ZA200700643B - RAGE fusion proteins and methods of use - Google Patents
RAGE fusion proteins and methods of useInfo
- Publication number
- ZA200700643B ZA200700643B ZA200700643A ZA200700643A ZA200700643B ZA 200700643 B ZA200700643 B ZA 200700643B ZA 200700643 A ZA200700643 A ZA 200700643A ZA 200700643 A ZA200700643 A ZA 200700643A ZA 200700643 B ZA200700643 B ZA 200700643B
- Authority
- ZA
- South Africa
- Prior art keywords
- methods
- fusion proteins
- rage fusion
- rage
- proteins
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Obesity (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59855504P | 2004-08-03 | 2004-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200700643B true ZA200700643B (en) | 2010-07-28 |
Family
ID=35149359
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200700643A ZA200700643B (en) | 2004-08-03 | 2007-01-23 | RAGE fusion proteins and methods of use |
| ZA200906459A ZA200906459B (en) | 2004-08-03 | 2009-09-16 | Rage fusion proteins and methods of use |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200906459A ZA200906459B (en) | 2004-08-03 | 2009-09-16 | Rage fusion proteins and methods of use |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US7981423B2 (fr) |
| EP (1) | EP1781700B1 (fr) |
| JP (1) | JP5188804B2 (fr) |
| KR (1) | KR101323411B1 (fr) |
| CN (1) | CN1993378A (fr) |
| AP (1) | AP2007003869A0 (fr) |
| AU (1) | AU2005271452B2 (fr) |
| BR (1) | BRPI0514052A (fr) |
| CA (1) | CA2570324C (fr) |
| CR (1) | CR20110556A (fr) |
| EA (1) | EA012082B1 (fr) |
| EC (1) | ECSP077221A (fr) |
| ES (1) | ES2473587T3 (fr) |
| GE (1) | GEP20105110B (fr) |
| IL (1) | IL180554A (fr) |
| MA (1) | MA29067B1 (fr) |
| MX (1) | MX2007001559A (fr) |
| NO (1) | NO20065949L (fr) |
| NZ (1) | NZ552128A (fr) |
| TN (1) | TNSN07037A1 (fr) |
| UA (1) | UA93356C2 (fr) |
| WO (1) | WO2006017647A1 (fr) |
| ZA (2) | ZA200700643B (fr) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465422B1 (en) * | 1998-04-17 | 2002-10-15 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting tumor invasion or spreading in a subject |
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| US7696169B2 (en) * | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| AU2004272607B2 (en) * | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
| GEP20105110B (en) * | 2004-08-03 | 2010-11-10 | Transtech Pharma Inc | Rage fusion proteins and their use |
| SG161242A1 (en) * | 2004-08-03 | 2010-05-27 | Transtech Pharma Inc | Rage fusion proteins and methods of use |
| WO2006119510A2 (fr) * | 2005-05-04 | 2006-11-09 | Receptor Biologix, Inc. | Isoformes d'un recepteur pour produits de glycation avancee (rage) et methodes d'identification et d'utilisation de celles-ci |
| WO2007076200A2 (fr) * | 2005-11-28 | 2007-07-05 | Medimmune, Inc. | Antagonistes de hmgb1 et/ou rage et leurs procedes d'utilisation |
| JP5314428B2 (ja) * | 2005-12-23 | 2013-10-16 | ジーコデール システムズ アクチボラゲット | 測位用パターン |
| EP1989227A2 (fr) * | 2006-02-09 | 2008-11-12 | Transtech Pharma, Inc. | Protéines hybrides rage et leurs procédés d'utilisation |
| SG171670A1 (en) * | 2006-05-05 | 2011-06-29 | Transtech Pharma Inc | Rage fusion proteins, formulations, and methods of use thereof |
| EP2450368A1 (fr) | 2007-01-30 | 2012-05-09 | Epivax, Inc. | Épitopes de lymphocytes t régulateurs, compositions et utilisations de ceux-ci |
| WO2008100470A2 (fr) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Protéines de fusion de l'immunoglobuline et procédés de fabrication |
| US20100254983A1 (en) * | 2007-06-07 | 2010-10-07 | Ann Marie Schmidt | Uses of rage antagonists for treating obesity and related diseases |
| KR101595634B1 (ko) * | 2007-06-14 | 2016-02-18 | 갈락티카 파마슈티칼스, 인크. | Rage 융합 단백질 |
| JP5620106B2 (ja) * | 2007-10-24 | 2014-11-05 | 株式会社糖鎖工学研究所 | 増強されたエフェクター機能を有するポリペプチド |
| NL2001557C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001554C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001556C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001555C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001551C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001558C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001553C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| NL2001552C2 (nl) * | 2008-05-06 | 2009-05-07 | Transtech Pharma | Rage-fusie-eiwitten, preparaten en werkwijzen voor het gebruik ervan. |
| RU2553225C2 (ru) | 2008-05-23 | 2015-06-10 | Сива Корпорейшн | Способ облегчения регенерации |
| AU2010240569A1 (en) | 2009-04-20 | 2011-10-20 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
| WO2011100508A2 (fr) * | 2010-02-12 | 2011-08-18 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Procédés et compositions liés à des fusions glycoprotéine-immunoglobuline |
| WO2011102845A1 (fr) * | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Compositions de protéines de fusion rage et méthodes d'utilisation |
| ES2725852T3 (es) | 2010-09-27 | 2019-09-27 | Siwa Corp | Eliminación selectiva de células modificadas por AGE para el tratamiento de la aterosclerosis |
| US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
| KR102231139B1 (ko) | 2011-06-28 | 2021-03-24 | 인히브릭스, 인크. | 세르핀 융합 폴리펩타이드 및 이의 이용 방법 |
| AU2012275295B2 (en) | 2011-06-28 | 2016-11-10 | Inhibrx, Lp | WAP domain fusion polypeptides and methods of use thereof |
| US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
| JP2015533483A (ja) * | 2012-09-07 | 2015-11-26 | サノフイ | メタボリックシンドロームを治療するための融合タンパク質 |
| WO2015023165A1 (fr) * | 2013-08-16 | 2015-02-19 | 가톨릭대학교 산학협력단 | Composite de régulation d'une inflammation et cellules souches mésenchymateuse stabilisées ayant une fonction optimisée de régulation de l'immunité par blocage de la molécule de signalisation stat3 |
| EP3194439B1 (fr) | 2014-09-19 | 2022-01-19 | Siwa Corporation | Anticorps anti-age pour le traitement de l'inflammation et de troubles auto-immuns |
| US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
| US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
| HUE058854T2 (hu) | 2016-02-19 | 2022-09-28 | Siwa Corp | Módszer és készítmény a rák kezelésére, az áttétes rákos sejtek elpusztítására és a rák áttétképzõdésének megelõzésére a fejlett glikációs végtermékek (AGE) elleni antitest alkalmazásával |
| KR20180133452A (ko) | 2016-04-15 | 2018-12-14 | 시와 코퍼레이션 | 신경퇴행성 질환을 치료하기 위한 항-노화 항체 |
| EP3470424B1 (fr) * | 2016-06-08 | 2025-04-23 | Shanghai Jiao Tong University School of Medicine | Séquence de région constante à chaîne lourde d'anticorps pour améliorer l'activité d'anticorps agonistes |
| JP2019518763A (ja) | 2016-06-23 | 2019-07-04 | シワ コーポレーション | 様々な疾患及び障害の治療において使用するためのワクチン |
| US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
| US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
| US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
| US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
| CA3053381A1 (fr) * | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Polypeptides modifies |
| US10457717B2 (en) | 2017-02-17 | 2019-10-29 | Denali Therapeutics Inc. | Engineered polypeptides |
| US10143187B2 (en) | 2017-02-17 | 2018-12-04 | Denali Therapeutics Inc. | Transferrin receptor transgenic models |
| CA3059803A1 (fr) | 2017-04-13 | 2018-10-18 | Siwa Corporation | Anticorps monoclonal humanise de produit final de glycation avancee |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| WO2019036753A1 (fr) | 2017-08-22 | 2019-02-28 | Monash University | Essais de criblage, modulateurs et modulation de l'activation d'un récepteur pour des produits terminaux de glycation avancée (rage) |
| US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
| JP7307178B2 (ja) | 2018-09-14 | 2023-07-11 | バイオエイジ ラブス, インコーポレイテッド | 改善された安定性およびリガンド結合親和性を有するrage融合タンパク質ならびにその使用 |
| WO2020160156A2 (fr) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anticorps anti-gal3 et leurs utilisations |
| EP4157338A4 (fr) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | Méthodes de traitement de maladies inflammatoires par blocage de la galectine-3 |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| US5567584A (en) * | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
| US6018026A (en) * | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
| NZ235148A (en) * | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
| MX9204374A (es) * | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| SE9201073D0 (sv) | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
| PT672141E (pt) | 1992-10-23 | 2003-09-30 | Immunex Corp | Metodos de preparacao de proteinas oligomericas soluveis |
| US5656261A (en) * | 1995-01-18 | 1997-08-12 | The Picower Institute For Medical Research | Preventing and reversing advanced glycosylation endproducts |
| DE69629176T2 (de) * | 1995-01-18 | 2004-06-03 | Alteon Inc. | Verwendung von thiazoliumverbindungen zum verhindern und umkehren der bildung von endprodukten der fortgeschrittenen glykosylierung |
| FI119756B (fi) * | 1995-01-18 | 2009-03-13 | Alteon Inc | Tiatsoliumyhdisteiden käyttö pitkälle edenneen glykosylaation lopputuotteiden muodostumisen estossa ja suunnan muutoksessa |
| CA2217572A1 (fr) * | 1995-04-05 | 1996-10-10 | The Picower Institute For Medical Research | Agents se liant a des produits finals de glycosylation evolues et leurs methodes d'utilisation |
| US5747035A (en) * | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| AU1832797A (en) | 1996-01-26 | 1997-08-20 | Trustees Of Columbia University In The City Of New York, The | A polypeptide from lung extract which binds amyloid-beta peptide |
| US5864018A (en) * | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| WO1997039121A1 (fr) | 1996-04-16 | 1997-10-23 | Schering Aktiengesellschaft | Peptides du recepteur de produits terminaux d'une glycosylation avancee, et utilisation de ces peptides |
| US6555651B2 (en) * | 1997-10-09 | 2003-04-29 | The Trustees Of Columbia University In The City Of New York | Ligand binding site of rage and uses thereof |
| US7258857B2 (en) * | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
| US6790443B2 (en) * | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US7081241B1 (en) * | 1998-10-06 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Extracellular rage binding protein (EN-RAGE) and uses thereof |
| JP2001514661A (ja) | 1997-03-11 | 2001-09-11 | ザ ジェネラル ホスピタル コーポレイション | アルツハイマー病の処置における使用のための薬剤の同定 |
| US6165476A (en) | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
| US7101838B2 (en) * | 1997-08-05 | 2006-09-05 | The Trustees Of Columbia University In The City Of New York | Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts |
| MY131805A (en) | 1997-09-18 | 2007-09-28 | Biogen Idec Inc | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis. |
| US6380165B1 (en) * | 1997-09-19 | 2002-04-30 | The Picower Institute For Medical Research | Immunological advanced glycation endproduct crosslink |
| US6761888B1 (en) * | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6323218B1 (en) * | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
| US6465422B1 (en) | 1998-04-17 | 2002-10-15 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting tumor invasion or spreading in a subject |
| WO2000018970A1 (fr) | 1998-09-29 | 2000-04-06 | Asahi Kasei Kabushiki Kaisha | Procede de commande de liberation de granules |
| US6753150B2 (en) * | 1998-10-05 | 2004-06-22 | The Trustees Of Columbia University In The City Of New York | Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage |
| AU765719B2 (en) * | 1998-10-06 | 2003-09-25 | Trustees Of Columbia University In The City Of New York, The | Extracellular novel rage binding protein (EN-RAGE) and uses thereof |
| US6197294B1 (en) * | 1998-10-26 | 2001-03-06 | Neurotech S.A. | Cell surface molecule-induced macrophage activation |
| US6589944B1 (en) | 1999-04-05 | 2003-07-08 | City Of Hope | Breakers of advanced glycation endproducts |
| US6787566B2 (en) * | 1999-04-05 | 2004-09-07 | City Of Hope | Breakers of advanced glycation endproducts |
| US6605642B2 (en) * | 1999-04-05 | 2003-08-12 | City Of Hope | Inhibitors of formation of advanced glycation endproducts (AGES) |
| US6939545B2 (en) * | 1999-04-28 | 2005-09-06 | Genetics Institute, Llc | Composition and method for treating inflammatory disorders |
| US6835200B2 (en) | 1999-06-22 | 2004-12-28 | Ndo Surgical. Inc. | Method and devices for tissue reconfiguration |
| FR2797402B1 (fr) | 1999-07-15 | 2004-03-12 | Biomerieux Stelhys | Utilisation d'un polypeptide pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique ou autoimmune |
| CA2382095A1 (fr) | 1999-08-13 | 2001-02-22 | The Trustees Of Columbia University In The City Of New York | Procedes d'inhibition de la liaison de la fibrille a feuillets beta au recepteur rage, et leurs consequences |
| EP1219639A4 (fr) | 1999-09-08 | 2009-03-25 | Toray Industries | Materiaux de circulation extracorporelle, adsorbants de facteurs de complication diabetique, reservoirs servant a eliminer des facteurs de complication diabetique et procede d'elimination de facteurs de complication diabetique |
| US20050170382A1 (en) * | 1999-10-06 | 2005-08-04 | The Trustees Of Columbia University In The City Of New York. | RAGE-related compositions |
| CA2356207C (fr) | 1999-10-21 | 2012-10-09 | Case Western Reserve University | Profilage de l'expression genetique d'une affection intestinale inflammatoire |
| JP2003516150A (ja) | 1999-12-08 | 2003-05-13 | ジェンセット | 潜在性分泌タンパク質をコードする全長ヒトcDNA |
| US6727353B2 (en) * | 2000-04-14 | 2004-04-27 | Icagen, Inc. | Nucleic acid encoding Kv10.1, a voltage-gated potassium channel from human brain |
| US6716635B2 (en) * | 2000-04-14 | 2004-04-06 | University Of Kentucky Research Foundation | Method for identifying regulators of protein-advanced glycation end product (protein-AGE) formation |
| AU2001255436A1 (en) | 2000-04-17 | 2001-10-30 | Transtech Pharma | Protein expression system arrays and use in biological screening |
| JP2005520479A (ja) | 2000-05-09 | 2005-07-14 | ジェネティクス インスティテュート,エルエルシー | 乾癬の確認、評価、予防および治療のための組成物、キットおよび方法 |
| US6613801B2 (en) | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
| US6908741B1 (en) | 2000-05-30 | 2005-06-21 | Transtech Pharma, Inc. | Methods to identify compounds that modulate RAGE |
| US20020104993A1 (en) * | 2000-08-07 | 2002-08-08 | Fitzgerald Eugene A. | Gate technology for strained surface channel and strained buried channel MOSFET devices |
| US6825164B1 (en) * | 2000-08-14 | 2004-11-30 | The Trustees Of Columbia University In The City Of New York | Method to increase cerebral blood flow in amyloid angiopathy |
| US6563015B1 (en) | 2000-08-14 | 2003-05-13 | The Trustees Of Columbia University In The City Of New York | Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) and mutant APP in brain and uses thereof |
| CA2424246A1 (fr) * | 2000-10-02 | 2002-04-11 | Shianlen Cahoon | Methodes et compositions pour traiter des maladies inflammatoires |
| AU2002213192A1 (en) | 2000-10-13 | 2002-04-22 | The Trustees Of Columbia University In The City Of New York | A method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury |
| US20050244849A1 (en) * | 2000-12-15 | 2005-11-03 | Genetics Institute, Llc | Screening assays for rheumatoid arthritis |
| PL366250A1 (en) * | 2000-12-29 | 2005-01-24 | Reddy Us Therapeutics, Inc. | Detection of compounds that modulate inflammatory responses |
| US6946277B2 (en) | 2001-01-31 | 2005-09-20 | Council Of Scientific And Industrial Research | Method for enhancing cellobiase activity of termitomyces clypeatus using a glycosylation inhibitor |
| CN100522242C (zh) * | 2001-02-19 | 2009-08-05 | 默克专利有限公司 | 具有降低的免疫原性的人工蛋白质 |
| DE10164805B4 (de) | 2001-02-28 | 2011-02-10 | Koch-Pelster, Brigitte, Dr. | Verfahren und Mittel zur Modifikation humaner Angiogenese |
| JP3837494B2 (ja) | 2001-03-19 | 2006-10-25 | 国立大学法人金沢大学 | 可溶型rageタンパク質 |
| CA2419492C (fr) * | 2001-03-22 | 2005-07-05 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Procedes et appareils destines a une analyse qualitative et quantitative sans gel du proteome et utilisations associees |
| US7304034B2 (en) * | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| US8188231B2 (en) | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
| WO2004004661A2 (fr) | 2002-07-09 | 2004-01-15 | Point Therapeutics, Inc. | Polytherapie a base de composes de boroproline |
| EP1575513A4 (fr) * | 2002-08-16 | 2007-04-04 | Wyeth Corp | Compositions et methodes de traitement de troubles associes au recepteur rage |
| AR047392A1 (es) | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| WO2004055055A1 (fr) | 2002-12-13 | 2004-07-01 | Licentia Ltd | Proteine transmembranaire amigo et utilisations de celle-ci |
| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| US8067371B2 (en) * | 2003-05-09 | 2011-11-29 | The Trustees Of Columbia University In The City Of New York | RAGE G82S-related methods and compositions for treating inflammatory disorders |
| WO2005000295A1 (fr) * | 2003-05-20 | 2005-01-06 | Transtech Pharma, Inc. | Antagonistes rage utilises contre l'amylose et les maladies associees |
| US20050008649A1 (en) * | 2003-06-02 | 2005-01-13 | University Of Miami | Chimeric molecules and methods of use |
| WO2005019429A2 (fr) | 2003-08-22 | 2005-03-03 | Potentia Pharmaceuticals, Inc. | Compositions et procedes permettant d'augmenter la phagocytose ou l'activite des phagocytes |
| ZA200601810B (en) * | 2003-09-05 | 2008-05-28 | Univ Columbia | Rage-related methods and compositions for treating glomerular injury |
| US20070167360A1 (en) * | 2003-10-31 | 2007-07-19 | Yan Shi D | Methods for treating multiple sclerosis |
| WO2005049852A2 (fr) | 2003-11-17 | 2005-06-02 | University Of Florida | Procedes et compositions destines a induire l'apoptose |
| WO2005051995A2 (fr) | 2003-11-19 | 2005-06-09 | Curagen Corporation | Nouvelle proteine de type recepteur specifique au produit d'extremite d'une glycosylation avancee et acides nucleiques codant cette proteine |
| GB0330079D0 (en) | 2003-12-20 | 2004-02-04 | Bioinvent Int Ab | Vaccine |
| CN100342017C (zh) | 2004-05-10 | 2007-10-10 | 中国医学科学院肿瘤医院肿瘤研究所 | 基因重组趋化抗原疫苗 |
| EP1768677B1 (fr) | 2004-07-02 | 2008-06-25 | Creabilis Therapeutics S.P.A. | Agents therapeutiques pour traiter des pathologies associees a la hmgb1 |
| US20060012414A1 (en) * | 2004-07-15 | 2006-01-19 | Texas Instruments Incorporated | Circuit and method for generating a polyphase clock signal and system incorporating the same |
| EP1771565B1 (fr) * | 2004-07-20 | 2012-09-05 | The Feinstein Institute for Medical Research | Derives de proteine rage |
| WO2006012373A2 (fr) | 2004-07-20 | 2006-02-02 | Critical Therapeutics, Inc. | Polytherapies hmgb |
| SG161242A1 (en) * | 2004-08-03 | 2010-05-27 | Transtech Pharma Inc | Rage fusion proteins and methods of use |
| GEP20105110B (en) * | 2004-08-03 | 2010-11-10 | Transtech Pharma Inc | Rage fusion proteins and their use |
| WO2006036922A2 (fr) | 2004-09-27 | 2006-04-06 | Centocor, Inc. | Corps mimetiques srage, compositions, et methodes d'utilisation |
| WO2006119510A2 (fr) | 2005-05-04 | 2006-11-09 | Receptor Biologix, Inc. | Isoformes d'un recepteur pour produits de glycation avancee (rage) et methodes d'identification et d'utilisation de celles-ci |
| US20080207499A1 (en) * | 2005-06-29 | 2008-08-28 | Gaetano Barile | Rage-related methods for treating and preventing diabetic retinopathy |
| EP1989227A2 (fr) * | 2006-02-09 | 2008-11-12 | Transtech Pharma, Inc. | Protéines hybrides rage et leurs procédés d'utilisation |
| SG171670A1 (en) * | 2006-05-05 | 2011-06-29 | Transtech Pharma Inc | Rage fusion proteins, formulations, and methods of use thereof |
| ES2541546T3 (es) | 2006-11-03 | 2015-07-21 | Wyeth Llc | Sustancias que inhiben la glucólisis en cultivo celular |
| WO2008100470A2 (fr) | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Protéines de fusion de l'immunoglobuline et procédés de fabrication |
| KR101595634B1 (ko) | 2007-06-14 | 2016-02-18 | 갈락티카 파마슈티칼스, 인크. | Rage 융합 단백질 |
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