ZA200601803B - FSH glycosylation mutant - Google Patents

FSH glycosylation mutant Download PDF

Info

Publication number: ZA200601803B
Authority: ZA; South Africa
Prior art keywords: fsh; mutant; subunit; vector; mutants
Prior art date: 2003-09-02

Application number

ZA200601803A

Other languages

English (en)

Inventor

Louise M Garone

Stephen J Arkinstall

William H Brondyk

Robert K Campbell

Jiang Xuliang

Sean D Mckenna

Tepper Mark

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-02

Filing date

2004-09-02

Publication date

2007-05-30

2004-09-02 Application filed by Applied Research Systems filed Critical Applied Research Systems

2007-05-30 Publication of ZA200601803B publication Critical patent/ZA200601803B/en

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238000001254 matrix assisted laser desorption--ionisation time-of-flight mass spectrum Methods 0.000 description 1
229960000485 methotrexate Drugs 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
238000002703 mutagenesis Methods 0.000 description 1
231100000350 mutagenesis Toxicity 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
210000000287 oocyte Anatomy 0.000 description 1
230000002611 ovarian Effects 0.000 description 1
239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
230000001817 pituitary effect Effects 0.000 description 1
230000008488 polyadenylation Effects 0.000 description 1
229920002981 polyvinylidene fluoride Polymers 0.000 description 1
230000001323 posttranslational effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
238000002731 protein assay Methods 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
230000012846 protein folding Effects 0.000 description 1
238000012797 qualification Methods 0.000 description 1
238000011002 quantification Methods 0.000 description 1
239000002287 radioligand Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000003362 replicative effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000012216 screening Methods 0.000 description 1
238000002864 sequence alignment Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000004017 serum-free culture medium Substances 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
238000010563 solid-state fermentation Methods 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
230000021595 spermatogenesis Effects 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
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230000002194 synthesizing effect Effects 0.000 description 1
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229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
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210000002700 urine Anatomy 0.000 description 1
230000035899 viability Effects 0.000 description 1
239000013603 viral vector Substances 0.000 description 1
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230000004584 weight gain Effects 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1
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108010055450 with HCG C-terminal peptide human follicle stimulating hormone Proteins 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Reproductive Health (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ZA200601803A 2003-09-02 2004-09-02 FSH glycosylation mutant ZA200601803B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US49980203P	2003-09-02	2003-09-02

Publications (1)

Publication Number	Publication Date
ZA200601803B true ZA200601803B (en)	2007-05-30

Family

ID=34272871

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200601803A ZA200601803B (en)	2003-09-02	2004-09-02	FSH glycosylation mutant

Country Status (23)

Country	Link
US (1)	US7700112B2 (pt)
EP (1)	EP1694271B1 (pt)
JP (1)	JP4653090B2 (pt)
KR (1)	KR101099809B1 (pt)
CN (1)	CN1984926B (pt)
AT (1)	ATE511829T1 (pt)
AU (1)	AU2004268683B2 (pt)
BR (1)	BRPI0413206A (pt)
CA (1)	CA2535522A1 (pt)
CY (1)	CY1112439T1 (pt)
DK (1)	DK1694271T3 (pt)
EA (1)	EA012175B1 (pt)
ES (1)	ES2367784T3 (pt)
HR (1)	HRP20110430T1 (pt)
IL (1)	IL174037A0 (pt)
MX (1)	MXPA06002119A (pt)
NO (1)	NO20061446L (pt)
PL (1)	PL1694271T3 (pt)
PT (1)	PT1694271E (pt)
SI (1)	SI1694271T1 (pt)
UA (1)	UA88879C2 (pt)
WO (1)	WO2005020934A2 (pt)
ZA (1)	ZA200601803B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007022799A1 (en)	2005-08-26	2007-03-01	Ares Trading S.A.	Process for the preparation of glycosylated interferon beta
EP1960419B1 (en)	2005-12-09	2016-03-16	Ares Trading S.A.	Method for purifying fsh or a fsh mutant
BRPI0620223A2 (pt) *	2005-12-22	2011-11-01	Serono Lab	mutantes de fsh
PL1981908T3 (pl) *	2006-01-17	2011-04-29	Merck Serono Sa	Nowe D3N warianty glikolizacji FSH
CN103399155A (zh) *	2007-03-26	2013-11-20	诺瓦提斯公司	用于监测肾功能的预测性的肾安全性生物标志物和生物标志物标签
AR081755A1 (es)	2010-04-02	2012-10-17	Hanmi Holdings Co Ltd	Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo
CN108676096B (zh) *	2018-05-22	2022-03-29	北京伟杰信生物科技有限公司	重组猪fsh-ctp融合蛋白及其制备方法与应用
WO2021092358A1 (en) *	2019-11-06	2021-05-14	The Regents Of The University Of Colorado, A Body Corporate	Modified follicle-stimulating hormone and methods of using the same
CN114213523B (zh) *	2021-11-15	2024-07-09	广州源博医药科技有限公司	一种用于重组蛋白的高糖基化修饰序列及其重组猪促卵泡激素和应用

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4923805A (en)	1983-11-02	1990-05-08	Integrated Genetics, Inc.	Fsh
US5639639A (en)	1983-11-02	1997-06-17	Genzyme Corporation	Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US4840896A (en)	1983-11-02	1989-06-20	Integrated Genetics, Inc.	Heteropolymeric protein
US5156957A (en)	1983-11-02	1992-10-20	Genzyme Corporation	Follicle stimulating hormone
US4845077A (en)	1984-04-03	1989-07-04	Serono Laboratories, Inc.	Method of inducing ovulation
US4589402A (en)	1984-07-26	1986-05-20	Serono Laboratories, Inc.	Method of in vitro fertilization
US5338835A (en)	1989-02-21	1994-08-16	Washington University	CTP-extended form of FSH
JP3045539B2 (ja)	1989-02-21	2000-05-29	ワシントンユニバーシティ	改変型生殖ホルモン
US5508261A (en)	1991-06-18	1996-04-16	University Of Medicine & Dentistry Of New Jersey	Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
US6407205B1 (en)	1997-06-04	2002-06-18	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	FSH-releasing peptides
ATE302018T1 (de) *	1997-06-20	2005-09-15	Akzo Nobel Nv	Gonadotropin releasing hormon antagonist
US6235755B1 (en)	1998-08-07	2001-05-22	Applied Research Systems Ars Holding N.A.	FSH mimetics for the treatment of infertility
CA2397680A1 (en)	2000-01-27	2001-08-02	Applied Research Systems Ars Holding N.V.	Use of fsh for treating infertility
US20020127652A1 (en) *	2000-02-11	2002-09-12	Schambye Hans Thalsgard	Follicle stimulating hormones
WO2001058493A1 (en) *	2000-02-11	2001-08-16	Maxygen Aps	Conjugates of follicle stimulating hormones
JP4310275B2 (ja)	2001-10-22	2009-08-05	アプライドリサーチシステムズアースホールディングエヌ．ヴィ．	変異体糖タンパク質

2004
- 2004-02-09 UA UAA200603350A patent/UA88879C2/ru unknown
- 2004-09-02 EA EA200600526A patent/EA012175B1/ru not_active IP Right Cessation
- 2004-09-02 MX MXPA06002119A patent/MXPA06002119A/es active IP Right Grant
- 2004-09-02 KR KR1020067004084A patent/KR101099809B1/ko not_active Expired - Fee Related
- 2004-09-02 ES ES04783331T patent/ES2367784T3/es not_active Expired - Lifetime
- 2004-09-02 BR BRPI0413206-8A patent/BRPI0413206A/pt not_active IP Right Cessation
- 2004-09-02 DK DK04783331.4T patent/DK1694271T3/da active
- 2004-09-02 US US10/934,707 patent/US7700112B2/en not_active Expired - Fee Related
- 2004-09-02 PL PL04783331T patent/PL1694271T3/pl unknown
- 2004-09-02 HR HR20110430T patent/HRP20110430T1/hr unknown
- 2004-09-02 ZA ZA200601803A patent/ZA200601803B/en unknown
- 2004-09-02 AT AT04783331T patent/ATE511829T1/de active
- 2004-09-02 EP EP04783331A patent/EP1694271B1/en not_active Expired - Lifetime
- 2004-09-02 SI SI200431701T patent/SI1694271T1/sl unknown
- 2004-09-02 CA CA002535522A patent/CA2535522A1/en not_active Abandoned
- 2004-09-02 CN CN2004800326655A patent/CN1984926B/zh not_active Expired - Fee Related
- 2004-09-02 JP JP2006525513A patent/JP4653090B2/ja not_active Expired - Fee Related
- 2004-09-02 PT PT04783331T patent/PT1694271E/pt unknown
- 2004-09-02 AU AU2004268683A patent/AU2004268683B2/en not_active Ceased
- 2004-09-02 WO PCT/US2004/029042 patent/WO2005020934A2/en not_active Ceased
2006
- 2006-03-01 IL IL174037A patent/IL174037A0/en unknown
- 2006-03-30 NO NO20061446A patent/NO20061446L/no not_active Application Discontinuation
2011
- 2011-07-19 CY CY20111100704T patent/CY1112439T1/el unknown

Also Published As

Publication number	Publication date
AU2004268683B2 (en)	2010-06-24
EA012175B1 (ru)	2009-08-28
WO2005020934A3 (en)	2007-02-15
HRP20110430T1 (hr)	2011-07-31
WO2005020934A2 (en)	2005-03-10
KR20070029620A (ko)	2007-03-14
MXPA06002119A (es)	2006-05-31
AU2004268683A2 (en)	2005-03-10
EP1694271B1 (en)	2011-06-08
DK1694271T3 (da)	2011-09-12
HK1101315A1 (en)	2007-10-12
KR101099809B1 (ko)	2011-12-27
CN1984926B (zh)	2012-04-11
CY1112439T1 (el)	2015-12-09
SI1694271T1 (sl)	2011-08-31
ATE511829T1 (de)	2011-06-15
UA88879C2 (en)	2009-12-10
NO20061446L (no)	2006-03-30
JP4653090B2 (ja)	2011-03-16
BRPI0413206A (pt)	2006-10-03
US20050100989A1 (en)	2005-05-12
EP1694271A2 (en)	2006-08-30
CN1984926A (zh)	2007-06-20
AU2004268683A1 (en)	2005-03-10
US7700112B2 (en)	2010-04-20
ES2367784T3 (es)	2011-11-08
IL174037A0 (en)	2006-08-01
JP2007508245A (ja)	2007-04-05
CA2535522A1 (en)	2005-03-10
PT1694271E (pt)	2011-07-07
PL1694271T3 (pl)	2011-11-30
EA200600526A1 (ru)	2007-04-27

Publication	Publication Date	Title
AU2004268683B2 (en)	2010-06-24	FSH glycosylation mutant
AU2007207697B2 (en)	2012-01-19	Novel FSH glycosylation variant D3N
IL192096A (en)	2012-02-29	Nucleic acid encoding fsh mutant, its preparation and pharmaceutical compositions containing it
US7317095B2 (en)	2008-01-08	Mutant glycoproteins
Roth	1993	Garone et al.(45) Date of Patent: Apr. 20, 2010
HK1101315B (en)	2012-09-28	Fsh glycosylation mutant