ZA200800176B - Pharmaceutical dosage form containing an active principle combination of nifedipine and/or nisoldipine and of an angiotensin II antogonist - Google Patents

Pharmaceutical dosage form containing an active principle combination of nifedipine and/or nisoldipine and of an angiotensin II antogonist

Info

Publication number: ZA200800176B
Authority: ZA; South Africa
Prior art keywords: antogonist; nisoldipine; nifedipine; angiotensin; dosage form
Prior art date: 2005-07-06

Application number

ZA200800176A

Other languages

English (en)

Inventor

Ohm Andreas

Benke Klaus

Tinel Hanna

Huetter Joachim

Original Assignee

Bayer Schering Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-06

Filing date

2008-01-07

Publication date

2009-09-30

2008-01-07 Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag

2009-09-30 Publication of ZA200800176B publication Critical patent/ZA200800176B/xx

Links

102000005862 Angiotensin II Human genes 0.000 title 1
101800000733 Angiotensin-2 Proteins 0.000 title 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 title 1
229950006323 angiotensin ii Drugs 0.000 title 1
239000002552 dosage form Substances 0.000 title 1
VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 title 1
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 title 1
229960001597 nifedipine Drugs 0.000 title 1
229960000227 nisoldipine Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200800176A 2005-07-06 2008-01-07 Pharmaceutical dosage form containing an active principle combination of nifedipine and/or nisoldipine and of an angiotensin II antogonist ZA200800176B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102005031577A DE102005031577A1 (de)	2005-07-06	2005-07-06	Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten

Publications (1)

Publication Number	Publication Date
ZA200800176B true ZA200800176B (en)	2009-09-30

Family

ID=37532983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200800176A ZA200800176B (en)	2005-07-06	2008-01-07	Pharmaceutical dosage form containing an active principle combination of nifedipine and/or nisoldipine and of an angiotensin II antogonist

Country Status (13)

Country	Link
US (1)	US8153160B2 (fr)
EP (1)	EP1904180A2 (fr)
JP (1)	JP2009500361A (fr)
KR (1)	KR20080031382A (fr)
CN (1)	CN101257946B (fr)
AU (1)	AU2006265367A1 (fr)
BR (1)	BRPI0612681A2 (fr)
CA (1)	CA2614085C (fr)
DE (1)	DE102005031577A1 (fr)
IL (1)	IL188583A0 (fr)
RU (1)	RU2008103551A (fr)
WO (1)	WO2007003330A2 (fr)
ZA (1)	ZA200800176B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102005031577A1 (de)	2005-07-06	2007-01-11	Bayer Healthcare Ag	Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten
WO2007057762A2 (fr) *	2005-11-16	2007-05-24	Pfizer Limited	Forme posologique a liberation controlee
WO2008123536A1 (fr) *	2007-03-28	2008-10-16	Takeda Pharmaceutical Company Limited	Composition pharmaceutique solide comprenant un dérivé de benzimidazole-7-carboxylate et un agent de contrôle du ph
PT2065035E (pt) *	2007-11-28	2010-10-04	Lesvi Laboratorios Sl	Formulações farmacêuticas contendo irbesartan
EP2106789A1 (fr) *	2008-03-31	2009-10-07	KRKA, tovarna zdravil, d.d., Novo mesto	Composition pharmaceutique comprenant du candesartan
EP2291178A4 (fr) *	2008-06-09	2013-07-24	Supernus Pharmaceuticals Inc	Formulations à libération contrôlée de pramipexole
WO2010015840A1 (fr) *	2008-08-08	2010-02-11	Cipla Limited	Dispositif d'administration osmotique avec libération modifiée
UY32126A (es) *	2008-09-25	2010-04-30	Takeda Pharmaceutical	Composición farmacéutica sólida
DE102008059206A1 (de) *	2008-11-27	2010-06-10	Bayer Schering Pharma Aktiengesellschaft	Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum
PE20120315A1 (es) *	2009-04-30	2012-04-07	Takeda Pharmaceutical	Una composicion farmaceutica que comprende candesartan, candesartan cilexetil, o azilsartan, combinado con amlodipino
EP2448411A4 (fr) *	2009-07-02	2012-11-28	Supernus Pharmaceuticals Inc	Procédé de traitement d'un trouble neurologique
CN102406623B (zh) *	2010-09-26	2014-08-27	上海星泰医药科技有限公司	一种尼索地平控释片剂及其制备方法
US9480681B2 (en) *	2011-09-23	2016-11-01	Emcure Pharmaceuticals Limited	Controlled release formulations of nisoldipine
IN2014DN09045A (fr)	2012-05-07	2015-05-22	Bayer Pharma AG
JP5871984B2 (ja) *	2013-04-15	2016-03-01	株式会社三和化学研究所	オルメサルタンメドキソミルを含有する医薬組成物
CN106562965A (zh) *	2016-11-06	2017-04-19	成都先先先生物科技有限公司	一种治疗肾性高血压的药物复方制剂

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4327725A (en) *	1980-11-25	1982-05-04	Alza Corporation	Osmotic device with hydrogel driving member
US4765989A (en) *	1983-05-11	1988-08-23	Alza Corporation	Osmotic device for administering certain drugs
US4612008A (en) *	1983-05-11	1986-09-16	Alza Corporation	Osmotic device with dual thermodynamic activity
NZ206600A (en) *	1983-05-11	1987-01-23	Alza Corp	Osmotic drug delivery device
US5082668A (en) *	1983-05-11	1992-01-21	Alza Corporation	Controlled-release system with constant pushing source
US4783337A (en) *	1983-05-11	1988-11-08	Alza Corporation	Osmotic system comprising plurality of members for dispensing drug
US4948592A (en) *	1986-05-09	1990-08-14	Alza Corporation	Pulsed drug delivery
DE3720757A1 (de) *	1987-06-24	1989-01-05	Bayer Ag	Dhp-manteltablette
US4931285A (en)	1988-04-28	1990-06-05	Alza Corporation	Aqueous based pharmaceutical coating composition for dosage forms
DE59000232D1 (de) *	1989-02-11	1992-09-10	Bayer Ag	Arzneimittel mit kontrollierter wirkstoffabgabe.
KR100222252B1 (ko) *	1990-12-14	1999-10-01	스튜어트 알. 수터	안지오텐신 ii 수용체 차단 조성물
US5160744A (en)	1991-06-27	1992-11-03	Alza Corporation	Verapmil therapy
US5178867A (en)	1991-08-19	1993-01-12	Alza Corporation	Dosage form for delivering drug in short-time period
US5543154A (en) *	1991-12-27	1996-08-06	Merck & Co., Inc.	Controlled release nifedipine delivery device
JP3220373B2 (ja)	1995-11-28	2001-10-22	バイエル薬品株式会社	持続性ニフエジピン製剤
DE19747261A1 (de) *	1997-10-25	1999-04-29	Bayer Ag	Osmotisches Arzneimittelfreisetzungssystem
WO2000059479A1 (fr) *	1999-04-06	2000-10-12	Pharmaquest Ltd.	Forme posologique pharmaceutique permettant l'administration intermittente de methylphenidate
US20040115134A1 (en) *	1999-06-22	2004-06-17	Elan Pharma International Ltd.	Novel nifedipine compositions
US20040219208A1 (en) *	2001-08-03	2004-11-04	Ryu Kawamura	Sustained-release medicines
JP2005508358A (ja)	2001-10-25	2005-03-31	デポメド・インコーポレイテッド	胃滞留型ロサルタン投与量を用いる治療方法
US20030161882A1 (en) *	2002-02-01	2003-08-28	Waterman Kenneth C.	Osmotic delivery system
AU2003227472A1 (en)	2002-03-27	2003-10-08	Bayer Aktiengesellschaft	Downsized core tablet containing nifedipine
EG24716A (en)	2002-05-17	2010-06-07	Novartis Ag	Combination of organic compounds
US8029822B2 (en) *	2003-05-22	2011-10-04	Osmotica Kereskedelmi és Seolgáltató KFT	Rupturing controlled release device having a preformed passageway
JP2009513543A (ja) *	2003-07-16	2009-04-02	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	クロルタリドンの組み合わせ
CA2536111A1 (fr)	2003-07-24	2005-02-03	Wockhardt Limited	Compositions orales pour le traitement de maladies
EP1686967A4 (fr) *	2003-11-25	2012-08-08	Smithkline Beecham Cork Ltd	Base libre de carvedilol, ses sels, formes anhydres ou solvats, compositions pharmaceutiques correspondantes, formulations a liberation controlee, et methodes de traitement ou d'administration
DE102005031577A1 (de)	2005-07-06	2007-01-11	Bayer Healthcare Ag	Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten
KR100888131B1 (ko)	2006-10-10	2009-03-11	한올제약주식회사	시간차 투약 원리를 이용한 심혈관계 질환 치료용 복합제제

2005
- 2005-07-06 DE DE102005031577A patent/DE102005031577A1/de not_active Withdrawn
2006
- 2006-06-29 US US11/922,745 patent/US8153160B2/en not_active Expired - Fee Related
- 2006-06-29 EP EP06776095A patent/EP1904180A2/fr not_active Withdrawn
- 2006-06-29 WO PCT/EP2006/006293 patent/WO2007003330A2/fr not_active Ceased
- 2006-06-29 KR KR1020087003113A patent/KR20080031382A/ko not_active Withdrawn
- 2006-06-29 CA CA2614085A patent/CA2614085C/fr not_active Expired - Fee Related
- 2006-06-29 RU RU2008103551/15A patent/RU2008103551A/ru not_active Application Discontinuation
- 2006-06-29 JP JP2008519837A patent/JP2009500361A/ja active Pending
- 2006-06-29 CN CN2006800244194A patent/CN101257946B/zh not_active Expired - Fee Related
- 2006-06-29 AU AU2006265367A patent/AU2006265367A1/en not_active Abandoned
- 2006-06-29 BR BRPI0612681-2A patent/BRPI0612681A2/pt not_active IP Right Cessation
2008
- 2008-01-03 IL IL188583A patent/IL188583A0/en unknown
- 2008-01-07 ZA ZA200800176A patent/ZA200800176B/xx unknown

Also Published As

Publication number	Publication date
HK1124558A1 (en)	2009-07-17
WO2007003330A3 (fr)	2008-01-10
RU2008103551A (ru)	2009-08-20
US20090214664A1 (en)	2009-08-27
CN101257946B (zh)	2013-10-30
CA2614085C (fr)	2013-10-15
CN101257946A (zh)	2008-09-03
AU2006265367A1 (en)	2007-01-11
IL188583A0 (en)	2008-06-05
WO2007003330A2 (fr)	2007-01-11
EP1904180A2 (fr)	2008-04-02
KR20080031382A (ko)	2008-04-08
BRPI0612681A2 (pt)	2010-11-30
US8153160B2 (en)	2012-04-10
JP2009500361A (ja)	2009-01-08
CA2614085A1 (fr)	2007-01-11
DE102005031577A1 (de)	2007-01-11

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