogenetic effect Effects 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 125000005628 tolylene group Chemical group 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- YUYCVXFAYWRXLS-UHFFFAOYSA-N trimethoxysilane Chemical group CO[SiH](OC)OC YUYCVXFAYWRXLS-UHFFFAOYSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31652—Of asbestos
- Y10T428/31663—As siloxane, silicone or silane
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0122393A GB0122393D0 (en) | 2001-09-17 | 2001-09-17 | Treating metal surfaces to enhance bio-compatibility |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200401905B true ZA200401905B (en) | 2005-06-22 |
Family
ID=9922200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200401905A ZA200401905B (en) | 2001-09-17 | 2004-03-09 | Treating surfaces to enhance bio-compatibility. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20040241325A1 (de) |
| EP (1) | EP1427458B1 (de) |
| JP (1) | JP4528894B2 (de) |
| AT (1) | ATE489125T1 (de) |
| AU (1) | AU2002329402B2 (de) |
| CA (1) | CA2460631C (de) |
| DE (1) | DE60238419D1 (de) |
| DK (1) | DK1427458T3 (de) |
| ES (1) | ES2355717T3 (de) |
| GB (1) | GB0122393D0 (de) |
| WO (1) | WO2003024500A1 (de) |
| ZA (1) | ZA200401905B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7655038B2 (en) | 2003-02-28 | 2010-02-02 | Biointeractions Ltd. | Polymeric network system for medical devices and methods of use |
| US8715771B2 (en) | 2003-02-26 | 2014-05-06 | Abbott Cardiovascular Systems Inc. | Coated stent and method of making the same |
| US7255891B1 (en) * | 2003-02-26 | 2007-08-14 | Advanced Cardiovascular Systems, Inc. | Method for coating implantable medical devices |
| EP1626748B1 (de) * | 2003-05-13 | 2012-07-11 | Medtronic, Inc. | Feuchtigkeitshärtbare materialien zur abgabe von mitteln, verfahren und medizinprodukte |
| CA2534039A1 (en) * | 2003-08-19 | 2005-03-03 | Polybiomed Limited | Polymeric drug release system for medical devices |
| US20090130163A1 (en) * | 2005-02-18 | 2009-05-21 | Abraxis Bio Scoence, Inc. | Drugs With Improved Hydrophobicity For Incorporation in Medical Devices |
| AU2012202903B2 (en) * | 2005-02-18 | 2014-12-11 | Abraxis Bioscience, Inc. | Drugs with improved hydrophobicity for incorporation in medical devices |
| US20090297578A1 (en) * | 2008-06-03 | 2009-12-03 | Trollsas Mikael O | Biosoluble coating comprising anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders |
| GB0819296D0 (en) * | 2008-10-21 | 2008-11-26 | Smith & Nephew | Coating II |
| US9669134B2 (en) | 2008-12-01 | 2017-06-06 | University College Cork, National University Of Ireland, Cork | IGF-I for myocardial repair |
| AU2009326818A1 (en) * | 2008-12-11 | 2011-07-07 | The Govenors Of The University Of Alberta | Methods and systems for inducing immunologic tolerance to non-self antigens |
| US9681939B2 (en) | 2011-11-18 | 2017-06-20 | Cook Medical Technologies Llc | Silane bonded medical devices and method of making same |
| WO2022046425A1 (en) * | 2020-08-25 | 2022-03-03 | Edwards Lifesciences Corporation | Implantable pressure sensor packaging |
| FR3135316B1 (fr) * | 2022-05-06 | 2024-05-03 | Commissariat Energie Atomique | Procede de traitement de surface pour ameliorer la performance d’un systeme thermodynamique avec cycle a absorption |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4373009A (en) * | 1981-05-18 | 1983-02-08 | International Silicone Corporation | Method of forming a hydrophilic coating on a substrate |
| WO1986007541A1 (fr) * | 1985-06-19 | 1986-12-31 | Yasushi Zyo | Composition susceptible d'avoir une activite anti-thrombotique et appareil medical devant etre en contact avec le sang |
| EP0257091B1 (de) * | 1986-02-24 | 1993-07-28 | Robert E. Fischell | Vorrichtung zum aufweisen von blutgefässen, sowie system zu deren einführung |
| US5221724A (en) * | 1987-08-12 | 1993-06-22 | Wisconsin Alumni Research Foundation | Polysiloxane polyurea urethanes |
| US5053048A (en) * | 1988-09-22 | 1991-10-01 | Cordis Corporation | Thromboresistant coating |
| US5059166A (en) * | 1989-12-11 | 1991-10-22 | Medical Innovative Technologies R & D Limited Partnership | Intra-arterial stent with the capability to inhibit intimal hyperplasia |
| US5356433A (en) * | 1991-08-13 | 1994-10-18 | Cordis Corporation | Biocompatible metal surfaces |
| DE69326631T2 (de) * | 1992-03-19 | 2000-06-08 | Medtronic, Inc. | Intraluminales Erweiterungsgerät |
| US5336518A (en) * | 1992-12-11 | 1994-08-09 | Cordis Corporation | Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents |
| DE4243799A1 (de) * | 1992-12-23 | 1994-06-30 | Bayer Ag | Siloxanblockcopolymer-modifizierte thermoplastische Polyurethane |
| US5350800A (en) * | 1993-01-19 | 1994-09-27 | Medtronic, Inc. | Method for improving the biocompatibility of solid surfaces |
| US6013855A (en) * | 1996-08-06 | 2000-01-11 | United States Surgical | Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces |
| US5728751A (en) * | 1996-11-25 | 1998-03-17 | Meadox Medicals, Inc. | Bonding bio-active materials to substrate surfaces |
| GB2325934A (en) * | 1997-06-03 | 1998-12-09 | Polybiomed Ltd | Treating metal surfaces to enhance bio-compatibility and/or physical characteristics |
| DE59808721D1 (de) * | 1997-11-24 | 2003-07-17 | Efmt Entwicklungs Und Forschun | Verfahren zur immobilisierung von mediatormolekülen auf anorganischen und metallischen implantatmaterialien |
| US6248127B1 (en) * | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
| US6099852A (en) * | 1998-09-23 | 2000-08-08 | Johnson & Johnson Vision Products, Inc. | Wettable silicone-based lenses |
| US6160032A (en) * | 1998-09-30 | 2000-12-12 | Medtronic Ave, Inc. | Biocompatible coating composition |
| DE10037850A1 (de) * | 2000-08-01 | 2002-02-21 | Herbert P Jennissen | Verfahren zur Herstellung bioaktiver Implantatoberflächen |
| US6841166B1 (en) * | 2001-08-21 | 2005-01-11 | The Regents Of The University Of Michigan | Nitric oxide-releasing polymers incorporating diazeniumdiolated silane derivatives |
-
2001
- 2001-09-17 GB GB0122393A patent/GB0122393D0/en not_active Ceased
-
2002
- 2002-09-17 DE DE60238419T patent/DE60238419D1/de not_active Expired - Lifetime
- 2002-09-17 CA CA 2460631 patent/CA2460631C/en not_active Expired - Fee Related
- 2002-09-17 JP JP2003528594A patent/JP4528894B2/ja not_active Expired - Fee Related
- 2002-09-17 AT AT02765028T patent/ATE489125T1/de not_active IP Right Cessation
- 2002-09-17 US US10/489,767 patent/US20040241325A1/en not_active Abandoned
- 2002-09-17 AU AU2002329402A patent/AU2002329402B2/en not_active Ceased
- 2002-09-17 EP EP20020765028 patent/EP1427458B1/de not_active Expired - Lifetime
- 2002-09-17 ES ES02765028T patent/ES2355717T3/es not_active Expired - Lifetime
- 2002-09-17 DK DK02765028T patent/DK1427458T3/da active
- 2002-09-17 WO PCT/GB2002/004227 patent/WO2003024500A1/en not_active Ceased
-
2004
- 2004-03-09 ZA ZA200401905A patent/ZA200401905B/en unknown
-
2010
- 2010-03-05 US US12/718,042 patent/US20100247931A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1427458A1 (de) | 2004-06-16 |
| CA2460631C (en) | 2012-03-27 |
| CA2460631A1 (en) | 2003-03-27 |
| US20100247931A1 (en) | 2010-09-30 |
| JP2005510266A (ja) | 2005-04-21 |
| EP1427458B1 (de) | 2010-11-24 |
| DE60238419D1 (de) | 2011-01-05 |
| WO2003024500A1 (en) | 2003-03-27 |
| DK1427458T3 (da) | 2011-02-28 |
| GB0122393D0 (en) | 2001-11-07 |
| ES2355717T3 (es) | 2011-03-30 |
| ATE489125T1 (de) | 2010-12-15 |
| AU2002329402B2 (en) | 2007-04-26 |
| JP4528894B2 (ja) | 2010-08-25 |
| US20040241325A1 (en) | 2004-12-02 |
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