ZA200610272B - Replacement of nucleus pulposus using a hydrogel - Google Patents

Replacement of nucleus pulposus using a hydrogel Download PDF

Info

Publication number: ZA200610272B
Authority: ZA; South Africa
Prior art keywords: hydrogel; prosthesis; sectional area; principal; cross
Prior art date: 2004-05-21

Application number

ZA200610272A

Other languages

English (en)

Inventor

Vresilovic Edward

Michael F Keane

Alastair J T Clemow

Nigel G Smith

Original Assignee

Synthes Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-21

Filing date

2005-05-23

Publication date

2008-07-30

2005-05-23 Application filed by Synthes Gmbh filed Critical Synthes Gmbh

2008-07-30 Publication of ZA200610272B publication Critical patent/ZA200610272B/en

Links

239000000017 hydrogel Substances 0.000 title claims description 127
238000003780 insertion Methods 0.000 claims description 30
230000037431 insertion Effects 0.000 claims description 30
239000000463 material Substances 0.000 claims description 17
239000007787 solid Substances 0.000 claims description 9
229920002451 polyvinyl alcohol Polymers 0.000 claims description 7
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 6
238000001125 extrusion Methods 0.000 claims description 6
239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
-1 poly(vinyl alcohol) Polymers 0.000 claims description 5
229920001577 copolymer Polymers 0.000 claims description 3
239000000203 mixture Substances 0.000 claims description 3
238000000465 moulding Methods 0.000 claims description 2
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims 2
239000007943 implant Substances 0.000 description 43
238000000034 method Methods 0.000 description 30
238000002513 implantation Methods 0.000 description 22
238000012360 testing method Methods 0.000 description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
239000007864 aqueous solution Substances 0.000 description 8
239000000243 solution Substances 0.000 description 7
239000012530 fluid Substances 0.000 description 6
230000036571 hydration Effects 0.000 description 6
238000006703 hydration reaction Methods 0.000 description 6
230000003204 osmotic effect Effects 0.000 description 6
229920000642 polymer Polymers 0.000 description 6
238000013461 design Methods 0.000 description 5
230000033001 locomotion Effects 0.000 description 5
230000001502 supplementing effect Effects 0.000 description 5
229920002307 Dextran Polymers 0.000 description 4
230000007850 degeneration Effects 0.000 description 4
239000000644 isotonic solution Substances 0.000 description 4
230000035882 stress Effects 0.000 description 4
208000008035 Back Pain Diseases 0.000 description 3
239000011324 bead Substances 0.000 description 3
230000008901 benefit Effects 0.000 description 3
230000008859 change Effects 0.000 description 3
238000012669 compression test Methods 0.000 description 3
230000000887 hydrating effect Effects 0.000 description 3
208000014674 injury Diseases 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
238000003860 storage Methods 0.000 description 3
239000013589 supplement Substances 0.000 description 3
238000001356 surgical procedure Methods 0.000 description 3
238000009864 tensile test Methods 0.000 description 3
208000002193 Pain Diseases 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
238000007906 compression Methods 0.000 description 2
230000006835 compression Effects 0.000 description 2
230000008878 coupling Effects 0.000 description 2
238000010168 coupling process Methods 0.000 description 2
238000005859 coupling reaction Methods 0.000 description 2
230000006378 damage Effects 0.000 description 2
238000006073 displacement reaction Methods 0.000 description 2
239000000499 gel Substances 0.000 description 2
238000005259 measurement Methods 0.000 description 2
230000036316 preload Effects 0.000 description 2
208000032766 Device expulsion Diseases 0.000 description 1
206010016654 Fibrosis Diseases 0.000 description 1
206010061246 Intervertebral disc degeneration Diseases 0.000 description 1
208000008930 Low Back Pain Diseases 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
229920003072 Plasdone™ povidone Polymers 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
230000032683 aging Effects 0.000 description 1
210000003484 anatomy Anatomy 0.000 description 1
238000013459 approach Methods 0.000 description 1
230000003416 augmentation Effects 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
238000000748 compression moulding Methods 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
230000007547 defect Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000009661 fatigue test Methods 0.000 description 1
230000004761 fibrosis Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
230000004927 fusion Effects 0.000 description 1
229920006158 high molecular weight polymer Polymers 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
238000001746 injection moulding Methods 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
238000012977 invasive surgical procedure Methods 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
238000011326 mechanical measurement Methods 0.000 description 1
239000002184 metal Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
238000012354 overpressurization Methods 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
230000037081 physical activity Effects 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
230000008569 process Effects 0.000 description 1
239000000047 product Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
230000009469 supplementation Effects 0.000 description 1
238000011477 surgical intervention Methods 0.000 description 1
230000008733 trauma Effects 0.000 description 1
238000012800 visualization Methods 0.000 description 1
239000011800 void material Substances 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools for implanting artificial joints
- A61F2/4603—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4611—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3468—Trocars; Puncturing needles for implanting or removing devices, e.g. prostheses, implants, seeds, wires
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3472—Trocars; Puncturing needles for bones, e.g. intraosseus injections
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/3008—Properties of materials and coating materials radio-opaque, e.g. radio-opaque markers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30242—Three-dimensional shapes spherical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2002/4495—Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools for implanting artificial joints
- A61F2/4603—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2002/4625—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use
- A61F2002/4627—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0071—Three-dimensional shapes spherical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Landscapes

Health & Medical Sciences (AREA)
Transplantation (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Orthopedic Medicine & Surgery (AREA)
Oral & Maxillofacial Surgery (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Dispersion Chemistry (AREA)
Prostheses (AREA)
Materials For Medical Uses (AREA)
Absorbent Articles And Supports Therefor (AREA)
Colloid Chemistry (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)

ZA200610272A 2004-05-21 2005-05-23 Replacement of nucleus pulposus using a hydrogel ZA200610272B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57276404P	2004-05-21	2004-05-21

Publications (1)

Publication Number	Publication Date
ZA200610272B true ZA200610272B (en)	2008-07-30

Family

ID=35149030

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200610272A ZA200610272B (en)	2004-05-21	2005-05-23	Replacement of nucleus pulposus using a hydrogel

Country Status (13)

Country	Link
US (3)	US20060100304A1 (de)
EP (1)	EP1778309B1 (de)
JP (1)	JP2008500145A (de)
KR (1)	KR101166178B1 (de)
CN (1)	CN101043909B (de)
AT (1)	ATE488258T1 (de)
AU (1)	AU2005245017A1 (de)
BR (1)	BRPI0511422A (de)
CA (1)	CA2567707C (de)
DE (1)	DE602005024815D1 (de)
NZ (1)	NZ551913A (de)
WO (1)	WO2005113032A2 (de)
ZA (1)	ZA200610272B (de)

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WO2004100841A1 (en)	1999-08-18	2004-11-25	Intrinsic Therapeutics, Inc.	Devices and method for augmenting a vertebral disc nucleus
US7717961B2 (en) *	1999-08-18	2010-05-18	Intrinsic Therapeutics, Inc.	Apparatus delivery in an intervertebral disc
US6723335B1 (en) *	2000-04-07	2004-04-20	Jeffrey William Moehlenbruck	Methods and compositions for treating intervertebral disc degeneration
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WO2004019815A2 (en) *	2002-08-27	2004-03-11	Sdgi Holdings, Inc.	Systems and methods for intravertebral reduction
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US7744651B2 (en)	2002-09-18	2010-06-29	Warsaw Orthopedic, Inc	Compositions and methods for treating intervertebral discs with collagen-based materials
EP1562524A4 (de) *	2002-11-05	2010-12-22	Spineology Inc	Semibiologisches bandscheiben-ersatzsystem
CN100394989C (zh)	2002-11-15	2008-06-18	华沙整形外科股份有限公司	包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节
WO2004069296A1 (en) *	2003-01-31	2004-08-19	Zimmer Orthobiologics Inc.	Hydrogel compositions comprising nucleus pulposus tissue
WO2005077013A2 (en) *	2004-02-06	2005-08-25	Georgia Tech Research Corporation	Surface directed cellular attachment
EP1729678A4 (de)	2004-02-06	2011-08-10	Georgia Tech Res Inst	Lasttragende biokompatible vorrichtung
KR20070056079A (ko) *	2004-07-27	2007-05-31	신세스 게엠바하	추간판 내 수핵의 보충 또는 교체
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ATE464076T1 (de)	2005-08-26	2010-04-15	Synthes Gmbh	Hydrogel-ballonprothese für nucleus pulposus
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US8241362B2 (en) *	2007-04-26	2012-08-14	Voorhies Rand M	Lumbar disc replacement implant for posterior implantation with dynamic spinal stabilization device and method
CN101686846B (zh)	2007-06-29	2011-09-14	新特斯有限责任公司	柔性链植入物和器械
US20110196492A1 (en) *	2007-09-07	2011-08-11	Intrinsic Therapeutics, Inc.	Bone anchoring systems
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- 2005-05-23 AU AU2005245017A patent/AU2005245017A1/en not_active Abandoned
- 2005-05-23 JP JP2007527545A patent/JP2008500145A/ja active Pending
- 2005-05-23 KR KR1020067026885A patent/KR101166178B1/ko not_active Expired - Fee Related
- 2005-05-23 US US11/134,309 patent/US20060100304A1/en not_active Abandoned
- 2005-05-23 AT AT05753226T patent/ATE488258T1/de not_active IP Right Cessation
- 2005-05-23 NZ NZ551913A patent/NZ551913A/en unknown
- 2005-05-23 BR BRPI0511422-5A patent/BRPI0511422A/pt not_active Application Discontinuation
- 2005-05-23 EP EP05753226A patent/EP1778309B1/de not_active Expired - Lifetime
- 2005-05-23 CA CA2567707A patent/CA2567707C/en not_active Expired - Fee Related
- 2005-05-23 DE DE602005024815T patent/DE602005024815D1/de not_active Expired - Lifetime
- 2005-05-23 ZA ZA200610272A patent/ZA200610272B/en unknown
- 2005-05-23 CN CN2005800242635A patent/CN101043909B/zh not_active Expired - Fee Related
- 2005-05-23 WO PCT/US2005/018028 patent/WO2005113032A2/en not_active Ceased
2009
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2012
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Also Published As

Publication number	Publication date
NZ551913A (en)	2009-11-27
CN101043909B (zh)	2011-01-12
US20060100304A1 (en)	2006-05-11
KR20070061771A (ko)	2007-06-14
EP1778309B1 (de)	2010-11-17
CA2567707C (en)	2013-01-29
CN101043909A (zh)	2007-09-26
JP2008500145A (ja)	2008-01-10
AU2005245017A1 (en)	2005-12-01
US8118874B2 (en)	2012-02-21
ATE488258T1 (de)	2010-12-15
WO2005113032A2 (en)	2005-12-01
EP1778309A2 (de)	2007-05-02
US20100016907A1 (en)	2010-01-21
CA2567707A1 (en)	2005-12-01
DE602005024815D1 (de)	2010-12-30
BRPI0511422A (pt)	2007-12-11
US20120143338A1 (en)	2012-06-07
WO2005113032A3 (en)	2006-05-04
KR101166178B1 (ko)	2012-07-18

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