ZA200810687B - CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives - Google Patents

CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives

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Publication number
ZA200810687B
ZA200810687B ZA200810687A ZA200810687A ZA200810687B ZA 200810687 B ZA200810687 B ZA 200810687B ZA 200810687 A ZA200810687 A ZA 200810687A ZA 200810687 A ZA200810687 A ZA 200810687A ZA 200810687 B ZA200810687 B ZA 200810687B
Authority
ZA
South Africa
Prior art keywords
alkane derivatives
cns active
substituted azabicyclic
fused bicycloheterocycle
azabicyclic alkane
Prior art date
Application number
ZA200810687A
Other languages
English (en)
Inventor
Jianguo Ji
Tao Lynch Christopher L Li
Murali Gopalakrishnan
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ZA200810687B publication Critical patent/ZA200810687B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/08—Diarylmethoxy radicals
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P37/02—Immunomodulators
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200810687A 2006-05-19 2008-12-18 CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives ZA200810687B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80219506P 2006-05-19 2006-05-19

Publications (1)

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ZA200810687B true ZA200810687B (en) 2010-05-26

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ID=38662941

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ZA200810687A ZA200810687B (en) 2006-05-19 2008-12-18 CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives
ZA2010/01298A ZA201001298B (en) 2006-05-19 2010-02-23 Cns active fused bicycloheterocycle substituted azabicycic

Family Applications After (1)

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ZA2010/01298A ZA201001298B (en) 2006-05-19 2010-02-23 Cns active fused bicycloheterocycle substituted azabicycic

Country Status (29)

Country Link
US (2) US7872017B2 (da)
EP (2) EP2431368B1 (da)
JP (3) JP5420398B2 (da)
KR (1) KR20090018972A (da)
CN (2) CN101448825A (da)
AT (1) ATE529423T1 (da)
AU (1) AU2007253950B2 (da)
BR (1) BRPI0711588A2 (da)
CA (1) CA2647830C (da)
CY (1) CY1112531T1 (da)
DK (1) DK2018380T3 (da)
EC (1) ECSP088918A (da)
ES (2) ES2525076T3 (da)
GT (1) GT200800248A (da)
HR (1) HRP20110917T1 (da)
IL (1) IL195234A0 (da)
MX (1) MX2008014672A (da)
MY (1) MY147661A (da)
NO (1) NO20085153L (da)
NZ (2) NZ589784A (da)
PL (1) PL2018380T3 (da)
PT (1) PT2018380E (da)
RS (1) RS52062B (da)
RU (2) RU2437884C2 (da)
SI (1) SI2018380T1 (da)
TW (1) TWI343385B (da)
UA (1) UA92083C2 (da)
WO (1) WO2007137030A2 (da)
ZA (2) ZA200810687B (da)

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