ZA200501869B - Liquid stable composition of oxazaphosphorine with mesna - Google Patents

Liquid stable composition of oxazaphosphorine with mesna

Info

Publication number: ZA200501869B
Authority: ZA; South Africa
Prior art keywords: oxazaphosphorine; mesna; cyclodextrin; stable composition; liquid stable
Prior art date: 2002-09-05

Application number

ZA200501869A

Other languages

English (en)

Inventor

Daftary Gautam Vinod

Pai Srikanth Annappa

Rivankar Sangeeta Hanurmesh

Praveen Kumar Subbappa

Original Assignee

Bharat Serums & Vaccines Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-05

Filing date

2005-03-04

Publication date

2007-11-28

2005-03-04 Application filed by Bharat Serums & Vaccines Ltd filed Critical Bharat Serums & Vaccines Ltd

2007-11-28 Publication of ZA200501869B publication Critical patent/ZA200501869B/xx

Links

ZZVDXRCAGGQFAK-UHFFFAOYSA-N 2h-oxazaphosphinine Chemical group N1OC=CC=P1 ZZVDXRCAGGQFAK-UHFFFAOYSA-N 0.000 title abstract 4
229960004635 mesna Drugs 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
XOGTZOOQQBDUSI-UHFFFAOYSA-M Mesna Chemical compound [Na+].[O-]S(=O)(=O)CCS XOGTZOOQQBDUSI-UHFFFAOYSA-M 0.000 title 1
239000007788 liquid Substances 0.000 title 1
ZNEWHQLOPFWXOF-UHFFFAOYSA-N coenzyme M Chemical compound OS(=O)(=O)CCS ZNEWHQLOPFWXOF-UHFFFAOYSA-N 0.000 abstract 4
229920000858 Cyclodextrin Polymers 0.000 abstract 3
239000001116 FEMA 4028 Substances 0.000 abstract 3
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 3
235000011175 beta-cyclodextrine Nutrition 0.000 abstract 3
229960004853 betadex Drugs 0.000 abstract 3
230000000118 anti-neoplastic effect Effects 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 2
HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 abstract 1
229960001101 ifosfamide Drugs 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Detergent Compositions (AREA)

ZA200501869A 2002-09-05 2005-03-04 Liquid stable composition of oxazaphosphorine with mesna ZA200501869B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IN809MU2002		2002-09-05

Publications (1)

Publication Number	Publication Date
ZA200501869B true ZA200501869B (en)	2007-11-28

Family

ID=31503923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200501869A ZA200501869B (en)	2002-09-05	2005-03-04	Liquid stable composition of oxazaphosphorine with mesna

Country Status (16)

Country	Link
US (1)	US20050272698A1 (fr)
EP (1)	EP1396268B1 (fr)
JP (1)	JP2006508917A (fr)
KR (1)	KR101037313B1 (fr)
CN (1)	CN1694713A (fr)
AT (1)	ATE328598T1 (fr)
AU (1)	AU2003276689B2 (fr)
BR (1)	BR0314068A (fr)
CA (1)	CA2497898C (fr)
DE (1)	DE60305813T2 (fr)
EA (1)	EA008776B1 (fr)
ES (1)	ES2266734T3 (fr)
MX (1)	MXPA05002453A (fr)
NZ (1)	NZ538584A (fr)
WO (1)	WO2004022699A2 (fr)
ZA (1)	ZA200501869B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100463678C (zh) *	2002-12-02	2009-02-25	印度血清及疫苗有限公司	用于肠胃外给药的异环磷酰胺组合物及其制备方法
US8093230B2 (en) *	2003-10-01	2012-01-10	Baxter International Inc.	Supersaturated aqueous ifosfamide compositions
DE10346134A1 (de) *	2003-10-01	2005-04-21	Baxter Healthcare Sa	Neue Verwendung, pharmazeutische Zubereitungen sowie Verfahren zu deren Herstellung
EP1799266A2 (fr) *	2004-09-13	2007-06-27	Bharat Serums & Vaccines Ltd.	Compositions d'emulsions stables destinees a l'administration intraveineuse et representant une efficacite de conservation
US20070202077A1 (en) *	2005-12-02	2007-08-30	Brodsky Robert A	Use of High-Dose Oxazaphosphorine Drugs for Treating Immune Disorders
WO2008034074A2 (fr)	2006-09-15	2008-03-20	The Johns Hopkins University	Utilisation de cyclophosphamide à doses élevées en combinaison avec des vaccins anti-idiotypiques dans le traitement anticancéreux
WO2008034076A2 (fr)	2006-09-15	2008-03-20	The Johns Hopkins University	Utilisation de cyclophosphamide à doses élevées en combinaison avec des thérapeutiques d'immunisation dans le traitement anticancer
WO2008034071A2 (fr)	2006-09-15	2008-03-20	The Johns Hopkins University	Procédé d'identification de patients approprié pour un traitement à la cyclophosphamide par de fortes doses
US9026372B2 (en) *	2007-11-21	2015-05-05	Accentia Biopharmaceuticals, Inc.	Methods for providing a system of care for a high-dose oxazaphosphorine drug regimen
WO2009067699A2 (fr) *	2007-11-21	2009-05-28	Accentia Biopharmaceuticals, Inc.	Procédés pour dispenser un système de soin pour un régime à base de médicament de type oxazaphosphorine
WO2016005962A2 (fr)	2014-07-11	2016-01-14	Dr. Reddy’S Laboratories Limited	Formulations liquides stables de cyclophosphamide et procédés associés
US10849916B2 (en)	2014-07-11	2020-12-01	Dr. Reddys Laboratories Limited	Stable liquid formulations of cyclophosphamide and its impurities

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0002495B1 (fr) *	1977-12-14	1984-02-15	Asta-Werke Aktiengesellschaft Chemische Fabrik	Composition à utiliser en thérapie cytostatique
US4727064A (en) *	1984-04-25	1988-02-23	The United States Of America As Represented By The Department Of Health And Human Services	Pharmaceutical preparations containing cyclodextrin derivatives
US6407079B1 (en) *	1985-07-03	2002-06-18	Janssen Pharmaceutica N.V.	Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
DE3722043A1 (de) *	1986-07-11	1988-01-14	Asta Werke Ag Chem Fab	Loesungen von oxazaphosphorinen mit verbesserter stabilitaet und verfahren zu deren herstellung
NO873860L (no) *	1986-10-31	1988-05-02	Asta Pharma Ag	Ifosfamid-lyofilisat og fremgangsmaate til deres fremstilling.
US4879286A (en) *	1987-01-28	1989-11-07	Lyphomed, Inc.	Cyclophosphamide
EP0334083B1 (fr) *	1988-03-19	1991-07-24	ASTA Pharma Aktiengesellschaft	Composition lyophilisée à base de ifosfamide-mesna et procédé pour sa préparation
IE62095B1 (en) *	1988-03-29	1994-12-14	Univ Florida	Pharmaceutical formulations for parenteral use
WO1991004026A1 (fr) *	1989-09-14	1991-04-04	Australian Commercial Research & Development Limited	Compositions de liberation de medicaments
US5227373A (en) *	1991-10-23	1993-07-13	Bristol-Myers Squibb Co.	Lyophilized ifosfamide compositions
US5602112A (en) *	1992-06-19	1997-02-11	Supergen, Inc.	Pharmaceutical formulation
SI9300470A (en) *	1993-09-10	1995-04-30	Lek Tovarna Farmacevtskih	Inclusion complexes of optically active and racemic ibuproxan with cyclodextrin derivates,process for their preparation,pharmaceutical preparations comprising the same and their use
US5919816A (en) *	1994-11-14	1999-07-06	Bionumerik Pharmaceuticals, Inc.	Formulations and methods of reducing toxicity of antineoplastic agents
PL178713B1 (pl) *	1995-03-31	2000-06-30	Centrum Badan Molekularnych I Makromolekularnych Pan	Środek farmaceutyczny o działaniu przeciwnowotworowym
DE19733305A1 (de) *	1997-08-01	1999-02-04	Asta Medica Ag	Pharmazeutische Zusammensetzung enthaltend Ifosfamid und Carnitin
ITMI20011338A1 (it)	2001-06-26	2002-12-26	Farmatron Ltd	Composizioni farmaceutiche orali a rilascio immediato del principio attivo

2003
- 2003-09-04 CA CA2497898A patent/CA2497898C/fr not_active Expired - Fee Related
- 2003-09-04 BR BR0314068-7A patent/BR0314068A/pt not_active IP Right Cessation
- 2003-09-04 WO PCT/IN2003/000298 patent/WO2004022699A2/fr not_active Ceased
- 2003-09-04 US US10/529,273 patent/US20050272698A1/en not_active Abandoned
- 2003-09-04 AU AU2003276689A patent/AU2003276689B2/en not_active Ceased
- 2003-09-04 CN CNA038249308A patent/CN1694713A/zh active Pending
- 2003-09-04 KR KR1020057003863A patent/KR101037313B1/ko not_active Expired - Fee Related
- 2003-09-04 EA EA200500315A patent/EA008776B1/ru not_active IP Right Cessation
- 2003-09-04 MX MXPA05002453A patent/MXPA05002453A/es active IP Right Grant
- 2003-09-04 JP JP2004534021A patent/JP2006508917A/ja active Pending
- 2003-09-04 NZ NZ538584A patent/NZ538584A/en not_active IP Right Cessation
- 2003-09-05 ES ES03255566T patent/ES2266734T3/es not_active Expired - Lifetime
- 2003-09-05 AT AT03255566T patent/ATE328598T1/de not_active IP Right Cessation
- 2003-09-05 EP EP03255566A patent/EP1396268B1/fr not_active Expired - Lifetime
- 2003-09-05 DE DE60305813T patent/DE60305813T2/de not_active Expired - Lifetime
2005
- 2005-03-04 ZA ZA200501869A patent/ZA200501869B/xx unknown

Also Published As

Publication number	Publication date
MXPA05002453A (es)	2005-05-27
CA2497898C (fr)	2012-02-07
WO2004022699A3 (fr)	2005-03-24
CA2497898A1 (fr)	2004-03-18
CN1694713A (zh)	2005-11-09
KR20050057229A (ko)	2005-06-16
EA200500315A1 (ru)	2005-08-25
WO2004022699A2 (fr)	2004-03-18
US20050272698A1 (en)	2005-12-08
AU2003276689A1 (en)	2004-03-29
EP1396268A1 (fr)	2004-03-10
JP2006508917A (ja)	2006-03-16
DE60305813T2 (de)	2007-06-28
KR101037313B1 (ko)	2011-05-26
EP1396268B1 (fr)	2006-06-07
DE60305813D1 (de)	2006-07-20
ES2266734T3 (es)	2007-03-01
AU2003276689B2 (en)	2009-04-09
NZ538584A (en)	2007-05-31
EA008776B1 (ru)	2007-08-31
BR0314068A (pt)	2005-07-05
ATE328598T1 (de)	2006-06-15

Publication	Publication Date	Title
ZA200501869B (en)	2007-11-28	Liquid stable composition of oxazaphosphorine with mesna
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BR0010242A (pt)	2002-02-19	Composições quìmicas que atraem artrópodes
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BRPI0415034A (pt)	2006-12-12	derivados de aminopiridina como inibidores de não-sintase induzìveis
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