ZA200901462B - Pharmacokinetically improved compounds - Google Patents

Pharmacokinetically improved compounds

Info

Publication number
ZA200901462B
ZA200901462B ZA200901462A ZA200901462A ZA200901462B ZA 200901462 B ZA200901462 B ZA 200901462B ZA 200901462 A ZA200901462 A ZA 200901462A ZA 200901462 A ZA200901462 A ZA 200901462A ZA 200901462 B ZA200901462 B ZA 200901462B
Authority
ZA
South Africa
Prior art keywords
improved compounds
pharmacokinetically improved
pharmacokinetically
compounds
improved
Prior art date
Application number
ZA200901462A
Other languages
English (en)
Inventor
Stewart Campbell
David Duffy
Michael Grogan
Steven Kates
Emanuele Ostuni
Olivier Schueller
Paul Sweetnam
Original Assignee
Surface Logix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surface Logix Inc filed Critical Surface Logix Inc
Publication of ZA200901462B publication Critical patent/ZA200901462B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/08—Six-membered rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Vascular Medicine (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200901462A 2006-08-24 2007-08-23 Pharmacokinetically improved compounds ZA200901462B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84030606P 2006-08-24 2006-08-24

Publications (1)

Publication Number Publication Date
ZA200901462B true ZA200901462B (en) 2010-07-28

Family

ID=39107450

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200901462A ZA200901462B (en) 2006-08-24 2007-08-23 Pharmacokinetically improved compounds

Country Status (15)

Country Link
US (2) US20100324037A1 (fr)
EP (2) EP2061322B1 (fr)
JP (2) JP2010501577A (fr)
KR (1) KR20090042863A (fr)
CN (1) CN101528042A (fr)
AU (1) AU2007287024A1 (fr)
BR (1) BRPI0716571A2 (fr)
CA (1) CA2661483A1 (fr)
ES (1) ES2548759T3 (fr)
IL (1) IL197224A0 (fr)
MX (1) MX2009002073A (fr)
NO (1) NO20090896L (fr)
TW (1) TW200826944A (fr)
WO (1) WO2008024494A2 (fr)
ZA (1) ZA200901462B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR9465A (es) * 2005-03-25 2008-06-19 Surface Logix Inc Compuestos mejorados farmacocineticamente
US9573956B2 (en) 2013-03-01 2017-02-21 Fundación Para La Investigación Médica Aplicada Compounds as dual inhibitors of phosphodiesterases and histone deacetylases
WO2016147659A1 (fr) * 2015-03-16 2016-09-22 Sumitomo Dainippon Pharma Co., Ltd. Dérivé imidazolo bicyclique
CN114085225A (zh) * 2021-06-04 2022-02-25 广东西捷药业有限公司 一种伐地那非类似物及其合成方法和应用
TWI806144B (zh) * 2021-09-01 2023-06-21 臺灣塑膠工業股份有限公司 纖維預浸布的含浸裝置及其方法
US12258350B1 (en) * 2024-11-14 2025-03-25 Retension Pharmaceuticals, Inc. Crystalline forms of 4-ethoxy-n-(2-methoxyethyl)-n-methyl-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5, 1-f][1,2,4]triazin-2-yl)benzenesulfonamide

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
WO1991007087A1 (fr) 1989-11-13 1991-05-30 Affymax Technologies N.V. Immobilisation adressable dans l'espace d'anti-ligands sur des surfaces
CA2097708A1 (fr) 1990-12-06 1992-06-07 Stephen P. A. Fodor Synthese a tres grande echelle de polymeres immobilises
EP1588761A3 (fr) 1991-11-22 2005-11-23 Affymetrix, Inc. Procédé de préparation de matrices de polymères
US5359115A (en) 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
JP2857540B2 (ja) 1992-06-22 1999-02-17 ファナック株式会社 カッタパスの自動再作成を行うｃａｄ／ｃａｍ方法及び装置
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
DK0665897T3 (da) 1992-10-01 2003-10-20 Univ Columbia Komplekse, kombinatoriske, kemiske biblioteker kodet med etiketter
US5480971A (en) 1993-06-17 1996-01-02 Houghten Pharmaceuticals, Inc. Peralkylated oligopeptide mixtures
US5440016A (en) * 1993-06-18 1995-08-08 Torrey Pines Institute For Molecular Studies Peptides of the formula (KFmoc) ZZZ and their uses
US5362899A (en) 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
HRP20020585B1 (hr) * 1997-11-12 2013-02-28 Bayer Schering Pharma Aktiengesellschaft 2-fenil supstituirani imidazotriazinoni kao inhibitori fosfodiesteraze
DE19827640A1 (de) * 1998-06-20 1999-12-23 Bayer Ag 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
US6451807B1 (en) * 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
BR0017043A (pt) * 1999-12-24 2003-01-07 Bayer Ag Imidazo[1,3,5]triazinonas e sua aplicação
US6699665B1 (en) 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
DE10107639A1 (de) * 2001-02-15 2002-08-22 Bayer Ag 2-Alkoxyphenyl-substituierte Imidazotriazinone
AU2002327385A1 (en) 2001-07-27 2003-02-17 Surface Logix, Inc. Resealable and sealable devices for biochemical assays
CA2458844A1 (fr) 2001-08-27 2003-03-06 Surface Logix, Inc. Immobilisation de molecules biologiques sur des surfaces enduites de couches monomoleculaires
DE10162435A1 (de) 2001-12-19 2003-07-17 Joerg Lahann Verfahren zur Erzeugung von Oberflächenbeschichtungen, die die Adsorption von Proteinen bzw. die Adhäsion von Bakterien und/oder Zellen vermindern
CA2485984A1 (fr) * 2002-05-23 2003-12-04 Pfizer Inc. Nouvelle combinaison
DE102004038328A1 (de) * 2004-08-06 2006-03-16 Bayer Healthcare Ag Neue Verwendungen von 2-Phenyl-substituierten Imidazotriazinon-Derivaten
WO2006089275A2 (fr) * 2005-02-18 2006-08-24 Surface Logix, Inc. Procedes de fabrication de composes a amelioration pharmacocinetique comportant des residus ou groupes fonctionnels et compositions pharmaceutiques comportant lesdits composes
CR9465A (es) * 2005-03-25 2008-06-19 Surface Logix Inc Compuestos mejorados farmacocineticamente

Also Published As

Publication number Publication date
IL197224A0 (en) 2009-12-24
MX2009002073A (es) 2009-05-25
ES2548759T3 (es) 2015-10-20
WO2008024494A9 (fr) 2009-04-02
WO2008024494A2 (fr) 2008-02-28
NO20090896L (no) 2009-03-09
TW200826944A (en) 2008-07-01
JP2010501577A (ja) 2010-01-21
US8853394B2 (en) 2014-10-07
WO2008024494A3 (fr) 2008-04-10
EP2061322A4 (fr) 2011-01-05
CN101528042A (zh) 2009-09-09
BRPI0716571A2 (pt) 2013-11-05
EP2061322B1 (fr) 2015-07-01
EP2705753A1 (fr) 2014-03-12
US20100324037A1 (en) 2010-12-23
US20130096114A1 (en) 2013-04-18
CA2661483A1 (fr) 2008-02-28
EP2061322A2 (fr) 2009-05-27
KR20090042863A (ko) 2009-04-30
AU2007287024A1 (en) 2008-02-28
JP2014055136A (ja) 2014-03-27

Similar Documents

Publication Publication Date Title
IL186299A0 (en) Pharmacokinetically improved compounds
GB0602424D0 (en) Compounds
GB0602046D0 (en) Compounds
EP1984379A4 (fr) Composes anti-arenaviridae
GB0605786D0 (en) Compounds
IL197224A0 (en) Pharmacokinetically improved compounds
EP2082022A4 (fr) Composés
EP2004174A4 (fr) Composés de naphtalènedione
GB0605784D0 (en) Compounds
GB0605785D0 (en) Compounds
IL185344A0 (en) Pharmacokinetically improved compounds
GB0602042D0 (en) Compounds
AP2009004767A0 (en) Cubstituted azolin-2-yl-amino compounds
GB0602560D0 (en) Compounds
EP1973905A4 (fr) Composes
GB0602412D0 (en) Compounds
GB0600427D0 (en) Compounds
GB0600929D0 (en) Compounds
GB0603551D0 (en) Compounds
GB0602856D0 (en) Compounds
GB0601612D0 (en) Compounds
GB0602040D0 (en) Compounds
GB0600426D0 (en) Compounds
GB0602134D0 (en) Compounds
GB0603133D0 (en) Compounds