ZA200710813B - Method of treating or preventing benign prostatic hyperplasia using modified pore-forming proteins - Google Patents
Method of treating or preventing benign prostatic hyperplasia using modified pore-forming proteinsInfo
- Publication number
- ZA200710813B ZA200710813B ZA200710813A ZA200710813A ZA200710813B ZA 200710813 B ZA200710813 B ZA 200710813B ZA 200710813 A ZA200710813 A ZA 200710813A ZA 200710813 A ZA200710813 A ZA 200710813A ZA 200710813 B ZA200710813 B ZA 200710813B
- Authority
- ZA
- South Africa
- Prior art keywords
- mpps
- treating
- prostate
- modified pore
- cells
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 title 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 title 1
- 210000005267 prostate cell Anatomy 0.000 abstract 3
- 230000008685 targeting Effects 0.000 abstract 3
- 101150017770 ENPP1 gene Proteins 0.000 abstract 2
- 230000004048 modification Effects 0.000 abstract 2
- 238000012986 modification Methods 0.000 abstract 2
- 210000002307 prostate Anatomy 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69026905P | 2005-06-14 | 2005-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200710813B true ZA200710813B (en) | 2008-10-29 |
Family
ID=37531919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200710813A ZA200710813B (en) | 2005-06-14 | 2007-12-12 | Method of treating or preventing benign prostatic hyperplasia using modified pore-forming proteins |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8916161B2 (de) |
| EP (1) | EP1891093B1 (de) |
| JP (1) | JP5220594B2 (de) |
| KR (1) | KR101365538B1 (de) |
| CN (1) | CN101238145B (de) |
| AT (1) | ATE502954T1 (de) |
| AU (1) | AU2006257664B2 (de) |
| CA (1) | CA2611839C (de) |
| DE (1) | DE602006020867D1 (de) |
| DK (1) | DK1891093T3 (de) |
| ES (1) | ES2366380T3 (de) |
| IL (1) | IL188143A (de) |
| NZ (1) | NZ564954A (de) |
| WO (1) | WO2006133553A1 (de) |
| ZA (1) | ZA200710813B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE502954T1 (de) | 2005-06-14 | 2011-04-15 | Protox Therapeutics Inc | Verfahren zur behandlung oder prävention gutartiger prostatahyperplasie unter verwendung modifizierter porenbildender proteine |
| CA2630559A1 (en) * | 2005-11-21 | 2007-05-24 | Protox Therapeutics Incorporated | Modified pore-forming protein toxins and use thereof |
| CA2657946A1 (en) * | 2006-06-09 | 2007-12-13 | Protox Therapeutics Incorporated | Modified protein toxins targeting cytokine -receptor bearing cells and use thereof for treating disease |
| CN101688253A (zh) * | 2007-07-12 | 2010-03-31 | 新泽西内科与牙科大学 | 抗毒素不稳定化技术 |
| PL2187965T3 (pl) | 2007-08-17 | 2020-05-18 | Purdue Research Foundation | Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania |
| EA022752B1 (ru) | 2008-12-09 | 2016-02-29 | Галозим, Инк. | Длинные растворимые полипептиды рн20 и их использование |
| JP2012512183A (ja) | 2008-12-15 | 2012-05-31 | プロトックス セラピューティクス インコーポレイテッド | 改変された孔形成性タンパク質プロアエロリシンを用いた前立腺炎の処置のための方法 |
| US20140152801A1 (en) | 2009-10-28 | 2014-06-05 | Alentic Microscience Inc. | Detecting and Using Light Representative of a Sample |
| US9041790B2 (en) | 2009-10-28 | 2015-05-26 | Alentic Microscience Inc. | Microscopy imaging |
| US9075225B2 (en) | 2009-10-28 | 2015-07-07 | Alentic Microscience Inc. | Microscopy imaging |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| AU2011316786A1 (en) * | 2010-10-22 | 2013-05-02 | Protox Therapeutics Corp. | Use of human serum albumin to decrease antigenicity of therapeutic proteins |
| WO2012109387A1 (en) | 2011-02-08 | 2012-08-16 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
| US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
| US20140044812A1 (en) * | 2012-08-07 | 2014-02-13 | Kuwait Institute For Scientific Research | Anesthetic and therapeutic composition for use in aquaculture |
| US10502666B2 (en) * | 2013-02-06 | 2019-12-10 | Alentic Microscience Inc. | Sample processing improvements for quantitative microscopy |
| WO2014205576A1 (en) | 2013-06-26 | 2014-12-31 | Alentic Microscience Inc. | Sample processing improvements for microscopy |
| EP3456700A1 (de) | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Markierte inhibitoren des prostataspezifischen membranantigens (psma), deren verwendung als kontrastmittel und pharmazeutika zur behandlung von prostatakrebs |
| CA2926183C (en) * | 2013-10-23 | 2018-07-03 | Gemvax & Kael Co., Ltd. | Composition for treating and preventing benign prostatic hyperplasia |
| EP3533473A3 (de) | 2013-11-14 | 2019-12-18 | Endocyte, Inc. | Verbindungen für positronenemissionstomografie |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN112368024A (zh) | 2018-04-17 | 2021-02-12 | 恩多塞特公司 | 治疗癌症的方法 |
| CN110033449B (zh) * | 2019-04-15 | 2023-06-27 | 苏州金唯智生物科技有限公司 | 电泳图的识别方法、装置、设备及存储介质 |
| CN114096264B (zh) | 2019-05-20 | 2025-03-14 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
| JP2022121814A (ja) * | 2021-02-09 | 2022-08-22 | 国立大学法人神戸大学 | 藻類抑制剤 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US5677274A (en) | 1993-02-12 | 1997-10-14 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Anthrax toxin fusion proteins and related methods |
| WO1994025616A1 (en) | 1993-04-28 | 1994-11-10 | Worcester Foundation For Experimental Biology | Cell-targeted lytic pore-forming agents |
| US5777078A (en) | 1993-04-28 | 1998-07-07 | Worcester Foundation For Experimental Biology | Triggered pore-forming agents |
| WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| US5866679A (en) | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
| US5599686A (en) | 1994-06-28 | 1997-02-04 | Merck & Co., Inc. | Peptides |
| US6143864A (en) | 1994-06-28 | 2000-11-07 | Merck & Co., Inc. | Peptides |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| EP1167379A3 (de) | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatorische Oligonukleotide |
| US6190657B1 (en) | 1995-06-07 | 2001-02-20 | Yale University | Vectors for the diagnosis and treatment of solid tumors including melanoma |
| US6066319A (en) | 1996-04-30 | 2000-05-23 | President And Fellows Of Harvard College | Drug delivery using terminal complement components |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| US5998362A (en) | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US6368598B1 (en) | 1996-09-16 | 2002-04-09 | Jcrt Radiation Oncology Support Services, Inc. | Drug complex for treatment of metastatic prostate cancer |
| US5798218A (en) | 1996-09-24 | 1998-08-25 | University Of British Columbia Innovation And Development Corporation | Compositions and methods for the specific detection of thy-1 antigen |
| US5948750A (en) | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| JP2001504334A (ja) | 1996-11-06 | 2001-04-03 | アメリカ合衆国 | プロテアーゼ活性化可能なPseudomonas体外毒素A様プロタンパク質 |
| WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| DK1005368T3 (da) | 1997-03-10 | 2010-01-04 | Ottawa Hospital Res Inst | Anvendelse af nukleinsyrer, der indeholder ikke-metyleret CpG dinukleotid i kombination med alun som hjælpestoffer |
| US6504014B1 (en) | 1997-05-19 | 2003-01-07 | The John Hopkins University | Tissue specific prodrug |
| US6265540B1 (en) | 1997-05-19 | 2001-07-24 | The Johns Hopkins University School Of Medicine | Tissue specific prodrug |
| US6545131B1 (en) | 1997-05-19 | 2003-04-08 | The Johns Hopkins University | Tissue specific prodrug |
| EP1003531B1 (de) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Verfahren zur Herstellung von Nukleinsäurekonstrukten |
| AU740597B2 (en) | 1997-07-10 | 2001-11-08 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| CA2299471C (en) | 1997-08-15 | 2007-12-18 | Cephalon Inc. | Combination of tyrosine kinase inhibitor and chemical castration to treat prostate cancer |
| US6391305B1 (en) | 1997-09-10 | 2002-05-21 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| GB9721901D0 (en) | 1997-10-16 | 1997-12-17 | Univ Manchester | Particles |
| CA2318127A1 (en) | 1998-01-20 | 1999-07-22 | University Of Victoria Innovation And Development Corporation | Detection of gpi anchored proteins |
| US6268377B1 (en) * | 1998-09-28 | 2001-07-31 | Merck & Co., Inc. | Method for treating androgen-related conditions |
| WO2000061613A2 (en) | 1999-04-09 | 2000-10-19 | The Johns Hopkins University | Channel forming toxins as antiviral agents |
| US6179831B1 (en) * | 1999-04-29 | 2001-01-30 | Galil Medical Ltd. | Method of cryoablating benign prostate hyperplasia |
| EP1052287A3 (de) | 1999-05-10 | 2003-07-09 | Transgene S.A. | Komplex zur Übertragung von einem interessierenden anionischen Substanz auf einer Zelle |
| EP1052288A1 (de) | 1999-05-10 | 2000-11-15 | Transgene S.A. | Komplex zur Ubertragung einer anionischen Substanz in einen Zell |
| WO2001009165A2 (en) | 1999-07-29 | 2001-02-08 | The Johns Hopkins University | ACTIVATION OF PEPTIDE PRODRUGS BY hK2 |
| US7053042B1 (en) | 1999-07-29 | 2006-05-30 | Samuel Denmeade | Activation of peptide prodrugs by hK2 |
| US6200573B1 (en) * | 1999-12-03 | 2001-03-13 | Starcor Pharmaceuticals, Inc. | Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia |
| AU2001259837A1 (en) | 2000-05-09 | 2001-11-20 | Greenville Hospital System | Therapeutic pore-forming peptides |
| AU2001261474B2 (en) * | 2000-05-15 | 2006-03-09 | Celgene Corporation | Compositions and methods for the treatment of cancer |
| US20020041880A1 (en) | 2000-07-05 | 2002-04-11 | Defeo-Jones Deborah | Method of treating cancer |
| FI116467B (fi) | 2000-09-29 | 2005-11-30 | Licentia Oy | Uudet peptidiligandit |
| WO2002038799A2 (en) | 2000-11-07 | 2002-05-16 | University Of Victoria Innovation And Development Corporation | Detection of proteases and screening for protease inhibitors |
| JP2004529676A (ja) * | 2000-11-13 | 2004-09-30 | ダブリュ アイ ティー アイ ピー コーポレーション | 断熱領域を有する治療カテーテル |
| WO2002043773A2 (en) | 2000-12-01 | 2002-06-06 | The Johns Hopkins University | Tissue specific prodrugs |
| US7456146B2 (en) | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
| WO2003005889A2 (en) * | 2001-07-10 | 2003-01-23 | Ams Research Corporation | Surgical kit for treating prostate tissue |
| JP4319908B2 (ja) * | 2001-08-24 | 2009-08-26 | ユニバーシティ オブ ビクトリア イノベーション アンド ディベロップメント コーポレーション | プロテアーゼ活性化配列を含むプロアエロリシンおよび前立腺癌の治療のための使用方法 |
| WO2004060915A2 (en) * | 2002-12-03 | 2004-07-22 | Sloan-Kettering Institute For Cancer Research | Prostate specific antigens, conjugates thereof, methods for their preparation and uses thereof. |
| CN100341569C (zh) * | 2004-09-17 | 2007-10-10 | 温州三天制药有限公司 | 一种治疗前列腺增生症的复方蛋白酶药物及制备方法 |
| ATE502954T1 (de) | 2005-06-14 | 2011-04-15 | Protox Therapeutics Inc | Verfahren zur behandlung oder prävention gutartiger prostatahyperplasie unter verwendung modifizierter porenbildender proteine |
-
2006
- 2006-06-14 AT AT06761050T patent/ATE502954T1/de active
- 2006-06-14 CA CA2611839A patent/CA2611839C/en not_active Expired - Fee Related
- 2006-06-14 JP JP2008516088A patent/JP5220594B2/ja not_active Expired - Fee Related
- 2006-06-14 KR KR1020087001038A patent/KR101365538B1/ko not_active Expired - Fee Related
- 2006-06-14 AU AU2006257664A patent/AU2006257664B2/en not_active Ceased
- 2006-06-14 WO PCT/CA2006/000971 patent/WO2006133553A1/en not_active Ceased
- 2006-06-14 DE DE602006020867T patent/DE602006020867D1/de active Active
- 2006-06-14 EP EP06761050A patent/EP1891093B1/de not_active Not-in-force
- 2006-06-14 DK DK06761050.1T patent/DK1891093T3/da active
- 2006-06-14 NZ NZ564954A patent/NZ564954A/en not_active IP Right Cessation
- 2006-06-14 ES ES06761050T patent/ES2366380T3/es active Active
- 2006-06-14 US US11/921,964 patent/US8916161B2/en not_active Expired - Fee Related
- 2006-06-14 CN CN2006800284736A patent/CN101238145B/zh not_active Expired - Fee Related
-
2007
- 2007-12-12 ZA ZA200710813A patent/ZA200710813B/xx unknown
- 2007-12-13 IL IL188143A patent/IL188143A/en not_active IP Right Cessation
-
2014
- 2014-11-24 US US14/551,811 patent/US9950029B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL188143A0 (en) | 2008-03-20 |
| EP1891093B1 (de) | 2011-03-23 |
| CN101238145B (zh) | 2013-04-24 |
| ATE502954T1 (de) | 2011-04-15 |
| AU2006257664A1 (en) | 2006-12-21 |
| KR20080042067A (ko) | 2008-05-14 |
| ES2366380T3 (es) | 2011-10-19 |
| DK1891093T3 (da) | 2011-07-11 |
| KR101365538B1 (ko) | 2014-02-21 |
| US20100233191A1 (en) | 2010-09-16 |
| EP1891093A1 (de) | 2008-02-27 |
| US8916161B2 (en) | 2014-12-23 |
| IL188143A (en) | 2012-10-31 |
| WO2006133553A1 (en) | 2006-12-21 |
| AU2006257664B2 (en) | 2013-01-10 |
| CA2611839A1 (en) | 2006-12-21 |
| CN101238145A (zh) | 2008-08-06 |
| EP1891093A4 (de) | 2008-10-01 |
| JP2008546650A (ja) | 2008-12-25 |
| DE602006020867D1 (de) | 2011-05-05 |
| JP5220594B2 (ja) | 2013-06-26 |
| NZ564954A (en) | 2011-02-25 |
| US20160375095A1 (en) | 2016-12-29 |
| CA2611839C (en) | 2016-02-02 |
| US9950029B2 (en) | 2018-04-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200710813B (en) | Method of treating or preventing benign prostatic hyperplasia using modified pore-forming proteins | |
| IL190796A0 (en) | Compositions and their uses for gene therapy of bone conditions | |
| WO2009044173A3 (en) | Methods of treating cancer using notch pathway inhibitors | |
| WO2012018404A3 (en) | Use of her3 binding agents in prostate treatment | |
| GB2434983A (en) | Methods and compositions for wound healing | |
| WO2005065418A3 (en) | Compositions and methods of use of targeting peptides for diagnosis and therapy | |
| PL1902141T3 (pl) | Kompozycje o działaniu trombolitycznym zawierające ADAMTS13 | |
| MX2008007307A (es) | Granulos/capsulas modificados que contienen ingrediente activo. | |
| MX2022009759A (es) | El uso de 1-(4-ciano-3-trifluorometil-fenil)-3-[7-(4-ciano-3-trifl uorometil-fenil)-6-tioxo-5-p-tolilo-5,7-diazaespiro[3.4]oct-8-ili deno]-tiourea. | |
| TW200730624A (en) | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38 | |
| TW200745162A (en) | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38 | |
| WO2001051633A3 (en) | Compositions and methods for the therapy and diagnosis of prostate cancer | |
| EA201001695A1 (ru) | Применение эпотилона d для лечения заболеваний, связанных с тау-белком | |
| WO2007100675A3 (en) | Collagenase for treating cellulite | |
| WO2007095340A3 (en) | Small-molecule modulators of trp-p8 activity | |
| SG165387A1 (en) | 5-lipoxygenase-activating protein (flap) inhibitors | |
| MX2008009579A (es) | Metodo para el tratamiento de dolor neuropatico. | |
| TNSN06059A1 (en) | Use of polypeptides of the cupredoxin family in cancer therapy | |
| WO2005020927A3 (en) | Method of promoting graft survival with anti-tissue factor antibodies | |
| WO2008134752A3 (en) | Methods and compositions for the treatment of cancer | |
| WO2007081878A8 (en) | Indoleamine 2,3-dioxygenase pathways in the generation of regulatory t cells | |
| EP2386639A3 (de) | Modifizierte porenformende Proteintoxine und Verwendung davon | |
| WO2005060960A3 (en) | Use of histamine to treat bone disease | |
| DK1185279T3 (da) | Midler til behandling af maligne sygdomme ved anvendelse af proteinet YB-1 | |
| DK1411971T3 (da) | Anvendelse af lang gentraxin PTX3 til behandling af kvindelig sterilitet |