ZA200904211B - Compositions, synthesis and methods of using indanone based cholinesterase inhibitors - Google Patents
Compositions, synthesis and methods of using indanone based cholinesterase inhibitorsInfo
- Publication number
- ZA200904211B ZA200904211B ZA200904211A ZA200904211A ZA200904211B ZA 200904211 B ZA200904211 B ZA 200904211B ZA 200904211 A ZA200904211 A ZA 200904211A ZA 200904211 A ZA200904211 A ZA 200904211A ZA 200904211 B ZA200904211 B ZA 200904211B
- Authority
- ZA
- South Africa
- Prior art keywords
- synthesis
- compositions
- methods
- cholinesterase inhibitors
- indanone based
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000544 cholinesterase inhibitor Substances 0.000 title 1
- QNXSIUBBGPHDDE-UHFFFAOYSA-N indan-1-one Chemical compound C1=CC=C2C(=O)CCC2=C1 QNXSIUBBGPHDDE-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86949906P | 2006-12-11 | 2006-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200904211B true ZA200904211B (en) | 2010-03-31 |
Family
ID=39512052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200904211A ZA200904211B (en) | 2006-12-11 | 2009-06-17 | Compositions, synthesis and methods of using indanone based cholinesterase inhibitors |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8247563B2 (pt) |
| EP (1) | EP2114166A4 (pt) |
| JP (1) | JP2010512328A (pt) |
| CN (1) | CN101626688A (pt) |
| AU (1) | AU2007333586A1 (pt) |
| BR (1) | BRPI0720211A2 (pt) |
| CA (1) | CA2672212A1 (pt) |
| IL (1) | IL198921A0 (pt) |
| MX (1) | MX2009005795A (pt) |
| NZ (1) | NZ578187A (pt) |
| RU (1) | RU2478619C2 (pt) |
| WO (1) | WO2008073452A1 (pt) |
| ZA (1) | ZA200904211B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007108011A2 (en) * | 2006-03-20 | 2007-09-27 | Ind-Swift Laboratories Limited | Process for the preparation of highly pure donepezil |
| ES2530540T3 (es) * | 2008-10-02 | 2015-03-03 | Korea Res Inst Chem Tech | Compuestos basados en uracilo y herbicidas que comprenden los mismos |
| EA202092673A3 (ru) | 2010-02-09 | 2021-05-31 | Дзе Джонс Хопкинс Юниверсити | Способы и композиции для улучшения когнитивной функции |
| ES2365316B1 (es) | 2010-03-18 | 2012-09-06 | Consejo Superior De Investigaciones Científicas (Csic) | Nuevos derivados de propargilamina con capacidad neuroprotectora para el tratamiento de las enfermedades de alzheimer y parkinson. |
| AU2011261375B2 (en) | 2010-06-04 | 2016-09-22 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| CN103524515B (zh) * | 2012-07-03 | 2016-07-06 | 浙江海正药业股份有限公司 | 具有乙酰胆碱酯酶抑制活性的苯并间二氧杂环戊烯衍生物及其制备方法和用途 |
| US9249098B2 (en) * | 2012-07-10 | 2016-02-02 | Xueheng Cheng | Derivatives of donepezil |
| CN103787954B (zh) * | 2012-10-26 | 2016-01-20 | 中国科学院上海药物研究所 | 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途 |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| AU2014228512A1 (en) | 2013-03-15 | 2015-10-01 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| BR102013030928A2 (pt) * | 2013-11-29 | 2015-09-22 | Cristália Produtos Químicos Farmacêuticos Ltda | processo para a preparação de cloridrato de donepezila formas i e iii; e de um composto intermediário do mesmo |
| TW201625586A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 環己烯－１－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
| TW201625601A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 噻吩－２－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
| TW201625584A (zh) * | 2014-07-02 | 2016-07-16 | 諾華公司 | 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
| CA2986598C (en) | 2015-05-22 | 2023-09-26 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| CN105859732B (zh) * | 2016-04-11 | 2018-04-06 | 浙江海正药业股份有限公司 | 制备ad‑35的工艺 |
| JP6899120B2 (ja) * | 2016-10-12 | 2021-07-07 | 株式会社ナノエッグ | アセチルコリンエステラーゼ（ＡＣｈＥ）阻害剤 |
| US11082516B2 (en) | 2017-12-01 | 2021-08-03 | Hewlett-Packard Development Company, L.P. | Computer devices to establish network connections |
| TWI799691B (zh) * | 2019-03-29 | 2023-04-21 | 景凱生物科技股份有限公司 | 具有側鏈烷基與烯基延伸的苯基衍生物及包括有其的藥學組合物 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| FR2484415A1 (fr) | 1980-06-13 | 1981-12-18 | Pharmindustrie | Nouveaux derives de l'indene, procedes pour leur preparation, et leur utilisation comme medicaments |
| US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| EP0535496A1 (en) * | 1991-09-25 | 1993-04-07 | Hoechst-Roussel Pharmaceuticals Incorporated | (1-Indanon-2yl)methylpiperidines, intermediates and a process for their preparation and their use as medicaments |
| US5272158A (en) * | 1991-10-29 | 1993-12-21 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| DE4439822A1 (de) | 1994-11-08 | 1996-08-29 | Bayer Ag | Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen |
| US5696070A (en) * | 1995-02-24 | 1997-12-09 | Kao Corporation | Quarternary ammonium salt, method for production thereof, and softener composition using salt |
| IL124452A0 (en) | 1995-12-15 | 1998-12-06 | Pfizer | Processes and intermediates for preparing 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-YL)methylpiperidine |
| SI9720038B (sl) * | 1996-06-07 | 2010-06-30 | Eisai Co Ltd | Polimorfi donepezil hidroklorida in postopek izdelave |
| WO1999025340A1 (en) | 1997-11-14 | 1999-05-27 | Eli Lilly And Company | Treatment for alzheimer's disease |
| EP1047674B1 (en) | 1998-01-16 | 2005-03-30 | Eisai Co., Ltd. | Process for production of donepezil derivatives |
| IL125809A (en) | 1998-08-17 | 2005-08-31 | Finetech Lab Ltd | Process and intermediates for production of donepezil and related compounds |
| WO2000051985A1 (en) | 1999-03-03 | 2000-09-08 | Eisai Co., Ltd. | Fluorides of 4-substituted piperidine derivatives |
| ES2284519T3 (es) | 1999-09-01 | 2007-11-16 | EISAI R&D MANAGEMENT CO., LTD. | Derivados de piperidina 4-sustituida. |
| WO2001032115A1 (en) | 1999-11-04 | 2001-05-10 | Xel Herbaceuticals | Transdermal administration of huperzine |
| NZ521576A (en) * | 2000-02-29 | 2005-06-24 | Mitsubishi Pharma Corp | Novel cyclic amide derivatives |
| WO2003061658A1 (en) | 2002-01-22 | 2003-07-31 | Eisai Co., Ltd. | Sigma receptor binder containing indanone derivative |
| US20060229316A1 (en) * | 2002-04-01 | 2006-10-12 | Lohray Braj B | Novel antiinfective compounds, process for their preparation and pharmaceutical compositions containing them |
| US7148354B2 (en) | 2002-07-24 | 2006-12-12 | Dr. Reddy's Laboratories Limited | Process for preparation of donepezil |
| US6953856B2 (en) | 2003-02-12 | 2005-10-11 | Usv, Limited | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
| AU2003247158A1 (en) * | 2003-07-01 | 2005-01-21 | Hetero Drugs Limited | Preparation of intermediates for acetyl cholinesterase inhibitors |
| EP1677783A2 (en) * | 2003-10-08 | 2006-07-12 | Nicholas Piramal India Limited | Fibrinogen receptor antagonists and their use |
| WO2005076749A2 (en) | 2004-02-11 | 2005-08-25 | Jubilant Organosys Limited | A novel process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine |
| JP2008280248A (ja) | 2005-11-02 | 2008-11-20 | Eisai R & D Management Co Ltd | アルツハイマー型痴呆症治療薬塩酸ドネペジルのプロドラッグ |
| AU2007203969B2 (en) | 2006-01-04 | 2012-04-05 | Cipla Limited | Process and intermediate for preparation of donepezil |
-
2007
- 2007-12-11 CA CA002672212A patent/CA2672212A1/en not_active Abandoned
- 2007-12-11 US US12/001,582 patent/US8247563B2/en not_active Expired - Fee Related
- 2007-12-11 NZ NZ578187A patent/NZ578187A/en not_active IP Right Cessation
- 2007-12-11 RU RU2009126589/04A patent/RU2478619C2/ru not_active IP Right Cessation
- 2007-12-11 MX MX2009005795A patent/MX2009005795A/es not_active Application Discontinuation
- 2007-12-11 CN CN200780051019A patent/CN101626688A/zh active Pending
- 2007-12-11 JP JP2009540335A patent/JP2010512328A/ja active Pending
- 2007-12-11 EP EP07867720A patent/EP2114166A4/en not_active Withdrawn
- 2007-12-11 AU AU2007333586A patent/AU2007333586A1/en not_active Abandoned
- 2007-12-11 BR BRPI0720211-3A2A patent/BRPI0720211A2/pt not_active IP Right Cessation
- 2007-12-11 WO PCT/US2007/025392 patent/WO2008073452A1/en not_active Ceased
-
2009
- 2009-05-25 IL IL198921A patent/IL198921A0/en unknown
- 2009-06-17 ZA ZA200904211A patent/ZA200904211B/xx unknown
-
2012
- 2012-06-08 US US13/492,038 patent/US8580822B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8580822B2 (en) | 2013-11-12 |
| EP2114166A4 (en) | 2011-05-25 |
| US20120252842A1 (en) | 2012-10-04 |
| NZ578187A (en) | 2012-05-25 |
| BRPI0720211A2 (pt) | 2013-12-24 |
| US8247563B2 (en) | 2012-08-21 |
| WO2008073452A8 (en) | 2009-01-22 |
| MX2009005795A (es) | 2009-06-08 |
| CA2672212A1 (en) | 2008-06-19 |
| JP2010512328A (ja) | 2010-04-22 |
| IL198921A0 (en) | 2010-02-17 |
| WO2008073452A1 (en) | 2008-06-19 |
| RU2478619C2 (ru) | 2013-04-10 |
| US20080153878A1 (en) | 2008-06-26 |
| AU2007333586A1 (en) | 2008-06-19 |
| CN101626688A (zh) | 2010-01-13 |
| RU2009126589A (ru) | 2011-01-20 |
| EP2114166A1 (en) | 2009-11-11 |
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