ZA200700367B - Anti-cancer composition comprising proline or its derivatives and an anti-tumour antibody - Google Patents

Anti-cancer composition comprising proline or its derivatives and an anti-tumour antibody Download PDF

Info

Publication number: ZA200700367B
Authority: ZA; South Africa
Prior art keywords: proline; carcinoma; cell; cancer; derivatives
Prior art date: 2004-06-14

Application number

ZA200700367A

Other languages

English (en)

Inventor

Zoser B Salama

Original Assignee

Zoser B Salama

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-14

Filing date

2005-06-07

Publication date

2008-07-30

2005-06-07 Application filed by Zoser B Salama filed Critical Zoser B Salama

2008-07-30 Publication of ZA200700367B publication Critical patent/ZA200700367B/en

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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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230000002485 urinary effect Effects 0.000 description 1
210000001635 urinary tract Anatomy 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Microbiology (AREA)
Mycology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

ZA200700367A 2004-06-14 2005-06-07 Anti-cancer composition comprising proline or its derivatives and an anti-tumour antibody ZA200700367B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57883204P	2004-06-14	2004-06-14

Publications (1)

Publication Number	Publication Date
ZA200700367B true ZA200700367B (en)	2008-07-30

Family

ID=35064616

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200700367A ZA200700367B (en)	2004-06-14	2005-06-07	Anti-cancer composition comprising proline or its derivatives and an anti-tumour antibody

Country Status (13)

Country	Link
US (1)	US7727530B2 (de)
EP (1)	EP1765328B1 (de)
JP (1)	JP2008502622A (de)
KR (1)	KR20070026646A (de)
CN (1)	CN1997365A (de)
AT (1)	ATE534386T1 (de)
AU (1)	AU2005251463A1 (de)
BR (1)	BRPI0512040A (de)
CA (1)	CA2568306A1 (de)
MX (1)	MXPA06014731A (de)
RU (1)	RU2007101074A (de)
WO (1)	WO2005120495A1 (de)
ZA (1)	ZA200700367B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY138883A (en) *	2000-08-29	2009-08-28	Government Of Malaysia As Represented By The Ministry Of Science Tehnology And Innovation Malaysia	Use of asiatic acid for treatment of cencer
US7759506B2 (en)	2002-02-25	2010-07-20	Diffusion Pharmaceuticals Llc	Bipolar trans carotenoid salts and their uses
CA2477245A1 (en)	2002-02-25	2003-09-04	Diffusion Pharmaceuticals Llc	Bipolar trans carotenoid salts and their uses
EP2540696B1 (de)	2005-02-24	2020-01-01	Diffusion Pharmaceuticals LLC	Trans-Karotinoide, deren Formulierung und Verwendung
CN101687757A (zh)	2007-04-13	2010-03-31	扩散药品有限公司	双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用
KR20100083820A (ko) *	2007-10-31	2010-07-22	디퓨젼 파마슈티컬즈 엘엘씨	저분자 확산을 촉진시키는 신규한 치료요법
EP2445339B1 (de)	2009-06-22	2019-08-07	Diffusion Pharmaceuticals LLC	Verteilungsverbessernde verbindung und ihre verwendung mit einem thrombolytikum
AU2011260390B2 (en) *	2010-06-01	2016-11-24	Ernst-Moritz-Arndt Universitat Greifswald	Means and methods for diagnosing pancreatic cancer in a subject
AU2011262361A1 (en)	2010-06-02	2013-01-10	Diffusion Pharmaceuticals Llc	Oral formulations of bipolar trans carotenoids
CA3018550A1 (en)	2016-03-24	2017-09-28	Diffusion Pharmaceuticals Llc	Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
KR102012554B1 (ko) *	2016-07-13	2019-08-23	주식회사 노브메타파마	사이클로 히스티딘-프롤린을 유효성분으로 포함하는 세포 보호용 조성물
CN114028388B (zh) *	2021-12-16	2023-05-12	郑州大学第一附属医院	脯氨酸在制备肺癌治疗药物中的应用
CN116092631A (zh) *	2023-01-17	2023-05-09	湖南安泰康成生物科技有限公司	铁死亡诱导剂与电场联用的肿瘤治疗系统

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4166452A (en)	1976-05-03	1979-09-04	Generales Constantine D J Jr	Apparatus for testing human responses to stimuli
US4256108A (en)	1977-04-07	1981-03-17	Alza Corporation	Microporous-semipermeable laminated osmotic system
US4265874A (en)	1980-04-25	1981-05-05	Alza Corporation	Method of delivering drug with aid of effervescent activity generated in environment of use
CA1281288C (en) *	1984-11-05	1991-03-12	Wilhelm Hoerrmann	Tumor therapy
US6153643A (en) *	1984-11-05	2000-11-28	Hoerrmann; Wilhelm	Anti-cancer-substance
US5665371A (en) *	1985-05-20	1997-09-09	Hoerrmann; Wilhelm	Medicines which contain derivatives of proline or hydroxyproline
US5549910A (en)	1989-03-31	1996-08-27	The Regents Of The University Of California	Preparation of liposome and lipid complex compositions
JP3218637B2 (ja)	1990-07-26	2001-10-15	大正製薬株式会社	安定なリポソーム水懸濁液
JP2958076B2 (ja)	1990-08-27	1999-10-06	株式会社ビタミン研究所	遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
US5795587A (en)	1995-01-23	1998-08-18	University Of Pittsburgh	Stable lipid-comprising drug delivery complexes and methods for their production
US5738868A (en)	1995-07-18	1998-04-14	Lipogenics Ltd.	Liposome compositions and kits therefor
US5837283A (en) *	1997-03-12	1998-11-17	The Regents Of The University Of California	Cationic lipid compositions targeting angiogenic endothelial cells
DE10359828A1 (de)	2003-12-12	2005-07-28	Zoser B. Dr.Rer.Nat. Salama	CHP-Gemcitabin- Kombinationsmittel und ihre Verwendung als Antitumorwirkstoffe, insbesondere Antimetastasierungswirkstoffe
US20080176923A1 (en) *	2003-12-18	2008-07-24	Salama Zoser B	Proline Derivatives Used as Pharmaceutical Active Ingredients for the Treatment of Tumors

2005
- 2005-06-07 WO PCT/EP2005/006184 patent/WO2005120495A1/en not_active Ceased
- 2005-06-07 MX MXPA06014731A patent/MXPA06014731A/es not_active Application Discontinuation
- 2005-06-07 AT AT05770217T patent/ATE534386T1/de active
- 2005-06-07 CN CNA2005800238112A patent/CN1997365A/zh active Pending
- 2005-06-07 AU AU2005251463A patent/AU2005251463A1/en not_active Abandoned
- 2005-06-07 ZA ZA200700367A patent/ZA200700367B/en unknown
- 2005-06-07 CA CA002568306A patent/CA2568306A1/en not_active Abandoned
- 2005-06-07 JP JP2007515831A patent/JP2008502622A/ja not_active Withdrawn
- 2005-06-07 RU RU2007101074/15A patent/RU2007101074A/ru not_active Application Discontinuation
- 2005-06-07 EP EP05770217A patent/EP1765328B1/de not_active Expired - Lifetime
- 2005-06-07 BR BRPI0512040-3A patent/BRPI0512040A/pt not_active IP Right Cessation
- 2005-06-07 KR KR1020067027243A patent/KR20070026646A/ko not_active Withdrawn
- 2005-06-08 US US11/147,648 patent/US7727530B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE534386T1 (de)	2011-12-15
BRPI0512040A (pt)	2008-02-06
CN1997365A (zh)	2007-07-11
US20050276810A1 (en)	2005-12-15
RU2007101074A (ru)	2008-07-20
MXPA06014731A (es)	2007-04-25
JP2008502622A (ja)	2008-01-31
CA2568306A1 (en)	2005-12-22
AU2005251463A1 (en)	2005-12-22
KR20070026646A (ko)	2007-03-08
US7727530B2 (en)	2010-06-01
WO2005120495A1 (en)	2005-12-22
EP1765328B1 (de)	2011-11-23
EP1765328A1 (de)	2007-03-28

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Brambilla et al.	1993	Carboplatin in combination as first-line therapy in advanced breast cancer
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