ZA826497B - Derivatives of aminomethyl 1h-indole-4-methanol and their salts,the process and the intermediates of their preparation,their use as medicaments and the compositions containing them - Google Patents

Derivatives of aminomethyl 1h-indole-4-methanol and their salts,the process and the intermediates of their preparation,their use as medicaments and the compositions containing them

Info

Publication number: ZA826497B
Authority: ZA; South Africa
Prior art keywords: formula; product; see diagramm; already indicated; significance
Prior art date: 1981-09-17

Application number

ZA826497A

Other languages

English (en)

Inventor

Jacques Guillaume

Lucien Nedelec

Guy Plassard

Neil Leslie Brown

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-09-17

Filing date

1982-09-06

Publication date

1983-07-27

1982-09-06 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1983-07-27 Publication of ZA826497B publication Critical patent/ZA826497B/xx

Links

-1 of aminomethyl 1h-indole-4-methanol Chemical compound 0.000 title abstract 21
150000003839 salts Chemical class 0.000 title abstract 3
239000003814 drug Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
239000000203 mixture Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 10
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 4
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 4
239000003638 chemical reducing agent Substances 0.000 abstract 3
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 2
229910052794 bromium Inorganic materials 0.000 abstract 2
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
239000000460 chlorine Substances 0.000 abstract 2
229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
229910052740 iodine Chemical group 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
239000011707 mineral Substances 0.000 abstract 2
150000007522 mineralic acids Chemical class 0.000 abstract 2
150000007524 organic acids Chemical class 0.000 abstract 2
235000005985 organic acids Nutrition 0.000 abstract 2
DITHIFQMPPCBCU-UHFFFAOYSA-N propa-1,2-diene Chemical compound [CH]=C=C DITHIFQMPPCBCU-UHFFFAOYSA-N 0.000 abstract 2
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000002475 indoles Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000011987 methylation Effects 0.000 abstract 1
238000007069 methylation reaction Methods 0.000 abstract 1
LEIMLDGFXIOXMT-UHFFFAOYSA-N trimethylsilyl cyanide Chemical compound C[Si](C)(C)C#N LEIMLDGFXIOXMT-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA826497A 1981-09-17 1982-09-06 Derivatives of aminomethyl 1h-indole-4-methanol and their salts,the process and the intermediates of their preparation,their use as medicaments and the compositions containing them ZA826497B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8117560A FR2512817A1 (fr)	1981-09-17	1981-09-17	Nouveaux derives de l'aminomethyl 1h-indole-4-methanol et leurs sels, leur procede de preparation, leur application a titre de medicaments, les compositions les renfermant et leurs intermediaires de preparation

Publications (1)

Publication Number	Publication Date
ZA826497B true ZA826497B (en)	1983-07-27

Family

ID=9262232

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA826497A ZA826497B (en)	1981-09-17	1982-09-06	Derivatives of aminomethyl 1h-indole-4-methanol and their salts,the process and the intermediates of their preparation,their use as medicaments and the compositions containing them

Country Status (14)

Country	Link
EP (1)	EP0076713B1 (de)
JP (1)	JPS5862161A (de)
AT (1)	ATE17347T1 (de)
AU (1)	AU550238B2 (de)
CA (1)	CA1200554A (de)
DE (1)	DE3268423D1 (de)
DK (1)	DK413482A (de)
ES (2)	ES8401463A1 (de)
FI (1)	FI77444C (de)
FR (1)	FR2512817A1 (de)
HU (1)	HU189177B (de)
IE (1)	IE54262B1 (de)
PT (1)	PT75565B (de)
ZA (1)	ZA826497B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2591595B1 (fr) *	1985-12-13	1988-09-09	Roussel Uclaf	Nouveaux derives du 4-morpholinyl 1h-indole, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant, et intermediaires
DE69319551T2 (de) *	1992-12-02	1998-10-29	Kissei Pharmaceutical	Indolin Verbindungen zur Behandlung von Dysurien
FR2792313A1 (fr) *	1999-04-13	2000-10-20	Synthelabo	Derives de 2-aminoethyl-indole, leur preparation et leur application en therapeutique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1532210A (fr) *	1963-06-21	1968-07-12	Ici Ltd	Composés hétérocycliques et leur procédé de préparation
FR2332010A1 (fr) *	1975-11-18	1977-06-17	Continental Pharma	Amino-alcool heterocyclique, son sel et son procede de preparation

1981
- 1981-09-17 FR FR8117560A patent/FR2512817A1/fr active Granted
1982
- 1982-09-06 ZA ZA826497A patent/ZA826497B/xx unknown
- 1982-09-13 AT AT82401660T patent/ATE17347T1/de not_active IP Right Cessation
- 1982-09-13 DE DE8282401660T patent/DE3268423D1/de not_active Expired
- 1982-09-13 EP EP82401660A patent/EP0076713B1/de not_active Expired
- 1982-09-15 PT PT75565A patent/PT75565B/pt not_active IP Right Cessation
- 1982-09-16 HU HU822951A patent/HU189177B/hu not_active IP Right Cessation
- 1982-09-16 DK DK413482A patent/DK413482A/da not_active Application Discontinuation
- 1982-09-16 FI FI823209A patent/FI77444C/fi not_active IP Right Cessation
- 1982-09-16 IE IE2266/82A patent/IE54262B1/en not_active IP Right Cessation
- 1982-09-16 AU AU88452/82A patent/AU550238B2/en not_active Ceased
- 1982-09-16 ES ES515755A patent/ES8401463A1/es not_active Expired
- 1982-09-17 JP JP57161090A patent/JPS5862161A/ja active Pending
- 1982-09-17 CA CA000411657A patent/CA1200554A/fr not_active Expired
1983
- 1983-06-30 ES ES523718A patent/ES523718A0/es active Granted

Also Published As

Publication number	Publication date
FI823209A0 (fi)	1982-09-16
FI823209L (fi)	1983-03-18
EP0076713A1 (de)	1983-04-13
ES515755A0 (es)	1983-12-16
ATE17347T1 (de)	1986-01-15
FI77444C (fi)	1989-03-10
EP0076713B1 (de)	1986-01-08
FI77444B (fi)	1988-11-30
IE822266L (en)	1983-03-17
HU189177B (en)	1986-06-30
ES8403869A1 (es)	1984-04-01
FR2512817B1 (de)	1983-12-30
AU8845282A (en)	1983-03-24
ES523718A0 (es)	1984-04-01
PT75565B (fr)	1985-12-09
IE54262B1 (en)	1989-08-02
AU550238B2 (en)	1986-03-13
DK413482A (da)	1983-03-18
PT75565A (fr)	1982-10-01
DE3268423D1 (en)	1986-02-20
JPS5862161A (ja)	1983-04-13
CA1200554A (fr)	1986-02-11
FR2512817A1 (fr)	1983-03-18
ES8401463A1 (es)	1983-12-16

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