ZA826022B - Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides - Google Patents

Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides

Info

Publication number: ZA826022B
Authority: ZA; South Africa
Prior art keywords: peptides; thioethers; amido; ethers; carboxyalkyl
Prior art date: 1981-08-21

Application number

ZA826022A

Other languages

English (en)

Inventor

James Walter Ryand

Alfred Chung

Original Assignee

Univ Miami

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-21

Filing date

1982-08-18

Publication date

1983-08-31

1982-08-18 Application filed by Univ Miami filed Critical Univ Miami

1983-08-31 Publication of ZA826022B publication Critical patent/ZA826022B/xx

Links

102000004196 processed proteins & peptides Human genes 0.000 title 2
108090000765 processed proteins & peptides Proteins 0.000 title 2
125000003368 amide group Chemical group 0.000 title 1
125000004181 carboxyalkyl group Chemical group 0.000 title 1
150000002170 ethers Chemical class 0.000 title 1
150000003568 thioethers Chemical class 0.000 title 1
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
150000003949 imides Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)

ZA826022A 1981-08-21 1982-08-18 Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides ZA826022B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US29513781A	1981-08-21	1981-08-21

Publications (1)

Publication Number	Publication Date
ZA826022B true ZA826022B (en)	1983-08-31

Family

ID=23136377

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA826022A ZA826022B (en)	1981-08-21	1982-08-18	Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides

Country Status (9)

Country	Link
EP (1)	EP0073143B1 (de)
JP (1)	JPS58113157A (de)
AT (1)	ATE16602T1 (de)
AU (1)	AU565789B2 (de)
DE (1)	DE3267599D1 (de)
IE (1)	IE54062B1 (de)
IL (1)	IL66596A (de)
NZ (1)	NZ201650A (de)
ZA (1)	ZA826022B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3211676A1 (de) *	1982-03-30	1983-10-06	Hoechst Ag	Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
GB8311286D0 (en) *	1983-04-26	1983-06-02	Searle & Co	Carboxyalkyl peptide derivatives
JPS6034993A (ja) *	1983-05-23	1985-02-22	ユーエスヴイー　フアーマシユーテイカル　コーポレーシヨン	高血圧治療用化合物
US4500518A (en) *	1984-04-19	1985-02-19	E. R. Squibb & Sons, Inc.	Amino thiol dipeptides
US4801721A (en) *	1984-08-16	1989-01-31	Ryan James W	Stereospecific synthesis of carboxyalkyl peptides
GB2167748A (en) *	1984-11-23	1986-06-04	Squibb & Sons Inc	Acylamino hydroxyalkanoyl amino and imino acids and esters
US5859031A (en) *	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
US5801187A (en)	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US5846979A (en)	1997-02-28	1998-12-08	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic esters, amides, thioesters, and ketones
US20010049381A1 (en)	1997-06-04	2001-12-06	Gpl Nil Holdings, Inc.,	Pyrrolidine derivative hair growth compositions and uses
US6274602B1 (en)	1998-06-03	2001-08-14	Gpi Nil Holdings, Inc.	Heterocyclic thioester and ketone hair growth compositions and uses
US6271244B1 (en)	1998-06-03	2001-08-07	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6187784B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Pipecolic acid derivative hair growth compositions and uses
US5945441A (en) *	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6187796B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Sulfone hair growth compositions and uses
EP1085853A1 (de)	1998-06-03	2001-03-28	GPI NIL Holdings, Inc.	Haarwuchszusammensetzungen basiernd auf heterozyklischem ester und amid und anwendungen
US6429215B1 (en)	1998-06-03	2002-08-06	Gpi Nil Holdings, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6172087B1 (en)	1998-06-03	2001-01-09	Gpi Nil Holding, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6331537B1 (en)	1998-06-03	2001-12-18	Gpi Nil Holdings, Inc.	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6384056B1 (en)	1998-08-14	2002-05-07	Gpi Nil Holdings, Inc.	Heterocyclic thioesters or ketones for vision and memory disorders
US6333340B1 (en)	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6339101B1 (en)	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6335348B1 (en)	1998-08-14	2002-01-01	Gpi Nil Holdings, Inc.	Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6376517B1 (en)	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
US6506788B1 (en)	1998-08-14	2003-01-14	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
JP4584464B2 (ja) *	1999-05-18	2010-11-24	シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ	Ｓ−（−）−クロロコハク酸またはその誘導体からｒ−（−）−カルニチンを調製するための方法
US20090005437A1 (en) *	2004-08-09	2009-01-01	Eyal Gottlieb	Alpha-Ketoglutarates and Their Use as Therapeutic Agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them

1982
- 1982-08-18 ZA ZA826022A patent/ZA826022B/xx unknown
- 1982-08-19 AT AT82304377T patent/ATE16602T1/de not_active IP Right Cessation
- 1982-08-19 DE DE8282304377T patent/DE3267599D1/de not_active Expired
- 1982-08-19 EP EP82304377A patent/EP0073143B1/de not_active Expired
- 1982-08-20 IE IE2016/82A patent/IE54062B1/en unknown
- 1982-08-20 JP JP57144586A patent/JPS58113157A/ja active Pending
- 1982-08-20 AU AU87447/82A patent/AU565789B2/en not_active Ceased
- 1982-08-20 IL IL66596A patent/IL66596A/xx unknown
- 1982-08-20 NZ NZ201650A patent/NZ201650A/en unknown

Also Published As

Publication number	Publication date
EP0073143A3 (en)	1983-04-06
NZ201650A (en)	1986-04-11
IL66596A0 (en)	1982-12-31
EP0073143A2 (de)	1983-03-02
IL66596A (en)	1988-02-29
JPS58113157A (ja)	1983-07-05
DE3267599D1 (en)	1986-01-02
ATE16602T1 (de)	1985-12-15
IE822016L (en)	1983-02-21
EP0073143B1 (de)	1985-11-21
AU8744782A (en)	1983-02-24
IE54062B1 (en)	1989-06-07
AU565789B2 (en)	1987-10-01

Publication	Publication Date	Title
DE3267599D1 (en)	1986-01-02	Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
NZ215008A (en)	1988-11-29	Heterocyclic compounds and herbicidal compositions
ES8501754A1 (es)	1984-12-01	"un metodo de preparacion de nuevas sulfonamidas sustituidas" nota: se solicita como divisional de la patente de invencion n 516.504.
DE3378052D1 (en)	1988-10-27	Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
NZ233735A (en)	1992-10-28	Heterocyclic substituted aminophenol derivatives
MY102705A (en)	1992-09-30	Proline derivaties and related compounds.
ES433835A1 (es)	1976-11-16	Un procedimiento de obtencion de un compuesto de piridini- loxi (tio) fenilurea.
DK0643705T3 (da)	1999-10-25	Fremgangsmåde til fremstilling af N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- og N-beta-hydroxyal
FI853717L (fi)	1986-03-30	3-amino-2-benzoyl- akrylsyraderivat och foerfarande foer deras framstaellning.
NO991637L (no)	1999-06-07	Aminotiazolderivater, fremgangsmÕte ved fremstilling derav og farmas°ytiske blandinger inneholdende disse
IE811582L (en)	1982-01-24	Amide derivatives.
EA200200558A1 (ru)	2002-12-26	2-( 1h-индол-3-ил)-2-оксоацетамиды, обладающие противоопухолевой активностью
AU6822798A (en)	1998-10-12	Cycloalkylalkanecarboxamides and the production and use thereof
GB1424450A (en)	1976-02-11	Isoindoline intermediates
HUP9802407A1 (hu)	1999-04-28	Eljárás kamptotecinszármazékok előállítására, valamint a közbenső termékként szolgáló vegyületek
ATE78163T1 (de)	1992-08-15	Stickstoff enthaltende heterozyklische verbindungen.
EP0660822A1 (de)	1995-07-05	Cyclische benzylamino-, benzylamido- und benzylimido derivate als antipsychotische wirkstoffe.
ES8104226A1 (es)	1981-04-16	Procedimiento para la preparacion de nuevas imidas de acido ciclobutandicarboxilico
CZ281393B6 (cs)	1996-09-11	Způsob výroby 6-(substituovaných amino)-propionyl derivátů forskolinu
ES431552A1 (es)	1977-02-01	Procedimiento para preparar triazinadionas herbicidas.
ES8308875A1 (es)	1983-10-01	Procedimiento para preparar 4-aminometil-5-acil-1,3-dihidro-2h-imidazol-2-onas.
TW336228B (en)	1998-07-11	Substituted biphenyloxazolines the invention relates to substituted biphenyloxazolines
ES8506701A1 (es)	1985-08-01	Un procedimiento para preparar nuevas 5-aminometil-imidazol-1-il-1,3-dialquil-1h-pirazol-4-il-aroil-metanonas
MY105537A (en)	1994-10-30	Preparation process of new thieno-triazolo- diazepine.
ES8601122A1 (es)	1985-11-01	Procedimiento para la obtencion de2-tiocianato-benzamidas