ZA795561B - 6-arylpyridazin-3-ones - Google Patents

6-arylpyridazin-3-ones

Info

Publication number: ZA795561B
Authority: ZA; South Africa
Prior art keywords: alkyl; biphenylyl; arylpyridazin; ones; phenoxyphenyl
Prior art date: 1978-10-19

Application number

ZA00795561A

Other languages

English (en)

Inventor

D Orth

H Kurmeier

E Schacht

R Lissner

J Gante

G Melzer

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-19

Filing date

1979-10-18

Publication date

1980-09-24

1979-10-18 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1980-09-24 Publication of ZA795561B publication Critical patent/ZA795561B/xx

Links

-1 4-biphenylyl Chemical group 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

ZA00795561A 1978-10-19 1979-10-18 6-arylpyridazin-3-ones ZA795561B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19782845456 DE2845456A1 (de)	1978-10-19	1978-10-19	6-arylpyridazin-3-one und verfahren zu ihrer herstellung

Publications (1)

Publication Number	Publication Date
ZA795561B true ZA795561B (en)	1980-09-24

Family

ID=6052528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA00795561A ZA795561B (en)	1978-10-19	1979-10-18	6-arylpyridazin-3-ones

Country Status (12)

Country	Link
US (1)	US4289774A (fr)
EP (1)	EP0010156B1 (fr)
JP (1)	JPS5557570A (fr)
AT (1)	ATE1624T1 (fr)
AU (1)	AU532749B2 (fr)
CA (1)	CA1134826A (fr)
DE (2)	DE2845456A1 (fr)
ES (1)	ES485153A1 (fr)
HU (1)	HU180264B (fr)
IL (1)	IL58473A (fr)
YU (1)	YU252479A (fr)
ZA (1)	ZA795561B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3124699A1 (de) *	1981-06-24	1983-01-13	Basf Ag, 6700 Ludwigshafen	Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3321012A1 (de) *	1983-06-10	1984-12-13	A. Nattermann & Cie GmbH, 5000 Köln	Substituierte 4,5-dihydro-6-(thien-2-yl)-3(2h)-pyridazinone und 6-(thien-2-yl)-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung
US4631279A (en) *	1984-10-15	1986-12-23	Eli Lilly And Company	6-(pyridinylphenyl)dihydropyridazinones as inotropic agents
EP0210530A1 (fr) *	1985-07-27	1987-02-04	MERCK PATENT GmbH	6-Arylalcénylpyridazinones
US4806535A (en) *	1987-07-22	1989-02-21	Rorer Pharmaceutical Corporation	Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds and their use for increasing cardiatonic contractility
GB8824458D0 (en) *	1988-10-19	1988-11-23	Orion Yhtymae Oy	Substituted pyridazinones
DE19514568A1 (de) *	1995-04-20	1996-10-24	Merck Patent Gmbh	Arylalkyl-pyridazinone
BR9806752A (pt) *	1997-01-15	2000-03-14	Byk Gulden Lomberg Chem Fab	Ftalazinonas.
US7074959B2 (en) *	2002-08-01	2006-07-11	New Mexico Highlands University	Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces
WO2013097052A1 (fr)	2011-12-30	2013-07-04	Abbott Laboratories	Inhibiteurs de bromodomaine
AU2012382373A1 (en)	2012-06-12	2014-12-11	Abbvie Inc.	Pyridinone and pyridazinone derivatives
PT3442972T (pt)	2016-04-15	2020-05-29	Abbvie Inc	Inibidores de bromodomínio

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1670683A1 (de) *	1966-03-31	1970-01-02	Bayer Ag	Verfahren zur Herstellung neuartiger Arylaether
FR1604863A (fr) *	1967-11-22	1972-04-17
US3689652A (en) *	1970-10-09	1972-09-05	William Vincent Curran	Method of lowering blood pressure in mammals
US3822260A (en) *	1970-10-09	1974-07-02	American Cyanamid Co	6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones
GB1383906A (en) *	1971-02-22	1974-02-12	Bdh Pharmaceuticals Ltd	Pyridazinones
US4088762A (en) *	1971-02-22	1978-05-09	Bdh Pharmaceuticals Limited	6-(P-PIPERAZINO)-PHENYL-4,5-DIHYDRO-3(2H)pyridazinones
US3812256A (en) *	1971-06-08	1974-05-21	American Cyanamid Co	Novel method for lowering blood pressure in mammals
US3840662A (en) *	1971-08-05	1974-10-08	Shimamoto Takio	Method of treating atherosclerosis using 4-hydroxymethyl-1-keto-1,2-dihydrophthalazine or acid salts thereof
GB1488330A (en) *	1973-12-19	1977-10-12	Smith Kline French Lab	Dihydropyridazinones
DE2435244A1 (de)	1974-07-22	1976-02-05	Lentia Gmbh	Verfahren zur herstellung von 3-phenylpyridazonen
JPS6037101B2 (ja) *	1977-03-09	1985-08-24	三共株式会社	フエニルピリダジノン誘導体の製法

1978
- 1978-10-19 DE DE19782845456 patent/DE2845456A1/de not_active Withdrawn
1979
- 1979-09-12 EP EP79103396A patent/EP0010156B1/fr not_active Expired
- 1979-09-12 AT AT79103396T patent/ATE1624T1/de not_active IP Right Cessation
- 1979-09-12 DE DE7979103396T patent/DE2963814D1/de not_active Expired
- 1979-10-16 IL IL58473A patent/IL58473A/xx unknown
- 1979-10-17 YU YU02524/79A patent/YU252479A/xx unknown
- 1979-10-18 ES ES485153A patent/ES485153A1/es not_active Expired
- 1979-10-18 CA CA000337906A patent/CA1134826A/fr not_active Expired
- 1979-10-18 AU AU51933/79A patent/AU532749B2/en not_active Ceased
- 1979-10-18 ZA ZA00795561A patent/ZA795561B/xx unknown
- 1979-10-19 HU HU79ME2311A patent/HU180264B/hu unknown
- 1979-10-19 US US06/086,604 patent/US4289774A/en not_active Expired - Lifetime
- 1979-10-19 JP JP13428379A patent/JPS5557570A/ja active Pending

Also Published As

Publication number	Publication date
DE2845456A1 (de)	1980-08-14
ES485153A1 (es)	1980-05-16
AU5193379A (en)	1980-04-24
EP0010156B1 (fr)	1982-10-06
CA1134826A (fr)	1982-11-02
IL58473A (en)	1985-07-31
EP0010156A1 (fr)	1980-04-30
US4289774A (en)	1981-09-15
IL58473A0 (en)	1980-01-31
DE2963814D1 (en)	1982-11-11
JPS5557570A (en)	1980-04-28
YU252479A (en)	1983-01-21
HU180264B (en)	1983-02-28
AU532749B2 (en)	1983-10-13
ATE1624T1 (de)	1982-10-15

Publication	Publication Date	Title
IL58473A0 (en)	1980-01-31	6-arylpyridazin-3-ones
SE7908727L (sv)	1980-06-12	Fosfinylalkanoylproliner
EP0123935A3 (en)	1986-01-22	Alkoxysilyl functional silicones
GR79661B (fr)	1984-10-31
ES445928A1 (es)	1977-05-01	Procedimiento para la preparacion de compuestos de imidazo- linio cuaternarios.
DE3061903D1 (en)	1983-03-17	Maytansinoids, their production and therapeutic compositions containing them
ES517981A0 (es)	1983-09-01	Un procedimiento de desdoblamiento de compuestos hemiacetilicos.
FI823458A0 (fi)	1982-10-11	Substituerade tiazolidinylestrar av mineralsyror
DE3264928D1 (en)	1985-08-29	Process for producing brominated 1,3-dioxolen-2-ones
DE3560110D1 (en)	1987-05-07	Derivatives of 2-alkoxyaminosulfonylbenzenesulfonylurea
EG17841A (en)	1990-08-30	New-benzotriazoles the preparation thereof and their use as fungicides
ES469896A1 (es)	1979-01-01	Procedimiento para la obtencion de derivados de la hidroxi-4tiazolinationa-2
JPS55164633A (en)	1980-12-22	Stabilized halogenated hydrocarbon composition
JPS57142982A (en)	1982-09-03	N-substituted polyglycidylurazole compound, manufacture and use
IL63747A0 (en)	1981-12-31	New cardenolide bis-digitoxosides,processes for the preparation thereof and pharmaceutical compositions containing them
FR2378519A1 (fr)	1978-08-25
GB1492380A (en)	1977-11-16	Substituted trithiolans and their use as flavouring agent
ES2119375T3 (es)	1998-10-01	Agentes tensioactivos.
JPS56142228A (en)	1981-11-06	Manufacture of chlorophenols
PH18551A (en)	1985-08-09	Fluorophenoxybenzyl esters and the composition containing same
ZA851771B (en)	1985-10-30	Novel carbacyclins,processes for their production and their use as medicinal agents
GB1090608A (en)	1967-11-08	Fungicidal compounds of n-cyanoalkyl haloacetamides and fungicidal compositions
FR2375209A1 (fr)	1978-07-21	Azetidin-2-ones substituees antibiotiques
KR830001863A (ko)	1983-05-19	아미드 유도체의 제조방법