ZA802916B - Analgesic mixture of nalbuphine and acetaminophen - Google Patents

Analgesic mixture of nalbuphine and acetaminophen

Info

Publication number: ZA802916B
Authority: ZA; South Africa
Prior art keywords: nalbuphine; acetaminophen; analgesic mixture; analgesic; mixture
Prior art date: 1979-05-18

Application number

ZA00802916A

Other languages

English (en)

Inventor

J Dudzinski

Original Assignee

Du Pont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-18

Filing date

1980-05-16

Publication date

1981-12-30

1980-05-16 Application filed by Du Pont filed Critical Du Pont

1981-12-30 Publication of ZA802916B publication Critical patent/ZA802916B/xx

Links

RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title 2
230000000202 analgesic effect Effects 0.000 title 1
239000000203 mixture Substances 0.000 title 1
NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 title 1
229960000805 nalbuphine Drugs 0.000 title 1
229960005489 paracetamol Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA00802916A 1979-05-18 1980-05-16 Analgesic mixture of nalbuphine and acetaminophen ZA802916B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/040,281 US4237140A (en)	1979-05-18	1979-05-18	Analgesic mixture of nalbuphine and acetaminophen

Publications (1)

Publication Number	Publication Date
ZA802916B true ZA802916B (en)	1981-12-30

Family

ID=21910135

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA00802916A ZA802916B (en)	1979-05-18	1980-05-16	Analgesic mixture of nalbuphine and acetaminophen

Country Status (12)

Country	Link
US (1)	US4237140A (2)
EP (1)	EP0019282B1 (2)
JP (1)	JPS55154917A (2)
AU (1)	AU529764B2 (2)
CA (1)	CA1139671A (2)
DE (1)	DE3061597D1 (2)
HU (1)	HU178867B (2)
IE (1)	IE49988B1 (2)
IL (1)	IL60095A (2)
NZ (1)	NZ193695A (2)
PH (1)	PH15265A (2)
ZA (1)	ZA802916B (2)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322427A (en) *	1981-04-16	1982-03-30	Bristol-Myers Company	Analgetic compositions and methods of use
US4366159A (en) *	1981-09-08	1982-12-28	Michael Richard Magruder	Nalbuphine-narcotic analgesic composition and method of producing analgesia
US4407805A (en) *	1982-06-30	1983-10-04	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and zomepirac
US4407804A (en) *	1982-06-30	1983-10-04	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and indomethacin
US4404211A (en) *	1982-06-30	1983-09-13	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and flurbiprofen
US4404208A (en) *	1982-06-30	1983-09-13	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and tiflamizole
US4404209A (en) *	1982-06-30	1983-09-13	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and sulindac
US4404210A (en) *	1982-06-30	1983-09-13	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and ibuprofen
US4402962A (en) *	1982-06-30	1983-09-06	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(trifluoromethylsulfonyl)-1H-imidazole
AU565634B2 (en) *	1982-06-30	1987-09-24	E.I. Du Pont De Nemours And Company	Synergistic compositions of nalbuphine and non-narcotic analgesic compounds
US4656177A (en) *	1982-07-22	1987-04-07	Analgesic Associates	Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
ZA835324B (en) *	1982-07-22	1984-09-26	Abraham Sunshine	Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4777174A (en) *	1982-07-22	1988-10-11	Analgesic Associates	Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4600579A (en) *	1983-06-07	1986-07-15	Mallinckrodt, Inc.	N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same
US4722928A (en) *	1985-12-02	1988-02-02	E. I. Du Pont De Nemours And Company	N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes
CA2095523C (en)	1991-09-06	2004-06-22	Robert B. Raffa	Composition comprising a tramadol material and acetaminophen and its use
US5558876A (en) *	1995-03-29	1996-09-24	Alcon Laboratories, Inc.	Topical ophthalmic acidic drug formulations
US6348216B1 (en) *	1996-06-10	2002-02-19	Knoll Pharmaceutical Company	Ibuprofen and narcotic analgesic compositions
US6361794B1 (en)	1996-06-12	2002-03-26	Basf Corporation	Method of making ibuprofen and narcotic analgesic composition
EP1041987B1 (en)	1997-12-22	2006-04-19	Euro-Celtique S.A.	Pharmaceutical oral dosage form comprising a combination of an opioid agonist and naltrexone
US6375957B1 (en)	1997-12-22	2002-04-23	Euro-Celtique, S.A.	Opioid agonist/opioid antagonist/acetaminophen combinations
EP2092936B1 (en)	2000-02-08	2013-03-20	Euro-Celtique S.A.	Tamper-resistant oral opioid agonist formulations
EP1387673B1 (en)	2001-05-11	2010-12-29	Endo Pharmaceuticals Inc.	Abuse-resistant controlled-release opioid dosage form
SI1416842T1 (sl)	2001-07-18	2009-06-30	Euro Celtique Sa	Farmacevtske kombinacije oksikodona in naloksona
US20030044458A1 (en)	2001-08-06	2003-03-06	Curtis Wright	Oral dosage form comprising a therapeutic agent and an adverse-effect agent
IL160222A0 (en) *	2001-08-06	2004-07-25	Euro Celtique Sa	Opioid agonist formulations with releasable and sequestered antagonist
US20030157168A1 (en)	2001-08-06	2003-08-21	Christopher Breder	Sequestered antagonist formulations
HUE032656T2 (en)	2002-04-05	2017-10-30	Euro Celtique Sa	Pharmaceutical composition containing oxicodone and naloxone
CN1703200B (zh)	2002-09-20	2012-02-29	奥尔制药公司	隔离亚单元和相关组合物及方法
US20040202717A1 (en)	2003-04-08	2004-10-14	Mehta Atul M.	Abuse-resistant oral dosage forms and method of use thereof
MY135852A (en)	2003-04-21	2008-07-31	Euro Celtique Sa	Pharmaceutical products
EP1604666A1 (en)	2004-06-08	2005-12-14	Euro-Celtique S.A.	Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1702558A1 (en)	2005-02-28	2006-09-20	Euro-Celtique S.A.	Method and device for the assessment of bowel function
HUE053838T2 (hu) *	2005-08-24	2021-07-28	Endo Pharmaceuticals Inc	Nyújtott felszabadulású nabulfin-készítmények
US8394812B2 (en)	2005-08-24	2013-03-12	Penwest Pharmaceuticals Co.	Sustained release formulations of nalbuphine
SI2719378T1 (sl)	2006-06-19	2016-11-30	Alpharma Pharmaceuticals Llc	Farmacevtski sestavki
US8623418B2 (en)	2007-12-17	2014-01-07	Alpharma Pharmaceuticals Llc	Pharmaceutical composition
SG174286A1 (en)	2009-03-10	2011-10-28	Euro Celtique Sa	Immediate release pharmaceutical compositions comprising oxycodone and naloxone
JP2016525138A (ja)	2013-07-23	2016-08-22	ユーロ−セルティークエス．エイ．	疼痛および腸内ディスバイオシスをもたらす疾患および／または腸内細菌移行に対するリスクを高める疾患に罹患している患者における痛みの治療への使用のためのオキシコドンおよびナロキソンの組み合わせ
PL3639828T3 (pl)	2013-12-24	2022-05-02	Virginia Commonwealth University	Zastosowanie utlenowanych siarczanów cholesterolu (ocs) w leczeniu ostrej niewydolności wątroby
JOP20190094A1 (ar) *	2016-10-27	2019-04-25	Broad Inst Inc	مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh)
WO2019070917A1 (en) *	2017-10-03	2019-04-11	The Schepens Eye Research Institute, Inc.	COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE DEGENERATION OF RETINAL PIGMENT EPITHELIUM AND METHODS USING SAME
EP3846815A4 (en) *	2018-09-03	2022-05-04	Jacob Biotech Ltd	PHARMACEUTICAL PREPARATIONS OF SEBACOYL-DINALBUPHINE AND ACETAMINOPHEN AND METHODS FOR PAIN MANAGEMENT

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL26896A (en) *	1966-01-19	1970-11-30	Endo Lab	14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
US4029798A (en) *	1975-06-02	1977-06-14	Sumitomo Chemical Company, Limited	Analgetic composition
JPS5946205B2 (ja) *	1976-01-01	1984-11-10	科研製薬株式会社	ベンゾイル誘導体を有効成分とする消炎鎮痛剤

1979
- 1979-05-18 US US06/040,281 patent/US4237140A/en not_active Expired - Lifetime
1980
- 1980-05-13 AU AU58351/80A patent/AU529764B2/en not_active Ceased
- 1980-05-13 NZ NZ193695A patent/NZ193695A/en unknown
- 1980-05-15 CA CA000352011A patent/CA1139671A/en not_active Expired
- 1980-05-15 EP EP80102696A patent/EP0019282B1/en not_active Expired
- 1980-05-15 DE DE8080102696T patent/DE3061597D1/de not_active Expired
- 1980-05-16 HU HU80801223A patent/HU178867B/hu not_active IP Right Cessation
- 1980-05-16 IE IE1019/80A patent/IE49988B1/en not_active IP Right Cessation
- 1980-05-16 PH PH24035A patent/PH15265A/en unknown
- 1980-05-16 ZA ZA00802916A patent/ZA802916B/xx unknown
- 1980-05-16 IL IL60095A patent/IL60095A/xx unknown
- 1980-05-17 JP JP6469980A patent/JPS55154917A/ja active Granted

Also Published As

Publication number	Publication date
IE49988B1 (en)	1986-01-22
EP0019282A1 (en)	1980-11-26
CA1139671A (en)	1983-01-18
NZ193695A (en)	1984-05-31
IL60095A (en)	1982-12-31
US4237140A (en)	1980-12-02
JPS55154917A (en)	1980-12-02
AU5835180A (en)	1980-11-20
AU529764B2 (en)	1983-06-16
IE801019L (en)	1980-11-18
IL60095A0 (en)	1980-07-31
DE3061597D1 (en)	1983-02-17
HU178867B (en)	1982-07-28
PH15265A (en)	1982-11-02
EP0019282B1 (en)	1983-01-12
JPH0144684B2 (2)	1989-09-29

Publication	Publication Date	Title
DE3061597D1 (en)	1983-02-17	Analgesic mixture of nalbuphine and acetaminophen
PT81583A (en)	1985-12-01	Process for the preparation of analgesic pharmaceutical compositions containing buprenorphine and natrexone
JPS56890A (en)	1981-01-07	Manufacture of hydrocarbon mixture
ZA849680B (en)	1985-07-31	Analgesic and anti-inflammatory compositions comprising xanthine and methods of using same
IL54795A (en)	1980-10-26	Analgesic compositions comprising substituted bicyclic and spiroaliphatic amines and certain novel compounds of these types
PH17898A (en)	1985-01-25	Analgesic mixture of nalsuphine and isuprofen
GB2134786B (en)	1986-05-08	Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
JPS5592379A (en)	1980-07-12	Phenolglycidylether or isomer mixture of phenolglycidylether and their manufacture
JPS55113749A (en)	1980-09-02	Manufacture of polyaminoopolyaryllpolymethylene type polyamine mixture
ZA804689B (en)	1982-06-30	Method of administering propranolol and novel dosage forms containing same
PH18216A (en)	1985-04-30	Analgesic mixture of nalbuphine and tiflamizole
GB2047534B (en)	1983-04-20	Analgesic and myotonolytic compositions
PH18219A (en)	1985-04-30	Analgesic mixture of nalbuphine and zomepirac
PH17939A (en)	1985-02-11	Analgesic mixture of nalbuphine and indomethacin
IL61039A0 (en)	1980-11-30	Preparation of 1-azolyl-1-phenoxy-alkan-2-ones and 1-azolyl-1-halo-alkan-2-ones used therefor
JPS5645444A (en)	1981-04-25	Manufacture of mixture of 33chloroanthranilic alkylester and 66chloroanthranilic alkylester
ZA802578B (en)	1981-05-27	Preparation of aryl-monourethanes and aryl-polyurethanes
PH17903A (en)	1985-01-25	Analgesic mixture of nalbuphine and sulindac
PH17913A (en)	1985-01-25	Analgesic mixture of nalbuphine and flurbiprofen
IL61273A (en)	1984-02-29	Preparation of anilines and certain novel anilines
ZA801443B (en)	1980-12-31	Process for the preparation of methane and ethane
JPS5616434A (en)	1981-02-17	Manufacture of 22 and 44hydroxybenzylalcohol mixture
JPS5622754A (en)	1981-03-03	Nnmmtrifluoromethylphenylanthranilate of ooalkoxycarbonylphenyl* its manufacture and its use
DE3064277D1 (en)	1983-08-25	Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof
JPS5328037A (en)	1978-03-15	Aluminothermyyreduced mixture and method of using same