ZA200603435B - Nucleic acids specifically binding bioactive ghrelin - Google Patents

Nucleic acids specifically binding bioactive ghrelin Download PDF

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Publication number
ZA200603435B
ZA200603435B ZA200603435A ZA200603435A ZA200603435B ZA 200603435 B ZA200603435 B ZA 200603435B ZA 200603435 A ZA200603435 A ZA 200603435A ZA 200603435 A ZA200603435 A ZA 200603435A ZA 200603435 B ZA200603435 B ZA 200603435B
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South Africa
Prior art keywords
ghrelin
nucleic acid
bioactive
detection
nucleic
Prior art date
Application number
ZA200603435A
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English (en)
Inventor
Klussmann Sven
Helmling Steffen
Eulberg Dirk
Maasch Christian
Buchner Klaus
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Noxxon Pharma Ag
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Publication date
Application filed by Noxxon Pharma Ag filed Critical Noxxon Pharma Ag
Publication of ZA200603435B publication Critical patent/ZA200603435B/en

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

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ZA200603435A 2003-11-10 2006-05-02 Nucleic acids specifically binding bioactive ghrelin ZA200603435B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025743 2003-11-10

Publications (1)

Publication Number Publication Date
ZA200603435B true ZA200603435B (en) 2007-06-27

Family

ID=34610046

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200603435A ZA200603435B (en) 2003-11-10 2006-05-02 Nucleic acids specifically binding bioactive ghrelin

Country Status (19)

Country Link
US (2) US20070031840A1 (cs)
EP (1) EP1682662A1 (cs)
JP (1) JP4823067B2 (cs)
KR (1) KR20060125743A (cs)
CN (1) CN1894407A (cs)
AP (1) AP2006003618A0 (cs)
AU (1) AU2004291656A1 (cs)
BR (1) BRPI0415872A (cs)
CA (1) CA2544805A1 (cs)
CR (1) CR8388A (cs)
EA (1) EA009376B1 (cs)
EC (1) ECSP066559A (cs)
IL (1) IL175443A0 (cs)
MA (1) MA28153A1 (cs)
NO (1) NO20062663L (cs)
OA (1) OA13282A (cs)
TN (1) TNSN06132A1 (cs)
WO (1) WO2005049828A1 (cs)
ZA (1) ZA200603435B (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7750140B2 (en) * 2002-08-01 2010-07-06 Noxxon Pharma Ag Ghrelin binding nucleic acids
EP2290071B1 (en) 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
CA2857881A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
AR052741A1 (es) * 2005-04-08 2007-03-28 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin
WO2008036765A2 (en) * 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
JP2010510964A (ja) * 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路
DK2104737T3 (da) * 2006-12-08 2013-05-27 Asuragen Inc Funktioner og formål for let-7 mikro-RNAer
WO2008073915A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Micrornas differentially expressed in leukemia and uses thereof
WO2008073920A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-21 regulated genes and pathways as targets for therapeutic intervention
CA2671270A1 (en) * 2006-12-29 2008-07-17 Asuragen, Inc. Mir-16 regulated genes and pathways as targets for therapeutic intervention
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
JP2010529966A (ja) * 2007-06-08 2010-09-02 アシュラジェン インコーポレイテッド 治療的介入の標的としてmiR−34によって調節される遺伝子および経路
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US20090186015A1 (en) * 2007-10-18 2009-07-23 Latham Gary J Micrornas differentially expressed in lung diseases and uses thereof
US8071562B2 (en) * 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
WO2009086156A2 (en) * 2007-12-21 2009-07-09 Asuragen, Inc. Mir-10 regulated genes and pathways as targets for therapeutic intervention
US20090263803A1 (en) * 2008-02-08 2009-10-22 Sylvie Beaudenon Mirnas differentially expressed in lymph nodes from cancer patients
EP2268832A2 (en) * 2008-03-06 2011-01-05 Asuragen, INC. Microrna markers for recurrence of colorectal cancer
EP2271757A2 (en) * 2008-03-26 2011-01-12 Asuragen, INC. Compositions and methods related to mir-16 and therapy of prostate cancer
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
EP2493910A1 (en) 2009-10-30 2012-09-05 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same
AU2012206750A1 (en) * 2011-01-10 2013-07-18 Noxxon Pharma Ag Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease

Family Cites Families (9)

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US5614395A (en) * 1988-03-08 1997-03-25 Ciba-Geigy Corporation Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
EP0786469B1 (en) * 1990-06-11 2006-03-01 Gilead Sciences, Inc. Methods of use of nucleic acid ligands
JPH11505527A (ja) * 1995-05-03 1999-05-21 ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ 鏡像異性体リガンドの同定
US5780221A (en) * 1995-05-03 1998-07-14 Whitehead Institute For Biomedical Research Identification of enantiomeric ligands
US20030211967A1 (en) * 2001-05-07 2003-11-13 Bryant Henry Uhlman Method for selectively inhibiting ghrelin action
AU2001259056A1 (en) * 2000-05-17 2001-11-26 Eli Lilly And Company Method for selectively inhibiting ghrelin action
CA2411667A1 (en) * 2000-05-30 2001-12-06 Merck & Co. Inc. Ghrelin analogs
US7750140B2 (en) * 2002-08-01 2010-07-06 Noxxon Pharma Ag Ghrelin binding nucleic acids
AR052741A1 (es) * 2005-04-08 2007-03-28 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin

Also Published As

Publication number Publication date
AP2006003618A0 (en) 2006-06-30
JP4823067B2 (ja) 2011-11-24
KR20060125743A (ko) 2006-12-06
BRPI0415872A (pt) 2007-01-09
EP1682662A1 (en) 2006-07-26
AU2004291656A1 (en) 2005-06-02
WO2005049828A1 (en) 2005-06-02
CR8388A (es) 2006-10-17
JP2007513608A (ja) 2007-05-31
US20070031840A1 (en) 2007-02-08
CA2544805A1 (en) 2005-06-02
OA13282A (en) 2007-01-31
ECSP066559A (cs) 2006-11-24
TNSN06132A1 (fr) 2007-11-15
US20100261291A1 (en) 2010-10-14
NO20062663L (no) 2006-08-09
EA200600735A1 (ru) 2006-10-27
MA28153A1 (fr) 2006-09-01
CN1894407A (zh) 2007-01-10
EA009376B1 (ru) 2007-12-28
IL175443A0 (en) 2006-09-05

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