ZA201006422B - Novel method for the production of sulphonylpyrroles as hdac inhibitors - Google Patents

Novel method for the production of sulphonylpyrroles as hdac inhibitors

Info

Publication number: ZA201006422B
Authority: ZA; South Africa
Prior art keywords: sulphonylpyrroles; production; novel method; hdac inhibitors; compound
Prior art date: 2008-03-12

Application number

ZA2010/06422A

Other languages

English (en)

Inventor

Matthias Muller

Bernd Muller

Thomas Maier

Original Assignee

4Sc Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-12

Filing date

2010-09-07

Publication date

2011-10-26

2010-09-07 Application filed by 4Sc Ag filed Critical 4Sc Ag

2011-10-26 Publication of ZA201006422B publication Critical patent/ZA201006422B/en

Links

JRZBWRPPYOMOJE-UHFFFAOYSA-N 2-sulfonylpyrrole Chemical class O=S(=O)=C1C=CC=N1 JRZBWRPPYOMOJE-UHFFFAOYSA-N 0.000 title 1
239000003276 histone deacetylase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
HFBMWMNUJJDEQZ-UHFFFAOYSA-N acryloyl chloride Chemical compound ClC(=O)C=C HFBMWMNUJJDEQZ-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Cardiology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Otolaryngology (AREA)
Psychiatry (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Transplantation (AREA)

ZA2010/06422A 2008-03-12 2010-09-07 Novel method for the production of sulphonylpyrroles as hdac inhibitors ZA201006422B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08004567A EP2100878A1 (en)	2008-03-12	2008-03-12	Novel method for the production of sulphonylpyrroles as HDAC inhibitors
PCT/EP2009/052870 WO2009112529A1 (en)	2008-03-12	2009-03-11	Novel method for the production of sulphonylpyrroles as hdac inhibitors

Publications (1)

Publication Number	Publication Date
ZA201006422B true ZA201006422B (en)	2011-10-26

Family

ID=39639400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA2010/06422A ZA201006422B (en)	2008-03-12	2010-09-07	Novel method for the production of sulphonylpyrroles as hdac inhibitors

Country Status (22)

Country	Link
US (1)	US8785659B2 (2)
EP (2)	EP2100878A1 (2)
JP (1)	JP5530939B2 (2)
KR (1)	KR101571915B1 (2)
CN (1)	CN101970404B (2)
AT (1)	ATE519739T1 (2)
AU (1)	AU2009224623C1 (2)
BR (1)	BRPI0909752B8 (2)
CA (1)	CA2719074C (2)
CY (1)	CY1111994T1 (2)
DK (1)	DK2265580T3 (2)
EA (1)	EA017929B1 (2)
ES (1)	ES2370592T3 (2)
IL (1)	IL207995A (2)
MX (1)	MX2010010015A (2)
NZ (1)	NZ587824A (2)
PL (1)	PL2265580T3 (2)
PT (1)	PT2265580E (2)
SI (1)	SI2265580T1 (2)
UA (1)	UA102091C2 (2)
WO (1)	WO2009112529A1 (2)
ZA (1)	ZA201006422B (2)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2100882A1 (en) *	2008-03-12	2009-09-16	4Sc Ag	(E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts
KR20180130565A (ko)	2016-04-14	2018-12-07	4에스체 악티엔게젤샤프트	아시아 환자에서의 레스미노스타트의 의학적 적용
TW201912183A (zh)	2017-08-31	2019-04-01	德商４Ｓｃ製藥公司	Hdac抑制劑與抗代謝藥劑組合用於癌症治療

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4960787A (en)	1989-02-06	1990-10-02	Ciba-Geigy Corporation	Certain pyrrolyl-substituted hydroxamic acid derivatives
EP0570594B1 (en)	1991-12-10	1997-07-30	Shionogi & Co., Ltd.	Hydroxamic acid derivative based on aromatic sulfonamide
WO1996038418A1 (en)	1995-06-02	1996-12-05	G.D. Searle & Co.	Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
DK1725528T3 (da)	2004-03-11	2013-09-02	4Sc Ag	Sulfonylpyrroler som hdac-inhibitorer
PT1861365E (pt) *	2005-03-15	2009-09-22	4Sc Ag	N-sulfonilpirroles e a sua utilização como inibidores de histona-desacetilase
PT1928872E (pt)	2005-09-21	2012-05-25	4Sc Ag	Utilização de novos sulfonilpirroles como inibidores de hdacs
JP5305909B2 (ja)	2005-09-21	2013-10-02	フォーエスシーアクチエンゲゼルシャフト	ヒストンデアセチラーゼインヒビターとしてのスルホニルピロール塩酸塩

2008
- 2008-03-12 EP EP08004567A patent/EP2100878A1/en not_active Ceased
2009
- 2009-03-11 DK DK09721108.0T patent/DK2265580T3/da active
- 2009-03-11 JP JP2010550194A patent/JP5530939B2/ja active Active
- 2009-03-11 US US12/921,928 patent/US8785659B2/en active Active
- 2009-03-11 PL PL09721108T patent/PL2265580T3/pl unknown
- 2009-03-11 MX MX2010010015A patent/MX2010010015A/es active IP Right Grant
- 2009-03-11 EA EA201001270A patent/EA017929B1/ru not_active IP Right Cessation
- 2009-03-11 NZ NZ587824A patent/NZ587824A/en unknown
- 2009-03-11 CA CA2719074A patent/CA2719074C/en active Active
- 2009-03-11 KR KR1020107020293A patent/KR101571915B1/ko active Active
- 2009-03-11 AT AT09721108T patent/ATE519739T1/de active
- 2009-03-11 PT PT09721108T patent/PT2265580E/pt unknown
- 2009-03-11 AU AU2009224623A patent/AU2009224623C1/en active Active
- 2009-03-11 UA UAA201011865A patent/UA102091C2/ru unknown
- 2009-03-11 CN CN2009801082773A patent/CN101970404B/zh active Active
- 2009-03-11 BR BRPI0909752A patent/BRPI0909752B8/pt active IP Right Grant
- 2009-03-11 ES ES09721108T patent/ES2370592T3/es active Active
- 2009-03-11 SI SI200930103T patent/SI2265580T1/sl unknown
- 2009-03-11 EP EP09721108A patent/EP2265580B1/en active Active
- 2009-03-11 WO PCT/EP2009/052870 patent/WO2009112529A1/en not_active Ceased
2010
- 2010-09-05 IL IL207995A patent/IL207995A/en active IP Right Grant
- 2010-09-07 ZA ZA2010/06422A patent/ZA201006422B/en unknown
2011
- 2011-11-03 CY CY20111101060T patent/CY1111994T1/el unknown

Also Published As

Publication number	Publication date
NZ587824A (en)	2012-05-25
BRPI0909752A2 (pt)	2015-10-06
EA201001270A1 (ru)	2011-04-29
AU2009224623C1 (en)	2014-01-23
EA017929B1 (ru)	2013-04-30
CN101970404A (zh)	2011-02-09
CY1111994T1 (el)	2015-11-04
UA102091C2 (ru)	2013-06-10
EP2265580B1 (en)	2011-08-10
KR101571915B1 (ko)	2015-11-25
IL207995A (en)	2013-04-30
CA2719074C (en)	2017-01-17
MX2010010015A (es)	2011-04-05
CN101970404B (zh)	2013-05-08
PT2265580E (pt)	2011-11-21
DK2265580T3 (da)	2011-10-31
JP2011513467A (ja)	2011-04-28
PL2265580T3 (pl)	2012-01-31
ES2370592T3 (es)	2011-12-20
EP2265580A1 (en)	2010-12-29
BRPI0909752B1 (pt)	2020-11-24
KR20100121656A (ko)	2010-11-18
CA2719074A1 (en)	2009-09-17
US8785659B2 (en)	2014-07-22
EP2100878A1 (en)	2009-09-16
JP5530939B2 (ja)	2014-06-25
US20110105568A1 (en)	2011-05-05
IL207995A0 (en)	2010-12-30
ATE519739T1 (de)	2011-08-15
SI2265580T1 (sl)	2011-12-30
HK1150319A1 (en)	2011-11-25
WO2009112529A1 (en)	2009-09-17
BRPI0909752B8 (pt)	2021-05-25
AU2009224623B2 (en)	2013-07-18
AU2009224623A1 (en)	2009-09-17

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