ZA806519B - Secondary amines,their preparation and use in pharmaceutical compositions - Google Patents

Secondary amines,their preparation and use in pharmaceutical compositions

Info

Publication number
ZA806519B
ZA806519B ZA00806519A ZA806519A ZA806519B ZA 806519 B ZA806519 B ZA 806519B ZA 00806519 A ZA00806519 A ZA 00806519A ZA 806519 A ZA806519 A ZA 806519A ZA 806519 B ZA806519 B ZA 806519B
Authority
ZA
South Africa
Prior art keywords
preparation
pharmaceutical compositions
secondary amines
methyl
iii
Prior art date
Application number
ZA00806519A
Other languages
English (en)
Inventor
A Ainsworth
D Smith
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of ZA806519B publication Critical patent/ZA806519B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/08Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • C07C51/487Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA00806519A 1979-10-25 1980-10-23 Secondary amines,their preparation and use in pharmaceutical compositions ZA806519B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7937084 1979-10-25

Publications (1)

Publication Number Publication Date
ZA806519B true ZA806519B (en) 1981-10-28

Family

ID=10508767

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00806519A ZA806519B (en) 1979-10-25 1980-10-23 Secondary amines,their preparation and use in pharmaceutical compositions

Country Status (11)

Country Link
US (1) US4329358A (da)
EP (1) EP0028105B1 (da)
JP (1) JPS5681546A (da)
AT (1) ATE2265T1 (da)
CA (1) CA1159467A (da)
DE (1) DE3061693D1 (da)
DK (1) DK452980A (da)
ES (2) ES496267A0 (da)
IL (1) IL61333A0 (da)
NZ (1) NZ195340A (da)
ZA (1) ZA806519B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2965655D1 (en) * 1978-06-28 1983-07-21 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
US4845127A (en) * 1978-07-03 1989-07-04 Eli Lilly And Company Phenethanolamines, compositions containing the same and method for effecting weight control
CA1219865A (en) * 1982-05-14 1987-03-31 Leo Alig Aziridine phenethanolamine derivatives
EP0099707B1 (en) * 1982-07-16 1986-12-10 Beecham Group Plc 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
DE3462789D1 (en) * 1983-08-17 1987-04-30 Beecham Group Plc 2-phenylethylamine derivatives
EP0142102B1 (en) * 1983-11-04 1987-09-23 Beecham Group Plc Tertiary amines
US4602044A (en) * 1983-12-19 1986-07-22 Eli Lilly And Company β-phenethanolamine antiobesity agents
GB8519154D0 (en) * 1985-07-30 1985-09-04 Ici Plc Aromatic ethers
US5198586A (en) * 1987-08-12 1993-03-30 Sanofi Process for the preparation of phenylethanolaminotetralins
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
JPH03154305A (ja) * 1989-11-13 1991-07-02 Jgc Corp 超電導コイルの製造方法
GB8925032D0 (en) * 1989-11-06 1989-12-28 Ici Plc Chemical compounds
GB9111426D0 (en) * 1991-05-28 1991-07-17 Ici Plc Chemical compounds
US5502078A (en) * 1991-05-28 1996-03-26 Zeneca Limited Chemical compounds
US5321036A (en) * 1993-02-10 1994-06-14 Bristol-Myers Squibb Company Thiazole and oxazole-based β3 adrenergic receptor agonists
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE741762A (da) * 1968-11-18 1970-05-19
GB1301134A (en) * 1970-07-18 1972-12-29 Pfizer Ltd SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES
US4086272A (en) * 1970-07-18 1978-04-25 Pfizer Inc. Phenyl-alkanolamine, alkylamine and alpha-aminoalkyl ketone derivatives as heart stimulants
GB1413911A (en) * 1973-08-18 1975-11-12 Pfizer Ltd Preparation of propanolamine derivatives
GB1593651A (en) * 1977-02-03 1981-07-22 Allen & Hanburys Ltd Amides
DK31578A (da) * 1977-02-03 1978-08-04 Allen & Hanburys Ltd Fremgangsmaade til fremstilling af benzenderivater
NZ190854A (en) * 1978-06-28 1984-10-19 Beecham Group Ltd 2-hydroxy-2-phenyl ethylamine derivatives;pharmaceutical compositions
DE2965655D1 (en) * 1978-06-28 1983-07-21 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
IL57671A (en) * 1978-07-03 1982-11-30 Lilly Co Eli Phenethanolamines,process for their preparation and pharmaceutical and animal feed compositions containing the same

Also Published As

Publication number Publication date
DE3061693D1 (en) 1983-02-24
CA1159467A (en) 1983-12-27
NZ195340A (en) 1984-11-09
ES8207124A1 (es) 1982-09-01
IL61333A0 (en) 1980-12-31
EP0028105B1 (en) 1983-01-19
JPS5681546A (en) 1981-07-03
US4329358A (en) 1982-05-11
ATE2265T1 (de) 1983-02-15
DK452980A (da) 1981-04-26
ES507414A0 (es) 1982-09-01
ES8202784A1 (es) 1982-02-16
ES496267A0 (es) 1982-02-16
EP0028105A1 (en) 1981-05-06

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