ZA797054B - Pharmaceutically active compounds - Google Patents

Pharmaceutically active compounds

Info

Publication number
ZA797054B
ZA797054B ZA00797054A ZA797054A ZA797054B ZA 797054 B ZA797054 B ZA 797054B ZA 00797054 A ZA00797054 A ZA 00797054A ZA 797054 A ZA797054 A ZA 797054A ZA 797054 B ZA797054 B ZA 797054B
Authority
ZA
South Africa
Prior art keywords
active compounds
pharmaceutically active
pharmaceutically
compounds
active
Prior art date
Application number
ZA00797054A
Other languages
English (en)
Inventor
M Hadley
F King
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of ZA797054B publication Critical patent/ZA797054B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA00797054A 1978-12-30 1979-12-28 Pharmaceutically active compounds ZA797054B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB7850380 1978-12-30
GB7909262 1979-03-15
GB7927831 1979-08-09

Publications (1)

Publication Number Publication Date
ZA797054B true ZA797054B (en) 1980-12-31

Family

ID=27260652

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00797054A ZA797054B (en) 1978-12-30 1979-12-28 Pharmaceutically active compounds

Country Status (14)

Country Link
US (5) US4273778A (da)
EP (3) EP0013138B1 (da)
AR (1) AR225301A1 (da)
AT (1) ATE24320T1 (da)
AU (2) AU527837B2 (da)
CA (2) CA1218062A (da)
DE (3) DE2967692D1 (da)
DK (1) DK553979A (da)
ES (1) ES487379A0 (da)
IE (2) IE49737B1 (da)
IL (1) IL59004A0 (da)
MX (1) MX6255E (da)
NZ (1) NZ192476A (da)
ZA (1) ZA797054B (da)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
FR2476088A2 (fr) * 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
US4424358A (en) 1979-01-16 1984-01-03 Delalande S.A. β-3-Amino nor-tropane compounds
IL61642A0 (en) * 1979-12-20 1981-01-30 Beecham Group Ltd Aniline derivatives,their preparation and pharmalceutical compositions containing them
US4416683A (en) * 1980-09-16 1983-11-22 Eli Lilly And Company Benzamides, compositions and agricultural method
US4943634A (en) * 1980-09-16 1990-07-24 Eli Lilly And Company N-heterocyclic benzamides
US5086184A (en) * 1980-09-16 1992-02-04 Dowelanco N-heterocyclic benzamides
FR2493848B2 (fr) 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
NZ199080A (en) * 1980-12-12 1984-07-31 Beecham Group Ltd 2-alkoxy-4-amino-5-alkylsulphonyl-n-(3beta-(8-hydrocarbyl-8-azabicyclo (3,2,1)octyl))benzamides
US4430435A (en) 1980-12-24 1984-02-07 Burroughs Wellcome Co. Assay system
EP0057536A1 (en) * 1981-01-26 1982-08-11 Beecham Group Plc Pharmaceutically active compounds
US4353922A (en) * 1981-03-13 1982-10-12 Syntex (U.S.A.) Inc. Anticholinergic bronchodilators
EP0067565A1 (en) * 1981-06-16 1982-12-22 Beecham Group Plc Pharmaceutically active compounds
EP0067615B1 (en) * 1981-06-17 1986-01-08 Beecham Group Plc Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions
EP0069481A1 (en) * 1981-06-17 1983-01-12 Beecham Group Plc Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them
EP0068699A1 (en) * 1981-06-22 1983-01-05 Beecham Group Plc Decahydroquinolyl benzamides, process for their preparation and pharmaceutical compositions containing them
EP0068700A1 (en) * 1981-06-29 1983-01-05 Beecham Group Plc Azobicycloalkylbenzamides, process for their preparation and pharmaceutical compositions containing them
EP0069482A1 (en) * 1981-06-29 1983-01-12 Beecham Group Plc Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them
GB2111479A (en) * 1981-10-01 1983-07-06 Beecham Group Plc Benzamides
EP0083737A1 (en) * 1981-12-15 1983-07-20 Beecham Group Plc N-azabicycloalkane benzamides, process for their preparation and pharmaceutical compositions containing them
EP0093488A3 (en) * 1982-03-18 1984-05-23 Beecham Group Plc Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them
IE56226B1 (en) * 1982-04-14 1991-05-22 Beecham Group Plc Substituted azabicyclo compounds,process for their preparation and pharmaceutical compositions containing them
ZA832549B (en) * 1982-04-14 1988-09-28 Beecham Group Plc Pharmaceutically active compounds
EP0095262B1 (en) * 1982-05-11 1986-12-03 Beecham Group Plc Azabicycloalkane derivatives, their preparation and medicaments containing them
AU1508183A (en) * 1982-06-04 1983-12-08 Beecham Group Plc Benzamide and anilide derivatives of 8-azabicyclo-(3.2.1)- -octane
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
EP0099194A3 (en) * 1982-07-03 1984-04-11 Beecham Group Plc Novel benzamides
JPS5936675A (ja) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
EP0101641A3 (en) * 1982-07-22 1984-03-28 Beecham Group Plc Sulfonylamino-aza-bicyclo-alkyl derivatives
EP0102195A3 (en) * 1982-08-03 1984-04-11 Beecham Group Plc Substituted aza bicycloalkyl derivatives with dopamine antagonist activity
EP0126087A1 (en) * 1982-09-24 1984-11-28 Beecham Group Plc Amino-azabicycloalkyl derivatives as dopamine antagonists
GB8302483D0 (en) * 1983-01-29 1983-03-02 Beecham Group Plc Compounds
FR2546169B1 (fr) * 1983-05-20 1986-03-21 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique
GB8317597D0 (en) * 1983-06-29 1983-08-03 Beecham Group Plc Pharmaceutical compounds
FR2548666A1 (fr) * 1983-07-08 1985-01-11 Delalande Sa Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique
DE3429830A1 (de) * 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach Automatische carbonsaeure- und sulfonsaeureester oder -amide
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
DE3581725D1 (de) * 1984-12-14 1991-03-14 Hoechst Roussel Pharma Aminoacyllabdane, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE86110T1 (de) * 1984-12-20 1993-03-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
US4698217A (en) * 1985-02-26 1987-10-06 Mobil Oil Corporation Crystalline silicate ZSM-58 and process for its preparation using a methyltropinium cation
EP0385517B1 (en) * 1985-03-14 1993-04-14 BEECHAM GROUP plc Medicaments for the treatment of emesis
GB8516371D0 (en) * 1985-06-28 1985-07-31 Beecham Group Plc Compounds
GB8518236D0 (en) * 1985-07-19 1985-08-29 Beecham Group Plc Compounds
EP0220011A3 (en) * 1985-10-12 1990-01-03 Beecham Group Plc Use of azabicloalkylbenzamides in the treatment of gastrointestinal motility disorders, migraine, emesis, cluster headaches, trigeminal neuralgia and arrhythmia
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
AT396870B (de) * 1986-08-07 1993-12-27 Sandoz Ag Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
DE3629598A1 (de) * 1986-08-30 1988-03-03 Boehringer Ingelheim Kg 3-brom-2,6-dimethoxibenzamide, ihre herstellung und verwendung
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
US4992546A (en) * 1987-07-31 1991-02-12 Warner-Lambert Company Process for preparing 6,8-diazabicyclo[3.2.2]nonane derivatives
US4968799A (en) * 1987-07-31 1990-11-06 Warner-Lambert Company Antibacterial agents
US4923879A (en) * 1987-07-31 1990-05-08 Warner-Lambert Company 1,8-Naphthyridines and their use as antibacterial agents
GB8727989D0 (en) * 1987-11-30 1988-01-06 Merck Sharp & Dohme Therapeutic agents
US5880260A (en) * 1988-11-18 1999-03-09 Oregon Health Sciences University Dopamine receptors and genes
WO1990005780A1 (en) * 1988-11-18 1990-05-31 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Dopamine receptors and genes
US4920219A (en) * 1988-11-29 1990-04-24 Rorer Pharmaceutical Corp. Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents
US5070094A (en) * 1989-09-05 1991-12-03 G. D. Searle & Co. N-benzyltropaneamides
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
EP0494140A4 (en) * 1989-09-27 1992-09-02 Rorer International (Holdings), Inc. Dibenzofurancarboxamides
US5223613A (en) * 1990-04-27 1993-06-29 G. D. Searle & Co. Azatetracycle compounds and process of preparing same
US5140023A (en) * 1990-04-27 1992-08-18 G. D. Searle & Co. Azatetracycle compounds
US5236932A (en) * 1990-07-19 1993-08-17 E. R. Squibb & Sons, Inc. Method for treating Parkinson's disease employing quinine
US5240146A (en) * 1990-12-14 1993-08-31 Smedley William H Variable proportion dispenser
MX9102686A (es) * 1990-12-27 1994-01-31 Erba Carlo Spa Carboxamidas de dihidrobenzofurano y proceso para su preparacion.
WO1992012149A1 (en) * 1991-01-09 1992-07-23 Smithkline Beecham Plc Azabicydic and azatricydic derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
US5395832A (en) * 1991-02-15 1995-03-07 Hokuriku Seiyaku Co., Ltd. Benzamide derivatives
US5227377A (en) * 1991-03-07 1993-07-13 G. D. Searle & Co. Meso-azacyclic amides of certain bicyclic carboxylic acids
US5137893A (en) * 1991-03-07 1992-08-11 G. D. Searle & Co. Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
US5196547A (en) * 1991-03-07 1993-03-23 G. D. Searle & Co. Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
US5234921A (en) * 1991-03-07 1993-08-10 G. D. Searle & Co. Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof as pharmaceuticals
EP0528026A1 (en) * 1991-03-07 1993-02-24 G.D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
US5219850A (en) * 1991-03-07 1993-06-15 G. D. Searle & Co. Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
US5260303A (en) * 1991-03-07 1993-11-09 G. D. Searle & Co. Imidazopyridines as serotonergic 5-HT3 antagonists
US5516782A (en) * 1991-03-07 1996-05-14 G. D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
PH31171A (en) * 1992-02-04 1998-03-20 Esai Co Ltd Aminobenzonic acid derivatives useful for treatinggastrointestinal conditions.
IT1255467B (it) * 1992-07-29 1995-11-02 Dompe Farmaceutici Spa Ammidi acriliche farmacologicamente attive
GB9404055D0 (en) * 1994-03-03 1994-04-20 Smithkline Beecham Plc Novel process
US5625065A (en) * 1994-06-27 1997-04-29 Eli Lilly And Company Stereoselective process for making endo-tropanamine and like compounds
GB9414900D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Plc Novel process
CA2289576A1 (en) 1997-05-30 1998-12-03 Neurosearch A/S Azacyclooctane and heptane derivatives, their preparation and use in therapy
DK0984966T3 (da) 1997-05-30 2003-05-05 Neurosearch As 9-azabicyclo[3.3.1]non-2-en derivater, som er cholinerge ligander på nikotin-ACh receptorer
UA58476C2 (uk) 1997-10-09 2003-08-15 Санофі-Сентелябо Похідні 8-азабіцикло[3.2.1]октан-3-метанаміну, фармацевтична композиція та лікарський засіб
FR2769628B1 (fr) * 1997-10-09 1999-11-12 Synthelabo Derives de n-(2,3-dihydro-1h-inden-2-yl)-n-propyl-8- azabicyclo[3.2.1.]octane-3-methanamine, leur preparation et leur application en therapeutique
IT1313660B1 (it) * 1999-10-01 2002-09-09 Dompe Spa Procedimento stereoselettivo per la preparazione di endo-3-amminoazabicicloalcani.
FR2831884B1 (fr) 2001-11-02 2003-12-26 Pf Medicament Nouveaux derives amides heteroaromatiques de 3 beta-amino azabicyclooctane, leur procede de preparation et leurs applications en therapeutique
HUP0202001A2 (hu) * 2002-06-14 2005-08-29 Sanofi-Aventis DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
AU2003276919B2 (en) 2002-09-25 2013-05-16 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
CA2516634A1 (en) 2003-02-27 2004-09-10 F. Hoffmann-La Roche Ag Ccr-3 receptor antagonists
DE602004010299T2 (de) 2003-12-22 2008-09-18 Memory Pharmaceuticals Corp. Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen
RU2417225C2 (ru) 2004-03-25 2011-04-27 Мемори Фармасьютиклз Корпорейшн Индазолы, бензотиазолы, бензоизотиазолы, бензизоксазолы и их получение и применение
JP2007534692A (ja) 2004-04-22 2007-11-29 メモリー・ファーマシューティカルズ・コーポレイション インドール、１ｈ−インダゾール、１，２−ベンズイソキサゾール、１，２−ベンゾイソチアゾール、ならびにその調製および使用
JP2007538011A (ja) 2004-05-07 2007-12-27 メモリー・ファーマシューティカルズ・コーポレイション １ｈ−インダゾール、ベンゾチアゾール、１，２−ベンゾイソキサゾール、１，２−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用
BRPI0517494A (pt) 2004-12-22 2008-10-14 Memory Pharm Corp composto, composição farmacêutica, método de ativação/estimulação seletiva de receptores nicotìnicos de a-7 em um paciente em que tal ativação/estimulação tem um efeito terapêutico, método de tratamento de um paciente que sofre de uma doença psicótica, uma doença neurodegenerativa que envolve uma disfunção do sistema colinérgico, e/ou uma condição de debilitação da memória e/ou da cognição, método de tratamento de um paciente que sofre de demência e/ou uma outra condição com perda da memória, método de tratamento de um paciente que sofre de debilitação da memória devido à debilitação cognitiva suave devido ao envelhecimento, mal de alzheimer, esquizofrenia, mal de parkinson, mal de huntington, mal de pick, mal de creutzfeldt-jakob, depressão, envelhecimento, trauma na cabeça, acidente vascular cerebral, hipoxia do snc, senilidade cerebral, demência de multiinfarto, hiv e/ou doença cardiovascular, método de tratamento e/ou prevenção da demência em um paciente com o mal de alzheimer, método de tratamento de um paciente para cortar o vìcio do álcool ou o tratamento de um paciente com a terapia anti-intoxicação, método de tratamento de um paciente para propiciar neuroproteção contra os danos associados com acidentes vasculares cerebrais e isquemia e excitotoxicidade induzida por glutamatos, método de tratamento de um paciente que sofre do vìcio da nicotina, dor, tontura do fuso horário, obesidade e/ou diabetes, método de indução do ato de parar fumar em um paciente, método de tratamento de um paciente que sofre de debilitação cognitiva suave (mci), demência vascular (vad), declìnio cognitivo associado com a idade (aacd), amnésia associada com a cirurgia com o coração aberto, parada cardìaca, anestesia geral, deficiências da memória devido à exposição a agentes anestésicos, debilitação cognitiva induzida pela privação do sono, sìndrome de fadiga crÈnica, narcolepsia, demência relacionada com a aids, debilitação cognitiva relacionada com a epilepsia, sìndrome de down, demência relacionada ao alcoolismo, debilitações da memória induzidas por drogas/substáncias, demência pugilìstica (sìndrome do boxeador), ou demência animal, método para o tratamento da perda da memória, método para o tratamento de um paciente que sofre de debilitação da memória, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da disfunção da transmissão do receptor nicotìnico de acetilcolina em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante de receptores nicotìnicos de acetilcolina defeituosos ou funcionando mal em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da transmissão suprimida do receptor nicotìnico de acetilcolina em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da perda de sinapses colinérgicas em um paciente, método para a proteção dos neurÈnios em um paciente com neurotoxicidade induzi
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
CA2721099C (en) 2008-04-11 2017-04-25 Janssen Pharmaceutica Nv Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase
NZ596137A (en) * 2009-05-14 2013-08-30 Janssen Pharmaceutica Nv Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase
CN104860946A (zh) * 2015-05-14 2015-08-26 湖北生物医药产业技术研究院有限公司 Ccr5拮抗剂的制备方法
BR112020015712A2 (pt) 2018-02-05 2020-12-08 Alkermes, Inc. Compostos para tratamento de dor
CN116751196B (zh) * 2023-05-08 2025-08-29 大连万福制药有限公司 一种高效合成马拉维诺中间体n-苄基托品胺的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB774858A (en) * 1954-10-20 1957-05-15 Sandoz Ltd Tropane and -Î-tropane derivatives and process for preparation thereof
GB1593146A (en) * 1976-11-05 1981-07-15 Beecham Group Ltd Octahydro-quinolizinyl benzamide derivatives
IL59004A0 (en) 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
FR2446823A1 (fr) * 1979-01-16 1980-08-14 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
US4424358A (en) * 1979-01-16 1984-01-03 Delalande S.A. β-3-Amino nor-tropane compounds

Also Published As

Publication number Publication date
EP0081054B1 (en) 1986-12-17
EP0013138A1 (en) 1980-07-09
DK553979A (da) 1980-08-15
DE2966476D1 (en) 1984-01-12
DE2967692D1 (de) 1989-12-14
US4705858A (en) 1987-11-10
IE49736B1 (en) 1985-12-11
AR225301A1 (es) 1982-03-15
CA1220473A (en) 1987-04-14
US4599420A (en) 1986-07-08
EP0013138B1 (en) 1983-12-07
IE49737B1 (en) 1985-12-11
EP0220339B1 (en) 1989-11-08
IL59004A0 (en) 1980-03-31
AU527837B2 (en) 1983-03-24
AU543825B2 (en) 1985-05-02
AU5425579A (en) 1980-07-03
EP0220339A1 (en) 1987-05-06
MX6255E (es) 1985-02-15
US4336259A (en) 1982-06-22
ES8101072A1 (es) 1980-12-01
CA1218062A (en) 1987-02-17
US4544660A (en) 1985-10-01
ES487379A0 (es) 1980-12-01
DE2967642D1 (de) 1987-01-29
AU9135182A (en) 1983-03-10
IE792524L (en) 1980-06-30
US4273778A (en) 1981-06-16
ATE24320T1 (de) 1987-01-15
NZ192476A (en) 1982-09-14
EP0081054A3 (en) 1983-08-24
EP0081054A2 (en) 1983-06-15

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