ZA200903193B - Novel Morphine derivatives - Google Patents

Novel Morphine derivatives

Info

Publication number: ZA200903193B
Authority: ZA; South Africa
Prior art keywords: morphine derivatives; novel morphine; novel; derivatives; pharmaceutical compositions
Prior art date: 2006-10-12

Application number

ZA200903193A

Other languages

English (en)

Inventor

Karine Larbouret

Roger Lahana

Cedric Castex

Original Assignee

Neorphys

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-12

Filing date

2009-05-08

Publication date

2010-03-31

2009-05-08 Application filed by Neorphys filed Critical Neorphys

2010-03-31 Publication of ZA200903193B publication Critical patent/ZA200903193B/xx

Links

BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 1
GNJCUHZOSOYIEC-GAROZEBRSA-N Morphine-6-glucuronide Chemical class O([C@H]1C=C[C@H]2[C@H]3CC=4C5=C(C(=CC=4)O)O[C@@H]1[C@]52CCN3C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O GNJCUHZOSOYIEC-GAROZEBRSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Pregnancy & Childbirth (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

ZA200903193A 2006-10-12 2009-05-08 Novel Morphine derivatives ZA200903193B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0654247A FR2907121B1 (fr)	2006-10-12	2006-10-12	Nouveaux derives morphiniques

Publications (1)

Publication Number	Publication Date
ZA200903193B true ZA200903193B (en)	2010-03-31

Family

ID=38038630

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200903193A ZA200903193B (en)	2006-10-12	2009-05-08	Novel Morphine derivatives

Country Status (20)

Country	Link
US (1)	US8158764B2 (pl)
EP (1)	EP2081944B1 (pl)
JP (1)	JP5180219B2 (pl)
KR (1)	KR20090079232A (pl)
CN (1)	CN101522700B (pl)
AT (1)	ATE473233T1 (pl)
AU (1)	AU2007306226C1 (pl)
CA (1)	CA2664569A1 (pl)
CY (1)	CY1110787T1 (pl)
DE (1)	DE602007007653D1 (pl)
DK (1)	DK2081944T3 (pl)
ES (1)	ES2347020T3 (pl)
FR (1)	FR2907121B1 (pl)
IL (1)	IL197769A (pl)
PL (1)	PL2081944T3 (pl)
PT (1)	PT2081944E (pl)
RU (1)	RU2426736C2 (pl)
SI (1)	SI2081944T1 (pl)
WO (1)	WO2008043962A1 (pl)
ZA (1)	ZA200903193B (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2939437B1 (fr) *	2008-12-10	2010-12-17	Sanofi Aventis	Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
FR2939796B1 (fr) *	2008-12-11	2010-12-17	Sanofi Aventis	Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique
US20180071269A1 (en)	2015-08-12	2018-03-15	Tianxin Wang	Therapeutical methods, formulations and nutraceutical formulations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2318687A (en)		1943-05-11		Means fob determining the sex of
US4939264A (en) *	1986-07-14	1990-07-03	Abbott Laboratories	Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
GB9116909D0 (en)	1991-08-06	1991-09-18	Salford Ultrafine Chem & Res	Morphine derivatives
GB2282758A (en)	1993-08-23	1995-04-19	Euro Celtique Sa	Oral morphine-6-glucuronide compositions
WO1997021416A2 (es) *	1995-11-29	1997-06-19	Rolabo Sl	Glicoconjugados de substancias opiaceas
DE19602963A1 (de)	1995-12-20	1997-07-31	Nycomed Arzneimittel Gmbh	Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
DE69815336T2 (de)	1997-04-14	2004-05-06	Ufc Ltd.	Morphin-derivate
GB9711118D0 (en) *	1997-05-29	1997-07-23	Rolabo Sl	Compound
ATE225363T1 (de)	1998-06-06	2002-10-15	Cenes Ltd	Synthese von morphin-6-glucuronid
FR2821272B1 (fr) *	2001-02-23	2004-12-17	Synt Em	Composes constitues d'une molecule analgesique liee a un vecteur capable de vectoriser ladite molecule a travers la barriere hematoencephalique et compositions pharmaceutiques les contenant
CN1289071C (zh)	2001-03-16	2006-12-13	Dmi生物科学公司	曲马朵物质在制备用于延缓男性射精的药物中的用途
WO2004075879A1 (en) *	2003-02-28	2004-09-10	Delex Therapeutics Inc.	Opioid delivery system
FR2864082B1 (fr) *	2003-12-22	2006-03-10	Synt Em	Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur
CA2593165A1 (en) *	2005-01-05	2006-07-13	Regents Of The University Of Minnesota	Analgesic conjugates
US7576207B2 (en) *	2006-04-06	2009-08-18	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use

2006
- 2006-10-12 FR FR0654247A patent/FR2907121B1/fr not_active Expired - Fee Related
2007
- 2007-10-11 PT PT07858552T patent/PT2081944E/pt unknown
- 2007-10-11 JP JP2009531887A patent/JP5180219B2/ja not_active Expired - Fee Related
- 2007-10-11 CN CN2007800381529A patent/CN101522700B/zh not_active Expired - Fee Related
- 2007-10-11 EP EP07858552A patent/EP2081944B1/fr not_active Not-in-force
- 2007-10-11 KR KR1020097009630A patent/KR20090079232A/ko not_active Ceased
- 2007-10-11 AU AU2007306226A patent/AU2007306226C1/en not_active Ceased
- 2007-10-11 AT AT07858552T patent/ATE473233T1/de active
- 2007-10-11 ES ES07858552T patent/ES2347020T3/es active Active
- 2007-10-11 DE DE602007007653T patent/DE602007007653D1/de active Active
- 2007-10-11 PL PL07858552T patent/PL2081944T3/pl unknown
- 2007-10-11 DK DK07858552.8T patent/DK2081944T3/da active
- 2007-10-11 SI SI200730364T patent/SI2081944T1/sl unknown
- 2007-10-11 CA CA002664569A patent/CA2664569A1/fr not_active Abandoned
- 2007-10-11 US US12/444,430 patent/US8158764B2/en not_active Expired - Fee Related
- 2007-10-11 RU RU2009117467/04A patent/RU2426736C2/ru not_active IP Right Cessation
- 2007-10-11 WO PCT/FR2007/052122 patent/WO2008043962A1/fr not_active Ceased
2009
- 2009-03-23 IL IL197769A patent/IL197769A/en not_active IP Right Cessation
- 2009-05-08 ZA ZA200903193A patent/ZA200903193B/xx unknown
2010
- 2010-09-16 CY CY20101100839T patent/CY1110787T1/el unknown

Also Published As

Publication number	Publication date
JP5180219B2 (ja)	2013-04-10
EP2081944B1 (fr)	2010-07-07
PT2081944E (pt)	2010-08-31
ES2347020T3 (es)	2010-10-22
WO2008043962A1 (fr)	2008-04-17
CY1110787T1 (el)	2015-06-10
US20100075912A1 (en)	2010-03-25
DK2081944T3 (da)	2010-09-20
AU2007306226C1 (en)	2012-06-28
RU2426736C2 (ru)	2011-08-20
JP2010505923A (ja)	2010-02-25
ATE473233T1 (de)	2010-07-15
EP2081944A1 (fr)	2009-07-29
US8158764B2 (en)	2012-04-17
IL197769A (en)	2013-07-31
CN101522700B (zh)	2012-08-22
CN101522700A (zh)	2009-09-02
HK1131156A1 (en)	2010-01-15
FR2907121B1 (fr)	2012-05-04
IL197769A0 (en)	2009-12-24
FR2907121A1 (fr)	2008-04-18
SI2081944T1 (sl)	2010-11-30
AU2007306226B2 (en)	2012-01-19
DE602007007653D1 (de)	2010-08-19
AU2007306226A1 (en)	2008-04-17
KR20090079232A (ko)	2009-07-21
RU2009117467A (ru)	2010-11-20
CA2664569A1 (fr)	2008-04-17
PL2081944T3 (pl)	2010-12-31

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