ZA200408342B - Tricyclic thrombin receptor antagonists - Google Patents

Tricyclic thrombin receptor antagonists

Info

Publication number: ZA200408342B
Authority: ZA; South Africa
Prior art keywords: receptor antagonists; thrombin receptor; tricyclic thrombin; tricyclic; antagonists
Prior art date: 2002-04-16

Application number

ZA200408342A

Other languages

English (en)

Inventor

Samuel Chackalamannil

William J Greenlee

Yan Xia

Mariappan Chelliah

Martin C Clasby

Yuguang Wang

Enrico P Veltri

Wenxue Wu

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-16

Filing date

2004-10-14

Publication date

2006-05-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29250954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200408342(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-10-14 Application filed by Schering Corp filed Critical Schering Corp

2006-05-31 Publication of ZA200408342B publication Critical patent/ZA200408342B/xx

Links

239000003856 thrombin receptor antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200408342A 2002-04-16 2004-10-14 Tricyclic thrombin receptor antagonists ZA200408342B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37307202P	2002-04-16	2002-04-16

Publications (1)

Publication Number	Publication Date
ZA200408342B true ZA200408342B (en)	2006-05-31

Family

ID=29250954

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200408342A ZA200408342B (en)	2002-04-16	2004-10-14	Tricyclic thrombin receptor antagonists

Country Status (33)

Country	Link
US (3)	US7304078B2 (de)
EP (5)	EP2062890B1 (de)
JP (2)	JP4558331B2 (de)
KR (1)	KR101026929B1 (de)
CN (1)	CN1659162B (de)
AR (1)	AR039570A1 (de)
AT (3)	ATE378330T1 (de)
AU (1)	AU2003221932B2 (de)
BR (1)	BRPI0309309B8 (de)
CA (1)	CA2482858C (de)
CY (3)	CY1107184T1 (de)
DE (3)	DE60335679D1 (de)
DK (2)	DK2065384T3 (de)
EC (1)	ECSP045368A (de)
ES (3)	ES2357876T3 (de)
FR (1)	FR15C0047I2 (de)
IL (1)	IL164585A (de)
LT (1)	LTC1495018I2 (de)
LU (1)	LU92759I2 (de)
MX (1)	MXPA04010308A (de)
MY (1)	MY144040A (de)
NL (1)	NL300746I2 (de)
NO (2)	NO330500B1 (de)
NZ (2)	NZ575139A (de)
PE (1)	PE20040412A1 (de)
PL (1)	PL214718B1 (de)
PT (2)	PT1495018E (de)
RU (2)	RU2329264C9 (de)
SG (1)	SG164279A1 (de)
SI (2)	SI2065384T1 (de)
TW (1)	TWI343919B (de)
WO (1)	WO2003089428A1 (de)
ZA (1)	ZA200408342B (de)

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US20040192753A1 (en) *	2000-06-15	2004-09-30	Samuel Chackalamannil	Methods of use of thrombin receptor antagonists
US7488742B2 (en) *	2000-06-15	2009-02-10	Schering Corporation	Thrombin receptor antagonists
MXPA06013903A (es) *	2004-05-28	2007-01-26	Schering Corp	Analogos restringidos de himbacina como antagonistas del receptor de trombina.
AU2005294265A1 (en) *	2004-10-06	2006-04-20	University Of Rochester	Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway
JP4681617B2 (ja) *	2005-01-14	2011-05-11	シェーリングコーポレイション	ヒンバシンアナログの合成
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ATE530516T1 (de)	2005-01-14	2011-11-15	Schering Corp	Exo- und diastereoselektive synthese von himbacin-analoga
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US20060172397A1 (en) *	2005-01-14	2006-08-03	Schering Corporation	Preparation of chiral propargylic alcohol and ester intermediates of himbacine analogs
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WO2008079260A2 (en) *	2006-12-22	2008-07-03	Schering Corporation	Disintegration promoters in solid dose wet granulation formulations
WO2008118320A1 (en) *	2007-03-23	2008-10-02	Schering Corporation	Reduction of adverse events.after percutaneous intervention by use of a thrombin receptor antagonist
WO2009097970A1 (de)	2008-02-05	2009-08-13	Sanofi-Aventis	Triazolopyridazine als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
KR20100120139A (ko)	2008-02-05	2010-11-12	사노피-아벤티스	Ｐａｒ１ 억제제로서의 트리아졸륨 염, 이들의 제조방법, 및 약제로서의 용도
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PL2558462T3 (pl)	2010-04-16	2015-03-31	Sanofi Sa	Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
ES2532902T3 (es)	2010-04-16	2015-04-01	Sanofi	Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1
KR101303348B1 (ko)	2010-06-25	2013-09-03	한국화학연구원	트롬빈 수용체 길항제인 ［6＋5］접합 바이사이클, 그의 제조방법 및 그를 포함하는 약제학적 조성물
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FR3090317B1 (fr)	2018-12-19	2021-05-07	Cvasthera	Utilisation d’un antagoniste de par-1 pour le traitement d’une maladie inflammatoire chronique intestinale
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2003
- 2003-04-14 US US10/412,982 patent/US7304078B2/en active Active
- 2003-04-14 RU RU2004133375/04A patent/RU2329264C9/ru active
- 2003-04-14 CA CA2482858A patent/CA2482858C/en not_active Expired - Lifetime
- 2003-04-14 JP JP2003586149A patent/JP4558331B2/ja not_active Expired - Fee Related
- 2003-04-14 AR ARP030101302A patent/AR039570A1/es active IP Right Grant
- 2003-04-14 EP EP09150996A patent/EP2062890B1/de not_active Expired - Lifetime
- 2003-04-14 AT AT03718393T patent/ATE378330T1/de active
- 2003-04-14 AU AU2003221932A patent/AU2003221932B2/en not_active Ceased
- 2003-04-14 AT AT09150995T patent/ATE494284T1/de active
- 2003-04-14 PT PT03718393T patent/PT1495018E/pt unknown
- 2003-04-14 AT AT07016461T patent/ATE455774T1/de not_active IP Right Cessation
- 2003-04-14 MY MYPI20031400A patent/MY144040A/en unknown
- 2003-04-14 ES ES09150995T patent/ES2357876T3/es not_active Expired - Lifetime
- 2003-04-14 SI SI200331969T patent/SI2065384T1/sl unknown
- 2003-04-14 EP EP03718393A patent/EP1495018B3/de not_active Expired - Lifetime
- 2003-04-14 NZ NZ575139A patent/NZ575139A/en not_active IP Right Cessation
- 2003-04-14 EP EP09150995A patent/EP2065384B1/de not_active Expired - Lifetime
- 2003-04-14 EP EP07016461A patent/EP1860106B1/de not_active Expired - Lifetime
- 2003-04-14 DE DE60335679T patent/DE60335679D1/de not_active Expired - Lifetime
- 2003-04-14 DK DK09150995.0T patent/DK2065384T3/da active
- 2003-04-14 EP EP08012015A patent/EP1982984B1/de not_active Expired - Lifetime
- 2003-04-14 BR BRPI0309309A patent/BRPI0309309B8/pt not_active IP Right Cessation
- 2003-04-14 DE DE60317493.0T patent/DE60317493T3/de not_active Expired - Lifetime
- 2003-04-14 SG SG200607217-7A patent/SG164279A1/en unknown
- 2003-04-14 DK DK03718393T patent/DK1495018T3/da active
- 2003-04-14 PT PT09150995T patent/PT2065384E/pt unknown
- 2003-04-14 CN CN038131129A patent/CN1659162B/zh not_active Expired - Fee Related
- 2003-04-14 MX MXPA04010308A patent/MXPA04010308A/es active IP Right Grant
- 2003-04-14 NZ NZ535880A patent/NZ535880A/en not_active IP Right Cessation
- 2003-04-14 DE DE60331114T patent/DE60331114D1/de not_active Expired - Lifetime
- 2003-04-14 ES ES03718393T patent/ES2297150T7/es active Active
- 2003-04-14 ES ES07016461T patent/ES2338171T3/es not_active Expired - Lifetime
- 2003-04-14 PL PL373332A patent/PL214718B1/pl unknown
- 2003-04-14 WO PCT/US2003/011510 patent/WO2003089428A1/en not_active Ceased
- 2003-04-14 KR KR1020047016409A patent/KR101026929B1/ko not_active Expired - Fee Related
- 2003-04-14 PE PE2003000375A patent/PE20040412A1/es active IP Right Grant
- 2003-04-14 SI SI200331110T patent/SI1495018T1/sl unknown
- 2003-04-15 TW TW092108648A patent/TWI343919B/zh not_active IP Right Cessation
2004
- 2004-10-14 IL IL164585A patent/IL164585A/en active IP Right Grant
- 2004-10-14 ZA ZA200408342A patent/ZA200408342B/xx unknown
- 2004-10-15 EC EC2004005368A patent/ECSP045368A/es unknown
- 2004-11-15 NO NO20044963A patent/NO330500B1/no not_active IP Right Cessation
2007
- 2007-04-10 US US11/733,635 patent/US7713999B2/en not_active Expired - Lifetime
- 2007-07-06 US US11/774,358 patent/US20070270439A1/en not_active Abandoned
2008
- 2008-02-07 CY CY20081100152T patent/CY1107184T1/el unknown
- 2008-02-21 RU RU2008106401/04A patent/RU2008106401A/ru not_active Application Discontinuation
2010
- 2010-03-05 JP JP2010049903A patent/JP2010132710A/ja not_active Withdrawn
2011
- 2011-03-30 CY CY20111100338T patent/CY1111363T1/el unknown
2015
- 2015-06-29 LU LU92759C patent/LU92759I2/xx unknown
- 2015-06-29 NL NL300746C patent/NL300746I2/nl unknown
- 2015-07-01 LT LTPA2015027C patent/LTC1495018I2/lt unknown
- 2015-07-03 FR FR15C0047C patent/FR15C0047I2/fr active Active
- 2015-07-09 NO NO2015016C patent/NO2015016I1/no not_active IP Right Cessation
- 2015-07-10 CY CY2015029C patent/CY2015029I2/el unknown

Also Published As

Publication number	Publication date
MY144040A (en)	2011-07-29
CY1111363T1 (el)	2015-08-05
BRPI0309309B1 (pt)	2018-09-04
RU2329264C2 (ru)	2008-07-20
ES2297150T3 (es)	2008-05-01
BRPI0309309B8 (pt)	2021-05-25
DE60317493D1 (en)	2011-01-13
TWI343919B (en)	2011-06-21
NO2015016I1 (no)	2015-07-20
MXPA04010308A (es)	2005-02-03
EP2065384A1 (de)	2009-06-03
US20030216437A1 (en)	2003-11-20
HK1129893A1 (en)	2009-12-11
LTC1495018I2 (lt)	2017-04-10
JP4558331B2 (ja)	2010-10-06
US7304078B2 (en)	2007-12-04
EP1860106A1 (de)	2007-11-28
EP2062890B1 (de)	2011-01-05
NO20044963L (no)	2004-11-15
ES2297150T7 (es)	2012-03-16
IL164585A (en)	2010-11-30
CY1107184T1 (el)	2012-10-24
ES2338171T3 (es)	2010-05-04
CY2015029I1 (el)	2016-04-13
DE60317493T3 (de)	2018-07-12
RU2008106401A (ru)	2009-08-27
IL164585A0 (en)	2005-12-18
PL373332A1 (en)	2005-08-22
TW200404068A (en)	2004-03-16
SI1495018T1 (sl)	2008-04-30
EP1982984A2 (de)	2008-10-22
EP1495018B3 (de)	2011-03-16
PT1495018E (pt)	2008-02-19
FR15C0047I1 (de)	2015-08-28
ES2357876T3 (es)	2011-05-03
EP1495018A1 (de)	2005-01-12
DE60317493T2 (de)	2008-09-18
WO2003089428A1 (en)	2003-10-30
EP2062890A1 (de)	2009-05-27
DK1495018T3 (da)	2008-02-18
US7713999B2 (en)	2010-05-11
NO330500B1 (no)	2011-05-02
EP1982984B1 (de)	2013-02-13
AU2003221932B2 (en)	2007-11-22
US20070179187A1 (en)	2007-08-02
CA2482858C (en)	2010-11-30
PE20040412A1 (es)	2004-07-12
CY2015029I2 (el)	2016-04-13
SI2065384T1 (sl)	2011-05-31
AR039570A1 (es)	2005-02-23
ATE378330T1 (de)	2007-11-15
DE60331114D1 (de)	2010-03-11
AU2003221932A1 (en)	2003-11-03
RU2329264C9 (ru)	2009-04-20
CA2482858A1 (en)	2003-10-30
LU92759I2 (en)	2015-08-31
EP2065384B1 (de)	2011-01-05
NL300746I1 (de)	2016-01-21
EP1860106B1 (de)	2010-01-20
ECSP045368A (es)	2005-01-03
PT2065384E (pt)	2011-03-16
KR20040099441A (ko)	2004-11-26
CN1659162A (zh)	2005-08-24
NZ575139A (en)	2010-08-27
JP2010132710A (ja)	2010-06-17
JP2005528406A (ja)	2005-09-22
RU2004133375A (ru)	2005-07-10
PL214718B1 (pl)	2013-09-30
DK2065384T3 (da)	2011-05-02
NL300746I2 (de)	2016-01-21
EP1982984A3 (de)	2008-10-29
DE60335679D1 (de)	2011-02-17
NZ535880A (en)	2007-11-30
ATE455774T1 (de)	2010-02-15
KR101026929B1 (ko)	2011-04-04
EP1495018B1 (de)	2007-11-14
HK1070887A1 (en)	2005-06-30
SG164279A1 (en)	2010-09-29
HK1123302A1 (en)	2009-06-12
NO2015016I2 (no)	2015-07-09
ATE494284T1 (de)	2011-01-15
FR15C0047I2 (fr)	2016-05-06
CN1659162B (zh)	2011-08-31
BR0309309A (pt)	2005-02-15
US20070270439A1 (en)	2007-11-22

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