ZA200700176B - Combination of anti-HIV reverse transcriptase and protease inhibitors - Google Patents

Combination of anti-HIV reverse transcriptase and protease inhibitors Download PDF

Info

Publication number: ZA200700176B
Authority: ZA; South Africa
Prior art keywords: tenofovir; combination; ritonavir; disoproxil fumarate; tmc114
Prior art date: 2004-07-08

Application number

ZA200700176A

Other languages

English (en)

Inventor

Hoetelmans Richard M Wilhelmus

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-08

Filing date

2007-01-05

Publication date

2008-04-30

2007-01-05 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2008-04-30 Publication of ZA200700176B publication Critical patent/ZA200700176B/en

Links

230000036436 anti-hiv Effects 0.000 title claims abstract description 9
239000000137 peptide hydrolase inhibitor Substances 0.000 title description 20
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title description 11
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108010092799 RNA-directed DNA polymerase Proteins 0.000 title description 9
239000003419 rna directed dna polymerase inhibitor Substances 0.000 title description 2
VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims abstract description 62
229960004556 tenofovir Drugs 0.000 claims abstract description 43
NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims abstract description 41
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Aiming, Guidance, Guns With A Light Source, Armor, Camouflage, And Targets (AREA)

ZA200700176A 2004-07-08 2007-01-05 Combination of anti-HIV reverse transcriptase and protease inhibitors ZA200700176B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP04103256		2004-07-08

Publications (1)

Publication Number	Publication Date
ZA200700176B true ZA200700176B (en)	2008-04-30

Family

ID=34929311

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200700176A ZA200700176B (en)	2004-07-08	2007-01-05	Combination of anti-HIV reverse transcriptase and protease inhibitors

Country Status (19)

Country	Link
US (1)	US20070208009A1 (da)
EP (1)	EP1765337B1 (da)
JP (1)	JP2008505870A (da)
CN (1)	CN1984654A (da)
AT (1)	ATE406161T1 (da)
AU (1)	AU2005261701A1 (da)
BR (1)	BRPI0513051A (da)
CA (1)	CA2572551A1 (da)
DE (1)	DE602005009366D1 (da)
DK (1)	DK1765337T3 (da)
ES (1)	ES2313394T3 (da)
HR (1)	HRP20080612T3 (da)
MX (1)	MXPA06014930A (da)
NZ (1)	NZ551841A (da)
PL (1)	PL1765337T3 (da)
RU (1)	RU2368380C2 (da)
SI (1)	SI1765337T1 (da)
WO (1)	WO2006005720A1 (da)
ZA (1)	ZA200700176B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2008520672A (ja) *	2004-11-16	2008-06-19	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	チプラナビルとダルナビルの共投与によるｈｉｖ感染症の治療方法
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GT200800303A (es)	2007-12-24	2009-09-18		Combinacion anti-retroviral
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WO2014184553A1 (en) *	2013-05-15	2014-11-20	Cipla Limited	Pharmaceutical antiretroviral compositions
HK1220390A1 (zh) *	2013-08-29	2017-05-05	Teva Pharmaceutical Industries Ltd.	包括恩曲他滨，替诺福韦，达芦那韦和利托那韦的单位剂型以及包含达芦那韦和利托那韦的单体片剂
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2005
- 2005-07-08 CN CNA2005800230750A patent/CN1984654A/zh active Pending
- 2005-07-08 EP EP05774136A patent/EP1765337B1/en not_active Expired - Lifetime
- 2005-07-08 WO PCT/EP2005/053266 patent/WO2006005720A1/en not_active Ceased
- 2005-07-08 AU AU2005261701A patent/AU2005261701A1/en not_active Abandoned
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- 2005-07-08 NZ NZ551841A patent/NZ551841A/en not_active IP Right Cessation
- 2005-07-08 SI SI200530488T patent/SI1765337T1/sl unknown
- 2005-07-08 PL PL05774136T patent/PL1765337T3/pl unknown
- 2005-07-08 AT AT05774136T patent/ATE406161T1/de not_active IP Right Cessation
- 2005-07-08 BR BRPI0513051-4A patent/BRPI0513051A/pt not_active IP Right Cessation
- 2005-07-08 DK DK05774136T patent/DK1765337T3/da active
- 2005-07-08 JP JP2007519807A patent/JP2008505870A/ja not_active Withdrawn
- 2005-07-08 MX MXPA06014930A patent/MXPA06014930A/es active IP Right Grant
- 2005-07-08 ES ES05774136T patent/ES2313394T3/es not_active Expired - Lifetime
- 2005-07-08 US US11/571,599 patent/US20070208009A1/en not_active Abandoned
- 2005-07-08 HR HR20080612T patent/HRP20080612T3/xx unknown
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- 2005-07-08 RU RU2007104774/15A patent/RU2368380C2/ru not_active IP Right Cessation
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Also Published As

Publication number	Publication date
JP2008505870A (ja)	2008-02-28
NZ551841A (en)	2009-04-30
CN1984654A (zh)	2007-06-20
HRP20080612T3 (hr)	2009-01-31
DE602005009366D1 (de)	2008-10-09
MXPA06014930A (es)	2007-02-28
SI1765337T1 (sl)	2009-02-28
BRPI0513051A (pt)	2008-04-22
EP1765337A1 (en)	2007-03-28
DK1765337T3 (da)	2009-01-05
EP1765337B1 (en)	2008-08-27
ES2313394T3 (es)	2009-03-01
AU2005261701A1 (en)	2006-01-19
CA2572551A1 (en)	2006-01-19
US20070208009A1 (en)	2007-09-06
WO2006005720A1 (en)	2006-01-19
PL1765337T3 (pl)	2009-02-27
RU2368380C2 (ru)	2009-09-27
RU2007104774A (ru)	2008-08-20
ATE406161T1 (de)	2008-09-15

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