ZA200610302B - Substituted quinazolones as anti-cancer agents - Google Patents
Substituted quinazolones as anti-cancer agentsInfo
- Publication number
- ZA200610302B ZA200610302B ZA200610302A ZA200610302A ZA200610302B ZA 200610302 B ZA200610302 B ZA 200610302B ZA 200610302 A ZA200610302 A ZA 200610302A ZA 200610302 A ZA200610302 A ZA 200610302A ZA 200610302 B ZA200610302 B ZA 200610302B
- Authority
- ZA
- South Africa
- Prior art keywords
- cancer agents
- quinazolones
- substituted
- substituted quinazolones
- cancer
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57926504P | 2004-06-15 | 2004-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200610302B true ZA200610302B (en) | 2008-10-29 |
Family
ID=34970483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200610302A ZA200610302B (en) | 2004-06-15 | 2006-12-08 | Substituted quinazolones as anti-cancer agents |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080275022A1 (pt) |
| EP (1) | EP1761506A1 (pt) |
| JP (1) | JP2008502666A (pt) |
| KR (1) | KR20070028536A (pt) |
| CN (1) | CN101001845A (pt) |
| AU (1) | AU2005254771A1 (pt) |
| BR (1) | BRPI0512075A (pt) |
| CA (1) | CA2568756A1 (pt) |
| IL (1) | IL179580A0 (pt) |
| MX (1) | MXPA06014696A (pt) |
| NO (1) | NO20070199L (pt) |
| WO (1) | WO2005123696A1 (pt) |
| ZA (1) | ZA200610302B (pt) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU0500126D0 (en) * | 2005-01-26 | 2005-04-28 | Sanofi Aventis | New compounds and process for their preparation |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| JP2009520784A (ja) * | 2005-12-22 | 2009-05-28 | アストラゼネカ アクチボラグ | キナゾリン誘導体、その製造方法および抗癌剤としてのその使用 |
| CN101421253A (zh) * | 2006-04-18 | 2009-04-29 | 阿斯利康(瑞典)有限公司 | 喹唑啉-4-酮衍生物、其制备方法及含有它们的药用组合物 |
| US7834023B2 (en) * | 2006-09-20 | 2010-11-16 | Portola Pharmaceuticals, Inc. | Substituted dihydroquinazolines as platelet ADP receptor inhibitors |
| CN101535304A (zh) | 2006-09-21 | 2009-09-16 | 埃迪威克斯生物科学公司 | 丝氨酸水解酶抑制剂 |
| SG158147A1 (en) | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
| KR100871128B1 (ko) * | 2007-04-17 | 2008-12-03 | 한국생명공학연구원 | 4-헥사데카노일-1,1-디메틸-피페라진-1-윰 아이오다이드를포함하는 항암제 |
| ES2523925T3 (es) * | 2007-09-26 | 2014-12-02 | Celgene Corporation | Derivados de quinazolinona sustituidos en posición 6, 7 u 8 y composiciones que los contienen y métodos de uso de los mismos |
| WO2013109142A1 (en) | 2012-01-16 | 2013-07-25 | Stichting Het Nederlands Kanker Instituut | Combined pdk and mapk/erk pathway inhibition in neoplasia |
| TW201441216A (zh) | 2012-12-21 | 2014-11-01 | Gilead Calistoga Llc | 肌醇磷酯３－激酶的抑制劑 |
| AU2013364070B2 (en) | 2012-12-21 | 2016-10-27 | Gilead Calistoga Llc | Isoquinolinone or quinazolinone phosphatidylinositol 3-kinase inhibitors |
| US9242969B2 (en) * | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| TR201806822T4 (tr) | 2013-06-14 | 2018-06-21 | Gilead Calistoga Llc | Fosfatidilinositol 3-kinaz inhibitörleri. |
| EP3046557A1 (en) | 2013-09-20 | 2016-07-27 | Stichting Het Nederlands Kanker Instituut | Rock in combination with mapk-pathway |
| WO2015041534A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk in combination with raf/erk/mek |
| US20170027940A1 (en) | 2014-04-10 | 2017-02-02 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
| WO2015178770A1 (en) | 2014-05-19 | 2015-11-26 | Stichting Het Nederlands Kanker Instituut | Compositions for cancer treatment |
| WO2016038582A1 (en) * | 2014-09-12 | 2016-03-17 | Novartis Ag | Compounds and compositions as raf kinase inhibitors |
| ES2892624T3 (es) * | 2015-12-18 | 2022-02-04 | Novartis Ag | Compuestos tricíclicos y composiciones como inhibidores de cinasas |
| KR101789430B1 (ko) | 2016-06-28 | 2017-10-25 | 동국대학교 산학협력단 | Smo 저해 활성을 갖는 신규 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 조성물 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| CN113603707B (zh) * | 2016-12-12 | 2023-03-31 | 石药集团中奇制药技术（石家庄）有限公司 | 一类含有三环杂芳基的化合物 |
| WO2019063708A1 (en) * | 2017-09-29 | 2019-04-04 | Bayer Aktiengesellschaft | SUBSTITUTED 3-PHENYLQUINAZOLIN-4 (3H) -ONES AND USES THEREOF |
| AR112840A1 (es) * | 2017-09-29 | 2019-12-18 | Bayer Ag | 3- fenilquinazolin-4(3h)-onas sustituidas y sus usos |
| KR102041376B1 (ko) * | 2018-04-10 | 2019-11-06 | 고려대학교 산학협력단 | 1-(4-(3-클로로-4(3-플루오로벤질옥시)페닐아미노)퀴나졸린-6-일)유레아를 포함하는 대장암 예방 또는 치료용 조성물 |
| EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CN110327344A (zh) * | 2019-06-12 | 2019-10-15 | 徐州医科大学 | 喹唑啉酮类化合物在制备与肿瘤有关药物方面的应用 |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| JP2025540768A (ja) * | 2022-11-30 | 2025-12-16 | ヘルムホルツ・ツェントルム・ミュンヘン・ドイチェス・フォーシュンクスツェントルム・フュア・ゲズントハイト・ウント・ウンベルト・ゲーエムベーハー | 新規抗がん治療としての３－フェニルキノアゾリノン類 |
| WO2025073765A1 (en) | 2023-10-03 | 2025-04-10 | Institut National de la Santé et de la Recherche Médicale | Methods of prognosis and treatment of patients suffering from melanoma |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000055153A1 (en) * | 1999-03-17 | 2000-09-21 | Astrazeneca Ab | Amide derivatives |
| AU4556800A (en) * | 1999-04-27 | 2000-11-10 | Smithkline Beecham Plc | Novel treatment |
| AU2002249275A1 (en) * | 2002-03-08 | 2003-09-22 | Warner-Lambert Company Llc | Oxo azabicyclic compounds |
| ATE447404T1 (de) * | 2002-03-29 | 2009-11-15 | Novartis Vaccines & Diagnostic | Substituierte benzazole und ihre verwendung als raf-kinase-hemmer |
-
2005
- 2005-06-14 CA CA002568756A patent/CA2568756A1/en not_active Abandoned
- 2005-06-14 US US11/569,918 patent/US20080275022A1/en not_active Abandoned
- 2005-06-14 CN CNA2005800274176A patent/CN101001845A/zh active Pending
- 2005-06-14 JP JP2007516027A patent/JP2008502666A/ja active Pending
- 2005-06-14 MX MXPA06014696A patent/MXPA06014696A/es not_active Application Discontinuation
- 2005-06-14 BR BRPI0512075-6A patent/BRPI0512075A/pt not_active Application Discontinuation
- 2005-06-14 WO PCT/GB2005/002327 patent/WO2005123696A1/en not_active Ceased
- 2005-06-14 KR KR1020077000950A patent/KR20070028536A/ko not_active Withdrawn
- 2005-06-14 AU AU2005254771A patent/AU2005254771A1/en not_active Abandoned
- 2005-06-14 EP EP05752424A patent/EP1761506A1/en not_active Withdrawn
-
2006
- 2006-11-26 IL IL179580A patent/IL179580A0/en unknown
- 2006-12-08 ZA ZA200610302A patent/ZA200610302B/xx unknown
-
2007
- 2007-01-11 NO NO20070199A patent/NO20070199L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101001845A (zh) | 2007-07-18 |
| JP2008502666A (ja) | 2008-01-31 |
| NO20070199L (no) | 2007-01-11 |
| WO2005123696A1 (en) | 2005-12-29 |
| AU2005254771A1 (en) | 2005-12-29 |
| CA2568756A1 (en) | 2005-12-29 |
| MXPA06014696A (es) | 2007-02-12 |
| US20080275022A1 (en) | 2008-11-06 |
| KR20070028536A (ko) | 2007-03-12 |
| EP1761506A1 (en) | 2007-03-14 |
| BRPI0512075A (pt) | 2008-02-06 |
| IL179580A0 (en) | 2007-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL179580A0 (en) | Substituted quinazolines as anti-cancer agents | |
| IL180088A0 (en) | Azine-carboxamides as anti-cancer agents | |
| LT2420498T (lt) | 5-pakeistieji chinazolinono dariniai, kaip priešvėžiniai agentai | |
| EP1730148A4 (en) | USE OF AMINOBENZOXAZOLES AS THERAPEUTIC AGENTS | |
| IL182094A0 (en) | Quinazoline derivatives | |
| IL177799A0 (en) | Substituted thiophene derivatives as anti-cancer agents | |
| IL222922A0 (en) | Neuropilin antagonists | |
| IL180959A0 (en) | Hiv inhibiting 5-heterocyclyl pyrimidines | |
| PL1584370T3 (pl) | Emulgator | |
| AU305435S (en) | Planer | |
| IL181722A0 (en) | 4-amino substituted-2-substituted | |
| EP1726304A4 (en) | COMPOSITION CONTAINING SOLIFENACIN | |
| EP1824825A4 (en) | PYRIDOXINES SUBSTITUTED AS ANTIPLATELET AGENTS | |
| AU156895S (en) | Planer | |
| IL179888A0 (en) | Compounds as ccr5 antagonists | |
| HK1101395A (en) | Substituted quinazolones as anti-cancer agents | |
| GB0504064D0 (en) | Anti-cancer compounds | |
| GB0514758D0 (en) | Anti-cancer agent | |
| GB0406160D0 (en) | Quinazoline derivatives | |
| GB0426653D0 (en) | Quinazoline derivatives | |
| GB0406163D0 (en) | Quinazoline derivatives | |
| GB0424972D0 (en) | Pyrimidine compounds | |
| GB0424784D0 (en) | Structures | |
| GB0423723D0 (en) | Structures | |
| GB0405119D0 (en) | Staddle stone |